期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 236, 期 -, 页码 41-46出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2015.04.021
关键词
Apigenin; Arthritis; Inflammation; P2X7/NF-kappa B
资金
- National twelve five major drug discovery project [2011ZX09102-002-01]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Research Innovation Program Project for Graduate Students in Jiangsu Province [CXZZ13_03]
- Fundamental Research Funds for the Central Universities [ZJ15030]
To evaluate the effect of apigenin (AP) on arthritis in rats stimulated by Freund's complete adjuvant (FCA) was the main purpose of the investigation. Arthritis model was established by the administration of 0.1 ml FCA in the palmar surface. AP and diclofenac sodium (DS) were administered to explore and evidence the protective effects against adjuvant-induced arthritis (AA). Cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) were detected to assess the anti-inflammatory effect of AP. Besides, pathological conditions were examined in rat paws. Related-proteins of nuclear factor kappa B (NF-kappa B) signal pathway activated by P2X7 were investigated to determine the molecular mechanism of AP and their expressions were measured by western blot. The data showed that AP significantly suppressed the expressions of P2X7/NF-kappa B signal-related proteins and alleviated inflammatory reactions. Therefore, it was assumed that AP might be a potential therapeutic candidate to treat arthritis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据