期刊
NMR IN BIOMEDICINE
卷 29, 期 6, 页码 751-758出版社
WILEY
DOI: 10.1002/nbm.3527
关键词
MRSI; blind source separation; non-negative matrix factorization; prostate cancer; nosologic imaging
资金
- PRIN [2012MTE38N]
- Progetto Premiale MIUR (MATHTECH)
- FWO [G.0869.12 N]
- iMinds Medical IT
- ERC [339804]
- EU MC ITN TRANSACT [316679]
- Cancer Research UK [22310] Funding Source: researchfish
In this study non-negative matrix factorization (NMF) was hierarchically applied to simulated and in vivo three-dimensional 3 T MRSI data of the prostate to extract patterns for tumour and benign tissue and to visualize their spatial distribution. Our studies show that the hierarchical scheme provides more reliable tissue patterns than those obtained by performing only one NMF level. We compared the performance of three different NMF implementations in terms of pattern detection accuracy and efficiency when embedded into the same kind of hierarchical scheme. The simulation and in vivo results show that the three implementations perform similarly, although one of them is more robust and better pinpoints the most aggressive tumour voxel(s) in the dataset. Furthermore, they are able to detect tumour and benign tissue patterns even in spectra with lipid artefacts. Copyright (C) 2016 John Wiley & Sons, Ltd.
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