The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation

Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution

(2016) Vitaly Sedlyarov et al.   Molecular Systems Biology

Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies

(2016) Sonika Patial et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements

(2016) Rui Fu et al.   RNA

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence

(2016) A. Galloway et al.   SCIENCE

Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner

(2015) F. Kratochvill et al.   CANCER RESEARCH

Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide

(2015) Tim Smallie et al.   JOURNAL OF IMMUNOLOGY

Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin

(2015) Ewan A. Ross et al.   JOURNAL OF IMMUNOLOGY

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway

(2015) Yasuhiro Murakawa et al.   Nature Communications

Tristetraprolin Regulates CXCL1 (KC) mRNA Stability

(2014) S. Datta et al.   JOURNAL OF IMMUNOLOGY

The Role of Mammalian MAPK Signaling in Regulation of Cytokine mRNA Stability and Translation

(2014) Christopher Tiedje et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Control of Pro-Angiogenic Cytokine mRNA Half-Life in Cancer: The Role of AU-Rich Elements and Associated Proteins

(2014) Paola Griseri et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Rapid Proteasomal Degradation of Posttranscriptional Regulators of the TIS11/Tristetraprolin Family Is Induced by an Intrinsically Unstructured Region Independently of Ubiquitination

(2014) L. V. Ngoc et al.   MOLECULAR AND CELLULAR BIOLOGY

Noncoding RNA and its associated proteins as regulatory elements of the immune system

(2014) Martin Turner et al.   NATURE IMMUNOLOGY

Ribosome profiling: new views of translation, from single codons to genome scale

(2014) Nicholas T. Ingolia   NATURE REVIEWS GENETICS

A census of human RNA-binding proteins

(2014) Stefanie Gerstberger et al.   NATURE REVIEWS GENETICS

eulerAPE: Drawing Area-Proportional 3-Venn Diagrams Using Ellipses

(2014) Luana Micallef et al.   PLoS One

p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex

(2014) Christopher Tiedje et al.   RNA

Translational Regulation of Specific mRNAs Controls Feedback Inhibition and Survival during Macrophage Activation

(2014) Johanna Schott et al.   PLoS Genetics

Global target mRNA specification and regulation by the RNA-binding protein ZFP36

(2014) Neelanjan Mukherjee et al.   GENOME BIOLOGY

Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action

(2013) Seth A. Brooks et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP

(2013) Thomas Hochdörfer et al.   CELLULAR SIGNALLING

Mutant tristetraprolin: a potent inhibitor of malignant glioma cell growth

(2013) Esther A. Suswam et al.   JOURNAL OF NEURO-ONCOLOGY

7-Aminoactinomycin D for apoptosis staining in flow cytometry

(2012) Nadine C.L. Zembruski et al.   ANALYTICAL BIOCHEMISTRY

Improved methodology for the affinity isolation of human protein complexes expressed at near endogenous levels

(2012) Michal Domanski et al.   BIOTECHNIQUES

Tristetraprolin Impairs Myc-Induced Lymphoma and Abolishes the Malignant State

(2012) Robert J. Rounbehler et al.   CELL

Dual-specificity MAP kinase phosphatases (MKPs)

(2012) Christopher J. Caunt et al.   FEBS Journal

Tristetraprolin Inhibits Poly(A)-Tail Synthesis in Nuclear mRNA that Contains AU-Rich Elements by Interacting with Poly(A)-Binding Protein Nuclear 1

(2012) Yu-Lun Su et al.   PLoS One

The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU–Rich Element–Dependent Translation

(2012) Christopher Tiedje et al.   PLoS Genetics

Ending the message: poly(A) signals then and now

(2011) N. J. Proudfoot   GENES & DEVELOPMENT

The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism

(2011) Samuel N. Breit et al.   GROWTH FACTORS

A synonymous polymorphism of the Tristetraprolin (TTP) gene, an AU-rich mRNA-binding protein, affects translation efficiency and response to Herceptin treatment in breast cancer patients

(2011) Paola Griseri et al.   HUMAN MOLECULAR GENETICS

Distinct Functions of the Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinases MK2 and MK3

(2011) Christian Ehlting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation

(2011) F. Kratochvill et al.   Molecular Systems Biology

Return to homeostasis: downregulation of NF-κB responses

(2011) Jürgen Ruland   NATURE IMMUNOLOGY

Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin

(2011) Heike Sandler et al.   NUCLEIC ACIDS RESEARCH

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

MAPKAP kinases MK2 and MK3 in inflammation: Complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin

(2010) Natalia Ronkina et al.   BIOCHEMICAL PHARMACOLOGY

Retroviral and Transposon-Based Tet-Regulated All-In-One Vectors with Reduced Background Expression and Improved Dynamic Range

(2010) Niels Heinz et al.   HUMAN GENE THERAPY

MAPKAP Kinase 2 Blocks Tristetraprolin-directed mRNA Decay by Inhibiting CAF1 Deadenylase Recruitment

(2010) Francesco P. Marchese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Tristetraprolin by MK2 Impairs AU-Rich Element mRNA Decay by Preventing Deadenylase Recruitment

(2010) S. L. Clement et al.   MOLECULAR AND CELLULAR BIOLOGY

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution

(2010) Julian König et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: Role for gly96/iex-1 in the regulation of NF-κB

(2009) Christian Sina et al.   INFLAMMATORY BOWEL DISEASES

Tristetraprolin Impairs NF-κB/p65 Nuclear Translocation

(2009) Yvonne M. Schichl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA-destabilizing Factor Tristetraprolin Negatively Regulates NF-κB Signaling

(2009) Jian Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of NF-κB-dependent Transcription by MKP-1

(2009) Elizabeth M. King et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoregulatory feedback loops terminating the NF-κB response

(2009) Florian Renner et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Genome-wide Analysis Identifies Interleukin-10 mRNA as Target of Tristetraprolin

(2008) Georg Stoecklin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide identification and characterization of transcripts translationally regulated by bacterial lipopolysaccharide in macrophage-like J774.1 cells

(2008) Hiroshi Kitamura et al.   PHYSIOLOGICAL GENOMICS

Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation

(2008) J. Emmons et al.   RNA

IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis

(2007) Alexander Arlt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH