Article
Endocrinology & Metabolism
Ximena Orozco-Ruiz, Andrea Anesi, Fulvio Mattivi, Monique M. B. Breteler
Summary: Visceral and subcutaneous adipose tissue function as endocrine organs and affect metabolic health through metabolite concentrations. This study found that certain metabolite concentrations associated with cardiometabolic risk markers are altered with increased visceral adipose tissue volume.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Imen Becetti, Meghan Lauze, Hang Lee, Miriam A. Bredella, Madhusmita Misra, Vibha Singhal
Summary: This study found that adults with obesity experience a reduction in branched-chain amino acid levels following metabolic and bariatric surgery (MBS), which may contribute to the metabolic advantages of MBS. The study also suggests that reducing dietary intake and serum branched-chain amino acid concentrations may reduce insulin resistance.
Article
Biochemistry & Molecular Biology
Marzieh Salehi, Ralph DeFronzo, Amalia Gastaldelli
Summary: This study investigated the effect of weight loss surgery on insulin kinetics. The results showed that the altered insulin clearance rate after surgery is mainly attributed to the liver rather than other organs. In addition, the endogenous insulin clearance rate is more sensitive to the increase in circulating insulin levels, while peripheral insulin sensitivity is similar among the three groups. After a meal, the weight loss surgery group had higher insulin secretion, independent of glycemic levels. Compared to sleeve gastrectomy, gastric bypass surgery resulted in greater post-meal insulin secretion and a reduction in post-meal insulin clearance rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Chunlan Zhang, Jingjing Zhang, Zhiguang Zhou
Summary: The fasting bile acid levels, especially 12a-hydroxylated bile acid levels, were found to increase significantly after Roux-en-Y gastric bypass (RYGB). However, no significant changes in fasting bile acid levels were observed following sleeve gastrectomy (SG).
Article
Surgery
Stefan Wallen, Gustaf Bruze, Johan Ottosson, Claude Marcus, Johan Sundstrom, Eva Szabo, Torsten Olbers, Maria Palmetun-Ekback, Ingmar Naslund, Martin Neovius
Summary: This study aimed to compare the use of opioids in patients with obesity who underwent bariatric surgery versus those who underwent intensive lifestyle modification. The results showed that patients who underwent bariatric surgery had a higher proportion of opioid users and a larger total opioid dose, especially in those who received additional surgery during follow-up.
Article
Multidisciplinary Sciences
Chang Ho Ahn, Eun Hye Choi, Hyunjung Lee, Woochan Lee, Jong-Il Kim, Young Min Cho
Summary: VSG surgery can reduce body weight, improve glucose tolerance, and induce unique gene expression changes in the liver, fat, and muscle, but not more significantly than the pair-fed group of sham-operated mice. VSG surgery can induce organ-specific gene expression changes in the liver, fat, and muscle, which may play critical roles in metabolic improvements after VSG.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Naama Shirazi, Nahum Beglaibter, Ronit Grinbaum, Wiessam Abu Ahmad, Anna Aronis
Summary: This study compared nutritional deficiencies and metabolic markers one year after OAGB and SG procedures. The results showed a higher risk of nutritional deficiencies after OAGB, but this risk can be minimized with nutritional recommendations and supplement plans, resulting in comparable metabolic improvement to SG after one year.
Article
Surgery
Karan R. Chhabra, Dana A. Telem, Grace F. Chao, David E. Arterburn, Jie Yang, Jyothi R. Thumma, Andrew M. Ryan, Blanche Blumenthal, Justin B. Dimick
Summary: In a large cohort of commercially insured patients, sleeve gastrectomy was found to have a superior safety profile to gastric bypass up to 2 years from surgery, even when accounting for selection bias. However, further exploration is needed regarding the higher risk of revisions in sleeve gastrectomy.
Article
Pharmacology & Pharmacy
Nele Steenackers, Tim Vanuytsel, Patrick Augustijns, Ellen Deleus, Wies Deckers, Christophe M. Deroose, Gwen Falony, Matthias Lannoo, Ann Mertens, Raf Mols, Roman Vangoitsenhoven, Lucas Wauters, Bart Van der Schueren, Christophe Matthys
Summary: This study investigated the effects of sleeve gastrectomy and Roux-en-Y gastric bypass on gastrointestinal motility, pH, and bile acid concentration. The findings showed that both surgeries increased pouch emptying and gastric emptying, and also led to higher pH levels and bile acid concentrations in the intestines. These results highlight the significant impact of these surgeries on gastrointestinal physiology.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Endocrinology & Metabolism
Sindre Lee, Hanne L. Gulseth, Torgrim M. Langleite, Frode Norheim, Thomas Olsen, Helga Refsum, Jorgen Jensen, Kare Birkeland, Christian A. Drevon
Summary: The study found that obesity and insulin resistance are associated with elevated plasma levels of BCAAs, and insulin sensitivity is correlated with BCAA levels in the body. Global mRNA-sequencing pathway analysis revealed reduced BCAA metabolism in individuals with insulin resistance compared to normal individuals at baseline. Additionally, exercise for 12 weeks was shown to increase BCAA metabolism in both groups, as indicated by enhanced expression of the gene encoding BCKDH.
Article
Surgery
Camille Marciniak, Xavier Lenne, Amelie Bruandet, Aghiles Hamroun, Michael Genin, Gregory Baud, Didier Theis, Francois Pattou, Robert Caiazzo
Summary: This study assessed the relevance of concomitant laparoscopic metabolic bariatric surgery (MBS) and cholecystectomy, and found that cholecystectomy should be avoided during sleeve gastrectomy (SG) and gastric bypass (GBP) procedures. Prophylactic cholecystectomy is not recommended for asymptomatic gallstones after MBS.
Article
Surgery
Daniel Leslie, Eric Wise, Adam Sheka, Hisham Abdelwahab, Ryan Irey, Ashley Benner, Sayeed Ikramuddin
Summary: The study compared the incidence of GERD, esophagitis, and BE postoperatively in patients undergoing VSG and RYGB, finding that VSG patients had a higher frequency of postoperative GERD, while BE was more prevalent among RYGB patients. De novo esophageal reflux symptomatology was more common in VSG patients, but RYGB patients had a higher rate of re-admission.
Article
Nutrition & Dietetics
Silvia Bettini, Gianni Segato, Luca Prevedello, Roberto Fabris, Chiara Dal Pra, Eva Zabeo, Chiara Compagnin, Fabio De Luca, Cristiano Finco, Mirto Foletto, Roberto Vettor, Luca Busetto
Summary: In patients with severe obesity, those undergoing OAGB surgery showed a greater improvement in lipid profile compared to LSG patients. The reduction in plasma lipid levels was independent of the significant decrease in BMI after surgery.
Article
Medicine, General & Internal
Georgios-Ioannis Verras, Francesk Mulita, Sjaak Pouwels, Chetan Parmar, Nikolas Drakos, Konstantinos Bouchagier, Charalampos Kaplanis, George Skroubis
Summary: Morbid obesity is a chronic disease with a rising incidence, and surgical treatment has shown superior outcomes compared to conventional weight loss measures. This study evaluated the long-term weight loss outcomes, comorbidity reduction, and adverse effects of Roux-en-Y Gastric Bypass (RYGB), Biliopancreatic Diversion (BPD), and Sleeve Gastrectomy (SG) at 10 years. RYGB and BPD resulted in significant weight loss, with no observed differences in diabetes resolution and adverse outcomes. Longer follow-up reports are important for comparing the outcomes of different bariatric operations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Andreas Plamper, Philipp Lingohr, Jennifer Nadal, Jonel Trebicka, Maximilian J. Brol, Anna Woestemeier, Sophia M-T Schmitz, Patrick H. Alizai, Ulf P. Neumann, Tom F. Ulmer, Karl P. Rheinwalt
Summary: This study compared the long-term outcomes of one anastomosis gastric bypass (OAGB) and sleeve gastrectomy (SG) in bariatric surgery patients. The results showed that OAGB had superior effects on weight loss, improvement of type 2 diabetes and sleep apnea, while SG was associated with more long-term problems such as insufficient weight loss/regain and reflux. However, OAGB had a higher risk of nutritional deficiencies.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)