Article
Oncology
Ana Luzarraga Aznar, Vicente Bebia, Carlos Lopez-Gil, Alexandra Giraldo, M. P. Montoya, Ramona Verges, Alberto Jauregui, Josep Castellvi, Assumpcio Perez-Benavente, Eva Colas, Antonio Gil-Moreno, Silvia Cabrera
Summary: The objective of this study was to describe the characteristics of patients with endometrial cancer diagnosed with a first recurrence involving the lung, and to explore the prognostic role of the molecular profile. The study also aimed to describe the prognostic outcomes after local treatment of isolated lung recurrence.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Review
Oncology
Heidi Rutten, Cornelia Verhoef, Willem Jan van Weelden, Anke Smits, Joelle Dhanis, Nelleke Ottevanger, Johanna M. A. Pijnenborg
Summary: The treatment strategies for recurrent endometrial cancer should be personalized based on the individual patient and tumor characteristics. Local and locoregional recurrences can be curatively treated with surgery or radiotherapy, while distant recurrences may require palliative systemic therapy. Further studies are needed to assess the effectiveness and toxicity of newer treatment strategies in this challenging condition.
Article
Oncology
A. Kulkarni, N. M. Andrews Wright, A. N. Forget, T. Ramsay, R. Mallick, J. I. Weberpals
Summary: The purpose of this study is to determine primary survival endpoints in women with recurrent and metastatic endometrial carcinoma treated with progestins. The study found that there may be a role for progestins in select subgroups of women.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mirza S. Baig, Wais Habib, Veronica Attard, Ban Sharif, Daniel Lindsay, Bhavin Upadhyay, Asif Saifuddin
Summary: This study aimed to determine the prevalence of pulmonary metastases on re-staging chest CT at the time of first local recurrence of trunk or extremity soft tissue sarcoma. The results showed that pulmonary metastases were diagnosed in 23.9% of cases, most commonly associated with grade 3 STS and specific sub-types of tumors. This supports the recommendation for chest CT at the time of local recurrence in line with UK guidelines for sarcoma management.
EUROPEAN RADIOLOGY
(2021)
Article
Urology & Nephrology
Nicholas H. Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A. Ornellas, Mario Catanzaro, Oliver W. Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Jad Chahoud, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E. Spiess
Summary: This study found that 31.9% of pSCC patients experienced post-ILND recurrence, which was associated with high pN staging. Over 95% of distant, inguinal, and pelvic recurrences occurred within 48 months post-ILND. Local recurrences occurred over a longer timeline, highlighting the necessity of long-term surveillance of the primary site.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Ido Laskov, Ayala Zilberman, Lihie Maltz-Yacobi, Shira Peleg Hasson, Aviad Cohen, Tamar Safra, Dan Grisaru, Nadav Michaan
Summary: Our study aimed to explore the effect of body mass index (BMI) change on cancer recurrence risk in endometrial cancer patients. We collected retrospective data on patients with endometrial adenocarcinoma and compared their BMI at surgery and during follow-up. The results showed that patients with an increase in BMI during follow-up had an increased risk of cancer recurrence compared to patients with no change or a decrease in BMI.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Shao-Jing Wang, Lily Wang, Lou Sun, Yu-Hsiang Shih, Shih-Tien Hsu, Chin-Ku Liu, Sheau-Feng Hwang, Chien-Hsing Lu
Summary: Postoperative sandwich chemoradiotherapy appears to be more effective than chemotherapy alone in terms of 5-year disease-specific survival and local control for stage III endometrial cancer patients, with tolerable toxicity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sunmin Park, Won Park, Shin Hyung Park, Joo-Young Kim, Jin Hee Kim, Haeyoung Kim, Yeon-Sil Kim, Won Kyung Cho, Won Sup Yoon, Dae Sik Yang
Summary: This study aimed to evaluate the oncologic outcomes in uterine cervical cancer patients with metachronous distant metastases according to disease burden. The results showed that salvage treatments in selected patients with a long disease-free interval, low metastatic burden, and/or lymphatic-only metastasis can lead to favorable oncologic outcomes.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
M. Naomi Horiba, Sandra J. Casak, Pallavi S. Mishra-Kalyani, Pourab Roy, Julia A. Beaver, Richard Pazdur, Paul G. Kluetz, Steven J. Lemery, Lola A. Fashoyin-Aje
Summary: Nivolumab has been approved by the FDA as an adjuvant treatment for esophageal cancer after surgery. The approval was based on the results of the CheckMate 577 trial, which showed that nivolumab can prolong disease-free survival in patients.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Courtney J. Riedinger, Jenna M. Patterson, Floor J. Backes, David O'Malley, Kristin L. Bixel, Larry J. Copeland, David E. Cohn, Paul J. Goodfellow, Casey M. Cosgrove
Summary: This study examined the patterns, presentation, and diagnosis of endometrial cancer recurrence. The majority of patients with recurrent endometrial cancer were symptomatic, with pain being the most common complaint. Patients with symptomatic presentation were less likely to receive treatment for recurrent disease, while asymptomatic recurrence was more commonly diagnosed in early-stage disease.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Maximilian Haist, Henner Stege, Friederike Rogall, Yuqi Tan, Imke von Wasielewski, Kai Christian Klespe, Friedegund Meier, Peter Mohr, Katharina C. Kaehler, Michael Weichenthal, Axel Hauschild, Dirk Schadendorf, Selma Ugurel, Georg Lodde, Lisa Zimmer, Ralf Gutzmer, Dirk Debus, Bastian Schilling, Alexander Kreuter, Jens Ulrich, Frank Meiss, Rudolf Herbst, Andrea Forschner, Ulrike Leiter, Claudia Pfoehler, Martin Kaatz, Fabian Ziller, Jessica C. Hassel, Michael Tronnier, Michael Sachse, Edgar Dippel, Patrick Terheyden, Carola Berking, Markus Heppt, Felix Kiecker, Sebastian Haferkamp, Christoffer Gebhardt, Jan Christoph Simon, Stephan Grabbe, Carmen Loquai
Summary: In this study, it was found that patients with BRAFmut melanoma who were treated with BRAF/MEK-directed targeted therapy (TT) had significantly reduced risk of recurrence and prolonged RFS compared to those treated with PD-1 inhibitors (anti-PD1). The choice of first-line treatment had a significant impact on the efficacy of treatments for tumor recurrence.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Xin Wang, Dong-Bing Zhao, Lin Yang, Yihebali Chi, Hong Zhao, Li-Ming Jiang, Jun Jiang, Yuan Tang, Ning Li, Wen-Yang Liu, Li-Zhou Dou, Shuang-Mei Zou, Li-Yan Xue, Jian-Song Ren, Yan-Tao Tian, Xu Che, Chun-Guang Guo, Xiao-Feng Bai, Yue-Min Sun, Shu-Lian Wang, Yong-Wen Song, Yue-Ping Liu, Hui Fang, Ye-Xiong Li, Jing Jin
Summary: This study compared the efficacy and safety of neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locally advanced gastric cancer. The results showed that neoadjuvant chemoradiotherapy resulted in better tumor regression but did not improve the R0 resection rate. There was no significant difference in postoperative complications between the two groups.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Peiying Fu, Haiying Sun, Ting Zhou, Pengfei Cui, Shixuan Wang, Ronghua Liu
Summary: This study found that postoperative adjuvant therapy did not significantly improve disease-free survival or overall survival in patients with early stage endometrial cancer. However, cancer stage and age had a significant impact on survival in patients with stage I endometrial cancer.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qian Cai, Yize Mao, Siqi Dai, Feng Gao, Qian Xiao, Wanming Hu, Tao Qin, Qiuxia Yang, Zhaozhou Li, Du Cai, Min-Er Zhong, Kefeng Ding, Xiao-Jian Wu, Rong Zhang
Summary: This multicenter study aimed to investigate the correlation between the growth pattern of liver metastases on preoperative MRI and early recurrence in patients with colorectal cancer liver metastases. The results showed that FEP and NC type liver metastases were associated with early recurrence, which could guide the clinical treatment of patients with this condition.
EUROPEAN RADIOLOGY
(2022)
Review
Oncology
Tiuri E. Kroese, Hanneke W. M. Van Laarhoven, Magnus Nilsson, Florian Lordick, Matthias Guckenberger, Jelle P. Ruurda, Domenico D'Ugo, Karin Haustermans, Eric Van Cutsem, Richard Van Hillegersberg, Peter S. N. Van Rossum
Summary: Local treatment may improve overall survival in patients with esophagogastric cancer and oligometastatic disease (OMD). The current literature defines OMD as the presence of metastases limited to one organ with no more than three lesions and the presence of an extra-regional lymph node station. Local treatment appears to be associated with improved OS compared to systemic therapy alone.
EUROPEAN JOURNAL OF CANCER
(2022)
Editorial Material
Oncology
Christine M. Bestvina, Everett E. Vokes
Article
Oncology
Christine M. Bestvina, Blase N. Polite
JOURNAL OF ONCOLOGY PRACTICE
(2017)
Article
Health Care Sciences & Services
Christine M. Bestvina, Kristen E. Wroblewski, Bobby Daly, Brittany Beach, Selina Chow, Andrew Hantel, Monica Malec, Michael T. Huber, Blase N. Polite
JOURNAL OF PALLIATIVE MEDICINE
(2018)
Review
Oncology
Christine M. Bestvina, Leah L. Zullig, S. Yousuf Zafar
Article
Respiratory System
Anthony Serritella, Christine M. Bestvina
THORACIC SURGERY CLINICS
(2020)
Review
Oncology
Antonio Passaro, Christine Bestvina, Maria Velez Velez, Marina Chiara Garassino, Edward Garon, Solange Peters
Summary: Lung cancer patients face unique challenges during the COVID-19 pandemic, and providing them with rational and safe treatment has become a crucial question. Oncologists worldwide have taken action to understand the impact of COVID-19 on cancer patients and have developed guidelines and recommendations accordingly.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Nicole K. Yun, Sherin J. Rouhani, Christine M. Bestvina, Ethan M. Ritz, Brendan A. Gilmore, Imad Tarhoni, Jeffrey A. Borgia, Marta Batus, Philip D. Bonomi, Mary Jo Fidler
Summary: This study investigated the predictive value of NLR and other markers in patients with EGFR-mutated NSCLC undergoing TKI therapy. The results showed that high NLR values were associated with worse survival outcomes, suggesting its potential as a predictive biomarker for treatment intensification. Prospective validation of NLR is warranted.
Article
Oncology
Christine M. Bestvina, Kelli B. Pointer, Theodore Karrison, Hania Al-Hallaq, Philip C. Hoffman, Michael J. Jelinek, Aditya Juloori, James M. Melotek, Septimiu Murgu, Julien Partouche, Everett E. Vokes, Ralph R. Weichselbaum, Sean P. Pitroda, Jyoti D. Patel, Steven J. Chmura
Summary: A randomized phase 1 trial combined nivolumab and ipilimumab with sequential or concurrent multisite SBRT in patients with stage IV NSCLC to evaluate safety and obtain preliminary activity data. Results showed that concurrent therapy was not more toxic than sequential therapy, and multisite SBRT was well tolerated in widely metastatic patients. Multimodality therapy resulted in durable metastasis control and encouraging early overall survival.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Editorial Material
Oncology
Sherin J. Rouhani, Christine M. Bestvina
Summary: This article provides an overview of the trial of pembrolizumab plus next line chemotherapy and places it in the context of evaluating different strategies for extending the benefit of immunotherapy after disease progression. It also includes a summary of other immunotherapy-based combinations currently under investigation.
Editorial Material
Oncology
Christine M. Bestvina, Marina C. Garassino, Joel W. Neal, Heather A. Wakelee, Maximilian Diehn, Everett E. Vokes
JOURNAL OF CLINICAL ONCOLOGY
(2023)