Review
Biochemistry & Molecular Biology
Soo Youn Song, Ye Won Jung, WonKyo Shin, Mia Park, Geon Woo Lee, Soohwa Jeong, Sukjeong An, Kyoungmin Kim, Young Bok Ko, Ki Hwan Lee, Byung Hun Kang, Mina Lee, Heon Jong Yoo
Summary: Endometriosis, a common gynecologic disease, often leads to various pain symptoms such as dysmenorrhea, dyspareunia, and chronic pelvic pain. Inflammatory responses, nervous system sensitization, and altered distribution of nerve fibers may contribute to chronic pain in these patients. Understanding these mechanisms is crucial in guiding treatment decisions for endometriosis-related pain symptoms.
Article
Obstetrics & Gynecology
Sawsan As-Sanie, Sara R. Till, Andrew D. Schrepf, Kendall C. Griffith, Alex Tsodikov, Stacey A. Missmer, Daniel J. Clauw, Chad M. Brummett
Summary: While most women with chronic pelvic pain experience significant pain relief following hysterectomy, higher levels of centralized pain before the surgery are a strong predictor of persistent pelvic pain in the long term.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Caroline K. Heres, Noah B. Rindos, Isabel R. Fulcher, Sarah E. Allen, Nathan R. King, Shana M. Miles, Nicole M. Donnellan
Summary: The study aimed to quantify postoperative opioid use after laparoscopic surgery for endometriosis or pelvic pain, and identify patient characteristics associated with greater postoperative opioid requirements. Results showed that most patients had a lower postoperative opioid requirement than prescribed, suggesting surgeons can prescribe fewer postoperative narcotics in this population. Patients with a previous surgery for pelvic pain, self-reported chronic pelvic pain syndrome, anxiety, and depression may represent a subset of patients with increased postoperative opioid requirements.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Adela G. Cope, Marnie M. Wetzstein, Kristin C. Mara, Shannon K. Laughlin-Tommaso, Nafisseh S. Warner, Tatnai L. Burnett
Summary: This study aimed to assess the impact of abdominal ice packs on opioid use and pain control after laparoscopic hysterectomy. The results showed no significant difference in postoperative opioid use or pain assessment with ice pack use, but most subjects expressed high satisfaction and willingness to recommend ice pack use to others.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Marie Timmermans, Michelle Nisolle, Geraldine Brichant, Laurie Henry, Evy Gillet, Betty Kellner, Stavros Karampelas
Summary: Chronic pelvic pain is commonly associated with additional pathologies such as adenomyosis and endometriosis. A retrospective study found that 40% of patients with associated pathologies did not experience relief from pelvic pain at the early follow-up and 32% at the 12-month follow-up after laparoscopic niche repair. Therefore, careful patient selection is important for uterine scar repair in patients with concomitant adenomyosis and endometriosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Adrian Zegrea, Emilia Ojala, Pia Suvitie, Pirita Varpe, Heikki Huhtinen, Johanna Makela-Kaikkonen, Tero Rautio, Paivi Harkki, Sinikka Salmenkyla, Mika Ukkonen, Maija Lavonius, Tarja Pinta
Summary: This study found that sacral neuromodulation (SNM) may be an effective treatment for refractory chronic pelvic pain in women with endometriosis. Patients experienced pain reduction and improved quality of life after SNM implantation.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Richard Cockrum, Frank Tu
Summary: Hysterectomy is an important treatment option for patients with chronic pelvic pain that is refractory to conservative therapy. However, the lack of a standardized definition for chronic pelvic pain hinders the ability to draw firm conclusions about the efficacy of the surgery. Nonetheless, favorable outcomes have been reported for well-selected patients, particularly those with midline pelvic pain linked to the uterus. Surgical planning should also consider the treatment of extrauterine pathology, such as endometriosis, and the potential benefits of ovarian conservation for young patients. Additionally, postoperative care should address the unique needs of patients with chronic pain, including managing opioid use and early treatment of complications or pain generators.
OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA
(2022)
Article
Obstetrics & Gynecology
Amy L. Shafrir, Elena Martel, Stacey A. Missmer, Daniel J. Clauw, Steven E. Harte, Sawsan As-Sanie, Christine B. Sieberg
Summary: This study investigated the association between pelvic floor, abdominal, and uterine tenderness with central nervous system pain amplification among women with endometriosis or CPP. The results suggest that high pelvic floor tenderness may be a marker of heightened pain sensitivity and central nervous system pain amplification, impacting treatment response. Further research is needed to explore the predictive value of this clinical phenotype on response to medical and behavioral treatments for endometriosis and CPP.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Martin D. Laguerre, Brittany J. Arkerson, Matthew A. Robinson, Nash S. Moawad
Summary: This study found that laparoscopic surgery is an effective management tool for treating endometriosis, with low rates of reoperation and high efficacy in treating infertility caused by endometriosis.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Megha Mistry, Paul Simpson, Edward Morris, Ann-Katrin Fritz, Babu Karavadra, Carole Lennox, Ed Prosser-Snelling
Summary: Research on the effects of cannabis-based products on the female reproductive system, particularly in the context of endometriosis, is limited and inconclusive. While some studies suggest potential benefits, there is a lack of well-designed, robust studies and randomized controlled trials. National guidance in the UK currently does not recommend the use of cannabis-based products due to insufficient evidence of their benefits. Further comprehensive research is needed before their use can be recommended or prescribed.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
M. Bourdon, V Antoine, U. Combes, L. Maitrot-Mantelet, L. Marcellin, C. Maignien, C. Chapron, P. Santulli
Summary: The study found no association between endometriosis and a history of childhood and/or adolescent sexual abuse, but there was a link between severe pelvic pain and sexual abuse.
HUMAN REPRODUCTION
(2023)
Article
Clinical Neurology
Frances M. De Blasio, Sapphire Love, Robert J. Barry, Katherine Wassink, Adele E. Cave, Mike Armour, Genevieve Z. Steiner-Lim
Summary: This study assessed the differences in resting electroencephalogram (EEG) oscillatory amplitudes between women with endometriosis and healthy controls, and explored the relationship with chronic pelvic pain. The results showed that women with endometriosis had higher amplitudes in the Delta and Beta frequency bands, and lower amplitudes in the Alpha frequency band. Delta and Beta amplitudes were positively associated with pain severity, but only Beta amplitude maintained this association after controlling for Delta-Beta amplitude coupling.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Health Care Sciences & Services
Augusto Pereira, Manuel Herrero-Trujillano, Gema Vaquero, Lucia Fuentes, Sofia Gonzalez, Agustin Mendiola, Tirso Perez-Medina
Summary: This study reviewed clinical data of 46 patients with endometriosis and chronic pelvic pain unresponsive to conventional therapies. The findings suggest that a combination of neuromodulators, myofascial pain therapies, and S3 pulsed radiofrequency plus inferior hypogastric plexus blockade can be effective in managing pain in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Camran Nezhat, Ellie Armani, Hsuan-Chih Carolina Chen, Zahra Najmi, Steven R. Lindheim, Ceana Nezhat
Summary: Endometriosis is a common condition with significant impacts on individuals' quality of life. Delayed diagnosis emphasizes the need for non-invasive screening, and this study evaluated the utility of a mobile app called Endometriosis Risk Advisor (EndoRA) in screening for endometriosis in patients with chronic pelvic pain and unexplained infertility. The results showed that EndoRA had high sensitivity but low specificity in detecting endometriosis, suggesting it can be a valuable screening tool for high-risk individuals.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Anja S. Frost, Jaden R. Kohn, Margot Le Neveu, Tara Brah, Obianuju Okonkwo, Mostafa A. Borahay, Harold Wu, Khara Simpson, Kristin E. Patzkowsky, Karen C. Wang
Summary: This study aimed to determine the effect of direct laparoscopic uterosacral bupivacaine administration on opioid usage and postoperative pain in patients undergoing minimally invasive hysterectomy. The results showed that the administration of bupivacaine did not reduce opioid usage or change pain scores in this type of surgery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Payton C. Schmidt, Neil S. Kamdar, Elisabeth Erekson, Carolyn W. Swenson, Shitanshu Uppal, Daniel M. Morgan
Summary: A prospective study was conducted to develop a preoperative risk assessment tool for predicting postoperative complications within 30 days of hysterectomy in women. The model demonstrated consistent discrimination ability in different validation cohorts. Modifiable risk factors identified included preoperative blood transfusion, poor glycemic control, and open abdominal surgery.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Christopher X. Hong, Neil S. Kamdar, Daniel M. Morgan
Summary: Prediction models for same-day discharge following minimally invasive hysterectomy were developed using both clinical and nonclinical attributes. Factors related to intraoperative, hospital, and surgeon attributes had the strongest predictive ability.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Letter
Obstetrics & Gynecology
Michelle H. Moniz, Alex F. Peahl, Dawn Zinsser, Giselle E. Kolenic, Molly J. Stout, Daniel M. Morgan
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Jennifer Travieso, Neil Kamdar, Daniel M. Morgan, Sawsan As-Sanie, Sara R. Till
Summary: The study aimed to evaluate the impact of adding pharmacologic prophylaxis to mechanical prophylaxis on perioperative outcomes in benign hysterectomy. The results showed that dual prophylaxis was associated with longer operative time and higher estimated blood loss in abdominal hysterectomy, while no differences were observed in the minimally invasive surgeries.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Editorial Material
Obstetrics & Gynecology
Jennifer Travieso, Neil Kamdar, Daniel M. Morgan, Sawsan As-Sanie, Sara R. Till
Summary: VTE is a potential preventable perioperative complication of benign hysterectomy, with lower rates when using mechanical prophylaxis compared to pharmacologic prophylaxis, which may increase operative time and bleeding risks.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2022)
Article
Public, Environmental & Occupational Health
Alex F. Peahl, Daniel M. Morgan, Elizabeth S. Langen, Lisa Kane Low, Chad M. Brummett, Yen-Ling Lai, Hsou-Mei Hu, Melissa Bauer, Jennifer Waljee
Summary: This retrospective cohort study aimed to evaluate variation in postpartum opioid prescribing rates and prescription size across providers and hospitals. The study analyzed claims data from 84 hospitals in a single-payer Preferred Provider Organization. The results showed that approximately 37.2% of patients filled a postpartum opioid prescription, with a median prescription size of 150 oral morphine equivalents. The variation in prescribing rates and prescription size was mainly attributable to providers and hospitals. Future efforts should focus on implementing best practices at the provider and hospital levels to improve postpartum opioid prescribing.
WOMENS HEALTH ISSUES
(2023)
Editorial Material
Obstetrics & Gynecology
Makazhia McGowan, Mara D'Amico, Minji Kang, Vivian Ling, Michelle H. Moniz, Daniel M. Morgan, Alex F. Peahl
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Kyle R. Latack, Michelle Moniz, Christopher X. Hong, Payton Schmidt, Anita Malone, Neil Kamdar, Brian Madden, Chelsea A. Pizzo, Michael P. Thompson, Daniel M. Morgan
Summary: Geographic variation in surgical approach for hysterectomy in prolapse repair was examined in this study. The results showed significant variation in the proportion of vaginal hysterectomy across different counties in Michigan. Vaginal hysterectomy was associated with higher rates of concurrent colporrhaphy and lower rates of concurrent colpopexy compared to laparoscopic approaches.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Elizabeth S. Langen, Amy J. Schiller, Kathryn Moore, Charley Jiang, Althea Bourdeau, Daniel M. Morgan, Lisa Kane Low
Summary: This study evaluates the impact of elective induction of labor (eIOL) at 39 weeks on nulliparous, term, singleton, vertex pregnancies. The results suggest that eIOL does not reduce the cesarean birth rate among these pregnancies, but it may decrease the occurrence of hypertensive disorders of pregnancy.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Elisabeth Erekson, Emily L. Whitcomb, Neil Kamdar, Steve Swift, Geoffrey W. Cundiff, Jerome Yaklic, Kris Strohbehn, Rony Adam, Jill Danford, Marcella G. Willis-Gray, Rose Maxwell, Autumn Edenfield, Samantha Pulliam, Merry Gong, Mackenzie Malek, Paul Hanissian, Geoffrey Towers, Noelani M. Guaderrama, Paul Slocum, Daniel Morgan
Summary: Surgery for stress urinary incontinence is an elective procedure that can greatly improve quality of life. Performing a standard set of perioperative tasks can optimize the quality of care in these procedures.
Meeting Abstract
Obstetrics & Gynecology
C. X. Hong, M. O'Leary, W. Horner, P. Schmidt, H. S. Harvie, N. Kamdar, D. Morgan
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
K. R. Latack, M. Moniz, C. X. Hong, P. Schmidt, A. Malone, N. Kamdar, B. Madden, D. Morgan
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
AnneMarie E. Opipari, Emily Kobernik, Molly J. Stout, Elizabeth S. Langen, Angela Liang, Natalie Saunders, Daniel M. Morgan
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Mary Duarte Thibault, Allison Milen, Luke Burns, Anca Tilea, Kenneth Piehl, Daniel Morgan
Summary: Combining interventions can effectively reduce the rate of postoperative symptomatic urinary tract infections (SUTIs). A retrospective analysis of female pelvic medicine and reconstructive surgery (FPMRS) practice showed a 50% decrease in the annual infection rate after implementing interventions.
Meeting Abstract
Obstetrics & Gynecology
C. X. Hong, N. Kamdar, D. Morgan
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)