Article
Biotechnology & Applied Microbiology
Stephen A. Glover, R. Schumacher
Summary: The binding mechanism of fluorenes or fluorenones with DNA depends on the position of substitution and specific chemical side chains, leading to varying intercalation efficacies; some fluorene derivatives do not intercalate into DNA, possibly due to a different insertion mode; the insertion of certain substances is crucial for the detection of frameshift mutations in S. typhimurium TA98.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2021)
Article
Chemistry, Multidisciplinary
Stephen A. Glover
Summary: This account describes the origins of research on the mutagenicity of N-acyloxy-N-alkoxyamides. The study focuses on their ability to mutate DNA in the Ames reverse mutation assay without the need for metabolic activation. The impact of structural variation on cellular access to, binding to, and reactivity with DNA is explored, with emphasis on hydrophobicity, electrophilic reactivity, steric effects, and intercalation.
AUSTRALIAN JOURNAL OF CHEMISTRY
(2023)
Article
Biochemical Research Methods
Ali Nematollahzadeh, Zeinab Mirzaei-Kalar, Hoda Abolhasani, Aziz Babapoor
Summary: The zinc-naproxen complex as a nano-drug (NanoD) was successfully synthesized using ultrasound assisted processes. The chemicophysical properties of NanoD were studied and its interaction with CT-DNA was investigated. The results showed high cytotoxicity activity of NanoD, especially in the HT-29 cell line, compared to cisplatin.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Steve Vincent, Suman Mallick, Guillaume Barnoin, Hoang-Ngoan Le, Alain Burger, Benoit Y. Michel
Summary: Forced intercalation (FIT) probes are a reliable and rapid method for detecting and imaging specific nucleic acid sequences. A chromone-based fluorogen was successfully incorporated into double-stranded DNA, resulting in a 10-fold increase in fluorescence upon duplex formation. This dye shows promising potential for selective sensing of sequences with a high ON/OFF contrast, making it suitable for bio-imaging applications.
Article
Chemistry, Inorganic & Nuclear
Matthew P. P. Sullivan, Muneebah Adams, Mie Riisom, Caitlin D. D. Herbert, Kelvin K. H. Tong, Jonathan W. W. Astin, Stephen M. F. Jamieson, Muhammad Hanif, David C. C. Goldstone, Christian G. G. Hartinger
Summary: Pt(terpyridine) complexes are known for their ability to intercalate with DNA. The addition of an NHC co-ligand significantly increased the anticancer activity of the complex compared to its chlorido derivative. While the compound showed high efficacy, it was well-tolerated by zebrafish embryos, especially when compared to cisplatin. DNA interaction studies suggest that the mode of action is related to intercalation.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Applied
Bingyong Liu, Jing Li, Wei Yang, Hui Yan, Xike Gao, Qing Zhang
Summary: BODIPY analogues based on naphthalene mono-imides were synthesized and studied for their molecular structures, conformational features, and stacking states. The chelation of boron difluoride was found to affect the optical and redox properties of the dyes, leading to modifications in the electronic structure of the molecules. Field-effect transistors devices using the BODIPY analogues exhibited n-type behavior with electron mobility up to 0.10 cm(2) V-1 s(-1).
Article
Chemistry, Medicinal
Helmy Sakr, Rezk R. Ayyad, Ali A. El-Helby, Mohamed M. Khalifa, Hazem A. Mahdy
Summary: The designed and synthesized triazolophthalazine derivatives showed promising cytotoxic activities against human cancer cell lines by acting as Topo II inhibitors and DNA intercalators, with compound IXb being the most potent counterpart. Additionally, compound IXb demonstrated excellent DNA binding affinity and significant Topo II inhibitory activity, inducing apoptosis and affecting the cell cycle. Molecular docking studies revealed the binding patterns of the designed compounds against the DNA-Topo II complex and DNA.
ARCHIV DER PHARMAZIE
(2021)
Article
Biology
Zorana Milanovic, Drina Jankovic, Sanja Vranjes-Duric, Magdalena Radovic, Zeljko Prijovic, Gordana Zavisic, Marko Peric, Dalibor Stankovic, Marija Mirkovic
Summary: Recent studies have shown promising results in cancer therapy with doxycycline as adjuvant therapy to conventional chemotherapy. The Lu-177-labeled tetracycline ligand, doxycycline hyclate, demonstrated high radiolabeling yield and stability in vitro. Biodistribution studies in CT26 colon tumor-bearing mice showed satisfactory accumulation in the tumor, suggesting potential for further in vivo studies for cancer treatment.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Chemistry, Physical
Bibi Hanifa, Muhammad Sirajuddin, Maciej Kubicki, Edward R. T. Tiekink
Summary: In this study, a series of isomeric 4-[(n-bromophenyl)carbamoyl]butanoic acids were synthesized and their structures were confirmed through various analytical techniques. The compounds showed antimicrobial activity against bacterial and fungal strains and exhibited good potential for bioavailability.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Elena Voloshina, Beate Paulus, Yuriy Dedkov
Summary: The interfaces of graphene with Ru(0001) and Ir(111) were modified using intercalation of a thin Mn layer, leading to the formation of surface alloys between atoms of the guest metal and the substrate. The unique structures formed on both Ru(0001) and Ir(111) interfaces were explained through phase diagram pictures and comparison of calculated total energies.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Adam J. Buric, Jonathan Dickerhoff, Danzhou Yang
Summary: XR5944 is a DNA-targeted agent with potent antitumor activity, featuring a novel DNA binding mode of bis-intercalation and major groove binding, as well as a unique mechanism of action involving transcription inhibition. This novel anticancer compound is the result of two decades of drug discovery by Professor William A. Denny and his colleagues.
Article
Chemistry, Medicinal
Kyung-Hwa Jeon, Seojeong Park, Jae-Ho Shin, Ah-Reum Jung, Soo-Yeon Hwang, Seung Hee Seo, Hyunji Jo, Younghwa Na, Youngjoo Kwon
Summary: Prostate cancer patients often receive AR-targeted drugs, which can lead to castration resistance due to AR amplification. To overcome this resistance, second-generation nonsteroidal antiandrogen drugs such as etoposide and mitoxantrone have been used in combination with enzalutamide. The study found that amplification of topo II alpha was associated with poor clinical outcome in prostate cancer, and a newly synthesized compound, compound 6, showed potential as a topo II alpha catalytic inhibitor.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Environmental Sciences
Kaline de Souza Pereira Godoi, Juliana Caroline Vivian Sposito, Aline do Nascimento Rocha, Liliam Silvia Candido, Caio Augusto Mussury Silva, Ana Paula Lemke, Sandra Verza da Silva, Silvana de Paula Quintao Scalon, Emerson Machado de Carvalho, Rosilda Mara Mussury
Summary: This study aimed to investigate the relationship between micronucleus frequency in Tradescantia pallida and environmental factors as well as cardiorespiratory diseases, in order to infer the impact of air pollution. The results showed a negative correlation between micronucleus frequency and relative humidity, while altitude did not affect the mutagenicity or genotoxicity of the plants studied. Municipalities with higher micronucleus frequencies were associated with increased vehicle traffic and cardiorespiratory diseases, indicating a potential link between vehicular pollution and health issues.
Article
Biochemistry & Molecular Biology
Jiri Holoubek, Klara Bednarova, Jan Haviernik, Ivana Huvarova, Zuzana Dvorakova, Jiri Cerny, Martina Outla, Jiri Salat, Eva Konkol'ova, Evzen Boura, Daniel Ruzek, Michaela Vorlickova, Ludek Eyer, Daniel Renciuk
Summary: We have identified seven potential G4s in the RNA genome of tick-borne encephalitis virus (TBEV), and their stability is critical for efficient TBEV replication. These G4s could be targeted to tackle TBEV infection.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Spectroscopy
Esra Oguzcan, Zeynep Koksal, Tugba Taskin-Tok, Ayse Uzgoren-Baran, Nuriye Akbay
Summary: The interaction type between modafinil and calf thymus DNA was examined using various methods, and the results suggest that modafinil can quench the fluorescence of DNA through both static and dynamic mechanisms. The binding of modafinil with DNA was found to be intercalation, and the docking studies showed that R-modafinil interacts better with DNA. The thermodynamic analysis indicated that the driving forces for the interaction are likely hydrogen bonding or van der Waals forces.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Stephen A. Glover, Adam A. Rosser
CANADIAN JOURNAL OF CHEMISTRY
(2016)
Article
Biotechnology & Applied Microbiology
Stephen A. Glover, Rhiannon R. Schumacher
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2016)
Article
Chemistry, Organic
Ben W. Greatrex, Jan Meisner, Stephen A. Glover, Warwick Raverty
JOURNAL OF ORGANIC CHEMISTRY
(2017)
Article
Crystallography
Richard Betz, Cedric McCleland, Stephen Glover
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE
(2011)
Article
Chemistry, Multidisciplinary
Stephen A. Glover, Meredith Adams
AUSTRALIAN JOURNAL OF CHEMISTRY
(2011)
Article
Chemistry, Multidisciplinary
Stephen A. Glover, Adam A. Rosser, Avat (Arman) Taherpour, Ben W. Greatrex
AUSTRALIAN JOURNAL OF CHEMISTRY
(2014)
Article
Chemistry, Multidisciplinary
Stephen A. Glover, Adam A. Rosser, Robert M. Spence
AUSTRALIAN JOURNAL OF CHEMISTRY
(2014)
Article
Chemistry, Organic
Stephen A. Glover, Adam A. Rosser
JOURNAL OF ORGANIC CHEMISTRY
(2012)
Article
Chemistry, Organic
Stephen A. Glover, Adam A. Rosser
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
(2015)
Article
Chemistry, Organic
Kieran P. Stockton, Stephen A. Glover, Ben W. Greatrex
Review
Biochemistry & Molecular Biology
Stephen A. Glover, Adam A. Rosser
Article
Biotechnology & Applied Microbiology
Stephen A. Glover, R. Schumacher
Summary: The binding mechanism of fluorenes or fluorenones with DNA depends on the position of substitution and specific chemical side chains, leading to varying intercalation efficacies; some fluorene derivatives do not intercalate into DNA, possibly due to a different insertion mode; the insertion of certain substances is crucial for the detection of frameshift mutations in S. typhimurium TA98.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2021)
Article
Chemistry, Multidisciplinary
Stephen A. Glover
Summary: This account describes the origins of research on the mutagenicity of N-acyloxy-N-alkoxyamides. The study focuses on their ability to mutate DNA in the Ames reverse mutation assay without the need for metabolic activation. The impact of structural variation on cellular access to, binding to, and reactivity with DNA is explored, with emphasis on hydrophobicity, electrophilic reactivity, steric effects, and intercalation.
AUSTRALIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Stephen A. Glover
AUSTRALIAN JOURNAL OF CHEMISTRY
(2017)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)