期刊
NEUROSURGICAL FOCUS
卷 40, 期 5, 页码 -出版社
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2016.2.FOCUS163
关键词
optogenetics; DREADD; designer receptor exclusively activated by designer drugs; stroke; ischemia; neuroregeneration; plasticity
Stroke is one of the leading contributors to morbidity, mortality, and health care costs in the United States. Although several preclinical strategies have shown promise in the laboratory, few have succeeded in the clinical setting. Optogenetics represents a promising molecular tool, which enables highly specific circuit-level neuromodulation. Here, the conceptual background and preclinical body of evidence for optogenetics are reviewed, and translational considerations in stroke recovery are discussed.
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