Review
Clinical Neurology
Sepehr Khosravi, Farzin Farahbakhsh, Marjan Hesari, Alireza Shahmohammadi, Alireza Aliakbargolkar, Vali Baigi, Zahra Eskandari, Zahra Ghodsi, James Harrop, Vafa Rahimi-Movaghar, Seyed Mohammad Ghodsi
Summary: This study aimed to investigate predictors of surgical outcomes for mild Degenerative Cervical Myelopathy (DCM) by conducting a systematic review of relevant studies. After screening 6,087 manuscripts, it was found that lower pre-operative JOA scores and quality-of-life measurement scores were associated with better surgical outcomes, while high-intensity pre-operative T2 MRI was associated with poor outcomes.
GLOBAL SPINE JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Brandon He, Kyle Sheldrick, Abhirup Das, Ashish Diwan
Summary: Degenerative cervical myelopathy (DCM) is a non-traumatic, chronic, and progressive disease, and current diagnostic and prognostic techniques have limitations. This article presents evidence on novel quantitative MRI (qMRI) techniques for assessing spinal cord integrity in DCM and suggests future research directions.
Review
Medicine, General & Internal
Melissa Lannon, Edward Kachur
Summary: Degenerative cervical myelopathy (DCM) is a common condition caused by narrowing of the spinal canal, leading to spinal cord compression and neurologic dysfunction. Clinicians should be aware of early signs and symptoms to consider surgical intervention for preventing severe deterioration in neurologic function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Connor Berlin, Alexandria C. Marino, Praveen V. Mummaneni, Juan Uribe, Luis M. Tumialan, Jay Turner, Michael Y. Wang, Paul Park, Erica F. Bisson, Mark Shaffrey, Oren Gottfried, Khoi D. Than, Kai-Ming Fu, Kevin Foley, Andrew K. Chan, Mohamad Bydon, Mohammed Ali Alvi, Cheerag Upadhyaya, Domagoj Coric, Anthony Asher, Eric A. Potts, John Knightly, Scott Meyer, Avery Buchholz
Summary: This study found that regardless of the severity of preoperative myelopathy, surgical decompression for CSM can lead to significant improvement in quality of life, neck disability, myelopathy score, and overall health within 3 months postoperatively. The findings of this study can help surgeons make decisions in patient selection, preoperative counseling, and expected postoperative time courses.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Article
Clinical Neurology
Lovisa Gerdhem, Anastasios Charalampidis, Paul Gerdhem
Summary: This retrospective study investigated the association between improvement after surgery for degenerative cervical myelopathy and preoperative disease severity, as well as identified predictors of outcome. The study aimed to improve patient selection as degenerative cervical myelopathy is a common cause of spinal cord compromise in adults. The results showed that surgery improved patient-reported outcome measures across all disease severity groups and identified predictors such as preoperative disease severity, symptom duration, and walking distance.
Article
Clinical Neurology
Nathan Evaniew, Raphaele Charest-Morin, W. Bradley Jacobs, Michael Johnson, Christopher S. Bailey, Sean Christie, Jerome Paquet, Andrew Nataraj, David W. Cadotte, Jefferson R. Wilson, Michael Craig, Mark Xu, Neil Manson, Hamilton Hall, Ken C. Thomas, Y. Raja Rampersaud, Greg McIntosh, Charles G. Fisher, Nicolas Dea
Summary: This prospective cohort study aimed to evaluate the associations between preoperative cervical sagittal alignment and health-related quality of life, function, and symptoms in patients with CSM. The study also examined whether surgery leads to changes in cervical sagittal alignment and if postoperative alignment is associated with health-related outcomes at 12 months of follow-up. The results showed that increased cSVA and T1 slope were associated with inferior health-related quality of life at presentation among CSM patients. However, no significant associations were observed between alignment parameters or change in alignment and any measures of health-related quality of life, function, or symptoms at 12 months after surgery. The study suggests that maintaining or improving cervical sagittal alignment may not have a significant impact on patient outcomes following surgical treatment for CSM.
Article
Orthopedics
Kevin C. Jacob, Madhav R. Patel, Alexander W. Parsons, Michael C. Prabhu, Max A. Ribot, Hanna Pawlowski, Nisheka N. Vanjani, Kern Singh
Summary: This study compares clinical outcomes in patients with myeloradiculopathy undergoing ACDF or CDR surgery. The results show that CDR patients have better perioperative outcomes, with shorter surgical times, less blood loss, and lower revision surgery rates. However, there is no significant difference in complication rates and patient-reported outcome measures (PROMs) between the two groups.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Article
Multidisciplinary Sciences
Anastasios Charalampidis, Nader Hejrati, Hari Ramakonar, Pratipal S. Kalsi, Eric M. Massicotte, Michael G. Fehlings
Summary: This study reports on the clinical outcomes and revision rates following four-level anterior cervical discectomy and fusion (ACDF). The results show that patients who undergo four-level ACDF experience significant improvement in clinical outcomes at a median 24 months follow up. Stand-alone four-level ACDF is also a valid option for managing complex cervical degenerative conditions.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Yasushi Oshima, Kosei Nagata, Hideki Nakamoto, Ryuji Sakamoto, Yujiro Takeshita, Nozomu Ohtomo, Naohiro Kawamura, Masaaki Iizuka, Takashi Ono, Koji Nakajima, Akiro Higashikawa, Takahiko Yoshimoto, Tomoko Fujii, Sakae Tanaka, Hiroyuki Oka, Ko Matsudaira
Summary: The Japanese version of the COMI-Neck is valid and reliable for Japanese-speaking patients with cervical spinal disorders. The COMI summary score showed no floor or ceiling effects preoperatively or postoperatively. Each of the COMI domains and the COMI summary score correlated well with the scores of the reference questionnaires.
EUROPEAN SPINE JOURNAL
(2021)
Article
Clinical Neurology
Blake A. Boehm, Innocent Njoku, Christopher G. Furey
Summary: This retrospective study analyzed surgical outcomes in 48 patients with degenerative cervical myelopathy (DCM) and found that cervical decompression surgery significantly improved neurological function. These results suggest that cervical decompression surgery is effective and has the potential to improve the neurological status in patients with severe forms of DCM.
Review
Medicine, General & Internal
Xiaoyu Yang, Aref-Ali Gharooni, Rana S. Dhillon, Edward Goacher, Edward W. Dyson, Oliver Mowforth, Alexandru Budu, Guy Wynne-Jones, Jibin Francis, Rikin Trivedi, Marcel Ivanov, Sashin Ahuja, Kia Rezajooi, Andreas K. Demetriades, David Choi, Antony H. Bateman, Nasir Quraishi, Vishal Kumar, Manjul Tripathi, Sandeep Mohindra, Erlick A. Pereira, Giles Critchley, Michael G. Fehlings, Peter J. A. Hutchinson, Benjamin M. Davies, Mark R. N. Kotter
Summary: The study assessed the reporting of study design and characteristics in multi-level DCM treated by posterior surgical approaches, finding heterogeneity in clinical and radiographic outcomes between different surgical methods. Majority of the studies were conducted in Asia, with a majority being retrospective studies, indicating a need for more high-level evidence studies in the future to elucidate the clinical effectiveness of posterior surgical treatments.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Jinkai Liu, Xiaotian Yang, Wanli Jing, Xing Guo, Rui Wang, Jiaming Zhou, Yuan Xue
Summary: This study evaluated the efficacy of duloxetine in the treatment of patients with axial symptoms following posterior cervical spine surgery. The results showed that patients treated with duloxetine had better outcomes in terms of pain scores, quality of life, and functional improvement compared to those receiving non-drug therapy. Therefore, oral duloxetine can be considered as a superior option for managing axial symptoms after cervical spine surgery.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Clinical Neurology
Harsh Wadhwa, Jigyasa Sharma, Kunal Varshneya, Parastou Fatemi, Jay Nathan, Zachary A. Medress, Martin N. Stienen, John K. Ratliff, Anand Veeravagu
Summary: This retrospective study reviewed readmission and reoperation rates for patients who had undergone ACDF or laminoplasty for multilevel CSM from a national administrative claims database. Results showed higher postoperative complication rates, longer length of stay, and higher readmission rates in the laminoplasty group, as well as higher hospital and total payments.
WORLD NEUROSURGERY
(2021)
Review
Medicine, General & Internal
Andrew S. Zhang, Christopher Myers, Christopher L. McDonald, Daniel Alsoof, George Anderson, Alan H. Daniels
Summary: Cervical myelopathy is a clinical syndrome caused by compression of the spinal cord between the C1 and T1 vertebrae. Diagnosis can be challenging due to its resemblance to other degenerative and neurological conditions. Confirmatory diagnosis requires careful correlation of appropriate imaging studies with patient history and physical examination. Treatment options focus on spinal canal decompression through anterior, posterior, or combined surgical approaches depending on the location of compression and patient factors. Favorable outcomes are observed when treatment is performed prior to the onset of severe symptoms.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Zeng Xu, Jie Zhou, Jianxi Wang, Hui Wang, Xiaodong Wu, Huajiang Chen
Summary: This study developed a novel wearable robot-based sensor system to evaluate dynamic cervical spine motion dysfunction in patients with cervical spondylotic myelopathy. Results showed significant differences in cervical motion process between CSM patients and healthy subjects, suggesting that ADCM system could be an effective objective and quantitative assessment tool.