Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin

Modulator of Apoptosis 1 (MOAP-1) Is a Tumor Suppressor Protein Linked to the RASSF1A Protein

(2015) Jennifer Law et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2

(2014) Su Sien Ong et al.   BIOCHEMICAL JOURNAL

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

(2014) Sascha Rutz et al.   NATURE

The E3 ubiquitin ligase UBR5 is recurrently mutated in mantle cell lymphoma

(2013) B. Meissner et al.   BLOOD

VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases

(2013) Tadashi Nakagawa et al.   BMC MOLECULAR BIOLOGY

EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer

(2013) Amber Bradley et al.   CARCINOGENESIS

Dyrk2-associated EDD-DDB1-VprBP E3 Ligase Inhibits Telomerase by TERT Degradation

(2013) Hae-Yun Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evading apoptosis in cancer

(2013) Kaleigh Fernald et al.   TRENDS IN CELL BIOLOGY

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

(2012) Thorkell Gudjonsson et al.   CELL

The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1

(2012) Nai-Jia Huang et al.   JOURNAL OF CELL BIOLOGY

Ubiquitylation of p53 by the APC/C inhibitor Trim39

(2012) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EDD Inhibits ATM-mediated Phosphorylation of p53

(2011) Shiyun Ling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase

(2011) Wenqing Jiang et al.   MOLECULAR CELL

The N-end rule pathway: emerging functions and molecular principles of substrate recognition

(2011) Shashikanth M. Sriram et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Transcription Factor IIS Cooperates with the E3 Ligase UBR5 to Ubiquitinate the CDK9 Subunit of the Positive Transcription Elongation Factor B

(2010) Marilena Cojocaru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The multiple levels of regulation by p53 ubiquitination

(2009) J T Lee et al.   CELL DEATH AND DIFFERENTIATION

Ovarian cancer tumor infiltrating T-regulatory (Treg) cells are associated with a metastatic phenotype

(2009) Jason C. Barnett et al.   GYNECOLOGIC ONCOLOGY

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase

(2009) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro

(2008) P M O'Brien et al.   BRITISH JOURNAL OF CANCER

TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process

(2008) San San Lee et al.   EXPERIMENTAL CELL RESEARCH

Genomic stability and tumour suppression by the APC/C cofactor Cdh1

(2008) Irene García-Higuera et al.   NATURE CELL BIOLOGY

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY