Article
Biochemistry & Molecular Biology
Jung-Hwan Park, Minho Moon, Jong-Seok Kim, Sang-Muk Oh
Summary: The study demonstrated that TOPK upregulates EMT and invasion of nonsmall-cell lung cancer cells through HIF-1α/Snail axis and hypoxic signaling. TOPK positively regulates HIF-1α expression, leading to Snail expression, EMT, and invasion of cancer cells. TOPK acts as a critical mediator of hypoxia signaling in nonsmall-cell lung cancer development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Huahua Tu, Wei Wang, Yanqing Feng, Linfei Zhang, Huadong Zhou, Caitao Cheng, Lei Ji, Qinghe Cai, Yong Feng
Summary: Beta-patchoulene (beta-PAE) is a compound extracted from patchouli with analgesic, anti-inflammatory, and antioxidant effects. This study found that beta-PAE can inhibit the growth, proliferation, migration, and epithelial-mesenchymal transition of hypoxia-induced hepatocellular carcinoma (HCC) cells, and promote apoptosis.
Review
Cell Biology
Nasim Kheshtchin, Jamshid Hadjati
Summary: Hypoxia, a common characteristic of solid tumors, contributes to different aspects of tumor progression and limits the efficacy of immunotherapies. Developing new immunotherapy strategies involving therapeutic targeting of HIF-1 molecules associated with hypoxia may enhance the clinical effectiveness of immunotherapy. Targeting hypoxia presents a potential opportunity to improve the clinical benefit of cancer immunotherapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rahul Advani, Sara Luzzi, Emma Scott, Caroline Dalgliesh, Joachim Weischenfeldt, Jennifer Munkley, David J. Elliott
Summary: This article discusses the expression of splicing regulators ESRP1 and ESRP2 in aggressively proliferating primary prostate tumors as markers of disease progression. It suggests that ESRP1 and ESRP2 act as lineage survival oncogenes in prostate cancer and highlights the need to identify the gene expression targets controlled by these regulators to develop targeted therapies.
Article
Biochemistry & Molecular Biology
Yoshiko Hashimoto, Tomoko Tsuzuki-Nakao, Naoko Kida, Yoshiyuki Matsuo, Tetsuo Maruyama, Hidetaka Okada, Kiichi Hirota
Summary: The endometrium undergoes repeated changes during the menstrual cycle, and chronic endometritis can lead to implantation failure and miscarriage. In this study, the effects of inflammatory cytokines, hypoxia-inducible factor (HIF), and inflammation on endometrial epithelial cells were investigated. The results showed that pro-inflammatory factors and hypoxia activated HIF-1 and promoted epithelial-mesenchymal transition (EMT) in endometrial epithelial cells.
Article
Nanoscience & Nanotechnology
Jiali Yuan, Yiqun Mo, Yuanbao Zhang, Yue Zhang, Qunwei Zhang
Summary: This study demonstrates that exposure to nickel nanoparticles can induce epithelial-mesenchymal transition (EMT) in human bronchial epithelial cells, leading to reduced histone acetylation through HIF-1 alpha-mediated HDAC3 upregulation. These findings contribute to a better understanding of the molecular mechanisms underlying nickel nanoparticle-induced fibrosis and carcinogenesis.
Article
Biochemistry & Molecular Biology
Agnieszka Synowiec, Klaudia Brodaczewska, Gabriel Wcislo, Aleksandra Majewska, Agata Borkowska, Aleksandra Filipiak-Duliban, Aleksandra Gawrylak, Kinga Wilkus, Katarzyna Piwocka, Agata Kominek, Halina Was, Slawomir Lewicki, Jacek Siewiera, Cezary Szczylik, Jolanta Szenajch, Jacek Z. Kubiak, Claudine Kieda
Summary: Resveratrol, when used in combination with cisplatin, shows promising results as an adjuvant therapy for ovarian cancer. However, its effectiveness is limited in a hypoxic tumor microenvironment. Under hypoxia, resveratrol does not exhibit cytotoxic effects, whereas it induces apoptosis in normoxia. These findings highlight the constraints of using resveratrol as an adjuvant therapy with cisplatin in ovarian cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elena Monti, Alessandro Mancini, Emanuela Marras, Marzia Bruna Gariboldi
Summary: Experimental evidence suggests that mitochondrial ROS plays a pivotal role in hypoxia-induced Epithelial-Mesenchymal Transition (EMT), and inhibiting mitochondrial ROS production could reverse EMT. UQCRB is a key factor in hypoxic signaling-induced EMT and may serve as a new therapeutic target for drug development.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Review
Oncology
Samantha Gogola, Michael Rejzer, Hisham F. Bahmad, Wassim Abou-Kheir, Yumna Omarzai, Robert Poppiti
Summary: Prostate cancer is the second most common cancer in men worldwide, and treatment options include radiation therapy, surgery, and active surveillance. However, in most cases, the cancer eventually becomes castration-resistant. The transition from androgen-dependent to androgen-independent state is not well understood, but epithelial-to-non-epithelial transition plays a crucial role. This review summarizes the factors and pathways involved in this transition, as well as the diagnostic and prognostic biomarkers.
Article
Biology
Amr Ali, Bassem Mekhaeil, Olga-Demetra Biziotis, Evangelia E. Tsakiridis, Elham Ahmadi, Jianhan Wu, Simon Wang, Kanwaldeep Singh, Gabe Menjolian, Thomas Farrell, Aruz Mesci, Stanley Liu, Tobias Berg, Jonathan L. Bramson, Gregory R. Steinberg, Theodoros Tsakiridis
Summary: This study demonstrates that canagliflozin can suppress prostate cancer cell proliferation and enhance their sensitivity to radiotherapy. It achieves this by blocking mitochondrial respiration, promoting AMPK activity, inhibiting MAPK and mTOR-p70S6k/4EBP1 pathways, activating cell cycle checkpoints, inhibiting proliferation partly through HIF-1α suppression, and mediating transcriptional reprogramming of metabolic and survival pathways. Canagliflozin may have potential in combination with radiotherapy for the prevention and treatment of prostate cancer.
COMMUNICATIONS BIOLOGY
(2023)
Review
Cell Biology
Minghui Zhang, Yu Zhang, Yubo Ding, Jialu Huang, Jingwei Yao, Zhuoyi Xie, Yufan Lv, Jianhong Zuo
Summary: This review examines the regulatory roles of HIF-1 alpha and lncRNAs in the EMT process of tumor cells and their relationship with tumorigenesis, and summarizes current drugs that inhibit tumor progression by modulating HIF-1 alpha.
Article
Oncology
Leah Davis, Matthias Recktenwald, Evan Hutt, Schuyler Fuller, Madison Briggs, Arnav Goel, Nichole Daringer
Summary: Hypoxia, or inadequate oxygen supply, is a characteristic of the tumor microenvironment and is associated with a poor prognosis and resistance to therapy. HIF-alpha, specifically the HIF-1 alpha and HIF-2 alpha subunits, play a crucial role in mediating the transcription of important proteins involved in tumor progression. While HIF-1 alpha has been extensively studied, the role of HIF-2 alpha is often overlooked. HIF-2 alpha can enhance the aggressive behavior of tumors, promoting metastasis, tissue remodeling, angiogenesis, and the upregulation of cancer stem cell factors. This review highlights the structure, function, hypoxic response, and roles of HIF-2 alpha in cancer progression, as well as discussing current therapeutic strategies and future directions.
Article
Biochemistry & Molecular Biology
Yijie Wang, Xiong Liu, Min Wang, Yu Wang, Shuo Wang, Lai Jin, Min Liu, Jun Zhou, Yan Chen
Summary: This study reveals that UBE3B is an E3 ligase for HIF-2 & alpha; and its depletion inhibits breast cancer progression. UBE3B physically interacts with HIF-2 & alpha; and promotes its polyubiquitination, thereby inhibiting its degradation. UBE3B depletion also inhibits breast cancer cell proliferation, migration, and invasion, and suppresses tumor growth and metastasis.
Article
Oncology
Yi-Hsuan Huang, Sung-How Sue, Zih-Syuan Wu, Shih-Ming Huang, Shih-Yu Lee, Zhi-Fu Wu
Summary: This study investigated the effects of tramadol on breast cancer cells and found that it inhibited cell growth, migration, colony formation, and invasion. Combination therapy with tramadol and doxorubicin showed synergistic effects. Tramadol may be a potential candidate for combination therapy, especially for triple-negative breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yijie Wang, Xiong Liu, Min Liu, Yu Wang, Shuo Wang, Lai Jin, Min Liu, Jun Zhou, Yan Chen
Summary: It has been found that UBE3B acts as an E3 ligase for HIF-2 alpha, promoting its polyubiquitination and inhibiting its degradation, which plays a crucial role in breast cancer growth and metastasis.
