期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 357, 期 9, 页码 2055-2060出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500268
关键词
aldehydes; alkylation; decarbonylation; heterocycles; metal-free conditions
资金
- National Natural Science Foundation of China [21202138]
- Xiangtan University Academic Leader Program [11QDZ20]
- New Teachers' Fund for Doctor Stations, Ministry of Education [20124301120007]
- University Student Innovation Program, Ministry of Education [201210530008]
- Project of Hunan Provincial Natural Science Foundation [13JJ4047, 12JJ7002]
- Excellent Young Scientist Foundation of Hunan Provincial Education Department [13B114]
A metal-free oxidative decarbonylative coupling of aliphatic aldehydes with various electron-deficient heterocycles has been developed. This reaction is supposed to be realized via a Minisci-type mechanism, based on the substrate scope, regioselectivity and radical trapping experiments. The ready availability of aliphatic aldehydes, metal-free conditions and broad substrate scope should make this method attractive for the late-stage alkylation of bioactive heterocycles.
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