Article
Oncology
Austin J. Iovoli, Mark K. Farrugia, Sung Jun Ma, Jon M. Chan, Michael R. Markiewicz, Ryan McSpadden, Kimberly E. Wooten, Vishal Gupta, Moni A. Kuriakose, Wesley L. Hicks, Anurag K. Singh
Summary: Repeat PET/CT imaging can provide valuable information for head and neck cancer patients in assessing treatment response, reducing the incidence of unnecessary biopsies and surgeries, and preventing treatment failure.
Article
Oncology
Terence S. Fu, Patrick Scheffler, David Forner, Christopher W. Noel, Shao Hui Huang, Ralph W. Gilbert, David P. Goldstein, Brian O'Sullivan, Hisham M. Mehanna, John Waldron, John R. de Almeida
Summary: The study compared the cost utility of image-guided surveillance using CT and PET-CT in managing advanced nodal HPV-positive oropharyngeal cancer patients post-chemoradiation. The results showed that the novel PET-CT approach was the most cost-effective strategy, leading to increased benefits for patients and lower healthcare costs.
Article
Otorhinolaryngology
Wataru Okano, Ryuichi Hayashi, Kazuto Matsuura, Takeshi Shinozaki, Toshifumi Tomioka
Summary: The study indicates that targeted neck dissection (ND) after definitive chemoradiotherapy is an effective intervention for patients with cervical disease recurrence, showing promising survival rates and control rates.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Computer Science, Artificial Intelligence
Valentin Oreiller, Vincent Andrearczyk, Mario Jreige, Sarah Boughdad, Hesham Elhalawani, Joel Castelli, Martin Vallieres, Simeng Zhu, Juanying Xie, Ying Peng, Andrei Iantsen, Mathieu Hatt, Yading Yuan, Jun Ma, Xiaoping Yang, Chinmay Rao, Suraj Pai, Kanchan Ghimire, Xue Feng, Mohamed A. Naser, Clifton D. Fuller, Fereshteh Yousefirizi, Arman Rahmim, Huai Chen, Lisheng Wang, John O. Prior, Adrien Depeursinge
Summary: This paper presents the post-analysis of the first edition of the HEad and neCK TumOR (HECKTOR) challenge, which focused on automatic segmentation of head and neck tumors in combined FDG-PET and CT images. A total of 64 teams participated in the challenge, and the best method achieved a high Dice Score Coefficient (DSC) and outperformed human inter-observer agreement and other methods.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Computer Science, Interdisciplinary Applications
Yiling Wang, Elia Lombardo, Michele Avanzo, Sebastian Zschaek, Julian Weingaertner, Adrien Holzgreve, Nathalie L. Albert, Sebastian Marschner, Giuseppe Fanetti, Giovanni Franchin, Joseph Stancanello, Franziska Walter, Stefanie Corradini, Maximilian Niyazi, Jinyi Lang, Claus Belka, Marco Riboldi, Christopher Kurz, Guillaume Landry
Summary: This study aimed to achieve prognosis for distant metastasis and overall survival in head and neck cancer patients using deep learning models, and investigate the predictive performance of combined PET/CT compared to single-modality inputs. The results showed that the PET-only model achieved the best predictive performance, suggesting that GTV segmentation may be less relevant for PET-based prognosis.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Otorhinolaryngology
Brendan C. Stack, Fenghai Duan, Rathan M. Subramaniam, Justin Romanoff, JoRean D. Sicks, Twyla Bartel, Chien Chen, Val J. Lowe
Summary: FDG-PET/CT is effective for assessing neck nodal disease. This study reports the risks and patterns of nodal disease based on primary site and nodal level, with oral cavity (level I), pharynx (level II), and larynx (level VI) being the levels at greatest risk for nodal disease in cN0.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Oncology
Moran Amit, Chuan Liu, Jobran Mansour, Frederico O. Gleber-Netto, Samantha Tam, Erez N. Baruch, Mohamed Aashiq, Adel K. El-Naggar, Amy C. Moreno, David I. Rosenthal, Bonnie S. Glisson, Renata Ferrarotto, Michael K. Wong, Kenneth Tsai, Elsa R. Flores, Michael R. Migden, Deborah A. Silverman, Goujun Li, Anshu Khanna, Ryan P. Goepfert, Priyadharsini Nagarajan, Randal S. Weber, Jeffrey N. Myers, Neil D. Gross
Summary: The study showed that elective neck dissection (END) did not improve survival rates for patients with cutaneous squamous cell carcinoma (cSCC) of the head and neck and no evidence of regional metastasis. Further research is needed to clarify the role of END in patients with advanced disease.
Article
Multidisciplinary Sciences
Paul Zwittag, Christian Asel, Michael Gabriel, Nina Rubicz, Belinda Bauer, Nikolaus Poier-Fabian
Summary: The aim of this study is to evaluate the diagnostic accuracy of MRI and PET/CT in the evaluation of cervical lymph nodes in patients with head and neck cancer. The study found that MRI and PET/CT have similar sensitivity, specificity, positive predictive value, and negative predictive value. The combination of MRI and PET/CT imaging modalities can improve diagnostic accuracy and potentially detect additional malignancies.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Dominic Raphael Schwaninger, Martin Hullner, Dominique Bichsel, Barbara Giacomelli-Hiestand, Nicole Selina Stutzmann, Panagiotis Balermpas, Silvio Valdec, Bernd Stadlinger
Summary: This study aimed to compare oral and maxillo-mandibular inflammatory foci on standard oral radiographs with FDG-PET/CT data and discuss whether FDG-PET/CT can support oral care specialists when performing oral focus examinations.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Otorhinolaryngology
Rusha Patel, Gary Marano, Joe Joseph, Jeffson Chung, Andrew Plata, Jeffrey A. Vos
Summary: This study shows that Ga-68-DOTATATE imaging is safe and effective for the diagnosis of head and neck squamous cell carcinoma (HNSCC). SSTR expression may be associated with HPV-mediated tumors and targeted therapies to SSTR should be explored.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gwenaelle Creff, Franck Jegoux, Xavier Palard, Adrien Depeursinge, Ronan Abgral, Remi Marianowski, Jean-Christophe Leclere, Thomas Eugene, Olivier Malard, Renaud De Crevoisier, Anne Devillers, Joel Castelli
Summary: This study confirmed the association of nodal MTV and maximal tumor-node distance with the risk of DMFS, as well as a higher risk of death. These prognostic factors can guide individualized treatment.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshimi Anzai, Chun-Pin Chang, Kerry Rowe, John Snyder, Vikrant Deshmukh, Michael Newman, Alison Fraser, Ken Smith, Ankita Date, Carlos Galvao, Marcus Monroe, Mia Hashibe
Summary: This study found that surveillance imaging in patients with head and neck cancer is associated with lower mortality. Specifically, for regionalized or distant squamous cell carcinoma, surveillance imaging was associated with a lower risk of death.
Article
Oncology
Rustain L. Morgan, Megan M. Eguchi, Jessica McDermott, Adam C. Mueller, Arya Amini, Julie A. Goddard, Premal S. Trivedi, Sana D. Karam
Summary: The study found that posttreatment imaging with PET was associated with improved survival in patients with advanced laryngeal carcinoma compared to CT imaging. There was a trend towards improved cancer-specific survival in patients with oral cavity or oropharyngeal malignancies who underwent PET/CT imaging, but it did not reach statistical significance.
Article
Multidisciplinary Sciences
Malek Z. O. Hassan, Ahmed Tawakol, Ying Wang, Raza M. Alvi, Magid Awadalla, Maeve Jones-O'Connor, Rula B. Bakar, Dahlia Banerji, Adam Rokicki, Lili Zhang, Connor P. Mulligan, Michael T. Osborne, Azmaeen Zarif, Basma Hammad, Annie W. Chan, Lori J. Wirth, Erica T. Warner, Roger K. Pitman, Katrina A. Armstrong, Daniel Addison, Tomas G. Neilan
Summary: The mechanisms linking chronic stress and higher mortality in individuals with cancer are not fully understood. This retrospective cohort study found that higher stress-associated neural activity in individuals with head and neck cancer was associated with poorer survival. Future research should investigate strategies to reduce this neural activity and improve cancer survival.
Review
Oncology
Richard H. Wiggins, John M. Hoffman, Gabriel C. Fine, Matthew F. Covington, Ahmed Ebada Salem, Bhasker R. Koppula, Kathryn A. Morton
Summary: PET-CT is an advanced imaging technique widely used in oncology for staging, therapeutic response assessment, restaging, and surveillance of tumors. This review article is part of a series of six articles that provide an overview of the value, applications, and interpretive strategies of PET-CT in common adult malignancies. The fifth article in the series focuses on PET-CT imaging in head and neck tumors and neuro oncology.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gary J. R. Cook, Wai-Lup Wong, Bal Sanghera, Stephen Mangar, Amarnath Challapalli, Amit Bahl, Paul Bassett, Darren Leaning, Christian Schmidkonz
Summary: 177Lu-PSMA-617 is an effective therapy for metastatic castration-resistant prostate cancer (mCRPC). The study reveals differences in biodistribution and liver activity between 99mTc-MIP-1404 and 68Ga-PSMA-11 tracers, suggesting the need for adjusted lesion-to-liver ratio if 99mTc-MIP-1404 is used for 177Lu-PSMA-617 therapy.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Nasir Rajah, Edward J. D. Webb, Claire Hulme, Sarah R. Kingsbury, Robert West, Adam Martin
Summary: One in ten working age people in the UK live with arthritis or a similar condition affecting their joints. This study examines how arthritis affects labor market outcomes, finding that it is associated with a 3 percentage point reduction in the probability of employment. The impact varies by demographic factors such as age, gender, education, occupation, and employer type.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Otorhinolaryngology
Hisham Mehanna, Ben Carter, Andrew K. Hartley, Ahmad K. Abou-Foul, Jill Brooks, June Jones, Lydia Fresco, Laura M. Moss, Terence M. N. Jones, Simon N. P. Rogers, Randall P. Morton, ETERMIN Study Management Grp
Summary: The study aims to determine patients' preferences and willingness to complete commonly used head-and-neck cancer quality of life questionnaires in routine follow-up clinics. Results showed that 82% of respondents found the questionnaires useful for communicating their health concerns, with patients preferring structured disease-specific instruments and disliking unstructured patient-generated lists. However, only 55% of patients expressed support for completing questionnaires routinely at the clinic.
CLINICAL OTOLARYNGOLOGY
(2023)
Review
Otorhinolaryngology
Hisham Mehanna
Summary: The purpose of this article is to provide readers with the latest evidence on the role of trans oral surgery (TOS) in diagnosing carcinoma of unknown primary in the head and neck. Recent findings suggest that tongue base mucosectomy is important in identifying the primary site in patients with negative imaging, PET CT scans, and ipsilateral tonsillectomy. There are still unanswered questions regarding the sequencing of operations and the use of intraoperative frozen section. An evidence-based approach to diagnosis is crucial in order to achieve higher detection rates and minimize morbidity in patients with head and neck carcinoma of unknown primary.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Halah Ahmed, Ian Paterson, Sadat A. A. Aziz, Ottavio Cremona, Max Robinson, Marco Carrozzo, Ruth A. Valentine
Summary: In this study, the role of Epsin3 and Notch1 in oral carcinogenesis was investigated, aiming to explore their potential as biomarkers. The results showed that Epsin3 was upregulated in oral epithelial dysplasia and oral squamous cell carcinoma, suggesting its potential as a biomarker for oral epithelial dysplasia. Notch signaling was downregulated in oral squamous cell carcinoma, possibly through an Epsin3-induced de-activation pathway.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Medicine, General & Internal
Janet A. Wilson, James O'Hara, Tony Fouweather, Tara Homer, Deborah D. Stocken, Luke Vale, Catherine Haighton, Nikki Rousseau, Rebecca Wilson, Lorraine Mcsweeney, Scott Wilkes, Jill Morrison, Kenneth Mackenzie, Kim Ah-See, Sean Carrie, Claire Hopkins, Nicola Howe, Musheer Hussain, Hisham Mehanna, Christopher Raine, Frank Sullivan, Alexander von Wilamowitz-Moellendorff, M. Dawn Teare
Summary: This study compares the clinical effectiveness and cost-effectiveness of conservative management and tonsillectomy in adults with recurrent acute tonsillitis. The results show that immediate tonsillectomy is more effective in reducing sore throat days and has better cost-effectiveness compared to conservative management.
Article
Oncology
Hisham Mehanna, Miren Taberna, Christian von Buchwald, Sara Tous, Jill Brooks, Marisa Mena, Francisca Morey, Christian Gronhoj, Jacob Hoygaard Rasmussen, Martin Garset-Zamani, Laia Bruni, Nikolaos Batis, Ruud H. Brakenhoff, C. Rene Leemans, Robert J. Baatenburg de Jong, Jens Peter Klussmann, Nora Wuerdemann, Steffen Wagner, Tina Dalianis, Linda Marklund, Haitham Mirghani, Andrew Schache, Jaqueline A. James, Shao Hui Huang, Brian O'Sullivan, Paul Nankivell, Martina A. Broglie, Markus Hoffmann, Elgar Susanne Quabius, Laia Alemany
Summary: The study aimed to quantify the discordance between p16 expression and HPV status in oropharyngeal cancer and evaluate its prognostic implications. The results showed that patients with p16-/HPV+ or p16+/HPV- had worse prognosis compared to p16+/HPV+ or p16-/HPV- patients. HPV testing should be mandatory in clinical trials and recommended in patient care settings where HPV status may have an impact.
Review
Oncology
Janine Dretzke, Ava Lorenc, Ada Adriano, Clare Herd, Hisham Mehanna, Paul Nankivell, David J. Moore
Summary: The current follow-up models in cancer are seen as unsustainable and inflexible. Patient-initiated follow-up (PIFU) is gaining interest as an alternative model, and it is important to determine its acceptability to patients and healthcare professionals (HCPs). The findings show that most women treated for breast or endometrial cancer and HCPs support PIFU, but further research is needed.
Article
Oncology
Karl Payne, Jill Brooks, Nikolaos Batis, Naeem Khan, Mohammed El-Asrag, Paul Nankivell, Hisham Mehanna, Graham Taylor
Summary: In this study, high-dimensional single-cell mass cytometry proteomic analysis was used to evaluate CTCs in HNSCC patients. The results revealed different sub-groups of CTCs with potential for novel biomarker development and immune checkpoint inhibitor treatment stratification.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Hanya Mahmood, Adam Shephard, Paul Hankinson, Mike Bradburn, Anna Luiza Damaceno Araujo, Alan Roger Santos-Silva, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Kris D. Mccombe, Stephanie G. Craig, Jacqueline James, Jill Brooks, Paul Nankivell, Hisham Mehanna, Nasir Rajpoot, Syed Ali Khurram
Summary: This study conducted a digital quantitative analysis of OED and developed a novel prognostic model that outperforms existing grading systems. The model had superior predictive potential for malignant transformation and OED recurrence. External validation supported the strength of this model for prognosis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Otorhinolaryngology
Joseph Califano, Andrew Yousef, Heba Mostafa, Alexandra Valsamakis, Xinlian Zhang, Nikolaos Batis, Christy Varghese, Joanna Parish, Michael Forman, Junko Jarrett, Karen Messer, Hisham Mehanna
Summary: The objective of this study was to identify low-risk HPV-related oropharyngeal cancer (HPVOPC) patients at risk of recurrence by detecting HPV16 DNA in plasma and salivary rinses. The combined plasma and salivary HPV DNA assays showed a sensitivity of 65% and a specificity of 87% in detecting recurrence, with a median lead time of 19 days. Therefore, the presence of HPV DNA in post-treatment plasma and salivary rinses is associated with recurrence, providing a potential opportunity for earlier detection.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Rehabilitation
Malcolm Brown, Dominic O'Connor, Richard Turkington, Martin Eatock, Rebecca Vince, Claire Hulme, Roy Bowdery, Rebecca Robinson, Jonathan Wadsley, Anthony Maraveyas, Gillian Prue
Summary: This study aimed to investigate the feasibility and safety of concurrent exercise training during adjuvant chemotherapy. The results showed that this training method was feasible and safe, and it prevented a decline in functional fitness and patient-reported outcomes. These findings provide further evidence for including exercise training as a standard of care for surgical rehabilitation and managing treatment-related toxicities.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2023)
Article
Otorhinolaryngology
Joseph Califano, Andrew Yousef, Heba Mostafa, Alexandra Valsamakis, Xinlian Zhang, Nikolaos Batis, Christy Varghese, Joanna Parish, Michael Forman, Junko Jarrett, Karen Messer, Hisham Mehanna
Summary: This cohort study suggests that the presence of HPV DNA in plasma and salivary rinses after treatment is associated with recurrence in low-risk HPVOPC patients, providing a potential opportunity for earlier detection of recurrence.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Otorhinolaryngology
Anna R. Giuliano, Marisa Felsher, Tim Waterboer, Haitham Mirghani, Hisham Mehanna, Craig Roberts, Ya-Ting Chen, Mark Lynam, Montse Pedros, Emilio Sanchez, Bradley Sirak, Shikha Surati, Laia Alemany, Edith Morais, Miquel Angel Pavon
Summary: The aim of this study was to assess the prevalence of oral HPV infection in the general US population and investigate the factors associated with high-risk and low-risk infection. The results showed that the burden of oral HPV was highest among older men and was associated with sexual behaviors.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)