The application of design of experiments (DoE) reaction optimisation and solvent selection in the development of new synthetic chemistry

CHEM21 selection guide of classical- and less classical-solvents

(2016) Denis Prat et al.   GREEN CHEMISTRY

Irreversibleendo-Selective Diels-Alder Reactions of Substituted Alkoxyfurans: A General Synthesis ofendo-Cantharimides

(2015) Robert W. Foster et al.   CHEMISTRY-A EUROPEAN JOURNAL

Optimization of stereoselective Michael addition of 2-(pentan-3-yloxy)acetaldehyde to N-[(Z)-2-nitroethenyl]acetamide with the aid of design of experiments

(2015) Viktória Hajzer et al.   MONATSHEFTE FUR CHEMIE

Exploring a cascade Heck–Suzuki reaction based route to kinase inhibitors using design of experiments

(2015) Andreas Ekebergh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Application of design of experiments (DoE) optimization to the one-pot synthesis of 4,6-dihydropteridinones

(2015) Steven Stone et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

B(OCH2CF3)3-mediated direct amidation of pharmaceutically relevant building blocks in cyclopentyl methyl ether

(2015) Valerija Karaluka et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Kinetic Resolution of Oxazinones: Rational Exploration of Chemical Space through the Design of Experiments

(2014) Polyssena Renzi et al.   CHEMISTRY-A EUROPEAN JOURNAL

A survey of solvent selection guides

(2014) Denis Prat et al.   GREEN CHEMISTRY

Improved synthesis of bioactive stilbene derivatives applying design of experiments to the Heck–Matsuda reaction

(2014) Carla Cristina Perez et al.   NEW JOURNAL OF CHEMISTRY

Design of Experiments (DoE) and Process Optimization. A Review of Recent Publications

(2014) Steven A. Weissman et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

DoE (Design of Experiments) Assisted Allylic Hydroxylation of Enones Catalysed by a Copper-Aluminium Mixed Oxide

(2013) Ana Leticia García-Cabeza et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Selection of a Greener Set of Solvents Evenly Spread in the Hansen Space by Space-Filling Design

(2013) Adrien Benazzouz et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Sanofi’s Solvent Selection Guide: A Step Toward More Sustainable Processes

(2013) Denis Prat et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a Sustainable Catalytic Ester Amidation Process

(2013) Nicola Caldwell et al.   ACS Sustainable Chemistry & Engineering

Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry

(2012) Alan Nadin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tools for characterizing the whole-cell bio-oxidation of alkanes at microscale

(2012) Chris Grant et al.   BIOTECHNOLOGY AND BIOENGINEERING

Evaluation of alternative solvents in common amide coupling reactions: replacement of dichloromethane and N,N-dimethylformamide

(2012) Donna S. MacMillan et al.   GREEN CHEMISTRY

On Hype, Malpractice, and Scientific Misconduct in Organic Synthesis

(2012) Rolf Carlson et al.   HELVETICA CHIMICA ACTA

Green Chemistry is Good Process Chemistry

(2012) Trevor Laird   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Beyond the Numbers: Charting Chemical Reaction Space

(2012) Paul M. Murray et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

(2011) Richard K. Henderson et al.   GREEN CHEMISTRY

Searching for green solvents

(2011) Philip G. Jessop   GREEN CHEMISTRY

An Alternative Approach to Aldol Reactions: Gold-Catalyzed Formation of Boron Enolates from Alkynes

(2010) Cindy Körner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Synthesis of GV143253A: A Case Study for the Use of Analytical and Statistical Tools to Elucidate the Reaction Mechanism and to Optimize the Process

(2010) Giuseppe Guercio et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Isocyanide based multicomponent reactions of oxazolidines and related systems

(2010) Robert W. Waller et al.   TETRAHEDRON

Experimental design in chemistry: A tutorial

(2009) Riccardo Leardi   ANALYTICA CHIMICA ACTA

Solvent subset selection for polymorph screening

(2008) Morten Allesø et al.   JOURNAL OF CHEMOMETRICS

Integration of high speed microwave chemistry and a statistical ‘design of experiment’ approach for the synthesis of the mitotic kinesin Eg5 inhibitor monastrol

(2008) Toma N. Glasnov et al.   TETRAHEDRON

Solvent Diversity in Polymorph Screening

(2007) Morten Allesø et al.   JOURNAL OF PHARMACEUTICAL SCIENCES