Article
Pharmacology & Pharmacy
Ying Jia, Qian Zhang, Zhiyuan Liu, Pan Pan, Yanfei Jia, Ping Zhu, Yang Jiao, Guiyu Kang, Xiaoli Ma
Summary: alpha 5-nicotinic acetylcholine receptor (alpha 5-nAChR) is involved in tobacco smoking-induced lung carcinogenesis. This study identifies a functional link between alpha 5-nAChR and NLRP3 inflammasome activation in lung adenocarcinoma (LUAD), suggesting that nicotine promotes lung cancer cell proliferation and migration via the alpha 5-nAChR/STAT3/NLRP3 axis.
Article
Cell Biology
Jiali Dai, Tianyu Qu, Dandan Yin, Yanan Cui, Chen Zhang, Erbao Zhang, Renhua Guo
Summary: Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment prolongs the survival of lung cancer patients with EGFR mutations, but resistance is common. LINC00969, a long non-coding RNA, is found to be elevated in lung cancer cells with gefitinib resistance. It regulates resistance to gefitinib by modifying histone and RNA methylation and suppressing key signaling pathways. These findings highlight LINC00969 as a potential biomarker and therapeutic target for overcoming EGFR-TKI resistance in lung cancer.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Bingling Dai, Hanbing Cao, Yu Hu, Zhengyan Gong, Xiaoyue Huang, Yanbin Chen, Feng Liu, Xiujuan Peng, Yanmin Zhang, Xinjun Lei
Summary: This study observed low expression levels of the NLRP3 inflammasome in a subset of HCC cells and demonstrated the activation of NLRP3 inflammasome through the nuclear factor kappa B signaling pathway by LPS + ATP. The activation of NLRP3 inflammasome inhibited HCC cell proliferation, arrested the cell cycle at the G1 phase, and suppressed cell migration.
Article
Biochemistry & Molecular Biology
Xinyan Li, Congcong Zhao, Chao Li, Mengmeng Zhang, Yuanchen Xie, Feifei Feng, Wu Yao, Na Wang
Summary: By constructing a mouse lung cancer model and analyzing the lung microbiota in bronchoalveolar lavage fluid, we found that the NLRP3 inflammasome may have an impact on the lung microbiota during the process of lung cancer. Comparing the wild-type and NLRP3 gene knockout groups, significant differences were observed in tumor formation rate, tumor number, and tumor size. The relative abundance of Proteobacteria and Sphingomonas was the highest at the phylum and genus level, respectively. The knockout of the NLRP3 gene caused changes in the lung microbiota, suggesting a regulatory relationship between the NLRP3 inflammasome and lung microbiota in lung cancer development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Immunology
Bhesh Raj Sharma, Thirumala-Devi Kanneganti
Summary: The NLRP3 inflammasome plays diverse roles in cancer and metabolic diseases, being involved in the release of inflammatory cytokines and inflammatory cell death upon activation. While inflammatory cytokines contribute to chronic inflammation and disease pathogenesis, fine tuning NLRP3 activity is crucial for maintaining cellular health.
Article
Immunology
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi
Summary: INF39 is a specific inhibitor for NLRP3 inflammasome activation, without affecting other inflammasomes. It exerts its anti-inflammatory effect by inhibiting the interaction of NEK7-NLRP3 and other downstream events.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Huan Liu, Xuepeng Yang, Ge Liu
Summary: NLRP3 inflammasome activation mediates ventilator-induced lung injury (VILI) and is accompanied by cell proliferation and transdifferentiation. Alleviating VILI in the early stage by inhibiting the inflammatory response and accelerating alveolar epithelial cell regeneration is significant.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Immunology
Xueyan Shi, Tao Li, Yanting Liu, Leijin Yin, Lan Xiao, Liyao Fu, Yaxi Zhu, Huan Chen, Kangkai Wang, Xianzhong Xiao, Huali Zhang, Sichuang Tan, Sipin Tan
Summary: This study found that heat shock factor 1 (HSF1) plays a protective role in septic acute lung injury (ALI) by suppressing the activation of the NLRP3 inflammasome. HSF1 can inhibit NLRP3 expression by inhibiting NF-κB phosphorylation, and it can also inhibit caspase-1 activation and IL-1β maturation by promoting NLRP3 ubiquitination.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Gulcin Tezcan, Ekaterina E. Garanina, Mohammad Alsaadi, Zarema E. Gilazieva, Ekaterina Martinova, Maria Markelova, Svetlana S. Arkhipova, Shaimaa Hamza, Alan McIntyre, Albert A. Rizvanov, Svetlana F. Khaiboullina
Summary: Our research suggests that NLRP3 activation using Nigericin could be a novel therapeutic approach to control the growth of tumors producing a low level of IL-1 beta and IL-18.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yeon-Ji Park, Niranjan Dodantenna, Yonghyeon Kim, Tae-Hwan Kim, Ho-Soo Lee, Young-Suk Yoo, June Heo, Jae-Ho Lee, Myung-Hee Kwon, Ho Chul Kang, Jong-Soo Lee, Hyeseong Cho
Summary: The NLRP3 inflammasome is activated through mitochondria-mediated ubiquitination by the E3 ligase MARCH5. Knockout of MARCH5 leads to an impaired secretion of IL-1β and IL-18 in myeloid cells, as well as a decreased mortality rate upon infection. MARCH5-dependent NLRP3 ubiquitination is essential for NLRP3-NEK7 complex formation and NLRP3 oligomerization.
Article
Cell Biology
XiaoYi Zhang, Chao Li, Dingyu Chen, XiaoFeng He, Yan Zhao, LiYa Bao, Qingrong Wang, JianJiang Zhou, Yuan Xie
Summary: This study demonstrates that CagA can promote the invasion and migration of gastric cancer cells by activating the NLRP3 inflammasome pathway. Inhibition of ROS effectively blocks NLRP3 activation and pyroptosis. Silencing of NLRP3 reduces the effects of CagA on gastric cancer cell migration and invasion.
INFLAMMATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Hao Luo, Xiaoming Liu, Huan Liu, Yong Wang, Kai Xu, Jianhua Li, Mengya Liu, Jianshuang Guo, Xiujun Qin
Summary: ACT001, a prodrug of micheliolide, has potential clinical application in treating thoracic tumors and protecting against radiation-induced lung injury (RILI). This study demonstrates that ACT001 can alleviate RILI, reduce inflammation and fibrosis in lung tissue, and inhibit the activation of the NLRP3 inflammasome and pyroptosis. These findings suggest that ACT001 may serve as a novel protective agent for RILI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Xin-Xin Guan, Hui-Hui Yang, Wen-Jing Zhong, Jia-Xi Duan, Chen-Yu Zhang, Hui-Ling Jiang, Yang Xiang, Yong Zhou, Cha-Xiang Guan
Summary: This study found that the activation of Fn14 worsens acute lung injury (ALI) by amplifying the activation of the NLRP3 inflammasome. Blocking Fn14 may be a potential way to treat ALI.
MOLECULAR MEDICINE
(2022)
Review
Cell Biology
Alireza Shadab, Mohamad Mahjoor, Mohammad Abbasi-Kolli, Hamed Afkhami, Parisa Moeinian, Amir-Reza Safdarian
Summary: This article investigates the activation of the NLRP3 inflammasome and its effects on the crosstalk between different organs, as well as the role of chronic inflammation in cancer pathogenesis. The research on the NLRP3 inflammasome may represent an innovative therapeutic target to reverse the malignancy consequences of inflammation.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Chemistry, Medicinal
Zhiguang Liu, Xiaochun Zhu, Chenglin Xu, Feng Min, Guofeng Yu, Chuhong Chen
Summary: This study aimed to investigate the effects of ulinastatin (UTI) on the malignant progression of prostate cancer and its underlying mechanism. The results demonstrated that UTI significantly inhibited cell proliferation, migration, and invasion, and promoted apoptosis in prostate cancer cells through the regulation of the RhoA/ROCK/NLRP3 inflammasome pathway. This study provides a promising candidate drug for the therapeutic treatment of prostate cancer.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Oncology
Wenrui Liu, Hui Kong, Xiaoning Zeng, Jingjing Wang, Zailiang Wang, Xiaopei Yan, Yanli Wang, Weiping Xie, Hong Wang
EXPERIMENTAL CELL RESEARCH
(2015)
Article
Oncology
Qinglin Li, Xiaopei Yan, Hui Kong, Weiping Xie, Hong Wang
MOLECULAR MEDICINE REPORTS
(2016)
Article
Mycology
XiaoPei Yan, Feng Zong, Hui Kong, YanLi Wang, XinYun Zhao, WenRui Liu, ZaiLiang Wang, WeiPing Xie
Article
Oncology
Xiang Li, Xiaopei Yan, Yanli Wang, Jingjing Wang, Fang Zhou, Hong Wang, Weiping Xie, Hui Kong
EXPERIMENTAL CELL RESEARCH
(2018)
Article
Health Care Sciences & Services
Ying Chen, Xiaopei Yan, Ning Li, Qin Zhang, Yantian Lv, Ting Ruan
Summary: The study showed that using cocktail specimens for pathogen detection in focal pulmonary infections yielded better results compared to other methods, and the use of antibiotics had minimal impact on the outcomes of mNGS analysis.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Respiratory System
Xiaopei Yin, Li Xu, Baoyu Shi, Hui Wang, Xiao Xu, Guopeng Xu
JOURNAL OF THORACIC DISEASE
(2020)