期刊
ORGANIC LETTERS
卷 18, 期 23, 页码 6124-6127出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03131
关键词
-
资金
- National Natural Science Foundation of China [21272074]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)
A copper-catalyzed oxidative dearomatization/spirocyclization of indole-2-carboxamides using tert-butyl hydro peroxide (TBHP) as the oxidant has been developed that provides rapid and efficient access to C2-spiro-pseudoindoxyls. Two of the sp(2) C-H bonds are functionalized during the reaction process, and the reaction likely proceeds via the formation of a highly reactive 3H-indol-3-one intermediate followed by aromatic electrophilic substitution with the N-aryl ring of the amide moiety.
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