Article
Clinical Neurology
Kirill Shumilov, Sophia Xiao, Allen Ni, Marta Celorrio, Stuart H. Friess
Summary: Traumatic brain injury (TBI) can cause damage to the white matter through axonal loss and demyelination. The proliferation of oligodendrocyte progenitor cells (OPCs) plays a crucial role in the process of remyelination. However, current treatments for TBI are unable to effectively stimulate OPC proliferation. This study demonstrates the potential of recombinant human erythropoietin (rhEPO) in promoting myelination by increasing the proliferation of oligodendrocyte lineage cells after TBI.
Review
Neurosciences
Jacob H. Hines
Summary: Oligodendrocytes are essential for neural function in gnathostomes, with well-established roles in myelination, but recent studies have shown their involvement in other aspects of central nervous system development, function, and maintenance. Advances in understanding myelin plasticity have revealed experience-dependent adaptations as a form of neural plasticity. The evolutionary origins and specializations of oligodendrocytes remain mysteries, prompting questions about when and for what functions the cell type emerged, and the genetic changes responsible for their evolutionary innovations.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Colin J. Murray, Haley A. Vecchiarelli, Marie-Eve Tremblay
Summary: Consumption of cannabis is increasing, especially among the elderly, but research on its impact on the aged brain is lacking. The aging process leads to changes in the brain's myelination process, which is associated with cognitive decline and neurological diseases. Animal studies suggest that cannabis can modulate the myelination process. However, research on the impact of cannabis on myelination in the aged brain is limited.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ning Li, Min Yao, Jiaxin Liu, Zhiyuan Zhu, Tsz-Lung Lam, Pingde Zhang, Karrie Mei-Yee Kiang, Gilberto Ka-Kit Leung
Summary: The study showed that VitD treatment improved hindlimb movement in rats post-TSCI, but those with prior deficiency did not benefit. Maintaining sufficient VitD levels was essential for preserving myelin integrity after injury.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lingyu Shi, Zongyi Wang, Yujiao Li, Zheng Song, Wu Yin, Bing Hu
Summary: This study reveals the critical role of chd7 in oligodendrocyte migration and myelination in zebrafish, potentially associated with CHARGE syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Na Suo, Bingqing He, Shihao Cui, Ying Yang, Min Wang, Qianting Yuan, Xin Xie
Summary: GPR149, an orphan G protein-coupled receptor enriched in OPCs, negatively regulates OPC to OL differentiation and myelination, impacting myelin development and remyelination. Deficiency of GPR149 enhances myelin regeneration. Further study suggests that GPR149 may regulate OL differentiation and myelin formation via the MAPK/ERK pathway.
Article
Cell Biology
Rosario Sanchez-Gonzalez, Christina Koupourtidou, Tjasa Lepko, Alessandro Zambusi, Klara Tereza Novoselc, Tamara Durovic, Sven Aschenbroich, Veronika Schwarz, Christopher T. Breunig, Hans Straka, Hagen B. Huttner, Martin Irmler, Johannes Beckers, Wolfgang Wurst, Andreas Zwergal, Tamas Schauer, Tobias Straub, Tim Czopka, Dietrich Truembach, Magdalena Goetz, Stefan H. Stricker, Jovica Ninkovic
Summary: The influx of cerebrospinal fluid after brain injury simultaneously activates toll-like receptor 2 (Tlr2) and chemokine receptor 3 (Cxcr3) pathways, leading to increased OPC proliferation and exacerbated glial reactivity. Interference with these pathways alleviated reactive gliosis, increased new neuron recruitment, and improved tissue restoration after injury.
Article
Endocrinology & Metabolism
Bahareh Nazari, Zeinab Namjoo, Fatemeh Moradi, Mansure Kazemi, Somayeh Ebrahimi-Barough, Esmaeil Sadroddiny, Jafar Ai
Summary: Transplantation of miR-219-overexpressing OPCs in animal models of spinal cord injury promoted differentiation and maturation of oligodendrocytes, leading to a reduction in cavity size at the injury site and improved functional recovery of hind limbs. This study suggests that miR-219 could be a potential therapeutic target for cell therapy in spinal cord injury.
METABOLIC BRAIN DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Young Rae Jo, Hye Ran Kim, So Young Jang, Hana Go, Min-Young Song, Da Kyeong Park, Yuna Oh, Juyeon Jo, Yoon Kyung Shin, Sung Joong Lee, Sang-Myung Cheon, Hyun Kyoung Lee, Kyung Eun Lee, Young Hye Kim, Hwan Tae Park
Summary: The study found that a large population of central neurons are derived from Cnp-expressing neuroglial stem cells; conditional gene targeting using the Cnp promoter, known to be OL-specific, can induce neuron-autonomous phenotypes.
Article
Clinical Neurology
Xiaohua Wang, Jing Zang, Yinxiang Yang, Siliang Lu, Qian Guan, Dou Ye, Zhaoyan Wang, Haipeng Zhou, Ke Li, Qian Wang, Youjia Wu, Zuo Luan
Summary: Transplanted human oligodendrocyte progenitor cells (hOPCs) survived in the brain of rats with preterm white matter injury (PWMI) and differentiated into mature oligodendrocytes, leading to myelin production and improvements in neurobehavior. This suggests that hOPC transplantation may be an effective therapeutic strategy for children with PWMI.
FRONTIERS IN NEUROLOGY
(2021)
Review
Cell & Tissue Engineering
Lin Zhong, Jingjing Wang, Peng Wang, Xiaoyin Liu, Peng Liu, Xu Cheng, Lujia Cao, Hongwei Wu, Jing Chen, Liangxue Zhou
Summary: Regenerative repair of the brain after traumatic brain injury remains a clinical challenge, and exosome therapy presents a promising strategy for novel regenerative therapies. Prior research has shown that exosomes produced by neural stem cells can participate in the physiological and pathological changes associated with TBI and have potential neuroregulatory and repair functions.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Neurosciences
Rebecca K. Holloway, Graeme Ireland, Gemma Sullivan, Julie-Clare Becher, Colin Smith, James P. Boardman, Pierre Gressens, Veronique E. Miron
Summary: Injury to the developing brain during the perinatal period often leads to hypomyelination, and dysregulation of inflammation and microglia may play a role. Activation of the NLRP3 inflammasome in microglia is associated with pathology, and blocking it can rescue myelination. The interaction between inflammasome product IL1 beta and follistatin may provide new therapeutic strategies for reinstating myelination following developmental injury.
Article
Neurosciences
Jiajia Wang, Lijun Yang, Mingqing Jiang, Chuntao Zhao, Xuezhao Liu, Kalen Berry, Ari Waisman, Abraham J. Langseth, Bennett G. Novitch, Dwight E. Bergles, Akiko Nishiyama, Q. Richard Lu
Summary: Through multiple experiments, it is shown that Olig2 is essential for the differentiation, myelination, and repair of immature OLs, contrary to previous findings. Additionally, the study highlights the importance of using Cre-dependent reporter genes in studying cell state progression.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Josine E. G. Vaes, Myrna J. V. Brandt, Nikki Wanders, Manon J. N. L. Benders, Caroline G. M. de Theije, Pierre Gressens, Cora H. Nijboer
Summary: Encephalopathy of prematurity (EoP) is a major cause of morbidity in preterm neonates, characterized by diffuse white matter injury with hypomyelination. Despite the lack of treatment options, research has identified promising trophic factors and cytokines that may have therapeutic potential to combat EoP by promoting oligodendrocyte survival and maturation and dampening neuroinflammation. Future perspectives include the translatability of these factors into clinical practice.
Article
Neurosciences
Melanie Piller, Inge L. Werkman, Evan A. Brown, Andrew J. Latimer, Sarah Kucenas
Summary: The study found that the ionotropic glutamate receptor subunit GluR4A plays a crucial role in OPC migration and myelination, disruption of which leads to abnormal migration and distribution of OPCs in the spinal cord. Through genetic and pharmacological experiments, it was discovered that voltage-gated calcium channels are downstream of glutamate receptor signaling in OPCs and can rescue migration and myelination defects caused by disrupted glutamate signaling.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Oncology
Desmond A. Brown, Victor M. Lu, Benjamin T. Himes, Terry C. Burns, Alfredo Quinones-Hinojosa, Kaisorn L. Chaichana, Ian F. Parney
CLINICAL & EXPERIMENTAL METASTASIS
(2020)
Article
Oncology
Jeanette E. Eckel-Passow, Kristen L. Drucker, Thomas M. Kollmeyer, Matt L. Kosel, Paul A. Decker, Annette M. Molinaro, Terri Rice, Corinne E. Praska, Lauren Clark, Alissa Caron, Alexej Abyzov, Anthony Batzler, Jun S. Song, Melike Pekmezci, Helen M. Hansen, Lucie S. McCoy, Paige M. Bracci, Joseph Wiemels, John K. Wiencke, Stephen Francis, Terry C. Burns, Caterina Giannini, Daniel H. Lachance, Margaret Wrensch, Robert B. Jenkins
Article
Oncology
Desmond A. Brown, Anshit Goyal, Panagiotis Kerezoudis, Mohammed Ali Alvi, Benjamin T. Himes, Mohamad Bydon, Jamie J. Van Gompel, Kaisorn L. Chaichana, Alfredo Quinones-Hinojosa, Terry C. Burns, Elizabeth Yan, Ian F. Parney
JOURNAL OF NEURO-ONCOLOGY
(2020)
Review
Medicine, General & Internal
Terry C. Burns, Alfredo Quinones-Hinojosa
Summary: Regenerative neurosurgery aims to treat neurological diseases by protecting, rejuvenating, or replacing irreversibly damaged cell types within the central nervous system (CNS). It involves introducing cells, neurotrophins, and genes with regenerative capacity into the CNS or its surrounding structures. Over the past three decades, significant progress has been made in regenerative neurosurgery, particularly in the fields of Parkinson's disease, stroke, amyotrophic lateral sclerosis, and spinal cord injury.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Oncology
Eliot Fletcher-Sananikone, Suman Kanji, Nozomi Tomimatsu, Luis Fernando Macedo Di Cristofaro, Rahul K. Kollipara, Debabrata Saha, John R. Floyd, Patrick Sung, Robert Hromas, Terry C. Burns, Ralf Kittler, Amyn A. Habib, Bipasha Mukherjee, Sandeep Burma
Summary: This study reveals that radiation therapy-induced senescence in non-neoplastic brain cells promotes the growth of glioblastoma. Senescent astrocytes secrete factors like HGF to activate Met in glioma cells. Treatment with senolytic drugs can attenuate tumor growth by selectively killing senescent astrocytes.
Article
Oncology
Hirokazu Takami, Christopher S. Graffeo, Avital Perry, Desmond A. Brown, Fredric B. Meyer, Terry C. Burns, Ian F. Parney
Summary: Hemangioblastoma is a rare tumor that mainly occurs in the cerebellum and can be either sporadic or related to VHL syndrome. This study reviewed a large series of cases and found that the presentation and clinical course of hemangioblastoma vary depending on the etiology. Different types of lesions have different characteristics and risks.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
Cecile Riviere-Cazaux, Archis R. Bhandarkar, Masum Rahman, Clark R. Zheng, Megan M. J. Bauman, Ryan M. Naylor, Jamie J. Van Gompel, Richard S. Zimmerman, Jaclyn J. White, Ian F. Parney, Kaisorn L. Chaichana, Kai J. Miller, Vance T. Lehman, Timothy J. Kaufmann, Terry C. Burns
Summary: LITT was associated with sustained local control in 81.8% of patients with metastatic central nervous system disease, showing promising results in terms of overall survival and disease progression outside the treated lesion.
WORLD NEUROSURGERY
(2022)
Article
Multidisciplinary Sciences
Sree Deepthi Muthukrishnan, Riki Kawaguchi, Pooja Nair, Rachna Prasad, Yue Qin, Maverick Johnson, Qing Wang, Nathan VanderVeer-Harris, Amy Pham, Alvaro G. Alvarado, Michael C. Condro, Fuying Gao, Raymond Gau, Maria G. Castro, Pedro R. Lowenstein, Arjun Deb, Jason D. Hinman, Frank Pajonk, Terry C. Burns, Steven A. Goldman, Daniel H. Geschwind, Harley Kornblum
Summary: This study reveals that radiation induces dynamic shifts in functional states of glioma cells, allowing them to acquire vascular-like cell phenotypes. These vascular-like cells provide trophic support to promote tumor cell proliferation. The study highlights the role of the P300 histone acetyltransferase in this adaptive conversion process.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Cecile Riviere-Cazaux, Bryan J. Neth, Matthew D. Hoplin, Bambi Wessel, Jason Miska, Sani H. Kizilbash, Terry C. Burns
Summary: By using DFMO and AMXT-1501 in patients with high-grade gliomas, the study aims to investigate the impact of polyamine depletion on the tumor biology and expects AMXT-1501 to enhance the cytotoxic effect of DFMO. This research is expected to provide important data for the clinical translation of novel therapeutic approaches.
Article
Oncology
Moustafa A. Mansour, Masum Rahman, Ahmad A. Ayad, Arthur E. Warrington, Terry C. Burns
Summary: High-grade gliomas are aggressive brain tumors with poor prognosis. Current standard care involves surgery followed by chemoradiation. However, surviving cancer cells after treatment may escape senescence and become more aggressive. In this study, P21 overexpression was found to induce apoptosis and senescence in human glioma cells, and these cells depended on Bcl-xL to avoid cell death.
Article
Clinical Neurology
Bryan J. Neth, Jeffrey L. Winters, Revathi Thirumushi Sairaj, Ali Gharibi Loron, Masum Rahman, Renee Hirte, Cecile Riviere-Cazaux, Michael W. Ruff, Terry C. Burns
Summary: In this case, a patient with recurrent glioblastoma needed urgent surgery only 4 days after receiving bevacizumab. Therapeutic plasma exchange effectively removed the drug and allowed for safe surgery without new complications. This approach shows promise for patients requiring urgent surgery after recent bevacizumab treatment.
NEURO-ONCOLOGY PRACTICE
(2023)
Article
Oncology
Panagiotis Kerezoudis, Yagiz Ugur Yolcu, Nadia N. Laack, Michael W. Ruff, Soumen Khatua, David J. Daniels, Terry C. Burns, Sani H. Kizilbash
Summary: The management of pineal parenchymal tumors remains controversial, with survival rates higher in patients with PPTID compared to pineoblastoma. Adjuvant chemoradiation was associated with improved survival in pineoblastoma patients, and females had lower hazards of death. Further research is needed to identify specific patient profiles and molecular subgroups more likely to benefit from multimodality therapy.
NEURO-ONCOLOGY ADVANCES
(2022)
Article
Clinical Neurology
Desmond A. Brown, Anshit Goyal, Kent R. Richter, Jack M. Haglin, Benjamin T. Himes, Victor M. Lu, Kendall Snyder, Joshua Hughes, Paul A. Decker, Michael Opoku-Darko, Michael J. Link, Terry C. Burns, Ian F. Parney
Summary: The objective of this study was to determine the frequency with which brain biopsy for presumed CNS relapse of systemic hematological malignancies yields new, actionable diagnostic information. The study found that brain biopsy in patients with a history of systemic DLBCL and a new brain MRI lesion had lower diagnostic utility compared with patients with non-DLBCL systemic malignancies. Patients with a history of systemic DLBCL gained minimal clinical benefit from brain biopsy but were at high risk of morbidity and mortality. In contrast, brain biopsy remained critical for patients with a history of non-DLBCL systemic malignancies due to the high likelihood of discovering distinct diagnostic entities.
JOURNAL OF NEUROSURGERY
(2022)
Meeting Abstract
Oncology
Hirokazu Takami, Terry C. Burns, Ian Parney
Meeting Abstract
Oncology
Renee Hirte, Ian E. Olson, Masum Rahman, Moustafa Mansour, Amanda Munoz Casabella, Terry C. Burns