Article
Multidisciplinary Sciences
Ramesh Koirala, Andrew Vae Priest, Chi-Fu Yen, Joleen S. Cheah, Willem-Jan Pannekoek, Martijn Gloerich, Soichiro Yamada, Sanjeevi Sivasankar
Summary: Cadherin cell-cell adhesion proteins are crucial for tissue morphogenesis and wound healing. Research has shown that vinculin can convert weak X-dimers of cadherin into strong strand-swap dimers, thereby regulating cell-cell adhesion. This process is mediated by myosin II-dependent changes in cytoskeletal tension, providing insight into the mechanisms of cadherin conformational regulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Vivek K. Gupta, Ovijit Chaudhuri
Summary: Cell-cycle progression and division in animal cells are regulated not only by biochemical factors, but also by mechanical interactions with the microenvironment. This review summarizes recent research on how cells interpret physical cues to promote cell-cycle progression and initiate cell division, as well as how dividing cells generate forces to successfully divide. Additionally, it discusses the potential contribution of force generation during division to larger tissue-scale processes involved in development and homeostasis.
TRENDS IN CELL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Shuo Hou, Ruibin Zhang, Didier Lereclus, Qi Peng, Jie Zhang, Leyla Slamti, Fuping Song
Summary: This study reveals how the transcription factor CpcR interacts with the sporulation network to control cell differentiation. It is found that CpcR positively regulates a Spo0E family gene, and variations in Spo0E expression can modulate spore production. This research highlights the diversity in sporulation modes and illustrates the diversity in strategies employed by bacteria to control this differentiation pathway and ensure their survival.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xuan Liang, Antonia Weberling, Chun Yuan Hii, Magdalena Zernicka-Goetz, Clare E. Buckley
Summary: In the process of polarization, individual cells must integrate their forming apical domains into a central apical membrane initiation site (AMIS). Cell adhesion and cell division are two interrelated mechanisms of apical polarity localization, which work together to ensure the orderly formation of lumens within tissues.
Article
Biotechnology & Applied Microbiology
Haiyang Wang, Ding Wang, Yongfeng Shen, Chenglong Sun, Qiang Hu, Li Jiang, Quan Du
Summary: Glioma stem-like cells (GSCs) play a crucial role in the malignant progression of glioma, and long non-coding RNAs (lncRNAs) are closely associated with glioma development. This study found that the downregulation of lncRNA growth arrest-specific 5 (GAS5) was correlated with poor patient survival in GSCs and high-grade glioma tissues. Functional assays revealed that downregulation of GAS5 promoted the malignant characteristics of GSCs. Mechanistically, GAS5 acted as a suppressor by directly targeting the miR-23a/E-cadherin axis.
CANCER GENE THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Jooske L. Monster, Lars J. S. Kemp, Martijn Gloerich, Rachel S. van der Post
Summary: Gastric cancer is the fourth leading cause of cancer-related deaths worldwide, and patients with diffuse-type gastric cancer have a poor prognosis with limited effectiveness of conventional chemotherapies. However, recent advancements in mouse and organoid models, as well as multi-omic analyses, are shedding light on the mechanisms responsible for DGC initiation and progression, offering potential opportunities for targeted therapies.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Cell Biology
Shiyang Chen, Yajuan Zheng, Xiaojuan Ran, Hui Du, Hua Feng, Lei Yang, Yating Wen, Changdong Lin, Shihui Wang, Mengwen Huang, Zhanjun Yan, Dianqing Wu, Hongyan Wang, Gaoxiang Ge, An Zeng, Yi Arial Zeng, Jianfeng Chen
Summary: T cell contact with intestinal stem cells and transient amplifying cells plays a crucial role in regulating ISC differentiation by influencing the Wnt and Notch signaling pathways through cell-cell signaling. This interaction is essential in maintaining intestinal homeostasis and highlighting the importance of immune cells in intestinal function.
Article
Biochemistry & Molecular Biology
Jyoti Singh, Yusuf Hussain, Abha Meena, Suaib Luqman, Rohit Anthony Sinha
Summary: This study elucidates the molecular mechanism of aescin in targeting protein kinases responsible for lung cancer proliferation and mobility, suggesting that it could be a safer and more viable therapeutic agent for lung cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Orthopedics
Lei Xiang, Wendi Yang, Feng Wang, Gaozhan Liu
Summary: The study found that circ_0083964 was highly expressed in RA synovial tissues and RA-FLSs. Inhibition of circ_0083964 constrained proliferation, metastasis and inflammation, and promoted apoptosis in RA-FLSs. Moreover, circ_0083964 acted as a sponge of miR-204-5p to suppress the progression of RA-FLSs.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Oncology
Ga-Young Jeong, Mi Kyung Park, Hee-Joo Choi, Hee Woon An, Young-Un Park, Hyung-Jun Choi, Jin Park, Hyung-Yong Kim, Taekwon Son, Ho Lee, Kyueng-Whan Min, Young-Ha Oh, Jeong-Yeon Lee, Gu Kong
Summary: NSD3 plays a critical epigenetic role in breast cancer progression by modulating NOTCH signaling pathway, promoting tumor development and metastasis. This study highlights NSD3 as a potential therapeutic target for metastatic breast cancer.
Article
Oncology
Giuseppina Daniela Naimo, Martina Forestiero, Alessandro Paoli, Rocco Malivindi, Luca Gelsomino, Balazs Gyorffy, Adele Elisabetta Leonetti, Francesca Giordano, Salvatore Panza, Francesca Luisa Conforti, Paola Ruffo, Maria Luisa Panno, Loredana Mauro, Sebastiano Ando
Summary: Adiponectin enhances ERa-positive breast cancer cell growth and distant metastasis by promoting E-cadherin expression and altering cell polarity through the ERa/LKB1 complex. The presence of E-cadherin is crucial for the proliferative effects of adiponectin on breast cancer cells. Furthermore, adiponectin treatment leads to the colocalization of LKB1 and Cdc42 in the nucleus, impairing their cytosolic cooperation in maintaining cell polarity. These findings highlight the importance of adiponectin in breast cancer progression and metastasis.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biotechnology & Applied Microbiology
Feng-Lian Yang, Yu-Xia Wei, Bi-Yun Liao, Gui-Jiang Wei, Hai-Mei Qin, Xiao-Xia Pang, Jun-Li Wang
Summary: The study revealed that HOTAIR and EZH2 are highly expressed in NPC, while E-cadherin is lowly expressed. By regulating trimethylation of H3K27, HOTAIR inhibits E-cadherin expression, promoting NPC cell progression and tumor growth.
Review
Oncology
Manuela Santarosa, Roberta Maestro
Summary: The loss of epithelial integrity and the role of autophagy in cancer progression, particularly in the context of dysregulation of cell adhesion molecules like E-cadherin, are crucial factors. Cell adhesion and EMT play significant roles in the transition process of cancer, while autophagy may have dual effects on tumor progression, acting as both a suppressor and a promoter through mechanisms like EMT and drug resistance.
Article
Public, Environmental & Occupational Health
Dale S. Mantey, Stephanie I. Clendennen, Aslesha Sumbe, Anna Wilkinson, Melissa B. Harrell
Summary: This study examines the impact of stress on e-cigarette use among young people and finds that perceived stress is associated with progression and continuation of e-cigarette use among young adults, but not with initiation.
PREVENTIVE MEDICINE
(2022)
Article
Oncology
Weimin Wang, Jun Jin, Zhen Zhou, Yunfan Wang, Ke Min, Xin Zuo, Jiaping Jiang, Yan Zhou, Jun Shi
Summary: The overall survival rate of colorectal cancer patients is low, and the identification of valuable prognostic markers is urgently needed. This study investigated the clinical significance of Snail and E-cad expression in colorectal cancer and found that low Snail and high E-cad expression are associated with better prognosis.
Article
Pathology
Neil M. Neumann, Philip E. LeBoit, Jarish N. Cohen
Summary: Superficial angiomyxomas (SAMs) are benign cutaneous tumors that are associated with Carney complex (CC) and often show loss of PRKAR1A protein expression, which can be detected by immunohistochemistry and used as an adjunctive diagnostic tool with high specificity.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Health Care Sciences & Services
Chiao-Yun Lin, Ren-Chin Wu, Lan-Yan Yang, Shih-Ming Jung, Shir-Hwa Ueng, Yun-Hsin Tang, Huei-Jean Huang, Hsiu-Jung Tung, Cheng-Tao Lin, Hsuan-Yu Chen, Angel Chao, Chyong-Huey Lai
Summary: Diagnostic agreement among pathologists for endometrial hyperplasia is poor. This study identified miR-30a-3p, miR-141, miR-200a, miR-200b, and complete PTEN loss as useful tissue biomarkers for predicting endometrial cancer risk in patients with simple or complex hyperplasia without atypia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Hsiu-Jung Tung, Ren-Chin Wu, Chiao-Yun Lin, Chyong-Huey Lai
Summary: Endometrial cancer is one of the most common gynecologic cancers worldwide, with increasing incidence rates. The latest molecular classifications have identified different subtypes, but undifferentiated/dedifferentiated EC has not been mentioned. This rare and aggressive type of cancer is resistant to conventional chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Pai-Jui Yeh, Ren-Chin Wu, Chien-Ming Chen, Cheng-Tang Chiu, Ming-Wei Lai, Chien-Chang Chen, Chia-Jung Kuo, Jun-Te Hsu, Ming-Yao Su, Puo-Hsien Le
Summary: This study comprehensively analyzed the risk factors, clinical characteristics, endoscopic features, outcomes, and prognostic factors of CMV esophagitis. Findings showed that male sex, immunocompromised status, and critical illness were risk factors for CMV esophagitis. The major clinical presentations included epigastric pain, fever, dysphagia, and gastrointestinal bleeding. The CMV group had higher mortality rates and longer hospital stays compared to the non-CMV group. Acute kidney injury and intensive care unit admission were predictors of in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Wei Wen Teo, Xinang Cao, Chan-Shuo Wu, Hong Kee Tan, Qiling Zhou, Chong Gao, Kim Vanuytsel, Sara S. Kumar, George J. Murphy, Henry Yang, Li Chai, Daniel G. Tenen
Summary: This study identified a long non-coding RNA (LEVER) that inhibits the Polycomb Repressive Complex 2 (PRC2) and controls nearby embryonic form of beta-globin gene. The findings provide additional evidence for the functional interaction between PRC2 and RNA. The study reveals the gene-regulatory role of PRC2-RNA interactions and demonstrates the ability of a local process to regulate the expression of neighboring genes.
COMMUNICATIONS BIOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Puo-Hsien Le, Yung-Kuan Tsou, Ren-Chin Wu
Summary: Squamous cell papilloma is a disease found in the esophagus.
Article
Multidisciplinary Sciences
Shih-Chiang Huang, Chi-Chung Chen, Jui Lan, Tsan-Yu Hsieh, Huei-Chieh Chuang, Meng-Yao Chien, Tao-Sheng Ou, Kuang-Hua Chen, Ren-Chin Wu, Yu-Jen Liu, Chi-Tung Cheng, Yu-Jen Huang, Liang-Wei Tao, An-Fong Hwu, I-Chieh Lin, Shih-Hao Hung, Chao-Yuan Yeh, Tse-Ching Chen
Summary: The study presents an artificial-intelligence-assisted workflow for lymph node metastasis assessment, which significantly improves the sensitivity of micrometastasis and isolated tumor cells identification in gastric cancer, while reducing review time. Trained on high-resolution images, the algorithm demonstrates high accuracy in identifying metastatic LNs, showing robustness in cross-site evaluation.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Rodney Cheng-En Hsieh, Sunil Krishnan, Ren-Chin Wu, Akash R. Boda, Arthur Liu, Michelle Winkler, Wen-Hao Hsu, Steven Hsesheng Lin, Mien-Chie Hung, Li-Chuan Chan, Krithikaa Rajkumar Bhanu, Anupallavi Srinivasamani, Ricardo Alexandre De Azevedo, Yung-Chih Chou, Ronald A. DePinho, Matthew Gubin, Eduardo Vilar, Chao Hsien Chen, Ravaen Slay, Priyamvada Jayaprakash, Shweta Mahendra Hegde, Genevieve Hartley, Spencer T. Lea, Rishika Prasad, Brittany Morrow, Coline Agnes Couillault, Madeline Steiner, Chun-Chieh Wang, Bhanu Prasad Venkatesulu, Cullen Taniguchi, Yon Son Betty Kim, Junjie Chen, Nils-Petter Rudqvist, Michael A. Curran
Summary: Radiation therapy induces up-regulation of CD47 and PD-L1 through the ATR-mediated DNA repair signaling pathway in CRC cells, which limits TAA cross-presentation and immune activation. Combination therapy with anti-SIRP alpha and anti-PD-1 reverses immune resistance, promotes TAA cross-presentation and robust antitumor immune priming.
SCIENCE IMMUNOLOGY
(2022)
Article
Biology
Geng-Hao Liu, Xin-Cheng Zhuo, Yueh-Hsiang Huang, Hsuan-Miao Liu, Ren-Chin Wu, Chia-Jung Kuo, Ning-Hung Chen, Li-Pang Chuang, Shih-Wei Lin, Yen-Lung Chen, Huang-Yu Yang, Tzung-Yan Lee
Summary: Sleep disturbances and gut health are important factors influencing aging and have significant effects on immunity and metabolism. This study found that sleep fragmentation affects the inflammatory state of the gut, while restorative sleep and acupuncture have positive effects on inflammatory gut remodeling and gut microbial recovery.
Article
Cell Biology
Neil M. Neumann, Daniel M. Kim, Robert J. Huebner, Andrew J. Ewald
Summary: In this study, the process of bifurcation of mammary epithelium was investigated. The researchers observed changes in cell migration speed and the role of TGF-0 signaling in this process, revealing the mechanism behind mammary epithelial bifurcation.
JOURNAL OF CELL SCIENCE
(2023)
Article
Virology
Lilly Gu, Erica Lin, Shuaitong Liu, Ning Yang, Nicholas Kurtansky, Neil M. Neumann, Joseph Stoll, Cecilia Lezcano, Melissa Pulitzer, Sarah Noor, Alina Markova, Anthony Rossi, Mark A. Dickson, Liang Deng
Summary: Multiple treatment modalities, including chemotherapy, radiation therapy, and cryotherapy, have been reported for Kaposi sarcoma (KS). A study found that combination therapy of cryotherapy and topical imiquimod can lead to complete resolution of cutaneous KS in a relatively short period of time.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Angel Chao, Huei-Jean Huang, Chiao-Yun Lin, Chia-Hwa Lee, Chien-Hsing Lin, An-Shine Chao, Chyong-Huey Lai, Ting-Chang Chang, Kai-Yun Wu, Ren-Chin Wu
Summary: This study provides the first comprehensive analysis of the genetic landscape of SCT-NOS and reveals dysregulation in the hypoxia signaling pathway as a key molecular feature of this rare tumor. Long-term follow-up with periodic measurements of androgen levels should be pursued in all cases to detect potential recurrences.
ENDOCRINE-RELATED CANCER
(2023)
Article
Pathology
Margaret A. Black, Neil M. Neumann, Gregor Krings, Saleh Najjar, Megan L. Troxell, Aihui Wang, W. Patrick Devine, Poonam Vohra, Cynthia Gasper, Yunn-Yi Chen, Jarish N. Cohen, Gregory R. Bean
Summary: This study examined the clinicopathologic, immunohistochemical, and genetic features of 8 breast HAs and compared them to 3 mammary MECs. The results showed that both breast HA and MEC exhibited cell type-dependent expression of high- and low-molecular-weight keratins and p63, as well as genetic features such as MAML2 fusion genes. However, there were differences in the growth pattern, tumor architecture, and cell distribution between the two types of tumors. The findings provide insights into the pathogenesis of MAML2-rearranged neoplasms of the breast and highlight the overlapping genetic features of MEC and HA.
Article
Polymer Science
Shuen-Yeo Chen, Fu-Ying Lee, Ren-Chin Wu, Chien-En Chao, Chia-Jung Lu, Shih-Jung Liu
Summary: In this study, hybrid resorbable 3D-printed mesh/electrospun nanofibrous biomolecule-eluting mats were developed for alveolar ridge preservation. The fabrication process involved 3D printing and coaxial electrospinning technologies. The study demonstrated the successful fabrication of resorbable drug-eluting nanofibrous mats for alveolar ridge preservation using 3D printing and coaxial electrospinning technologies.
Article
Dermatology
Neil M. Neumann, Chien-Kuang Cornelia Ding, Amanda Borgen, Carlos U. Corvera, Jeffrey P. North, Amir Qorbani, Andrew E. Horvai
Summary: This article reports a rare case of primary cutaneous malignant perivascular epithelioid cell tumor (PEComa). The tumor rapidly grew from 3 cm to 12 cm within 3 months. Histological examination revealed an infiltrative neoplasm resembling undifferentiated pleomorphic sarcoma. Immunohistochemical evaluation supported the diagnosis of PEComa. Next-generation sequencing identified pathogenic gene deletions and copy number changes. This case demonstrates the rare transformation of cutaneous PEComa into a malignant sarcoma, highlighting the importance of prompt surgical management.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)