期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 357, 期 14-15, 页码 3255-3261出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500275
关键词
3H-benzo[e]indoles; heterocycles; iodocyclization; phenylacetylenes; pyrroles
资金
- UFSM
- CAPES
- CNPq
A facile and expedient iodocyclization of 4-(2-prop-1-ynylphenyl)-1H-pyrroles towards the synthesis of polysubstituted 3H-benzo[e]indoles is reported. The transformation was optimized and the best results were obtained by using iodine (1.2 equiv,) in dichloromethane, and potassium carbonate as base. The starting 1,2,3,4-tetrasubstituted pyrroles were efficiently obtained by means of a nickel(II) chloride-promoted four-component (nitromethane, amine, 2-alkynylbenzaldehyde and ethyl acetoacetate) reaction. Further functionalization of the resulting 5-iodoheterocycles was also explored.
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