Review
Public, Environmental & Occupational Health
Felix Jebasingh, Nihal Thomas
Summary: Early onset hypertension is a major medical disorder that has emerged in both developing and developed countries in the current millennium. Low birth weight has been associated with hypertension, possibly due to foetal onset adult disease and the impact of low nephron mass.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
F. Coghe, D. Fanni, C. Gerosa, A. Ravarino, M. Mureddu, G. Cerrone, P. Coni, G. Pichiri, T. Congiu, M. Piras, F. Cau, V. Aimola, A. Balestrieri, E. Lai, M. Manchia, A. Scano, G. Orru, G. La Nasa, P. Van Eyken, L. Saba, M. Scartozzi, M. Castagnola, G. Faa
Summary: The increasing incidence of cancers has led oncologists to seek new explanations beyond the somatic mutation theory. The exposure of embryos and fetuses to environmental factors during gestation may influence the susceptibility to cancer later in life. Epigenetic factors and gene expression similarities between embryonic development and cancer are important mediators in prenatal human development. Maternal obesity can also impact embryo-fetal development and increase the risk of certain cancers.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Alexandra Crivelli-Meyer, Olivier Giannini, Mario Giovanni Bianchetti, Giacomo Domenico Simonetti
Summary: A majority of adults remember their own birth weight, making it reasonable to include this information in risk stratification for cardiovascular and renal diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Computer Science, Information Systems
Ilia Rattsev, Natalie Flaks-Manov, Angie C. Jelin, Jiawei Bai, Casey Overby Taylor
Summary: This study developed a 4-step framework using a clinical phenotyping tool to assess risk factors for recurrent preterm birth, showing that the models stratified by delivery subtype performed better in predicting preterm birth risk.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Tom G. Richardson, Daniel J. M. Crouch, Grace M. Power, Fernanda Morales-Berstein, Emma Hazelwood, Si Fang, Yoonsu Cho, Jamie R. J. Inshaw, Catherine C. Robertson, Carlo Sidore, Francesco Cucca, Steven S. Rich, John A. Todd, George Davey Smith
Summary: This study shows that childhood body size has a direct effect on the risk of type 1 diabetes, even after accounting for body size at birth and during adulthood. It also suggests that childhood body size influences the risk of asthma, eczema, and hypothyroidism, but these effects are mediated by body size in later life.
NATURE COMMUNICATIONS
(2022)
Review
Medicine, General & Internal
Maria Eugenia Bianchi, Jaime M. Restrepo
Summary: Based on studies conducted over the past 40 years, low birthweight has been found to be a significant predictor of perinatal death and morbidity, as well as an increased risk of chronic non-communicable diseases (NCDs) in adulthood. The Barker hypothesis suggests that adults with low birthweight or an unhealthy intrauterine environment, combined with a rapid catch-up in growth, are more susceptible to NCDs. This research has had a major impact on pediatric and obstetric practices.
FRONTIERS IN MEDICINE
(2022)
Article
Automation & Control Systems
Abdul Wahid, Dost Muhammad Khan, Sajjad Ahmad Khan, Ijaz Hussain, Zardad Khan
Summary: A novel robust penalized estimator for high-dimensional Cox regression model is proposed to deal with noisy and non-normal survival data, providing robustness to outliers and high leverage points. The method uses weighted partial likelihood and l1-norm to achieve better accuracy and sparsity, showing competitive performance in both simulation study and real survival datasets.
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
(2021)
Article
Public, Environmental & Occupational Health
Alicia R. Riley, Daniel Collin, Jacob M. Grumbach, Jacqueline M. Torres, Rita Hamad
Summary: The extreme right-left partisanship in the current US context affects state policies, with left-leaning state policy orientation being associated with lower odds of adverse birth outcomes, especially for infants born in the US and White mothers. However, the association between left-leaning state policy orientation and lower odds of adverse birth outcomes may be explained by stable characteristics of states.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2021)
Article
Endocrinology & Metabolism
Zijun Liao, Xianghui Xie, Jing Wang, Yiren Chen, Ting Zhang, Gongshu Liu, Fangfang Chen
Summary: This study investigates the impact of factors in the first 1,000 days of life on metabolic phenotypes of obesity in preschool children. The results show that maternal obesity and accelerated BMI growth rate between 6 and 24 months are related to both metabolically healthy and metabolically unhealthy overweight or obesity. Children with these early life factors should receive weight control interventions to prevent metabolic abnormalities.
Article
Environmental Sciences
Felipe Parra do Nascimento, Marcia Furquim de Almeida, Nelson Gouveia
Summary: This study aimed to investigate whether maternal education and area-level socioeconomic status modify the effect of ozone, nitrogen dioxide, and PM10 on preterm births and term low birth weight. Results indicated that socioeconomic status plays a significant modifying role in the relationship between air pollution exposure and adverse birth outcomes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Anran Cai, Lutzen Portengen, Gokhan Ertaylan, Juliette Legler, Roel Vermeulen, Virissa Lenters, Sylvie Remy
Summary: This study investigated the molecular mechanisms underlying the association between metabolism-disrupting chemicals (MDCs) and birth weight. Through transcriptome analysis, several metabolism-related gene expressions associated with both an MDC and birth weight were identified, and pathways related to genetic information processing were found to be overlapping. This study provides valuable insights into the potential mechanisms of MDC-induced altered birth weight.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Developmental Biology
Sophia Han, Charlotte C. Ellberg, Isoken N. Olomu, Arpita K. Vyas
Summary: Research indicates that alterations in the human microbiome are linked to disease states such as obesity and diabetes. During pregnancy, these conditions are associated with maternal microbial dysbiosis. The review also discusses the connections between the maternal microbiome in disease states and the offspring microbiome, highlighting the impact of offspring microbiome alterations on postnatal health outcomes.
Article
Nutrition & Dietetics
Teofana Otilia Bizerea-Moga, Laura Pitulice, Cristina Loredana Pantea, Orsolya Olah, Otilia Marginean, Tudor Voicu Moga
Summary: This study aimed to investigate the correlation between extreme birth weights and metabolic syndrome in obese children. The findings showed that birth weight had an independent effect on triglycerides and insulin resistance, while obesity was directly associated with hypertension, impaired glucose metabolism, and hypertriglyceridemia. Larger prospective studies in normal-weight patients are needed to further understand this relationship.
Article
Environmental Sciences
Lili Xiong, Zenghui Xu, Chaojie Wang, Fanjuan Kong, Donghua Xie, Hua Wang
Summary: The study explores the association between trimester-specific exposure to air pollutants and the risk of Birth defects (BDs) among Chinese births. The findings suggest that exposure to PM2.5 and O3 during pregnancy is associated with increased risks of BDs, with different pollutants during different trimesters showing links to different BD types. These results provide valuable insights for public health policy.
ATMOSPHERIC POLLUTION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Xin Huang, Jun Liu, Lu Qi, Jonathan D. Adachi, Jing Wu, Ziyi Li, Qiong Meng, Guowei Li, Gregory Y. H. Lip
Summary: Low birth weight is associated with an increased risk of cardiovascular events, while high birth weight is not associated with cardiovascular outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Obstetrics & Gynecology
Patrick Sloan, Cynthia Rodriguez, Bruce A. Bedell, Jeffrey C. Murray, John M. Dagle, Kelli Ryckman, Lori R. Holtz
Summary: This study aimed to determine the prevalence of virus in a preterm cohort and explore its association with histologic chorioamnionitis, spontaneous preterm labor, and pre-eclampsia. The results showed a higher detection rate of virus in maternal samples compared to cord blood from infants. However, there was no significant correlation between the presence or quantity of virus in maternal blood and the aforementioned conditions in this well-defined cohort.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Pediatrics
Scott P. Oltman, Elizabeth E. Rogers, Rebecca J. Baer, Elizabeth A. Jasper, James G. Anderson, Martina A. Steurer, Matthew S. Pantell, Mark A. Petersen, J. Colin Partridge, Deborah Karasek, Kharah M. Ross, Sky K. Feuer, Linda S. Franck, Larry Rand, John M. Dagle, Kelli K. Ryckman, Laura L. Jelliffe-Pawlowski
Summary: The study demonstrated that metabolites from routine newborn screening can be used to create a metabolic vulnerability profile to evaluate the risk of neonatal mortality and major morbidity in preterm infants. The model showed exceptional performance for predicting mortality or major morbidity outcomes, and could potentially improve clinical monitoring and research into biological pathways associated with preterm birth complications.
PEDIATRIC RESEARCH
(2021)
Article
Surgery
Namrata Singh, Rebecca J. Baer, Maya Swaminathan, Shireesh Saurabh, Jeffrey A. Sparks, Gretchen Bandoli, Elena Flowers, Laura L. Jelliffe-Pawlowski, Kelli K. Ryckman
Summary: This study evaluated the impact of bariatric surgery on pregnancy outcomes in women with ARDs, as well as assessed the risk of bariatric surgery on similar outcomes in women without ARDs.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Obstetrics & Gynecology
Sonia T. Anand, Elizabeth A. Chrischilles, Rebecca J. Baer, Mary E. Charlton, Patrick J. Breheny, William W. Terry, Monica R. McLemore, Deborah A. Karasek, Laura L. Jelliffe-Pawlowski, Kelli K. Ryckman
Summary: In both California and Iowa, women with a history of leukemia or lymphoma are at increased risk for preterm birth. This highlights the importance of counseling and monitoring for women with a history of leukemia or lymphoma before and during pregnancy.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Molly E. McCarthy, Scott P. Oltman, Elizabeth E. Rogers, Kelli Ryckman, Laura L. Jelliffe-Pawlowski, Valery A. Danilack
Summary: The study analyzed data from 736,435 California infants born between 2005-2011 to determine the effects of SES and SGA on infant metabolite levels. Findings showed that SGA was significantly associated with 36 metabolites, while SES was significantly associated with 41 out of 42 metabolites. The study also revealed a dose-response relationship between SGA and metabolite levels as SES worsened, and significant interaction between SES and SGA on 14 metabolites.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Sonia T. Anand, Kelli K. Ryckman, Rebecca J. Baer, Mary E. Charlton, Patrick J. Breheny, William W. Terry, Kord Kober, Scott Oltman, Elizabeth E. Rogers, Laura L. Jelliffe-Pawlowski, Elizabeth A. Chrischilles
Summary: The study found significant metabolic changes in newborns born to mothers with a history of leukemia or lymphoma, with higher levels of certain acylcarnitines and lower levels of citrulline. These findings suggest potential metabolic implications for offspring, which could impact future metabolic consequences.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Nichole L. Nidey, Allison M. Momany, Lane Strathearn, Knute D. Carter, George L. Wehby, Wei Bao, Guifeng Xu, Francesca A. Scheiber, Karen Tabb, Tanya E. Froehlich, Kelli Ryckman
Summary: The study found that children born to mothers with perinatal depression were more likely to be diagnosed with ADHD, suggesting the need for increased interventions and screening efforts targeted towards this vulnerable population to reduce the adverse consequences of ADHD.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Medical Laboratory Technology
Kelli K. Ryckman, Abhismitha Ramesh, Hyunkeun Cho, Scott P. Oltman, Elizabeth E. Rogers, John M. Dagle, Laura L. Jelliffe-Pawlowski
Summary: Newborn metabolic screening is a promising method for predicting neonatal morbidity and mortality. However, the type of syringe used for blood collection, specifically in this study the electrolyte-balanced dry lithium heparin syringe, may have an impact on the levels of targeted metabolites and biomarkers. While the median levels did not differ significantly by syringe type, there was considerable variability for certain metabolites, suggesting the need to consider sample collection methods when utilizing these markers in prediction models for neonatal outcomes.
CLINICAL BIOCHEMISTRY
(2022)
Article
Health Care Sciences & Services
Margaret Carrel, Barbara C. Keino, Kelli K. Ryckman, Stephanie Radke
Summary: The closure of rural hospitals and labor & delivery units has impacted access to timely care. In the past decade, Iowa has lost over a quarter of its labor & delivery units. The study found that certain areas in the state consistently have travel times exceeding 30 minutes.
JOURNAL OF RURAL HEALTH
(2023)
Article
Psychology, Clinical
Guifeng Xu, Linda G. Snetselaar, Lane Strathearn, Kelli Ryckman, Faryle Nothwehr, James Torner
Summary: The study found a significant positive association between a history of ADHD diagnosis and CVD in a nationally representative sample of U.S. adults. Further investigation is needed to replicate the findings and determine the underlying mechanisms.
Article
Obstetrics & Gynecology
Martina A. Steurer, Kelli K. Ryckman, Rebecca J. Baer, Jean Costello, Scott P. Oltman, Charles E. McCulloch, Laura L. Jelliffe-Pawlowski, Elizabeth E. Rogers
Summary: A resiliency score has been developed and validated to predict survival and survival without neonatal morbidity in preterm neonates.
JOURNAL OF PERINATOLOGY
(2023)
Editorial Material
Nursing
Margaret Carrel, Barbara C. Keino, Nicole L. Novak, Kelli K. Ryckman, Stephanie Radke
Summary: Patient decisions to bypass the closest labor & delivery facility can lead to changes in the provision of healthcare in rural areas. In Iowa, more than half of the deliveries occurred in facilities further away from the parents' residences than the closest L&D facility. Bypassing behavior is more common among White, non-Hispanic individuals with private insurance, and it is increasing among micropolitan birth parents who already have a greater travel burden.
BIRTH-ISSUES IN PERINATAL CARE
(2023)
Article
Obstetrics & Gynecology
Kelli K. Ryckman, Paul J. Holdefer, Eva Sileo, Claire Carlson, Nancy Weathers, Elizabeth A. Jasper, Hyunkeun Cho, Scott P. Oltman, John M. Dagle, Laura L. Jelliffe-Pawlowski, Elizabeth E. Rogers
Summary: This study found that diagnostic hospital billing codes are a reliable metric to evaluate complications and surgeries in preterm neonates, except for more ambiguous diagnoses such as necrotizing enterocolitis and its surgery.
JOURNAL OF PERINATOLOGY
(2023)
Article
Multidisciplinary Sciences
Lin Ammar, Hilary A. Tindle, Angela M. Miller, Margaret A. Adgent, Hui Nian, Kelli K. Ryckman, Mulubrhan Mogos, Mariann R. Piano, Ethan Xie, Brittney M. Snyder, Abhismitha Ramesh, Chang Yu, Tina V. Hartert, Pingsheng Wu
Summary: The use of electronic cigarettes (ECs) during pregnancy, either alone or in combination with combustible cigarettes (CCs), is associated with increased risks of preterm birth and low birth weight. Quitting EC use can reduce these risks. ECs should not be considered a safe alternative or a viable strategy for smoking cessation during pregnancy.
Article
Obstetrics & Gynecology
Samhita Jain, Scott Oltman, Elizabeth Rogers, Kelli Ryckman, Mark Petersen, Rebecca J. Baer, Larry Rand, Xianhua Piao, Laura Jelliffe-Pawlowski
Summary: This retrospective cohort study examined the relationship between maternal immune activation (MIA) and neurologic morbidity in offspring. The study found that maternal inflammatory environment, combined with pre-existing risk factors such as obesity, poverty, and prematurity, increases the susceptibility of offspring to neurologic morbidities.
JOURNAL OF PERINATOLOGY
(2023)