Article
Oncology
Tamara V. Azizova, Evgeny V. Bragin, Maria V. Bannikova, Nobuyuki Hamada, Evgeniya S. Grigoryeva
Summary: This study reports an increased risk of normal-tension glaucoma (NTG) in radiation workers exposed to chronic doses greater than 1Gy. If confirmed in other cohorts, this finding has significant implications for normal tissue complications in radiotherapy patients and ocular radiation protection in radiation workers.
Article
Biology
Daniel O. Stram, Mikhail Sokolnikov, Bruce A. Napier, Vadim V. Vostrotin, Alexander Efimov, Dale L. Preston
Summary: This study re-examined lung cancer mortality rates among workers at the Mayak nuclear facility in Russia, finding that both external gamma-ray and internal plutonium exposures significantly increased lung cancer incidence rates when considering dose uncertainty.
RADIATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Tamara V. Azizova, Evgeniya S. Grigoryeva, Nobuyuki Hamada
Summary: Research shows that there is a correlation between radiation dose rate and the risk of mortality from ischemic heart disease among occupationally chronically exposed workers. The risk increases with higher dose rates, and also with longer duration of exposure at high rates. These findings contribute to the scientific basis for recommendations on the radiation protection system.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Tamara Azizova, Maria B. Moseeva, Evgeniya S. Grigoryeva, Nobuyuki Hamada
Summary: This study reports the incidence risks for cerebrovascular diseases and strokes in a cohort of Russian nuclear workers chronically exposed to ionizing radiation. The findings suggest a significant association between cumulative radiation dose and CeVD incidence, but no significant association with stroke or its types.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2022)
Article
Biology
Tamara Azizova, Maria Bannikova, Ksenia Briks, Evgeniya S. Grigoryeva, Nobuyuki Hamada
Summary: Heart diseases are a major cause of death. A study on a cohort of Russian nuclear workers revealed that chronic occupational exposure to external gamma and/or internal alpha radiation is associated with an increased risk of certain types of heart diseases. Linear model analysis showed a positive correlation between the risks and gamma radiation dose, which remained significant after adjusting for non-radiation factors.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2023)
Article
Immunology
Thomas Benet, Selilah Amour, Martine Valette, Mitra Saadatian-Elahi, Ludwig Serge Aho-Glele, Philippe Berthelot, Marie-Agnes Denis, Jacqueline Grando, Caroline Landelle, Karine Astruc, Adeline Paris, Sylvie Pillet, Bruno Lina, Philippe Vanhems
Summary: This study found the high occurrence of asymptomatic and paucisymptomatic influenza among healthcare workers, representing a significant portion of the influenza burden. This emphasizes the importance of systematically implementing infection control measures among healthcare workers to prevent nosocomial transmission of influenza, regardless of respiratory symptoms.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Environmental Sciences
Kayo Togawa, Maria E. Leon, Pierre Lebailly, Laura E. Beane Freeman, Karl-Christian Nordby, Isabelle Baldi, Ewan MacFarlane, Aesun Shin, Sue Park, Robert T. Greenlee, Torben Sigsgaard, Ioannis Basinas, Jonathan N. Hofmann, Kristina Kjaerheim, Jeroen Douwes, Rachel Denholm, Gilles Ferro, Malcolm R. Sim, Hans Kromhout, Joachim Schuz
Summary: This study evaluated cancer incidence in male and female agricultural workers in an international consortium, AGRICOH, compared to their respective general populations. The results showed that agricultural workers have a lower risk of various cancers, but an elevated risk of prostate cancer, multiple myeloma (female), and melanoma of skin (female). There were significant variations in cancer risks between different cohorts.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Tamara Azizova, Maria Bannikova, Evgeniya S. Grigoryeva, Ksenia Briks, Nobuyuki Hamada
Summary: This study investigated mortality from diseases of the circulatory system (DCS) in Russian nuclear workers and found no significant associations between mortality and gamma-ray exposure or internal exposure to plutonium. However, a significant association was observed between gamma-ray exposure and mortality from ischemic stroke in male workers in the subcohort. Positive associations were also found between internal exposure and mortality from DCS and ischemic heart disease (IHD) in women.
JOURNAL OF RADIOLOGICAL PROTECTION
(2022)
Article
Allergy
Christian Romero-Mesones, Maria-Jesus Cruz, Isam Alobid, Blanca Barroso, Ebymar Arismendi, Pilar Barranco, Diana Betancor, Irina Bobolea, Blanca Cardaba, Elena Curto, Gemma Domenech, Javier Dominguez-Ortega, David Espejo, Francisco-Javier Gonzalez-Barcala, Juan-Alberto Luna-Porta, Carlos Martinez-Rivera, Mendez-Brea, Joaquim Mullol, Jose-Maria Olaguibel, Cesar Picado, Vicente Plaza, Victoria del Pozo, Santiago Quirce, Manuel-Jorge Rial, Jose-Maria Rodrigo-Munoz, Joaquin Sastre, Sandra Serrano, Lorena Soto-Retes, Antonio Valero, Marcela Valverde-Monge, Xavier Munoz
Summary: Work-related asthma (WRA) represents a significant burden in specialized asthma units. There are no significant differences in the severity of asthma, treatment adherence, lung function abnormalities, and number of exacerbations between those working and not working. This suggests that advice regarding changing jobs should be customized for individual patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Hilary L. Colbeth, Kevin T. Chen, Sally Picciotto, Sadie Costello, Ellen A. Eisen
Summary: This study investigates the relationship between exposure to metalworking fluids (MWFs) and incidence of various types of cancer, finding that oil-based straight and water-based synthetic MWF exposure are associated with increased risk of certain cancers.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Julio C. Hernando-Rodriguez, Nuria Matilla-Santander, Chantelle Murley, Katrina Blindow, Signild Kvart, Melody Almroth, Bertina Kreshpaj, Emelie Thern, Kathryn Badarin, Carles Muntaner, Virginia Gunn, Eva Padrosa, Mireia Julia, Theo Bodin
Summary: This study compares the use of sickness absence benefits (SABs) due to a common mental disorder (CMD) between precariously employed and non-precariously employed workers with CMDs. The study found that the use of SABs due to a CMD was slightly lower among precariously employed workers compared with those in standard employment. Women with three consecutive years in precarious employment had reduced SABs use, while men in precarious employment showed weaker evidence of association. Those in standard employment with high income also showed a lower use of SABs.
Article
Immunology
Stefano Porru, Maria Grazia Lourdes Monaco, Gianluca Spiteri, Angela Carta, Maria Diletta Pezzani, Giuseppe Lippi, Davide Gibellini, Evelina Tacconelli, Ilaria Dalla Vecchia, Emma Sala, Emanuele Sansone, Giuseppe De Palma, Carlo Bonfanti, Massimo Lombardo, Luigina Terlenghi, Enrico Pira, Ihab Mansour, Maurizio Coggiola, Catalina Ciocan, Alessandro Godono, Adonina Tardon, Marta-Maria Rodriguez-Suarez, Guillermo Fernandez-Tardon, Francisco-Jose Jimeno-Demuth, Rafael-Vicente Castro-Delgado, Tania Iglesias Cabo, Maria Luisa Scapellato, Filippo Liviero, Angelo Moretto, Paola Mason, Sofia Pavanello, Anna Volpin, Luigi Vimercati, Silvio Tafuri, Luigi De Maria, Stefania Sponselli, Pasquale Stefanizzi, Antonio Caputi, Fabriziomaria Gobba, Alberto Modenese, Loretta Casolari, Denise Garavini, Cristiana D'Elia, Stefania Mariani, Francesca Larese Filon, Luca Cegolon, Corrado Negro, Federico Ronchese, Francesca Rui, Paola De Michieli, Nicola Murgia, Marco Dell'Omo, Giacomo Muzi, Tiziana Fiordi, Angela Gambelunghe, Ilenia Folletti, Dana Mates, Violeta Claudia Calota, Andra Neamtu, Ovidiu Perseca, Catalin Alexandru Staicu, Angelica Voinoiu, Eleonora Fabianova, Jana Beresova, Zora Kl'ocova Adamcakova, Roman Nedela, Anna Lesnakova, Jana Holcikova, Paolo Boffetta, Mahsa Abedini, Giorgia Ditano, Shuffield Seyram Asafo, Giovanni Visci, Francesco Saverio Violante, Carlotta Zunarelli, Giuseppe Verlato
Summary: This research investigated the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort of over 60,000 health workers. The study found that age and previous infection significantly modified breakthrough infection rates, and previous SARS-CoV-2 infection and antibody titer were inversely related to the risk of breakthrough infection.
Article
Oncology
Giedre Smailyte, Auguste Kaceniene, Rita Steponaviciene, Ausrele Kesminiene
Summary: Among the Chernobyl cleanup workers, only incidence of mouth and pharynx cancers was increased compared to the expected, while an increased risk of thyroid cancer was observed among those who were younger than 30 years when entering the Chernobyl zone, had radiation dose above 100 mSv, and had shorter duration of stay. The findings are consistent with increased cancer risk related to behavioral factors observed in other cohorts of workers.
CANCER EPIDEMIOLOGY
(2021)
Article
Medical Laboratory Technology
Andrea Padoan, Luigi Dall'Olmo, Foscarina della Rocca, Francesco Barbaro, Chiara Cosma, Daniela Basso, Annamaria Cattelan, Vito Cianci, Mario Plebani
Summary: The study found significant differences in antibody levels at day 12 after receiving the BNT162b2 vaccine between infection-naive individuals and those with previous natural infection, but no differences were observed thereafter. There were no statistically significant differences between males and females, while individuals over 60 years of age had lower antibody levels at day 12 but not at day 28. The influence of sex and age on vaccine responses warrants further investigation, with age showing particular significance.
CLINICA CHIMICA ACTA
(2021)
Article
Biology
Nezahat Hunter, Richard G. E. Haylock, Michael Gillies, Wei Zhang
Summary: This study examines the relationship between long-term low-dose external radiation exposure and solid cancer incidence. The findings show a strong association between external dose and solid cancers in individuals only exposed to external radiation, which remains linear when accounting for smoking. Furthermore, there is a statistically significant increasing trend for colorectal, bladder, and pleural cancer with radiation dose.
RADIATION RESEARCH
(2022)
Article
Environmental Sciences
Tamara Azizova, Evgeniya Grigoryeva, Galina Zhuntova, Evgeniya Kirillova, Christopher Loffredo
Summary: Findings from animal experiments and epidemiological studies show contradictory conclusions about the effects of ionizing radiation on offspring. This paper introduces a database of families of workers from the Mayak nuclear facility, which could be used for investigating non-targeted and transgenerational radiation effects on offspring of exposed parents.
Review
Biology
Mark P. Little, Tamara Azizova, Nobuyuki Hamada
Summary: Studies have shown correlations between ionizing radiation and circulatory diseases, cataracts, and other ocular endpoints, with dose-response relationships observed. Additionally, neurological detriment may occur following radiation exposure at low-moderate doses.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Biology
Tamara V. Azizova, Maria V. Bannikova, Evgeniya S. Grigoryeva, Valentina L. Rybkina
Summary: The study found that occupational exposure to low dose-rate ionizing radiation at the Russian nuclear facility Mayak Production Association (PA) increases the risk of basal cell carcinoma (BCC), but does not significantly affect the risk of squamous cell carcinoma (SCC). Gender, age at hire, attained age, and facility type did not have a significant impact on the incidence risk of BCC and SCC.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2021)
Article
Environmental Sciences
Tamara Azizova, Maria Bannikova, Evgeniya S. Grigoryeva, Ksenia Briks, Nobuyuki Hamada
Summary: This study investigated mortality from diseases of the circulatory system (DCS) in Russian nuclear workers and found no significant associations between mortality and gamma-ray exposure or internal exposure to plutonium. However, a significant association was observed between gamma-ray exposure and mortality from ischemic stroke in male workers in the subcohort. Positive associations were also found between internal exposure and mortality from DCS and ischemic heart disease (IHD) in women.
JOURNAL OF RADIOLOGICAL PROTECTION
(2022)
Article
Biology
Tamara Azizova, Maria B. Moseeva, Evgeniya S. Grigoryeva, Nobuyuki Hamada
Summary: This study reports the incidence risks for cerebrovascular diseases and strokes in a cohort of Russian nuclear workers chronically exposed to ionizing radiation. The findings suggest a significant association between cumulative radiation dose and CeVD incidence, but no significant association with stroke or its types.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2022)
Editorial Material
Biology
Elizabeth A. Ainsbury, Claudia Dalke, Mariateresa Mancuso, Munira Kadhim, Roy A. Quinlan, Tamara Azizova, Lawrence T. Dauer, Joseph R. Dynlacht, Rick Tanner, Nobuyuki Hamada
Summary: Recent studies have shown that the lens of the eye is more sensitive to radiation than previously believed, leading to a reduction in occupational lens dose limits in the European Union countries, Japan, and elsewhere. This Commentary introduces the work of the LDLensRad Consortium in advancing the understanding of the mechanisms of low dose radiation cataract.
RADIATION RESEARCH
(2022)
Article
Oncology
Tamara V. Azizova, Evgeny V. Bragin, Maria V. Bannikova, Nobuyuki Hamada, Evgeniya S. Grigoryeva
Summary: This study reports an increased risk of normal-tension glaucoma (NTG) in radiation workers exposed to chronic doses greater than 1Gy. If confirmed in other cohorts, this finding has significant implications for normal tissue complications in radiotherapy patients and ocular radiation protection in radiation workers.
Article
Biology
Tamara Azizova, Maria Bannikova, Ksenia Briks, Evgeniya S. Grigoryeva, Nobuyuki Hamada
Summary: Heart diseases are a major cause of death. A study on a cohort of Russian nuclear workers revealed that chronic occupational exposure to external gamma and/or internal alpha radiation is associated with an increased risk of certain types of heart diseases. Linear model analysis showed a positive correlation between the risks and gamma radiation dose, which remained significant after adjusting for non-radiation factors.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2023)
Article
Hematology
T. Azizova, E. Bragin, M. Bannikova, E. S. Grigoryeva, A. Korobkin
Summary: This study aimed to assess the incidence and mortality rates of malignant neoplasms of the hematopoietic and lymphoid tissues (HLTT) in workers chronically exposed to occupational ionizing radiation. The results showed that the rates were associated with sex, attained age, and follow-up period, with higher rates in males compared to females. The study also revealed an increasing trend in the incidence rates of chronic leukemia and lymphoma by the end of the follow-up period.
GEMATOLOGIYA I TRANSFUZIOLOGIYA
(2023)
Article
Environmental Sciences
Sergey Osovets, Tamara Azizova, Maria B. Moseeva
Summary: This study aimed to estimate threshold doses and uncertainties for human health effects after short-term high-dose-rate radiation exposure. Results showed that the effective dose threshold technique provided more accurate and statistically significant threshold dose estimates compared to the quantile technique, which had higher relative uncertainties.
RADIATION PROTECTION DOSIMETRY
(2023)