Article
Optics
David Escofet-Martin, Anthony O. Ojo, Brian Peterson
Summary: We demonstrate a multi-photon excitation scheme for luminescence thermometry using ScVO4:Bi3+. The scheme offers advantages in suppressing fluorescence interference and provides similar temperature sensitivity and precision compared to single-photon excitation schemes.
Review
Optics
Aleksandar Ciric, Miroslav D. Dramic
Summary: This article reviews the effects of temperature changes on luminescence and provides advanced and user-friendly software for fitting experimental data and calculating figures of merit for luminescence thermometry.
JOURNAL OF LUMINESCENCE
(2022)
Article
Optics
Shulang Lin, Li Gong, Zhiwei Huang
Summary: This article reports a novel two-photon fluorescence tomography (TPFT) technique that enables super-resolution deeper tissue 3D imaging without the need for z-scanning. By using phase-shifted optical beatings of Bessel beams, the lateral and axial resolutions are improved, and the penetration depth is increased. This method allows for depth-resolved imaging without mechanical depth-scanning.
LASER & PHOTONICS REVIEWS
(2023)
Article
Engineering, Electrical & Electronic
Emanuel P. Santos, Roberta S. Pugina, Eloisa G. Hilario, Alyson J. A. Carvalho, Carlos Jacinto, Francisco A. M. G. Rego-Filho, Askery Canabarro, Anderson S. L. Gomes, Jose Mauricio A. Caiut, Andre L. Moura
Summary: Luminescence thermometry has been widely explored for both fundamental and applied research. Researchers have focused on improving the performance of photoluminescence thermometers by developing new functionalized materials and utilizing automated machine learning tools, achieving higher accuracy and real-time applications.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Engineering, Environmental
K. Elzbieciak-Piecka, M. Suta, L. Marciniak
Summary: This study demonstrates the potential of transition metal ions, such as Cr3+, in remote temperature sensing using ratiometric luminescence thermometry. By co-doping LaScO3:Cr3+ with various lanthanide ions, the luminescence properties can be tuned, affecting the thermal quenching behavior and offering a new approach for potential future applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jun Yang, Hanliang Du, Zhenhao Chai, Zheng Ling, Ben Q. Li, Xuesong Mei
Summary: Fluorescence quantum dots (QDs) functionalized with the membrane transport protein transferrin (Tf) were used as a thermo-sensor specific for tumor cell membrane in this study. Combined with 3D thermal imaging technology, a novel targeted nanoscale 3D thermometry method was proposed to measure the local and global temperature distribution on the tumor cell surface. The method shows potential in measuring temperature distribution across intracellular organelles.
Article
Multidisciplinary Sciences
Xiangyu Ou, Xian Qin, Bolong Huang, Jie Zan, Qinxia Wu, Zhongzhu Hong, Lili Xie, Hongyu Bian, Zhigao Yi, Xiaofeng Chen, Yiming Wu, Xiaorong Song, Juan Li, Qiushui Chen, Huanghao Yang, Xiaogang Liu
Summary: The research demonstrates a flat-panel-free, high-resolution, three-dimensional imaging approach using lanthanide-doped nanomaterials and flexible substrates, termed X-ray luminescence extension imaging.
Article
Nanoscience & Nanotechnology
Joanna Drabik, Lukasz Marciniak
Summary: The luminescence thermometry method utilizes the strong thermal dependence of thermally induced excited state absorption to improve temperature readout parameters, and can be applied for 2D thermal imaging of microelectronic printed circuit boards using the strong color changes exhibited by phosphors.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Optics
Fabian Wagner, Florian Schiffers, Florian Willomitzer, Oliver Cossairt, Andreas Velten
Summary: The development of single-photon counting detectors and arrays has significantly progressed in recent years, particularly in applications such as LIDAR devices. This work presents a 3D imaging device based on real thermal light intensity interferometry, utilizing gated SPAD technology to image a basic 3D scene efficiently. The synchronized photon counting approach proposed in this study allows for the use of more light modes to enhance 3D ranging performance, with advantages including robustness to atmospheric scattering and autonomy through external light sources, making it a promising option for future applications.
Article
Engineering, Environmental
Luyao Pu, Yu Wang, Jiaoyin Zhao, Minkun Jin, Leipeng Li, Panlai Li, Zhijun Wang, Chongfeng Guo, Hao Suo
Summary: A facile hydrothermal method was developed to construct monodispersed candy-like NaY(MoO4)2:Yb3+/Nd3+ micro-thermometers, which exhibited efficient near-infrared anti-stokes luminescence. By leveraging active lattice phonon and phonon-assisted Yb3+ -> Nd3+ energy transfer, the luminescence intensity was greatly enhanced with high sensitivity and resolution for multi-mode thermometry.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Wojciech M. Piotrowski, Riccardo Marin, Maja Szymczak, Emma Martin Rodriguez, Dirk H. Ortgies, Paloma Rodriguez-Sevilla, Miroslav D. Dramicanin, Daniel Jaque, Lukasz Marciniak
Summary: Lifetime-based luminescence thermometry enables accurate deep-tissue monitoring of temperature changes, but short lifetimes and poor brightness limit its performance. A solution to these limitations is the design and optimization of luminescent nanothermometers co-doped with transition metal and lanthanide ions, which exhibit strong near-infrared emission and long temperature-dependent photoluminescence lifetime. These nanothermometers, combined with a custom-made instrument, allow for obtaining 2D thermal maps for deep-tissue thermal mapping. This study provides foundations for the deployment of lifetime-based thermometry for accurate deep-tissue temperature monitoring.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Alexey A. Kalinichev, Aliia Shamsieva, Igor D. Strelnik, Elvira Musina, Erkki Lahderanta, Andrey A. Karasik, Oleg G. Sinyashin, Ilya E. Kolesnikov
Summary: Over the past decade, luminescence thermometry has become one of the fastest growing scientific areas, with many research groups working on designing highly sensitive and accurate thermometers. A study introduced a binuclear helical charged complex as a multimode optical thermometer, utilizing various temperature-dependent parameters for thermal sensing.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Chemistry, Multidisciplinary
David K. Limberg, Ji-Hwan Kang, Ryan C. Hayward
Summary: This study demonstrates a 3D printing method based on TTAP, which utilizes a continuous visible LED light source to achieve submicron resolution. This approach eliminates the need for high-intensity femtosecond laser pulses, offering the potential for low-cost 3D printing with high resolution.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Zhihao Zhang, Huimin Li, Ran Pang, Wenjing Wang, Da Li, Lihong Jiang, Su Zhang, Hongjie Zhang
Summary: Afterglow materials exhibit distinct temperature-dependent luminescence compared to general optical materials due to extra energy transfer paths. These paths significantly impact the intensity and relative intensity of the emission, but are often overlooked. By investigating the influence of these paths on temperature-dependent luminescence, we have arrived at interesting conclusions and comprehensively illustrated their effects on optical thermometry and anti-thermal quenching performance.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Aleksandar Ciric, Stevan Stojadinovic, Zoran Ristic, Ivana Zekovic, Sanja Kuzman, Zeljka Antic, Miroslav D. Dramicanin
Summary: The introduction of luminescent Sm2+-doped gamma-aluminium oxide coatings onto aluminum alloys provides them with thermometric functionality and super sensitivity to temperature changes. These coatings offer excellent temperature resolution and three different methods for temperature read-outs, making them versatile for various luminescence thermometry setups.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Nanoscience & Nanotechnology
Jingke Yao, Tamara Munoz-Ortiz, Francisco Sanz-Rodriguez, Emma Martin Rodriguez, Dirk H. Ortgies, Jose Garcia Sole, Daniel Jaque, Riccardo Marin
Summary: Bi2Se3 nanostructured clusters, prepared via a microwave-assisted method, offer a more affordable alternative to gold nanoshells as contrast agents for optical coherence tomography (OCT). They can be prepared quickly, exhibit strong near-infrared extinction properties, and have a high photon-to-heat conversion efficiency, making them promising candidates for photothermal therapy agents. In vitro studies demonstrate the effectiveness of Bi2Se3 clusters as OCT contrast agents, showing comparable performance to gold nanoshells.
Article
Biochemical Research Methods
Christoph Gerke, Irene Zabala Gutierrez, Diego Mendez-Gonzalez, M. Carmen Iglesias-de la Cruz, Francisca Mulero, Daniel Jaque, Jorge Rubio-Retama
Summary: We present a simple methodology to design a pretargeted drug delivery system based on clickable antibodies and nanoparticles. The system shows high reaction rate constants and bio-orthogonality, making it suitable for in vivo applications.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Physics, Condensed Matter
Gabriel Lopez-Pena, Khouloud Hamraoui, Karima Horchani-Naifer, Christoph Gerke, Dirk H. H. Ortgies, Emma Martin Rodriguez, Guanying Chen, Daniel Jaque, Jorge Rubio Retama
Summary: This study presents a solution to the lack of control over the absolute temperature in thermal therapies by using core-shell-shell nanostructures doped with lanthanide ions. The luminescence lifetime of Yb3+ is used for thermal reading, while the non-radiative deexcitations of Nd3+ ions enable simultaneous heating. Proof-of-concept experiments demonstrate the great potential of these lanthanide-doped nanostructures for in vivo photo-thermal treatments with reliable thermal feedback.
PHYSICA B-CONDENSED MATTER
(2022)
Editorial Material
Optics
Riccardo Marin, Erving Ximendes, Daniel Jaque
Summary: The efficacy of photodynamic treatments of tumors can be significantly improved by utilizing the unique properties of the tumor microenvironment.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Optics
Matthias J. Grotevent, Sergii Yakunin, Dominik Bachmann, Carolina Romero, Javier R. Vazquez de Aldana, Matteo Madi, Michel Calame, Maksym Kovalenko, Ivan Shorubalko
Summary: This paper demonstrates a Fourier-transform waveguide spectrometer using HgTe-quantum-dot-based photoconductors, with a spectral response up to 2 μm and a spectral resolution of 50 cm(-1). The small size of the spectrometer enables its integration into consumer electronics and space devices.
Article
Chemistry, Multidisciplinary
Zhuolei Zhang, Artiom Skripka, Jakob C. Dahl, Chaochao Dun, Jeffrey J. Urban, Daniel Jaque, P. James Schuck, Bruce E. Cohen, Emory M. Chan
Summary: This article demonstrates the controllable synthesis of low-phonon-energy KPb2X5 (X=Cl, Br) nanoparticles and the ability to tune nanocrystal phonon energies as low as 128 cm(-1). KPb2Cl5 nanoparticles are moisture resistant and can be efficiently doped with lighter lanthanides. The low phonon energies of KPb2X5 nanoparticles promote upconversion luminescence from higher lanthanide excited states and enable highly nonlinear, avalanche-like emission from KPb2Cl5 : Nd3+ nanoparticles. The realization of nanoparticles with tunable, ultra-low phonon energies facilitates the discovery of nanomaterials with phonon-dependent properties, precisely engineered for applications in nanoscale imaging, sensing, luminescence thermometry and energy conversion.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemical Research Methods
Jose Lifante, Maria de la Fuente-Fernandez, Marta Roman-Carmena, Nuria Fernandez, Daniel Jaque Garcia, Miriam Granado, Erving Ximendes
Summary: The prevalence of nonalcoholic fatty liver (NAFLD) is increasing worldwide, and accurate diagnosis is crucial to prevent complications. Ultrasonography may underestimate NAFLD prevalence, hence a need for a noninvasive method. In this study, an integrated approach using autofluorescence and reflectance signals accurately estimated triglyceride density in the livers of mice.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Chemistry, Multidisciplinary
Tamara Munoz-Ortiz, Idoia Alayeto, Jose Lifante, Dirk H. Ortgies, Riccardo Marin, Emma Martin Rodriguez, Maria del Carmen Iglesias de la Cruz, Gines Lifante-Pedrola, Jorge Rubio-Retama, Daniel Jaque
Summary: Nanothermometry utilizes nanoparticles as thermal probes, enabling remote and minimally invasive sensing. It has emerged as a powerful tool in biomedicine. However, the lack of 3D thermal imaging capability and readily available tools in clinic hinders its translation to the bedside.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Paloma Rodriguez-Sevilla, Graham Spicer, Ana Sagrera, Alejandro P. Adam, Alejo Efeyan, Daniel Jaque, Sebastian A. Thompson
Summary: Fast, accurate, reliable, and remote measurement of intracellular temperature is crucial for understanding cellular processes. Nanothermometers based on GFP provide temperature readouts from the analysis of its luminescence polarization, but their reliability is still debated. This study sheds light on the issue by identifying cell activity as a bias mechanism that affects the reliability of intranuclear thermal measurements using GFP and other widely used thermometers. It emphasizes the importance of judiciously assessing the performance and reliability of chosen intracellular thermometers to advance the field and ensure indisputable results.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Liyan Ming, Irene Zabala-Gutierrez, Paloma Rodriguez-Sevilla, Jorge Rubio Retama, Daniel Jaque, Riccardo Marin, Erving Ximendes
Summary: This article introduces a luminescence lifetime estimation method based on U-NET to improve the estimation accuracy under extremely low signal-to-noise ratio conditions. The effectiveness of U-NET is demonstrated in luminescence lifetime thermometry and its sensing performance improvement is verified through two experiments under extreme measurement conditions.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Carlos D. S. Brites, Riccardo Marin, Markus Suta, Albano N. Carneiro Neto, Erving Ximendes, Daniel Jaque, Luis D. Carlos
Summary: Luminescence (nano)thermometry is a remote sensing technique that utilizes the temperature dependency of luminescence features to measure temperature. It has potential applications in various fields and requires the establishment of a theoretical background, standardized practices, and improved readouts through multiparametric analysis and artificial intelligence algorithms. Challenges in luminescence thermometry and the need for continuous innovation are also discussed.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Artiom Skripka, Minji Lee, Xiao Qi, Jia-Ahn Pan, Haoran Yang, Changhwan Lee, P. James Schuck, Bruce E. E. Cohen, Daniel Jaque, Emory M. M. Chan
Summary: Photonavalanching nanoparticles (ANPs) with highly nonlinear upconverted emission have great potential for subdiffraction imaging, nanoscale sensing, and optical computing. We use Gd3+-assisted energy migration to tune the emission wavelengths of Tm3+-sensitized ANPs and generate highly nonlinear emission from Eu3+, Tb3+, Ho3+, and Er3+ ions. The upconversion intensities of these spectrally discrete ANPs scale with a nonlinearity factor s = 10-17 under 1064 nm excitation at power densities as low as 7 kW cm(-2). This strategy can be extended to fluorophores adjacent to ANPs, as shown with CdS/CdSe/CdS core/shell/shell quantum dots.
Article
Chemistry, Multidisciplinary
Ana C. C. Soares, Tasso O. Sales, Erving C. Ximendes, Daniel Jaque, Carlos Jacinto
Summary: In recent years, there has been significant interest in infrared emitting luminescent nanothermometers due to their potential for new diagnosis and therapy procedures. However, concerns have been raised regarding their reliability, as tissues can induce spectral distortions even in the commonly used second biological window. In this study, the effectiveness of shifting the operation range of these nanothermometers to the third biological window is demonstrated, showing minimal distortion by tissue and opening the path to reliable luminescence thermometry. Advanced analysis of emission spectra allows for sub-degree thermal uncertainties.
NANOSCALE ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
W. M. Piotrowski, R. Marin, M. Szymczak, E. Martin Rodriguez, D. H. Ortgies, P. Rodriguez-Sevilla, P. Bolek, M. D. Dramicanin, D. Jaque, L. Marciniak
Summary: Near-infrared (NIR) luminescence thermometry is a reliable method for remote thermal sensing and imaging. Lanthanide (Ln(3+))-based nanophosphors are commonly used as NIR nanothermometers, but the combination of Ln(3+) with transition metal (TM) ions can enhance the sensitivity of the thermometric approach. However, there are few examples of luminescence nanothermometers combining both TM and Ln(3+), leaving room for further exploration of these systems.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Marina Paris Ogayar, Diego Mendez-Gonzalez, Irene Zabala Gutierrez, Alvaro Artiga, Jorge Rubio-Retama, Oscar G. Calderon, Sonia Melle, Aida Serrano, Ana Espinosa, Daniel Jaque, Riccardo Marin
Summary: Luminescence nanothermometry is a technique that uses luminescence signals from nanosized materials to remotely and minimally invasively measure temperature. However, in a biomedical context, the reliability of temperature measurement is compromised by bias caused by environmental conditions. This study reveals an unexpected source of bias induced by metal ions, which enhances the emission of Ag2S nanothermometers. These findings highlight the need for caution when using luminescence nanothermometry in complex biological environments.
