Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Roberto Crea, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Traumatic brain injuries are a significant public health issue with long-term consequences such as cerebral atrophy and increased risk of dementia and Alzheimer's Disease. Hidrox (R) treatment has shown benefits in reducing TBI-induced neurodegeneration and improving cognitive function and memory impairment.
Review
Biochemistry & Molecular Biology
Cristina Pagano, Beatrice Savarese, Laura Coppola, Giovanna Navarra, Giorgio Avilia, Chiara Laezza, Maurizio Bifulco
Summary: Cannabis sativa-derived compounds, such as THC and CBD, and components of the endocannabinoid system, such as AEA and 2-AG, have been extensively studied for their antioxidant effects. Many diseases are characterized by imbalanced ROS production, and these compounds have shown potential in reducing ROS levels in various pathological conditions. Further research on the antioxidant properties of cannabis sativa-derived compounds could have future clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Rafael Carecho, Diogo Carregosa, Bernardo Oliveira Ratilal, Ines Figueira, Maria Angeles Avila-Galvez, Claudia Nunes dos Santos, Natasa Loncarevic-Vasiljkovic
Summary: Traumatic brain injury (TBI) is a major cause of death and disability in young adults worldwide. The underlying mechanisms of TBI are still not fully understood, despite advances in our knowledge. Secondary brain injury processes occur gradually following the initial acute damage, providing a therapeutic window for interventions. Nutritional interventions, particularly (poly)phenols found in fruits and vegetables, have shown promise in enhancing the repair processes after TBI. However, more research is needed to fully understand the effects and limitations of (poly)phenols in TBI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sarvenaz Sobhani, Ali-Asghar Tehrani, Golnar Sobhani, Sulail Fatima, Luis Ulloa, Majid Motaghinejad, Alina Atif
Summary: This study evaluates the potential of melatonin to protect against titania-induced neurotoxicity and explores the role of the Keap1/Nrf2/ARE signaling pathway. Results showed that melatonin could improve behavioral alterations induced by titania and reduce oxidative stress levels, as well as protect hippocampal cells from damage.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Rania Z. ElGamal, Mariane G. Tadros, Esther T. Menze
Summary: This study evaluates the neuroprotective effects of the DPP4 inhibitor linagliptin in a rotenone-induced rat model of Parkinson's disease. The results show that linagliptin can prevent motor deficits and tissue damage caused by rotenone through anti-inflammatory, anti-apoptotic, and antioxidant mechanisms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Environmental Sciences
Guowei Xu, Yuqin Gu, Nan Yan, Yongfang Li, Lin Sun, Bing Li
Summary: Curcumin has been shown to alleviate arsenic-induced liver and kidney dysfunction by reducing arsenic deposition, improving biochemical indexes, modulating myeloperoxidase activities and inflammatory cytokine secretion, as well as inhibiting MAPKs/NF-kappa B while activating Nrf2 pathways in mice.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Neurosciences
Ramona D'Amico, Daniela Impellizzeri, Tiziana Genovese, Roberta Fusco, Alessio Filippo Peritore, Rosalia Crupi, Livia Interdonato, Gianluca Franco, Ylenia Marino, Alessia Arangia, Enrico Gugliandolo, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Marika Cordaro
Summary: This study explores a new neuroprotective strategy for Parkinson's disease by supplementing with Acai berry. The results show that daily supplementation with Acai berry significantly reduces motor and non-motor symptoms and protects dopaminergic neurons from damage. This beneficial effect may be attributed to the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) to counteract oxidative stress and neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Chemistry, Medicinal
Yueke Zhou, Cheng Qian, Yu Tang, Mengyao Song, Teng Zhang, Guanglu Dong, Weiwei Zheng, Chunmei Yang, Chongjin Zhong, Aiyun Wang, Yang Zhao, Yin Lu
Summary: This article provides a detailed overview of the antioxidant and anti-inflammatory abilities of the active ingredient quercetin and its application in treating oxidative stress-related disorders.
PHYTOTHERAPY RESEARCH
(2023)
Review
Chemistry, Medicinal
Md Ataur Rahman, Raju Dash, Abdullah Al Mamun Sohag, Mahboob Alam, Hunjoo Ha, Il Soo Moon, Md Jamal Uddin, Md Abdul Hannan, Hyewhon Rhim
Summary: Marine sterols have shown potential in combating Alzheimer's disease, with their anti-inflammatory and antioxidant properties providing various health benefits, including anti-aging and anti-cancer effects. Through interactions with different proteins and enzymes, marine sterols participate in regulating multiple cellular systems.
Article
Neurosciences
Fabiola Paciello, Anna Pisani, Marco Rinaudo, Sara Cocco, Gaetano Paludetti, Anna Rita Fetoni, Claudio Grassi
Summary: Several studies have shown that noise-induced hearing loss is a risk factor for sensory aging and cognitive decline, including neurodegenerative diseases. However, the molecular mechanisms underlying this association are not fully understood. A recent study found that early noise exposure in mice accelerated the onset of age-related cochlear dysfunctions and had detrimental effects on memory processes. The study suggests that the combined detrimental effect of noise and sensory aging on hearing function can increase the risk of sensory and cognitive degenerative processes.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Daphne Atlas
Summary: Understanding neurodegenerative diseases has been a challenge for scientists for decades, with a decrease in lifespan often linked to the development of these disorders. Oxidative stress and inflammatory damages are key factors contributing to neurodegeneration. Novel amino acid based compounds and thioredoxin mimetic peptides designed to cross the blood-brain-barrier show potential for effective treatment of neurodegenerative diseases by reversing oxidative stress, mitochondrial stress, inflammatory damages, and preventing premature cell death. Perspectives on the clinical prospects of these compounds are discussed in this review.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Environmental Sciences
Daifullah Al Aboud, Roua S. Baty, Khalaf F. Alsharif, Khalid Ebrahim Hassan, Ahmed S. Zhery, Ola A. Habotta, Ehab K. Elmahallawy, Hatim K. Amin, Ahmed E. Abdel Moneim, Rami B. Kassab
Summary: Arsenic exposure induces hepatic oxidative damage and inflammation, while treatment with thymoquinone or ebselen improves liver function and antioxidant status, and alleviates inflammation, apoptosis, and fibrosis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Neurosciences
Sajad Fakhri, Sana Piri, Seyed Zachariah Moradi, Haroon Khan
Summary: Radiation for therapeutic purposes has been shown to have positive effects in different situations, but it also carries the risk of increasing the likelihood of developing neurodegenerative diseases. High doses of radiation can have destructive effects on neurodegeneration, and current drugs have limitations. Polyphenols and other natural compounds are promising candidates for preventing and treating radiation-induced neurodegenerative disorders.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hongmin Lu, Hongjing Zhao, Yu Wang, Menghao Guo, Mengyao Mu, Yachen Liu, Xiaopan Nie, Puyi Huang, Mingwei Xing
Summary: This study investigated the alleviation of exogenous gill toxicity in carp induced by As-III with zinc (Zn2+), and found that Zn2+ can reduce oxidative stress levels and increase antioxidant enzyme activity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xin Shi, Panpan Li, Hanhan Liu, Verena Prokosch
Summary: This article reviews the impact of oxidative stress (OS) on endothelial dysfunction (ED) in the retina and explores the mechanistic links between the two and their role in different retinal neurodegenerative diseases. Understanding the role of endothelial function may lead to new therapeutic approaches.