Article
Biochemistry & Molecular Biology
Carla F. S. Guazelli, Victor Fattori, Camila R. Ferraz, Sergio M. Borghi, Rubia Casagrande, Marcela M. Baracat, Waldiceu A. Verri
Summary: Hesperidin methyl chalcone (HMC) exhibits significant protective effects in a mouse model of acetic acid-induced colitis, reducing neutrophil infiltration, edema, and colon damage while increasing antioxidant status. In addition, HMC inhibits pro-inflammatory cytokines in the colon, possibly through NF-kappa B inhibition. These findings suggest HMC as a promising therapeutic approach for the treatment of ulcerative colitis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Nayara A. Artero, Marilia F. Manchope, Thacyana T. Carvalho, Telma Saraiva-Santos, Mariana M. Bertozzi, Jessica A. Carneiro, Anelise Franciosi, Amanda M. Dionisio, Tiago H. Zaninelli, Victor Fattori, Camila R. Ferraz, Maiara Piva, Sandra S. Mizokami, Doumit Camilios-Neto, Rubia Casagrande, Waldiceu A. Verri
Summary: Arthroplasty is a surgical procedure used to replace dysfunctional joints, but it can cause problems like arthritis and prosthesis failure. Flavonoids have been found to have analgesic and anti-inflammatory effects, but their effectiveness against arthritis caused by prosthesis-wearing molecules is unknown. This study investigated the effects of HMC on arthritis triggered by TiO2, and found that HMC can reduce arthritis symptoms without causing damage to the kidneys, liver, or stomach.
Article
Biochemistry & Molecular Biology
So-Yeon Kim, Sang-Deok Han, Minju Kim, Tamanna Jahan Mony, Eun-Seok Lee, Kyeong-Min Kim, Seung-Hyuk Choi, Sun Hee Hong, Ji Woong Choi, Se Jin Park
Summary: The study demonstrated that Mentha arvensis essential oil (MAEO) exerts anti-inflammatory effects in an atopic dermatitis (AD) model by inhibiting the ERK/NF-kappa B signaling pathway.
Article
Multidisciplinary Sciences
Mahdieh Alipour, Simin Sharifi, Mohammad Samiei, Shahriar Shahi, Marziyeh Aghazadeh, Solmaz Maleki Dizaj
Summary: This study synthesized hesperetin nanocrystals and evaluated their effects on bone strength, osteogenic differentiation, and inflammation. The results showed that these nanocrystals have the potential to enhance bone formation and reduce inflammation.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Songsong Liu, Kang Liu, Yuwei Wang, Chou Wu, Yang Xiao, Siqi Liu, Jingsu Yu, Zeqiang Ma, Huanjie Liang, Xiangling Li, Yixing Li, Lei Zhou
Summary: Obesity is a serious health issue worldwide, and its prevalence poses an economic burden on healthcare systems. Flavonoids, such as hesperidin methyl chalcone (HMC), have shown therapeutic potential in preventing and treating obesity. In this study, HMC treatment was found to reduce triglyceride accumulation and improve energy metabolism and oxidative stress in cells. Furthermore, HMC enhanced lipase activity, improved lipid metabolic disorders and liver injury, and regulated energy metabolism changes induced by high-fat diet in mice. These findings suggest that HMC provides a novel approach for the prevention and treatment of obesity and related diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Pharmacology & Pharmacy
Suizhi Cheng, Li Che, Qingqing Yang, Rongjing Sun, Yuhong Nie, Haoyue Shi, Yiwen Ding, Li Wang, Zuo Du, Zhenzhong Liu
Summary: In this study, it was found that folic acid (FA) effectively protected esophageal cells in the MNNG-induced esophageal inflammation model by inhibiting the NF-kappa B pathway and down-regulating the expression of inflammatory molecules IL-6, IL-8, and TNF-alpha. These findings are of great significance for further research and development of therapeutic strategies for preventing esophageal inflammation.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Urology & Nephrology
Guibao Ke, Xueqin Chen, Ruyi Liao, Lixia Xu, Li Zhang, Hong Zhang, Sujuan Kuang, Yue Du, Juan Hu, Zhiwen Lian, Caoshuai Dou, Qianmei Zhang, Xingchen Zhao, Fengxia Zhang, Shuangshuang Zhu, Jianchao Ma, Zhuo Li, Sijia Li, Chaosheng He, Xia Chen, Yingzhen Wen, Zhonglin Feng, Minghao Zheng, Ting Lin, Ruizhao Li, Bohou Li, Wei Dong, Yuanhan Chen, Wenjian Wang, Zhiming Ye, Chunyu Deng, Houqin Xiao, Jie Xiao, Xinling Liang, Wei Shi, Shuangxin Liu
Summary: The expression of Receptor activator of NF-kappa B (RANK) is increased in podocytes of patients with diabetic nephropathy. Mouse models of podocyte-specific RANK depletion and overexpression showed that RANK depletion alleviated the development of kidney diseases, while RANK overexpression aggravated the condition. The findings suggest that RANK mediates the development of diabetic nephropathy by promoting glomerular oxidative stress and proinflammatory cytokine production.
KIDNEY INTERNATIONAL
(2021)
Article
Environmental Sciences
P. Snega Priya, Raghul Murugan, Bader O. Almutairi, Selvaraj Arokiyaraj, P. Shanjeev, Jesu Arockiaraj
Summary: This study investigated the protective effects of cordycepin against gut inflammation induced by Cadmium (Cd) exposure. The results showed that cordycepin significantly reduced Cd-induced embryotoxicity and oxidative stress. It also normalized the levels of liver-related biomarkers affected by Cd exposure and downregulated the expression of inflammatory genes.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Review
Immunology
Attinder Chadha, Kris Chadee
Summary: Protozoan parasites evade host defenses by hijacking host cellular signaling pathways and transcription factors, with the NF-kappa B pathway being a key target. These parasites manipulate the NF-kappa B pathway to thwart immune responses and ensure survival in the host.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Physiology
Monica Z. Luque, Andreo F. Aguiar, Amanda K. da Silva-Araujo, Tiago H. Zaninelli, Olivia K. Heintz, Telma Saraiva-Santos, Mariana M. Bertozzi, Natalia A. Souza, Eros O. Junior, Waldiceu A. A. Verri, Sergio M. Borghi
Summary: This study evaluated the effects of hesperidin methyl chalcone on delayed-onset muscle soreness (DOMS). The results showed that taking hesperidin methyl chalcone can improve performance during exercise, reduce muscle soreness, and enhance muscle strength recovery and postural balance without causing adverse effects.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Immunology
LuLu Qian, Jun-Zhao Li, XueMei Sun, Jie-Bin Chen, Ying Dai, Qiu-Xiang Huang, Ying-Ji Jin, Qing-Ning Duan
Summary: The study demonstrates that safinamide can inhibit the production of pro-inflammatory cytokines by macrophages, reduce the release of inflammatory mediators, prevent leukocyte migration, and decrease the generation of related enzymes. These effects are mainly achieved through safinamide's inhibition of the TLR4/NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Gui-juan Jin, Xuehuizi Peng, Zhi-Guo Chen, Yu-lin Wang, Wen-jun Liao
Summary: Celastrol, a compound from Tripterygium wilfordii Hook F., showed analgesic effects in rats with neuropathic pain by inhibiting the TLR4/NF-kappa B signaling pathway and exerting anti-inflammatory effects in the spinal cord.
JOURNAL OF NATURAL MEDICINES
(2022)
Article
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Obaid Afzal, Waleed Hassan Almalki, Imran Kazmi, Mohammad Arshad Javed Shaikh, Lakshmi Thangavelu, Monica Gulati, Sachin Kumar Singh, Niraj Kumar Jha, Piyush Kumar Gupta, Dinesh Kumar Chellappan, Brian George Oliver, Kamal Dua, Gaurav Gupta
Summary: Nutraceuticals, as dietary supplements, have the potential to improve health, prevent diseases, and maintain normal body function. This review discusses the medical value of nutraceuticals in targeting the NF-kappa B pathway to mitigate inflammatory lung diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Patricia Garcia-Fernandez, Colette Reinhold, Nurcan Ueceyler, Claudia Sommer
Summary: Polyneuropathy (PNP) refers to diseases of the peripheral nervous system, with 50% of cases presenting with neuropathic pain. Certain types of PNP show pain restricted to the distal leg skin, indicating a local regulatory process leading to pain. This study suggests that a pro-inflammatory pathway mediated by NF-κB may contribute to pain development in patients with painful PNP. Our findings support the hypothesis of local inflammatory processes involved in pain in PNP, and suggest disrupted anti-inflammatory pathways in inflammatory PNP involving TRPV1 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Marion Mussbacher, Martina Derler, Jose Basilio, Johannes A. Schmid
Summary: Nuclear factor kappa B (NF-kappa B) is a dimeric transcription factor that regulates the expression of chemokines, cytokines, transcription factors, and regulatory proteins, playing a crucial role in inflammation and immunity. Understanding its specific roles in different cell types, tissues, and under different stimuli is important. This review focuses on the role of NF-kappa B in monocytes and macrophages, innate immune cells that exhibit high plasticity and adjust their functions against pathogens and cues from the environment. NF-kappa B activation in macrophages has significant implications in inflammatory diseases and its temporal dynamics are complex.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Renato D. R. Cardoso, Sandmary D. Chambo, Tiago H. Zaninelli, Beatriz H. S. Bianchini, Matheus Deroco Veloso da Silva, Mariana M. Bertozzi, Telma Saraiva-Santos, Anelise Franciosi, Geovana Martelossi-Cebinelli, Pamela E. Garcia-Miguel, Sergio M. Borghi, Rubia Casagrande, Waldiceu A. Verri
Summary: In the study, it was found that RvD5 enhances bacteria phagocytosis, reduces inflammatory mediators, and protects kidneys from tissue injury in gram-negative Escherichia coli infection and LPS endotoxemia. This effect is associated with improved histopathological parameters, reduced leukocyte infiltration, decreased pro-inflammatory cytokine production, and increased antioxidant markers. RvD5 also reduces the activation of NF kappa B and promotes the Nrf2 pathway.
Article
Biochemistry & Molecular Biology
Nayara A. Artero, Marilia F. Manchope, Thacyana T. Carvalho, Telma Saraiva-Santos, Mariana M. Bertozzi, Jessica A. Carneiro, Anelise Franciosi, Amanda M. Dionisio, Tiago H. Zaninelli, Victor Fattori, Camila R. Ferraz, Maiara Piva, Sandra S. Mizokami, Doumit Camilios-Neto, Rubia Casagrande, Waldiceu A. Verri
Summary: Arthroplasty is a surgical procedure used to replace dysfunctional joints, but it can cause problems like arthritis and prosthesis failure. Flavonoids have been found to have analgesic and anti-inflammatory effects, but their effectiveness against arthritis caused by prosthesis-wearing molecules is unknown. This study investigated the effects of HMC on arthritis triggered by TiO2, and found that HMC can reduce arthritis symptoms without causing damage to the kidneys, liver, or stomach.
Article
Public, Environmental & Occupational Health
Rafaela Pires Erthal, Glaucia Eloisa Munhoz de Lion Siervo, Giovanna Fachetti Frigoli, Tiago Henrique Zaninelli, Waldiceu Aparecido Verri, Glaura Scantamburlo Alves Fernandes
Summary: This study found that low doses of malathion can impair sperm quality and function by downregulating gene expression, and can also damage the sperm's antioxidant profile during critical periods of development.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Cristina P. B. Melo, Priscila Saito, Renata M. M. Martinez, Larissa Staurengo-Ferrari, Ingrid C. C. Pinto, Camilla C. A. Rodrigues, Stephanie Badaro-Garcia, Josiane A. A. Vignoli, Marcela M. M. Baracat, Allan J. C. Bussmann, Sandra R. R. Georgetti, Waldiceu A. A. Verri, Rubia Casagrande
Summary: This study investigates the protective effect of AT-RvD1 on UVB-induced inflammation and oxidative stress in hairless mice. The results show that AT-RvD1 can restrict various inflammatory and oxidative stress markers and restore the skin's natural antioxidant defense. AT-RvD1 achieves this by upregulating the Nrf2 pathway and promoting the expression of ARE genes.
Editorial Material
Pharmacology & Pharmacy
Miriam S. N. Hohmann, Waldiceu A. Verri, Flavia A. Guarnier, Barbara St. Pierre Schneider, Sergio M. Borghi
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Daniel Segelcke, Jan Linnemann, Bruno Pradier, Daniel Kronenberg, Richard Stange, S. Helene Richter, Dennis Goerlich, Nicola Baldini, Gemma Di Pompo, Waldiceu A. Verri Jr, Sofia Avnet, Esther M. Pogatzki-Zahn
Summary: Bone metastases are a common complication in advanced cancer patients, causing severe pain and reducing their quality of life. This study aimed to identify the pain phenotypes of cancer-induced bone pain (CIBP) in rats. CIBP in the splint bone caused mechanical hypersensitivity, resting pain, and antalgic gait in both sexes. The progression of tumor growth led to the establishment of the CIBP phenotype, which appeared earlier in male rats and affected social behaviors in both sexes.
Article
Cell Biology
Carina Z. Segato-Vendrameto, Camila Zanluca, Amanda Z. Zucoloto, Tiago H. Zaninelli, Mariana M. Bertozzi, Telma Saraiva-Santos, Camila R. Ferraz, Larissa Staurengo-Ferrari, Stephanie Badaro-Garcia, Marilia F. Manchope, Amanda M. Dionisio, Felipe A. Pinho-Ribeiro, Sergio M. Borghi, Ana Luiza Pamplona Mosimann, Rubia Casagrande, Juliano Bordignon, Victor Fattori, Claudia N. Duarte dos Santos, Waldiceu A. Verri
Summary: This article investigates therapeutic strategies against Chikungunya virus, finding that inhibiting viral proteins and using recombinant antibodies can alleviate virus-induced pain symptoms.
Article
Chemistry, Medicinal
Tiago H. Zaninelli, Sandra S. Mizokami, Mariana M. Bertozzi, Telma Saraiva-Santos, Felipe A. Pinho-Ribeiro, Gabriele Inacio de Oliveira, Renata Streck, Eduardo J. A. Araujo, Nilton S. Arakawa, Sergio M. Borghi, Rubia Casagrande, Waldiceu A. Verri
Summary: In this study, it was found that kaurenoic acid (KA), extracted from Sphagneticola trilobata, has analgesic properties and can be used for the treatment of neuropathic pain. KA inhibits neuropathic pain induced by chronic constriction injury (CCI) by activating the NO/cGMP/PKG/ATP-sensitive potassium channel signaling pathway. KA also reduces activation of sensory neurons and increases the levels of neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) in dorsal root ganglion (DRG) neurons. These findings suggest that KA inhibits CCI neuropathic pain by activating the nNOS-NO pathway to silence nociceptive signaling.
Review
Pharmacology & Pharmacy
Tiago H. Zaninelli, Geovana Martelossi-Cebinelli, Telma Saraiva-Santos, Sergio M. Borghi, Victor Fattori, Rubia Casagrande, Waldiceu A. Verri Jr
Summary: Gout arthritis is an intermittent inflammatory disease that affects approximately 10% of the global population. Current therapies are not fully effective and have numerous side effects, highlighting the need for new drug targets and effector molecules in the development of novel treatments for gout arthritis.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Pharmacology & Pharmacy
Carla F. S. Guazelli, Victor Fattori, Barbara B. Colombo, Isabela S. Ludwig, Laisa G. Vicente, Renata M. Martinez, Sandra R. Georgetti, Alexandre Urbano, Rubia Casagrande, Marcela M. Baracat, Waldiceu A. Verri Jr
Summary: Improved therapies for inflammatory bowel diseases are needed. The researchers investigated the activity of trans-chalcone (T) and developed microcapsules containing T for colitis treatment. In vitro experiments showed controlled release of T in simulated intestinal fluid. In vivo experiments demonstrated that MT significantly improved colitis outcomes and reduced colon damage.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Fernanda S. S. Rasquel-Oliveira, Matheus Deroco Veloso da Silva, Geovana Martelossi-Cebinelli, Victor Fattori, Rubia Casagrande, Waldiceu A. A. Verri Jr
Summary: During infection, inflammation can be harmful when it becomes excessive or chronic. Specialized pro-resolving lipid mediators (SPMs), derived from omega-3 and -6 polyunsaturated fatty acids, play a crucial role in resolving inflammation and promoting a coordinated immune response against pathogens. SPMs regulate leukocyte influx, reduce cytokine and chemokine levels, enhance bacterial clearance, inhibit viral replication, stimulate tissue healing, and decrease antibiotic requirements. Understanding the biosynthesis and effects of SPMs in different infections could have important implications for developing new therapeutic strategies.
Editorial Material
Biochemistry & Molecular Biology
Sergio Marques Borghi, Wander Rogerio Pavanelli
Article
Microbiology
Vera Lucia Hideko Tatakihara, Aparecida Donizette Malvezi, Rito Santo Pereira, Bruno Fernando Cruz Lucchetti, Lucas Felipe Dos Santos, Rubens Cecchini, Lucy Megumi Yamauchi, Sueli Fumie Yamada-Ogatta, Katrina M. Miranda, Waldiceu A. Verri, Marli Cardoso Martins-Pinge, Phileno Pinge-Filho
Summary: This study found that a nitric oxide donor called Angeli's salt (AS) can reduce the number of parasites and the severity of Chagas disease in mice. In addition, AS treatment can enhance the antioxidant capacity of infected animals' red blood cells. These results suggest that AS could be a promising therapy for Chagas disease.
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)