期刊
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
卷 36, 期 4, 页码 388-394出版社
WILEY-BLACKWELL
DOI: 10.1111/opo.12305
关键词
age of myopia onset; axial length; children; high myopia; myopia; spherical equivalent
资金
- Singapore Ministry of Health's National Medical Research Council (NMRC), Singapore [NMRC/0695/2002]
Purpose: To investigate the effect of age of myopia onset on the severity of myopia later in life among myopic children. Methods: In this prospective study, school children aged 7-9 years from the Singapore Cohort Of the Risk factors for Myopia (SCORM) were followed up till 11 years (n = 928). Age of myopia onset was defined either through questionnaire at baseline (age 7-9 years) or subsequent annual follow-up visits. Age of onset of myopia was a surrogate indicator of duration of myopia progression till age 11 years. Cycloplegic refraction and axial length were measured at every annual eye examination. High myopia was defined as spherical equivalent of <=-5.0 D. A questionnaire determined the other risk factors. Results: In multivariable regression models, younger age of myopia onset (per year decrease) or longer duration of myopia progression was associated with high myopia (odds ratio (OR) = 2.86; 95% CI: 2.39 to 3.43), more myopic spherical equivalent (regression coefficient (beta) = -0.86 D; 95% CI: -0.93 to -0.80) and longer axial length (beta = 0.28 mm; 95% CI: 0.24 to 0.32) at aged 11 years, after adjusting for gender, race, school, books per week and parental myopia. In Receiver Operating Curve (ROC) analyses, age of myopia onset alone predicted high myopia by 85% (area under the curve = 0.85), while the addition of other factors including gender, race, school, books per week and parental myopia only marginally improved this prediction (area under the curve = 0.87). Conclusions: Age of myopia onset or duration of myopia progression was the most important predictor of high myopia in later childhood in myopic children. Future trials to retard the progression of myopia to high myopia could focus on children with younger age of myopia onset or with longer duration of myopia progression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据