Full-length p53 tetramer bound to DNA and its quaternary dynamics

DelEnsembleElec: Computing Ensemble-Averaged Electrostatics Using DelPhi

(2016) Lane W. Votapka et al.   Communications in Computational Physics

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain

(2015) M D'Abramo et al.   ONCOGENE

Structure of full-length p53 tumor suppressor probed by chemical cross-linking and mass spectrometry

(2015) Christian Arlt et al.   PROTEOMICS

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53

(2015) Andreas C. Joerger et al.   STRUCTURE

POVME 2.0: An Enhanced Tool for Determining Pocket Shape and Volume Characteristics

(2014) Jacob D. Durrant et al.   Journal of Chemical Theory and Computation

Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein

(2014) Soheila Emamzadah et al.   JOURNAL OF MOLECULAR BIOLOGY

Small molecule induced reactivation of mutant p53 in cancer cells

(2013) Xiangrui Liu et al.   NUCLEIC ACIDS RESEARCH

Mapping the Structural and Dynamical Features of Multiple p53 DNA Binding Domains: Insights into Loop 1 Intrinsic Dynamics

(2013) Suryani Lukman et al.   PLoS One

Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

(2013) Christopher D. Wassman et al.   Nature Communications

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

(2013) Liz J. Valente et al.   Cell Reports

Allele-Specific p53 Mutant Reactivation

(2012) Xin Yu et al.   CANCER CELL

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

FTMAP: extended protein mapping with user-selected probe molecules

(2012) C. H. Ngan et al.   NUCLEIC ACIDS RESEARCH

Sequence-dependent sliding kinetics of p53

(2012) J. S. Leith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity

(2011) Tom J Petty et al.   EMBO JOURNAL

Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

(2011) Eviatar Natan et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element

(2011) S. Emamzadah et al.   MOLECULAR CANCER RESEARCH

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

(2010) R. Melero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single-molecule characterization of p53 search on DNA

(2010) A. Tafvizi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tumor Suppressor p53: From Structures to Drug Discovery

(2010) A. C. Joerger et al.   Cold Spring Harbor Perspectives in Biology

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Structure of the Human Telomere in K+Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

(2009) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

Conformational analysis of nucleic acids revisited: Curves+

(2009) R. Lavery et al.   NUCLEIC ACIDS RESEARCH

Flexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics

(2008) Leonardo G. Trabuco et al.   STRUCTURE