Article
Chemistry, Medicinal
Kseniya N. Sedenkova, Victoria I. Uvarova, Anna A. Nazarova, Aleksandra V. Peisikova, Evgeny V. Khvatov, Maksim V. Sukhorukov, Vasilisa S. Frolenko, Alexander S. Goryashchenko, Ivan S. Kholodilov, Yuri K. Grishin, Viktor B. Rybakov, Marat T. Makenov, Evgeny S. Morozkin, Lyudmila S. Karan, Liubov I. Kozlovskaya, Aydar A. Ishmukhametov, Dmitry I. Osolodkin, Elena B. Averina
Summary: A series of tetrahydroquinazoline N-oxides were synthesized and their antiviral activity against flaviviruses such as TBEV, YFV, and WNV was assessed. Most of the compounds showed activity against TBEV and WNV, and a few also demonstrated inhibitory activity against YFV. The mechanism of action of these compounds appears to affect the early stages of viral replication cycle after cell entry.
ARCHIV DER PHARMAZIE
(2023)
Review
Virology
E. Taylor Stone, Amelia K. Pinto
Summary: The Flaviviridae family consists of diverse arthropod-borne viruses that cause globally relevant diseases in humans. Infection with certain flaviviruses, like West Nile virus, Zika virus, Japanese encephalitis virus, tick-borne encephalitis virus, and Powassan virus, can lead to neuroinvasive diseases such as meningitis or encephalitis. T cells have been identified as a contributor to neuroinflammation, but their role in tick-borne flavivirus encephalitis requires further study. Understanding the involvement of T cells in tick-borne flavivirus encephalitis is crucial for improving vaccine safety and efficacy, as well as developing treatments for human disease.
Article
Virology
Sebastian Napp, Francisco Llorente, Cecile Beck, Eduard Jose-Cunilleras, Merce Soler, Lola Pailler-Garcia, Rayane Amaral, Pilar Aguilera-Sepulveda, Maria Pifarre, Rafael Molina-Lopez, Elena Obon, Olga Nicolas, Sylvie Lecollinet, Miguel angel Jimenez-Clavero, Nuria Busquets
Summary: The surveillance in Catalonia has detected flaviviruses beyond WNV, with a widespread circulation of viruses like WNV and USUV. Chickens and horses could be sentinels for these viruses, but current diagnostic techniques have limitations. There is overlap between WNV and USUV in some regions, but no significant geographical aggregation was observed, and human infections have not been reported so far. Zoonotic flaviviruses like WNV, USUV, and TBEV should be monitored within a One Health framework.
Review
Virology
Baohua Hou, Hui Chen, Na Gao, Jing An
Summary: Flaviviruses, transmitted by mosquitoes or ticks, cause a range of severe diseases globally. The similarity of antigenicity among several mosquito-borne flaviviruses complicates prevention and control due to cross-reactive immune responses. Effective vaccines are only available for yellow fever and Japanese encephalitis, while vaccines for other flavivirus diseases are still in development. The development of a dengue fever vaccine is hindered by antibody-dependent enhancement caused by cross-reactive immune responses. Cross-reactive immunity from prior infection of mosquito-borne flavivirus may also impact the outcome of subsequent heterologous flavivirus infection.
Review
Virology
Xijing Qian, Zhongtian Qi
Summary: Mosquito-borne flavivirus infections, including dengue and Zika virus infections, are global threats to public health. Currently, there are no specific antiviral agents available for the treatment of these diseases, but drug development targeting critical factors in the viral infection process is making progress.
Article
Virology
Sarah Schreier, Kristin Cebulski, Andrea Kroeger
Summary: Tick-borne encephalitis virus (TBEV) is primarily transmitted to humans through tick bites or consumption of contaminated milk. Interferon alpha receptor 1-deficient mice show neurologic manifestations after infection with TBEV and Langat virus (LGTV). Different routes of LGTV infection in mice lead to varying disease outcomes, with intranasal inoculation being sufficient to establish disease.
JOURNAL OF VIROLOGY
(2021)
Article
Parasitology
Manon Lemasson, Gregory Caignard, Yves Unterfinger, Houssam Attoui, Lesley Bell-Sakyi, Edouard Hirchaud, Sara Moutailler, Nicholas Johnson, Damien Vitour, Jennifer Richardson, Sandrine A. Lacour
Summary: This study presents the first description of the protein-protein interaction network between TBEV/LIV and I. ricinus, shedding light on key interactions between the virus and tick vector. By investigating these interactions, the study lays the foundation for a deeper understanding of the vector competence of I. ricinus.
PARASITES & VECTORS
(2021)
Article
Veterinary Sciences
Pavel Kvapil, Josko Racnik, Marjan Kastelic, Pavlina Pittermannova, Tatjana Avsic-Zupanc, Eva Bartova, Kamil Sedlak
Summary: A small percentage of zoo animals were found to have antibodies to tick-borne encephalitis virus (TBEV), while a few animals also showed antibodies to West Nile virus (WNV) and Usutu virus (USUV). This study revealed the potential presence of infectious pathogens in zoo animals, highlighting the importance of monitoring and screening for diseases in zoological collections.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Infectious Diseases
Laura Koenenkamp, Ute Ziegler, Torsten Naucke, Martin H. Groschup, Imke Steffen
Summary: Flavivirus diagnostics are complicated by cross-reactivity of antibodies between different species, especially in regions with multiple endemic viruses. This study developed a luciferase immunoprecipitation system to compare antibody responses against TBEV and WNV in dogs. The NS1 protein was found to be a suitable antigen for distinguishing between the two viruses, with sensitivity and specificity similar to virus neutralization tests.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Veterinary Sciences
Laura Grassi, Michele Drigo, Hana Zelena, Daniela Pasotto, Rudi Cassini, Alessandra Mondin, Giovanni Franzo, Claudia Maria Tucciarone, Martina Ossola, Elena Vidorin, Maria Luisa Menandro
Summary: This study investigated the prevalence of tick-borne zoonotic pathogens and flaviviruses in wild ungulates in Europe. The results showed a high prevalence of these pathogens and a significant seroprevalence for flaviviruses. Wild ungulates play a crucial role in the circulation and spread of these diseases.
BMC VETERINARY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yanan Zhang, Dening Liang, Fei Yuan, Yiran Yan, Zuoshu Wang, Pan Liu, Qi Yu, Xing Zhang, Xiangxi Wang, Aihua Zheng
Summary: Mosquito-borne flaviviruses (MBFs) adapt to transmission between mosquitoes and vertebrates. In this study, a model using chimeras of dual-host affiliated insect-specific flaviviruses (dISFs) and MBFs was developed to study the dual-host adaptation of MBFs. The researchers found that the dISFs could enter vertebrate cells as efficiently as MBFs but failed to replicate. However, when certain regions of the dISF were replaced with those from Zika virus (ZIKV), replication in vertebrate cells was rescued. This study also identified essential host factors that interact with specific regions of the virus genome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Mareike Kubinski, Jana Beicht, Isabel Zdora, Giulietta Saletti, Magdalena Kircher, Monique Petry-Gusmag, Imke Steffen, Christina Puff, Klaus Jung, Wolfgang Baumgaertner, Guus F. Rimmelzwaan, Albert D. M. E. Osterhaus, Chittappen Kandiyil Prajeeth
Summary: In this study, researchers transferred serum or T cells from mice infected with LGTV to naive mice and challenged them with a lethal dose of TBEV. They found that LGTV infection induced cross-reactive antibodies and T cells against TBEV. The serum from LGTV infected mice effectively protected against severe disease, while the transfer of T cells did not provide protection.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Virology
Ahmed M. E. Elrefaey, Philippa Hollinghurst, Christine M. Reitmayer, Luke Alphey, Kevin Maringer
Summary: Mosquito-borne viruses of the Flavivirus genus, such as dengue, Japanese encephalitis, West Nile, yellow fever, and Zika viruses, pose a significant threat to global public health. Understanding the complex interactions between these viruses and their hosts is crucial for developing antiviral therapies and strategies to prevent their spread.
Article
Public, Environmental & Occupational Health
Alaka Lamsal, Kristin Skarsfjord Edgar, Andrew Jenkins, Hans Renssen, Lene Jung Kjaer, Kristian Alfsnes, Srijana Bastakoti, Malene Dieseth, Kirstine Klitgaard, Heidi Elisabeth H. Lindstedt, Katrine M. Paulsen, Rose Vikse, Lars Korslund, Vivian Kjelland, Snorre Stuen, Petter Kjellander, Madeleine Christensson, Malin Teraevaeinen, Laura Mark Jensen, Manoj Regmi, Dhiraj Giri, Leif Marsteen, Rene Bodker, Arnulf Soleng, Ashild Kristine Andreassen
Summary: This study confirms the presence of TBEV in southern Scandinavia and identifies potential areas of concern for public health. The study also highlights a strong correlation between relative humidity and TBEV prevalence in ticks in Sweden and Norway.
ZOONOSES AND PUBLIC HEALTH
(2023)
Editorial Material
Cell Biology
Rafael K. Campos, Shannan L. Rossi, Robert B. Tesh, Scott C. Weaver
Summary: Emerging zoonotic mosquito-borne viruses pose increasing health threats and require global preparedness to effectively mitigate the impacts in terms of health, society, and economy.
SCIENCE TRANSLATIONAL MEDICINE
(2023)