期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 43, 页码 10180-10184出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob02079h
关键词
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资金
- National Natural Science Foundation of China (NSFC) [21302046]
- Hundred-Talent Program Fund of Hubei University of Technology
- open project program of Hubei Key Laboratory of Drug Synthesis and Optimization [OPP2015YB02]
A simple and efficient transition-metal-free oxidative halogenation (Cl, Br) of the C5 C-H bond of 8-aminoquinoline amides has been developed. This method employed low-cost and innoxious sodium halides as halogenation reagents and oxone as an oxidant. The reactions demonstrated air and moisture tolerance, and good functional group compatibility, giving highly selective C5-halogenated products in good to excellent yields.
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