The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma

Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels

(2015) Ken Fujimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EIF5A2 predicts outcome in localised invasive bladder cancer and promotes bladder cancer cell aggressiveness in vitro and in vivo

(2014) J-H Wei et al.   BRITISH JOURNAL OF CANCER

A Hypusine-eIF5A-PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer

(2014) K. Fujimura et al.   CANCER RESEARCH

Comparative Proteomic Analysis of Anti-Cancer Mechanism by Periplocin Treatment in Lung Cancer Cells

(2014) Zejun Lu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Increased Expression of EIF5A2, Via Hypoxia or Gene Amplification, Contributes to Metastasis and Angiogenesis of Esophageal Squamous Cell Carcinoma

(2014) Yan Li et al.   GASTROENTEROLOGY

Identification of genomic alterations in oesophageal squamous cell cancer

(2014) Yongmei Song et al.   NATURE

Genomic and molecular characterization of esophageal squamous cell carcinoma

(2014) De-Chen Lin et al.   NATURE GENETICS

Genome-Wide Analyses and Functional Classification of Proline Repeat-Rich Proteins: Potential Role of eIF5A in Eukaryotic Evolution

(2014) Ajeet Mandal et al.   PLoS One

Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies

(2013) Mark D. Minden et al.   AMERICAN JOURNAL OF HEMATOLOGY

Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation

(2013) Elisabeth Mémin et al.   CANCER RESEARCH

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

N1-guanyl-1,7-diaminoheptane (GC7) enhances the therapeutic efficacy of doxorubicin by inhibiting activation of eukaryotic translation initiation factor 5A2 (eIF5A2) and preventing the epithelial–mesenchymal transition in hepatocellular carcinoma cells

(2013) Bin Lou et al.   EXPERIMENTAL CELL RESEARCH

Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer

(2013) Feng-wei Wang et al.   International Journal of Biological Sciences

Overexpression of CK20, MAP3K8 and EIF5A correlates with poor prognosis in early-onset colorectal cancer patients

(2013) Berrin Tunca et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells

(2013) Catherine A Taylor et al.   Molecular Cancer

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

Tumor metastasis: moving new biological insights into the clinic

(2013) Liling Wan et al.   NATURE MEDICINE

Integrative Genomic Characterization of Oral Squamous Cell Carcinoma Identifies Frequent Somatic Drivers

(2013) C. R. Pickering et al.   Cancer Discovery

NAC1 Is an Actin-Binding Protein That Is Essential for Effective Cytokinesis in Cancer Cells

(2012) Kai Lee Yap et al.   CANCER RESEARCH

DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA

(2012) Xiangyi He et al.   CARCINOGENESIS

A tumour suppressor network relying on the polyamine–hypusine axis

(2012) Claudio Scuoppo et al.   NATURE

SIX1 promotes epithelial–mesenchymal transition in colorectal cancer through ZEB1 activation

(2012) H Ono et al.   ONCOGENE

Expression of Eukaryotic Initiation Factor 5A and Hypusine Forming Enzymes in Glioblastoma Patient Samples: Implications for New Targeted Therapies

(2012) Michael Preukschas et al.   PLoS One

Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer

(2012) O. Straume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

eIF5A isoforms and cancer: two brothers for two functions?

(2011) M. Caraglia et al.   AMINO ACIDS

Translational control of eIF5A in various diseases

(2011) Annette Kaiser   AMINO ACIDS

Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial–mesenchymaltransition

(2011) Wei Zhu et al.   GUT

Amplification of the ch19p13.2 NACC1 locus in ovarian high-grade serous carcinoma

(2011) Ie-Ming Shih et al.   MODERN PATHOLOGY

The immediate early gene Ier2 promotes tumor cell motility and metastasis and predicts poor survival of colorectal cancer patients

(2011) A Neeb et al.   ONCOGENE

YAP is a candidate oncogene for esophageal squamous cell carcinoma

(2010) Tomoki Muramatsu et al.   CARCINOGENESIS

The antitumor activity of the fungicide ciclopirox

(2010) Hongyu Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

The unique hypusine modification of eIF5A promotes islet β cell inflammation and dysfunction in mice

(2010) Bernhard Maier et al.   JOURNAL OF CLINICAL INVESTIGATION

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis

(2010) Chia-Hsin Chan et al.   NATURE CELL BIOLOGY

Functional significance of eIF5A and its hypusine modification in eukaryotes

(2009) M. H. Park et al.   AMINO ACIDS

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells

(2009) Y. Eberhard et al.   BLOOD

Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma

(2009) Dong-Jiang Tang et al.   HEPATOLOGY

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer

(2008) Lars Zender et al.   CELL

Crosstalk between small GTPases and polarity proteins in cell polarization

(2008) Sandra Iden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE