Cancer heterogeneity is not compatible with one unique cancer cell metabolic map

Monocarboxylate transporters in the brain and in cancer

(2016) Jhudit Pérez-Escuredo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600Eand Pten Loss

(2016) Lee Ann Jolly et al.   CANCER RESEARCH

Single-Cell Sequencing for Precise Cancer Research: Progress and Prospects

(2016) Xiaoyan Zhang et al.   CANCER RESEARCH

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Plant nodulation inducers enhance horizontal gene transfer ofAzorhizobium caulinodanssymbiosis island

(2016) Jun Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology–Genomic Integration Analysis

(2016) Rachael Natrajan et al.   PLOS MEDICINE

Cellular and molecular processes in ovarian cancer metastasis. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis

(2015) Tsz-Lun Yeung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Common Responses of Tumors and Wounds to Hypoxia

(2015) Valéry L. Payen et al.   CANCER JOURNAL

Metabolic coupling in urothelial bladder cancer compartments and its correlation to tumor aggressiveness

(2015) Julieta Afonso et al.   CELL CYCLE

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells

(2015) Jhudit Pérez-Escuredo et al.   CELL CYCLE

Metabolic and mind shifts

(2015) Cyril Corbet et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters

(2015) Ibtissam Marchiq et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Rethinking glutamine addiction

(2015) Abigail S. Krall et al.   NATURE CELL BIOLOGY

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity

(2015) Noemi Andor et al.   NATURE MEDICINE

The increase in tumor oxygenation under carbogen breathing induces a decrease in the uptake of [18F]-fluoro-deoxy-glucose

(2015) Marie-Aline Neveu et al.   RADIOTHERAPY AND ONCOLOGY

Teamwork: The tumor cell edition

(2015) A. S. Cleary   SCIENCE

A generic cycling hypoxia-derived prognostic gene signature: application to breast cancer profiling

(2015) Romain Boidot et al.   Oncotarget

The SIRT1/HIF2  Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy

(2014) C. Corbet et al.   CANCER RESEARCH

Single Cell Genomics: Advances and Future Perspectives

(2014) Iain C. Macaulay et al.   PLoS Genetics

Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and “swarm intelligence”

(2013) M. Tarabichi et al.   CANCER AND METASTASIS REVIEWS

Location, Location, Location: Macrophage Positioning within Tumors Determines Pro- or Antitumor Activity

(2013) Lee B. Rivera et al.   CANCER CELL

The Relationship between Tumor Blood Flow, Angiogenesis, Tumor Hypoxia, and Aerobic Glycolysis

(2013) L. Ostergaard et al.   CANCER RESEARCH

Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

(2013) Tania Fiaschi et al.   CELL CYCLE

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Organized proteomic heterogeneity in colorectal cancer liver metastases and implications for therapies

(2013) Andrei Turtoi et al.   HEPATOLOGY

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force

(2013) F. Polet et al.   JOURNAL OF INTERNAL MEDICINE

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Intratumor Heterogeneity: Evolution through Space and Time

(2012) C. Swanton   CANCER RESEARCH

Mitochondrial dysfunction in breast cancer cells prevents tumor growth

(2012) Rosa Sanchez-Alvarez et al.   CELL CYCLE

Glucose Oxidation Modulates Anoikis and Tumor Metastasis

(2012) S. Kamarajugadda et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolic symbiosis in cancer: Refocusing the Warburg lens

(2012) Erica C. Nakajima et al.   MOLECULAR CARCINOGENESIS

The challenges posed by cancer heterogeneity

(2012) Sangeeta Bhatia et al.   NATURE BIOTECHNOLOGY

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolic reprogramming of the tumor

(2012) L M R Ferreira et al.   ONCOGENE

Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis

(2012) Dania Daye et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hallmarks of cancer: of all cancer cells, all the time?

(2012) Sébastien L. Floor et al.   TRENDS IN MOLECULAR MEDICINE

A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer

(2011) Joaquim Calbo et al.   CANCER CELL

Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors

(2011) R. Boidot et al.   CANCER RESEARCH

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments

(2011) N. Draoui et al.   Disease Models & Mechanisms

Single-cell dissection of transcriptional heterogeneity in human colon tumors

(2011) Piero Dalerba et al.   NATURE BIOTECHNOLOGY

Origins of regulated cell-to-cell variability

(2011) Berend Snijder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor-Associated Macrophages (TAMs) Form an Interconnected Cellular Supportive Network in Anaplastic Thyroid Carcinoma

(2011) Bernard Caillou et al.   PLoS One

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Identification of Cyclooxygenase-2 as a Major Actor of the Transcriptomic Adaptation of Endothelial and Tumor Cells to Cyclic Hypoxia: Effect on Angiogenesis and Metastases

(2010) G. Daneau et al.   CLINICAL CANCER RESEARCH

Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress

(2009) Mark W. Dewhirst   RADIATION RESEARCH

Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells

(2009) Olivier Feron   RADIOTHERAPY AND ONCOLOGY

The Pervasive Presence of Fluctuating Oxygenation in Tumors

(2008) L. I. Cardenas-Navia et al.   CANCER RESEARCH

Impact of cyclic hypoxia on HIF-1α regulation in endothelial cells - new insights for anti-tumor treatments

(2008) Philippe Martinive et al.   FEBS Journal