4.6 Article

Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-D-glucosaminidases

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ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 12, 页码 3193-3197

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob00297h

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  1. Australian Research Council
  2. University of Western Australia
  3. National Health and Medical Research Council [APP1073250]
  4. Canadian Institute of Health Research [MOP-123341]
  5. Brain Canada
  6. Canada Research Chairs Program

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The synthesis of analogues of the potent N-acetylhexosaminidase inhibitor, PUGNAc, are described. These compounds were assayed against a set of biologically important N-acetyl-D-glucosaminidases and were found to vary in both potency and selectivity.

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