Article
Chemistry, Multidisciplinary
Chang Min Lee, Jongsung Lee, Mi-Ae Kang, Hee Taek Kim, Jongbok Lee, Kyungmoon Park, Yung-Hun Yang, Kyu Yun Jang, See-Hyoung Park
Summary: Linifanib has been shown to efficiently inhibit receptor tyrosine kinases, and in this study, its anti-cancer effects in ovarian cancer were investigated. Linifanib was found to inhibit proliferation and induce apoptosis in SKOV3 cells, as well as cause DNA damage and increase intracellular ROS levels.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Chia-Cheng Wei, Shang-Wei Li, Chia-Tung Wu, Chun Ming How, Min-Hsiung Pan
Summary: This study using a nematode model found that dietary exposure to MG may exacerbate AD pathology, as high levels of MG exposure led to decreased locomotive behaviors, increased A beta protein accumulation, impaired 5-HT reuptake, increased oxidative stress, and disrupted autophagy pathway. Treatment with the citrus flavonoid nobiletin reduced MG-induced toxicity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Oncology
Huynh Diem Thi Ngoc, Yujin Jin, Chang-Seon Myung, Kyung-Sun Heo
Summary: Breast cancer is the most common cause of cancer-related deaths among women globally. Ginsenoside Rh1 exhibits potential anticancer effects on breast cancer cells by inducing cell cycle arrest, apoptosis, and autophagy via inhibition of the ROS-mediated PI3K/Akt pathway.
Article
Biochemistry & Molecular Biology
Ju Won Eom, Joo Weon Lim, Hyeyoung Kim
Summary: Anticancer agents induce apoptosis in gastric cancer cells by increasing reactive oxygen species (ROS) production, activating NADPH oxidase, and promoting DNA fragmentation.
Article
Food Science & Technology
Jingna Wu, Changhong Lin, Xiaoting Chen, Nan Pan, Zhiyu Liu
Summary: Polysaccharides extracted from Bangia fuscopurpurea (BFP) show potential as anti-cancer agents in human ovarian cancer cells. The mechanisms of action involve inhibition of cell migration and invasion, induction of apoptosis and autophagy, and changes in gene and protein expression related to these processes. BFP may have utility in the development of functional foods for cancer therapy.
FOOD SCIENCE & NUTRITION
(2021)
Article
Biotechnology & Applied Microbiology
Jiamen Shen, Jiatian Dong, Feng Shao, Jiaying Zhao, Lifeng Gong, Huipeng Wang, Wenjie Chen, Yafei Zhang, Yuankun Cai
Summary: This study found that graphene oxide (GO) exhibits anticancer effects against colorectal cancer. GO activates the AMPK/mTOR/ULK1 signaling pathway through the production of reactive oxygen species (ROS), leading to apoptosis and autophagy, thereby inhibiting tumor growth.
Article
Chemistry, Medicinal
Liqun Qu, Jianhui Wu, Yong Tang, Xiaoyun Yun, Hang Hong Lo, Lu Yu, Wenhua Li, Anguo Wu, Betty Yuen Kwan Law
Summary: The study found that Licochalcone B (LCB) has neuroprotective effects against oxidative stress-induced damage in neuronal cells. It reduces cell cytotoxicity and apoptosis, lowers the level of oxidative stress markers, and induces autophagy and signaling pathways to protect against damage.
Article
Oncology
Xiulan Shao, Fengying Zhang, Xiang Gao, Fengying Xu
Summary: Ovarian cancer is a leading cause of cancer-related death among women worldwide, and Siomycin A has shown anticancer effects on ovarian cancer cells by inducing ROS production and inhibiting antioxidant enzymes, leading to cell apoptosis.
Article
Microbiology
Jaskaran Kaur, Yogita Rawat, Vikas Sood, Neha Periwal, Deepak Kumar Rathore, Shrikant Kumar, Niraj Kumar, Sankar Bhattacharyya
Summary: In this study, it was found that Dengue virus can infect human megakaryocytes and suppress platelet biogenesis. Differentiating megakaryocyte cells were shown to support higher viral replication, while the virus did not increase its entry into the cells. Dengue replication inhibited the accumulation of intracellular reactive oxygen species (ROS) by enhancing the activity of the transcription factor NFE2L2. Interestingly, modulation of NFE2L2 activity had opposite effects on intracellular ROS and virus replication. Additionally, differentiated cells with intracellular virus replication showed reduced levels of surface markers compared to uninfected differentiated cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Jie Du, Fan Jiang, Shen-Sheng Xu, Zi-Feng Huang, Li-Li Chen, Li Li
Summary: Tephrosin exhibits potent anticancer activity against pancreatic cancer cells by suppressing cell viability and promoting apoptosis through increased ROS production and DNA damage. Additionally, it demonstrates strong antitumor activity with low toxicity in a mouse model.
Article
Oncology
Makoto Takeuchi, Toshihiko Nishisho, Shunichi Toki, Shinji Kawaguchi, Shunsuke Tamaki, Takeshi Oya, Yoshihiro Uto, Toyomasa Katagiri, Koichi Sairyo
Summary: In this study, the antitumor effect of blue light (BL) on synovial sarcoma (SS) was investigated. BL was found to inhibit the growth of SS cells and induce apoptosis. This suggests that BL could be a promising therapeutic strategy for SS.
Article
Chemistry, Medicinal
Jianjian Wu, Dejuan Wang, Jiuyao Zhou, Juntao Li, Ruoxin Xie, Yiyuan Li, Jiayu Huang, Bihao Liu, Jianguang Qiu
Summary: In this study, it was found that GNA could induce apoptosis and autophagy in PCa cells through ROS-mediated ER stress and the JNK signaling pathway. GNA significantly suppressed prostate tumor growth with low toxicity.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Stefania Magnano, Patricia Hannon Barroeta, Ronan Duffy, Jeff O'Sullivan, Daniela M. Zisterer
Summary: The study evaluated the role of autophagy in mediating cisplatin resistance in oral squamous cell carcinoma (OSCC) cells. Results demonstrated that cisplatin induces both apoptosis and autophagy in OSCC cells through the ROS/JNK pathway. However, autophagy did not play a significant role in acquired resistance to cisplatin or have a pro-survival effect in the cells. This suggests a complex interplay between apoptosis and autophagy pathways in OSCC.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Qinying Liu, Yi Yang, Miaomiao Cheng, Fangting Cheng, Shanshan Chen, Qiuhong Zheng, Yang Sun, Li Chen
Summary: Autophagy, a highly conserved catabolic process, can be utilized as a cancer therapeutic approach by inhibiting its late stage. Dicitrinone B (DB), a rare carbon-bridged citrinin dimer, was found to block autophagy at a late stage in breast cancer cells, leading to inhibition of cell growth and promotion of apoptosis without affecting lysosomal function. Additionally, DB enhanced intracellular reactive oxygen species (ROS) production, which in turn contributed to the inhibition of autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yu He, Yuchuan Shi, Yang Yang, Huanhuan Huang, Yifan Feng, Yunmeng Wang, Lei Zhan, Bing Wei
Summary: Chrysin shows potential therapeutic effects on EC by inducing both cell autophagy and apoptosis to inhibit cell proliferation and promote cell death. Additionally, chrysin induces intracellular ROS production, leading to autophagy activation. The study revealed that chrysin-induced autophagy in EC cells is mediated through the inhibition of the ROS-mediated Akt/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)