Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Immunology
Zarema Albakova, Yana Mangasarova
Summary: Heat shock proteins act as molecular chaperones, supporting tumor development by regulating various cellular processes in cancer. Investigating their intracellular and extracellular immunologic functions provides crucial insights for the development of effective immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hossein Javid, Pedram Hashemian, Shaghayegh Yazdani, Alireza Sharbaf Mashhad, Mehdi Karimi-Shahri
Summary: Heat shock proteins (HSPs) are a family of large molecular chaperones that play important roles in various processes of tumor cells. They have clinical applications in cancer diagnosis, prognosis, and treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Plant Sciences
Minghui Chen, Lu Gan, Jingxue Zhang, Yu Shen, Jin Qian, Mengli Han, Chuanjie Zhang, Jibiao Fan, Shengnan Sun, Xuebing Yan
Summary: In this study, 16 wild bermudagrass germplasms were collected from 16 different sites for physiological and transcriptome analysis, revealing differential gene expression related to plant growth, photosystem, redox system, and transcriptional regulation under cold stress. Additionally, a wild bermudagrass accession with relatively strong cold resistance was identified through weight evaluation of various physiological indexes. These findings provide important insights and resources for further research on bermudagrass responses to low-temperature stress.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Plant Sciences
Jyoti Devi, Vidya Sagar, Gyan P. Mishra, Prakash Kumar Jha, Nakul Gupta, Rakesh K. Dubey, Prabhakar M. Singh, Tusar K. Behera, P. V. Vara Prasad
Summary: In the era of climate change, heat stress poses a serious threat to pea plants, affecting their productivity and germination ability. Pea plants employ various defense strategies to tolerate heat stress, but the specific temperature thresholds and responses are still unknown. Traditional breeding methods and modern genomics technologies can be used to screen and develop heat-tolerant pea genotypes. Precise phenotyping and genomic studies can help identify candidate genes, and transgenic technology can be an alternative approach for developing heat-tolerant pea genotypes.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Xianguo Zhao, Yahong Li, Zhangwu Zhao, Juan Du
Summary: Global warming has serious impacts on insect sleep, which is critical for animals due to its important physiological functions. Understanding the regulation mechanism of sleep changes is essential for studying the impact of global warming, and can provide insights into improving sleep quality. This study found that extra sex combs (ESC) act as a regulatory factor in buffering sleep-related stresses through regulating Heat shock proteins (Hsps).
Article
Oncology
Zarema Albakova, Mohammad Kawsar Sharif Siam, Pradeep Kumar Sacitharan, Rustam H. Ziganshin, Dmitriy Y. Ryazantsev, Alexander M. Sapozhnikov
Summary: HSPs are molecular chaperones aberrantly expressed in cancer and implicated in regulating apoptosis, immune responses, angiogenesis, and metastasis. Proteomic profiling of HSPs in EVs from various biological fluids of cancer patients and the divergent expression of miRNAs in patient samples offer potential as diagnostic tools. Understanding the relationships between HSP networks, co-chaperones, and miRNA regulation may lead to novel biomarker discovery in cancer.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Jinhui Lue, Qian Zhao, Yuefan Guo, Danni Li, Heying Xie, Cuicui Liu, Xin Hu, Suling Liu, Zhaoyuan Hou, Xunbin Wei, Deyou Zheng, Richard G. Pestell, Zuoren Yu
Summary: This study identified a miR-29a-PTEN-AKT axis as a downstream signaling pathway of ER alpha in breast cancer metastasis. Low level of miR-29a was associated with reduced metastasis and better survival in ER alpha+ luminal subtype of BC, while high level of miR-29a was detected in ER alpha- triple negative breast cancer (TNBC) with distant metastasis and poor survival. Targeting miR-29a suppressed cellular invasion, EMT and lung metastasis in TNBC cells in vitro and in TNBC tumor-bearing mice in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zarema Albakova, Yana Mangasarova, Alexander Sapozhnikov
Summary: Heat shock proteins (HSPs) play critical roles in immune cells, but their role in T cell activation and their dysregulated expression in B-cell lymphoma (BCL) patients have been discovered in this study. Inhibiting HSP90 may have different effects on CD4+ and CD8+ T cell responses, suggesting potential new targets for cancer treatment.
Review
Plant Sciences
Golam Jalal Ahammed, Yelan Guang, Youxin Yang, Jinyin Chen
Summary: Rising atmospheric CO2 has significant impacts on plant response to heat stress by alleviating its deleterious effects. Despite evidence supporting the positive impact of elevated CO2 on thermotolerance, the precise molecular mechanisms underlying this phenomenon remain unclear. Further research is needed to unveil the intricate crosstalk between plant hormones in mediating high CO2-induced thermotolerance.
PLANT CELL REPORTS
(2021)
Article
Medicine, Research & Experimental
Shuxian Yang, Haiyan Xiao, Li Cao
Summary: This review summarizes the significant roles of heat shock proteins in cancer diagnosis, metabolism regulation, and therapeutic targeting, highlighting the importance of research and future directions in this field.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Integrative & Complementary Medicine
Seonhee Kim, Harsha Nagar, Ikjun Lee, Su-Jeong Choi, Shuyu Piao, Byeong Hwa Jeon, Shin Kwang Kang, Hee-Jung Song, Cuk-Seong Kim
Summary: Breast cancer is a common and deadly disease, especially in triple-negative breast cancer (TNBC) cases. This study investigates the potential of sericite, a natural mineral, as an antitumor agent for TNBC. The results show that sericite can inhibit cell proliferation, induce cell cycle arrest, and promote apoptotic cell death. These findings suggest that sericite could be a potential therapeutic option for TNBC.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
James Stokes, Sankalp Vinayak, Jazalyn Williams, Shalie Malik, Rajesh Singh, Upender Manne, Taofeek K. Owonikoko, Manoj K. Mishra
Summary: Resveratrol is a natural polyphenol found in fruits, vegetables, and peanuts, known for its regenerative, anti-oxidant, and anti-cancer properties. It inhibits the growth of pathogenic bacteria and cancer development through various mechanisms. The gut plays a crucial role in maintaining optimal health by regulating nutrient assimilation, metabolism, immunity, and protecting the host from invasive bacteria.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Plant Sciences
Tung-Yi Lin, Wei-Jyun Hua, Hsin Yeh, Ai-Jung Tseng
Summary: The study demonstrates that FIPs LZ-8 and GMI induce changes in the proteomic profile of tumor lesions in LLC1 cell-bearing mouse, potentially regulating heat shock proteins (HSPs)-related cell viability and inhibiting cell migration and inducing apoptosis. Inhibition of HSPs may contribute to the anti-lung cancer activity of FIPs.
Review
Immunology
Michael Kasperkiewicz, Stefan Tukaj
Summary: This mini review briefly summarizes the promising double-edged sword of targeting Hsp90/70 in the therapy of AIBDs and COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell & Tissue Engineering
Elham Sabouri, Alireza Rajabzadeh, Seyedeh Elnaz Enderami, Ehsan Saburi, Fatemeh Soleimanifar, Ghasem Barati, Mohamad Rahmati, Gholamreza Khamisipour, Seyed Ehsan Enderami
Summary: Stem cell-based therapy shows promising results in treating diabetes by inducing insulin-producing cells from various sources, which can serve as an alternative to islets. The use of soluble growth factors, small molecules, gene-encoding transcription factors, and microRNAs for stem cell differentiation has been explored, with a focus on miRNAs and their roles in pancreatic development and function.
CURRENT STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Navid Pourzardosht, Zahra Sadat Hashemi, Maysam Mard-Soltani, Abolfazl Jahangiri, Mohammad Reza Rahbar, Alireza Zakeri, Ebrahim Mirzajani, Saeed Khalili
Summary: This study aimed to screen for an inhibitory compound to block the interaction between PD1 and PD-L1 molecules, and found that liothyronine (T3) may have the ability to inhibit this interaction and has potential in cancer treatment. These abilities of T3 could be used to restore the ability of the immune system to eliminate tumor cells.
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
(2022)
Review
Cell & Tissue Engineering
Mohsen Karami Fath, Farhad Zahedi, Zahra Sadat Hashemi, Saeed Khalili
Summary: Neurological diseases have diverse etiologies, and developing effective treatments is challenging. Cell therapy, particularly using BM-MSCs, is considered promising. Various chemical compounds have been shown to facilitate the differentiation of BM-MSCs into neurons, involving different signaling pathways such as ERK, AKT, BMP, and histone deacetylase inhibitors, offering potential for improved differentiation.
CURRENT STEM CELL RESEARCH & THERAPY
(2021)
Article
Environmental Sciences
Atefeh Khalili Doroodzani, Sina Dobaradaran, Razegheh Akhbarizadeh, Alireza Raeisi, Elham Rahmani, Marzieh Mahmoodi, Iraj Nabipour, Saeed Keshmiri, Amir Hossein Darabi, Gholamreza Khamisipour, Mehdi Mahmudpour, Mozhgan Keshtkar
Summary: The study found significantly higher levels of EPAHs in maternal and fetal serum in the industrial area compared to the urban area, with Naphthalene being the predominant PAH detected. Maternal exposure to PAHs may affect fetal weight, head circumference, and height, with maternal diet also being associated with PAHs levels.
ENVIRONMENTAL POLLUTION
(2021)
Review
Biochemistry & Molecular Biology
Zahra Sadat Hashemi, Mahboubeh Zarei, Mohsen Karami Fath, Mahmoud Ganji, Mahboube Shahrabi Farahani, Fatemeh Afsharnouri, Navid Pourzardosht, Bahman Khalesi, Abolfazl Jahangiri, Mohammad Reza Rahbar, Saeed Khalili
Summary: Peptides are valuable in targeting protein-protein interactions, with in silico tools playing a crucial role in the design and optimization of interfering peptides. The future prospects in this field are promising.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Pediatrics
Seyedeh Maryam Hosseini Bandari, Mehdi Allahbakhshian Farsani, Gholamreza Khamisipour
Summary: In this study, the expression of oxidative stress resistance genes was found to be significantly higher in ALL patients compared to healthy individuals. However, no significant relationship was found between the expression of these genes and the disease stage or blast percentage. Targeting these critical genes of oxidative stress pathways could be a potential treatment for ALL with fewer side effects.
IRANIAN JOURNAL OF PEDIATRIC HEMATOLOGY AND ONCOLOGY
(2021)
Article
Environmental Sciences
Gohar Parhizkar, Atefeh Khalili Doroodzani, Sina Dobaradaran, Bahman Ramavandi, Seyed Enayat Hashemi, Alireza Raeisi, Iraj Nabipour, Saeed Keshmiri, Amirhossein Darabi, Sima Afrashte, Gholamreza Khamisipour, Mozhgan Keshtkar
Summary: This study compared childhood exposure to metal(loids) in an industrial and an urban area in Southwest Iran using toenail tissue as a biomarker, finding significantly higher levels in the industrial area. The toenail samples from the industrial area showed higher average levels of certain metals compared to the urban area.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Zahra Sadat Hashemi, Mahboubeh Zarei, Shaden M. H. Mubarak, Anahita Hessami, Maysam Mard-Soltani, Bahman Khalesi, Alireza Zakeri, Mohammad Reza Rahbar, Abolfazl Jahangiri, Navid Pourzardosht, Saeed Khalili
Summary: This study examines the effects of mutations in the spike protein of SARS-CoV-2 on its structural consequences and therapeutic efficacy. By predicting the 3D structure of mutant spike proteins and analyzing their interactions with ACE2 proteins and an engineered therapeutic ACE2, the study finds that mutations alter the interaction orientation and increase the affinity between the spike protein and ACE2. Additionally, mutations also impact the cavity size and residue depth. The study concludes that mutated spike proteins demonstrate higher binding affinity and designed ACE2-based therapeutics remain highly effective against COVID-19.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2022)
Article
Genetics & Heredity
Zahra Derakhshan, Gholamreza Khamisipour, Fatemeh Hosseinpour Soleimani, Niloofar Motamed
Summary: This study evaluated the expression levels of miR-28-3p, miR-31-5p, miR378a-3p, and miR-382-5p in patients with acute lymphoblastic leukemia (ALL). The results showed that miR-378a-3p and miR-31-5p were significantly upregulated in patients with newly diagnosed ALL, but decreased significantly after treatment. On the other hand, miR-28-3p and miR-382-5p were significantly downregulated in newly diagnosed ALL patients and increased significantly after treatment. These miRNAs may play a potential role in the pathogenesis of ALL and could be considered as diagnostic markers and therapeutic targets in future studies.
Article
Biochemistry & Molecular Biology
Mohsen Karami Fath, Malihe Naderi, Hosna Hamzavi, Mahmoud Ganji, Shima Shabani, Faezeh Noorabad Ghahroodi, Bahman Khalesi, Navid Pourzardosht, Zahra Sadat Hashemi, Saeed Khalili
Summary: COVID-19 is a rapidly spreading disease without a definite cure. Adequate intake of micronutrients and antioxidants plays a crucial role in fighting against the disease.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Hosseinpour-Soleimani, Gholamreza Khamisipour, Zahra Derakhshan, Bahram Ahmadi
Summary: This study aimed to determine the expression levels of miRNAs in patients with acute lymphoblastic leukemia (ALL) and evaluate their value as biomarkers or therapeutic targets. The results showed that miR-217 was significantly decreased, while miR-22, miR-122, and miR-367 were increased. ROC analysis demonstrated that miR-217 and miR-367 could differentiate ALL patients from healthy individuals.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Fateme Mohammadi, Zahra Sadat Hashemi, Ramin Sarrami Forooshani, Shaban Alizadeh
Summary: Trained exosomes derived from natural killer cells have been found to have a stronger anti-tumor effect on cancer cells compared to non-trained exosomes. They inhibit cell proliferation and induce apoptosis in tumor cells. This antitumor activity is achieved through the up-regulation of caspase 3 and P53 genes in the apoptotic signaling pathway.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Cell Biology
Mostafa Ebrahimdoost, Mohsen Mohammadi, Narges Obeidi, Seyed Amin Mohammadi, Gholamreza Khamisipour
Summary: The anticancer activity of AMP-WF3 peptide from Poecilia Mexicana fish was evaluated against leukemic cell line Jurkat, and its cytotoxicity compared with normal cells. AMP-WF3 exhibited higher cytotoxicity against Jurkat cells with minimal effects on normal cells. The apoptotic activity of AMP-WF3 on Jurkat cells was significantly higher than that on HDF and PBMCs. The expression of P21, P53, and BCL-2 genes showed different changes in Jurkat cells, PBMCs, and HDF cells.
Article
Medicine, Research & Experimental
Zivar Zangeneh, Gholamreza Khamisipour, Ali Reza Andalib
Summary: MARCH-1 gene transduction can decrease the levels of proinflammatory factors and increase the M2 phenotype characterized by scavenger receptors, demonstrating anti-inflammatory features and offering a new strategy for treating inflammatory conditions.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Cell Biology
Samila Farokhimanesh, Mahdi Forouzandeh Moghadam, Marzieh Ebrahimi, Zahra Sadat Hashemi
Summary: Therapeutic genes with miRNA response elements have shown potential in specific gene expression for cancer therapy. Chimeric vectors regulated by miR-200 family response elements could be a promising therapeutic tool for inhibiting metastatic behaviors in cancer cells.