Mechanisms of small molecule–DNA interactions probed by single-molecule force spectroscopy

Dissecting the Dynamic Pathways of Stereoselective DNA Threading Intercalation

(2016) Ali A. Almaqwashi et al.   BIOPHYSICAL JOURNAL

Dynamic Tuning of DNA-Nanoparticle Superlattices by Molecular Intercalation of Double Helix

(2015) Suchetan Pal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Superresolution imaging of single DNA molecules using stochastic photoblinking of minor groove and intercalating dyes

(2015) Helen Miller et al.   METHODS

A ruthenium dimer complex with a flexible linker slowly threads between DNA bases in two distinct steps

(2015) Meriem Bahira et al.   NUCLEIC ACIDS RESEARCH

Exploded view of higher order G-quadruplex structures through click-chemistry assisted single-molecule mechanical unfolding

(2015) Sangeetha Selvam et al.   NUCLEIC ACIDS RESEARCH

Single-molecule kinetics and footprinting of DNA bis-intercalation: the paradigmatic case of Thiocoraline

(2015) Joan Camunas-Soler et al.   NUCLEIC ACIDS RESEARCH

The impact of DNA intercalators on DNA and DNA-processing enzymes elucidated through force-dependent binding kinetics

(2015) Andreas S. Biebricher et al.   Nature Communications

Thread Insertion of a Bis(dipyridophenazine) Diruthenium Complex into the DNA Double Helix by the Extrusion of AT Base Pairs and Cross-Linking of DNA Duplexes

(2014) D. Roeland Boer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA as a target for antimicrobials

(2014) Albert Bolhuis et al.   BIOORGANIC CHEMISTRY

Tuning the Cellular Uptake Properties of Luminescent Heterobimetallic Iridium(III)-Ruthenium(II) DNA Imaging Probes

(2014) Ashley Wragg et al.   CHEMISTRY-A EUROPEAN JOURNAL

Force-induced melting of DNA—evidence for peeling and internal melting from force spectra on short synthetic duplex sequences

(2014) Niklas Bosaeus et al.   NUCLEIC ACIDS RESEARCH

Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex

(2014) Ali A. Almaqwashi et al.   NUCLEIC ACIDS RESEARCH

Multiple-binding-site mechanism explains concentration-dependent unbinding rates of DNA-binding proteins

(2014) Charles E. Sing et al.   NUCLEIC ACIDS RESEARCH

Effect of YOYO-1 on the mechanical properties of DNA

(2014) Binu Kundukad et al.   Soft Matter

Controlled release of an anti-cancer drug from DNA structured nano-films

(2014) Younghyun Cho et al.   Scientific Reports

DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

(2013) Kahlin Cheung-Ong et al.   CHEMISTRY & BIOLOGY

Initial DNA Interactions of the Binuclear Threading Intercalator Λ,Λ-[μ-bidppz(bipy)4Ru2]4+: An NMR Study with [d(CGCGAATTCGCG)]2

(2013) Lisha Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

The structural basis of actinomycin D–binding induces nucleotide flipping out, a sharp bend and a left-handed twist in CGG triplet repeats

(2013) Yu-Sheng Lo et al.   NUCLEIC ACIDS RESEARCH

Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching using fluorescence microscopy

(2013) G. A. King et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ruthenium(ii) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics

(2012) Martin R. Gill et al.   CHEMICAL SOCIETY REVIEWS

Single-molecule kinetics reveal microscopic mechanism by which High-Mobility Group B proteins alter DNA flexibility

(2012) Micah J. McCauley et al.   NUCLEIC ACIDS RESEARCH

Force spectroscopy reveals the DNA structural dynamics that govern the slow binding of Actinomycin D

(2012) Thayaparan Paramanathan et al.   NUCLEIC ACIDS RESEARCH

Dynamics and Multiple Stable Binding Modes of DNA Intercalators Revealed by Single-Molecule Force Spectroscopy

(2011) D. Hern Paik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoselectivity for DNA Threading Intercalation of Short Binuclear Ruthenium Complexes

(2011) Johanna Andersson et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Correlation Between Cellular Localization and Binding Preference to RNA, DNA, and Phospholipid Membrane for Luminescent Ruthenium(II) Complexes

(2011) Maria Matson et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Ruthenium(II) Complex Enantiomers as Cellular Probes for Diastereomeric Interactions in Confocal and Fluorescence Lifetime Imaging Microscopy

(2011) Frida R. Svensson et al.   Journal of Physical Chemistry Letters

A sequence-specific threading tetra-intercalator with an extremely slow dissociation rate constant

(2011) Garen G. Holman et al.   Nature Chemistry

AT-Specific DNA Binding of Binuclear Ruthenium Complexes at the Border of Threading Intercalation

(2010) Johanna Andersson et al.   CHEMISTRY-A EUROPEAN JOURNAL

Torsional Mechanics of DNA Are Regulated by Small-Molecule Intercalation

(2010) Alfredo Celedon et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Torsional sensing of small-molecule binding using magnetic tweezers

(2010) J. Lipfert et al.   NUCLEIC ACIDS RESEARCH

Mechanical and structural properties of YOYO-1 complexed DNA

(2010) K. Gunther et al.   NUCLEIC ACIDS RESEARCH

Concentration-dependent exchange accelerates turnover of proteins bound to double-stranded DNA

(2010) J. S. Graham et al.   NUCLEIC ACIDS RESEARCH

Biophysical characterization of DNA binding from single molecule force measurements

(2010) Kathy R. Chaurasiya et al.   Physics of Life Reviews

DNA-psoralen: Single-molecule experiments and first principles calculations

(2009) M. S. Rocha et al.   APPLIED PHYSICS LETTERS

Interaction of Oxazole Yellow Dyes with DNA Studied with Hybrid Optical Tweezers and Fluorescence Microscopy

(2009) C.U. Murade et al.   BIOPHYSICAL JOURNAL

Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics

(2009) Christoph Kleimann et al.   BIOPHYSICAL JOURNAL

Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends

(2009) Brenno Neto et al.   MOLECULES

A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells

(2009) Martin R. Gill et al.   Nature Chemistry

Unraveling the structure of DNA during overstretching by using multicolor, single-molecule fluorescence imaging

(2009) J. van Mameren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Overstretching in the Presence of Glyoxal: Structural Evidence of Force-Induced DNA Melting

(2008) Leila Shokri et al.   BIOPHYSICAL JOURNAL

Optical tweezers experiments resolve distinct modes of DNA-protein binding

(2008) Micah J. McCauley et al.   BIOPOLYMERS

Drugs and their molecular targets: an updated overview

(2008) Yves Landry et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Mechanically Manipulating the DNA Threading Intercalation Rate

(2008) Thayaparan Paramanathan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy

(2008) Keir C Neuman et al.   NATURE METHODS

See me, feel me: methods to concurrently visualize and manipulate single DNA molecules and associated proteins

(2008) J. van Mameren et al.   NUCLEIC ACIDS RESEARCH