期刊
NMR IN BIOMEDICINE
卷 29, 期 11, 页码 1536-1545出版社
WILEY-BLACKWELL
DOI: 10.1002/nbm.3607
关键词
diffusional kurtosis imaging; multiple sclerosis; neuromyelitis optica; normal-appearing brain tissues
Multiple sclerosis (MS) and neuromyelitis optica (NMO) are two common types of inflammatory demyelinating disease of the central nervous system. Early distinction of NMO from MS is crucial but quite challenging. In this study, 13 NMO spectrum disorder patients (Expanded Disability Status Scale (EDSS) of 3.0 +/- 1.7, ranging from 2 to 6.5; disease duration of 5.3 +/- 4.7years), 17 relapsing-remitting MS patients (EDSS of 2.6 +/- 1.4, ranging from 1 to 5.5; disease duration of 7.9 +/- 7.8years) and 18 healthy volunteers were recruited. Diffusional kurtosis imaging was employed to discriminate NMO and MS patients at the early or stable stage from each other, and from healthy volunteers. The presence of alterations in diffusion and diffusional kurtosis metrics in normal-appearing white matter (NAWM) and diffusely increased mean diffusivity (MD) in the cortical normal-appearing gray matter (NAGM) favors the diagnosis of MS rather than NMO. Meanwhile, normal diffusivities and kurtosis metrics in all NAWM as well as increases in MD in the frontal and temporal NAGM suggest NMO. Our results suggest that diffusion and diffusional kurtosis metrics may well aid in discriminating the two diseases.
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