Review
Cardiac & Cardiovascular Systems
Imma Forzano, Roberta Avvisato, Fahimeh Varzideh, Stanislovas S. S. Jankauskas, Angelo Cioppa, Pasquale Mone, Luigi Salemme, Urna Kansakar, Tullio Tesorio, Valentina Trimarco, Gaetano Santulli
Summary: L-arginine (L-Arg) is a semi-essential amino acid that plays a role in the formation of nitric oxide. Studies suggest that L-Arg has beneficial effects in diabetes and can attenuate glucose intolerance in diabetic patients. This article provides a comprehensive overview of the main studies investigating the effects of L-Arg in diabetes, including both preclinical and clinical reports.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sagar Salave, Dhwani Rana, Hemant Kumar, Nagavendra Kommineni, Derajram Benival
Summary: The present study aimed to develop PTH (1-34)-loaded stealth nanoliposomes (PTH-LPs) using the Quality by Design (QbD) approach and evaluate their biocompatibility and osteogenic potential on osteoblast-like cells. The results demonstrated that lipid concentration had a positive impact on particle size and %EE, while cholesterol concentration reduced %EE.
Review
Biochemistry & Molecular Biology
Agnieszka Zawada, Alicja Ewa Ratajczak, Anna Maria Rychter, Aleksandra Szymczak-Tomczak, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Diabetes mellitus affects bone mineral density and fracture risk, but the impact of other medications remains unknown. Pharmacotherapy for diabetes should focus on preventing bone mineral disorders and improving treatment and quality of life for patients. Additionally, diabetes patients need to pay attention to osteoporosis prevention.
Article
Biochemistry & Molecular Biology
Juan Yang, Yuan Zou, Jian Guo, Xiaoquan Yang, Bei Jin
Summary: Research shows that consuming soybean foods can reduce bone fractures in postmenopausal women. This study investigated the effects of soy beta-conglycinin (7S) and isoflavones (7S-ISO) on osteoporosis in ovariectomized rats. The results showed that the 7S-ISO group had higher bone mineral density and bone biomechanics compared to other groups. The levels of certain serum markers were also significantly different in the 7S-ISO group.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
He Xia, Jing Guo, Jian Shen, Shiman Jiang, Shengyi Han, Lanjuan Li
Summary: The ketogenic diet exacerbates acute pancreatitis, while butyrate supplementation reverses this effect.
Article
Gastroenterology & Hepatology
Orly Ben-Yacov, Anastasia Godneva, Michal Rein, Smadar Shilo, Maya Lotan-Pompan, Adina Weinberger, Eran Segal
Summary: This study aims to explore the interaction between dietary modifications, microbiome composition, and host metabolic responses in a personalized postprandial-targeting (PPT) diet versus a Mediterranean (MED) diet in pre-diabetes. The results show that the PPT diet has a more significant impact on gut microbiome composition compared to the MED diet. Additionally, specific dietary changes are associated with changes in microbiome composition, and causal mediation analysis identifies nine microbial species that partially mediate the association between dietary changes and clinical outcomes.
Review
Public, Environmental & Occupational Health
Xiaoxia Gao, Qingxiang Zheng, Xiumin Jiang, Xiaoqian Chen, Yanping Liao, Yuqing Pan
Summary: The study aimed to examine the effect of diet quality on the risk of gestational diabetes mellitus. The findings showed that higher diet quality before and during pregnancy reduced the risk of gestational diabetes mellitus, while poorer diet quality increased this risk.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Thanh D. Hoang, Gregory S. Schmidt, Tuan D. Nguyen, Francois O. Tuamokumo, Mohamed K. M. Shakir
Summary: In patients with primary hyperparathyroidism, BMI is strongly correlated with bone mineral density and the probability of osteoporosis. Other parameters such as alkaline phosphatase, ionized calcium, and vitamin D are also significantly correlated with bone density.
ENDOCRINE PRACTICE
(2021)
Article
Nutrition & Dietetics
Fuyuko Takahashi, Yoshitaka Hashimoto, Yukiko Kobayashi, Ayumi Kaji, Ryosuke Sakai, Takuro Okamura, Naoko Nakanishi, Saori Majima, Hiroshi Okada, Takafumi Senmaru, Emi Ushigome, Mai Asano, Masahide Hamaguchi, Masahiro Yamazaki, Wataru Aoi, Masashi Kuwahata, Michiaki Fukui
Summary: This study showed that household income was related to dietary fiber intake and dietary acid load in men but not in women.
Article
Nutrition & Dietetics
Jia-Yi Dong, Takashi Kimura, Satoyo Ikehara, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Hiroyasu Iso
Summary: This study found that higher intakes of miso soup and natto before and during early pregnancy were associated with a lower incidence of gestational diabetes mellitus. However, the association for tofu intake appeared to be nonlinear.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Environmental Sciences
Yishuang Duan, Hongwen Sun, Yiming Yao, Liping Han, Liming Chen
Summary: This study identified differential metabolic biomarkers related to T2DM, particularly in galactose metabolism, amino acid metabolism, and pyrimidine metabolism. The positive associations between most urinary mPAEs and T2DM suggest that PAE exposure may contribute to T2DM risk through disturbing various metabolic pathways. No clear evidence was found for the roles of metabolism in the associations between bisphenol exposure and T2DM.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Orthopedics
Lulu Cheng, Siyu Wang, Hailan Tang
Summary: This study utilized a two-sample Mendelian randomization approach to evaluate the causal impact of DM2 on OP, and found that DM2 has a protective effect on OP.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Endocrinology & Metabolism
Camila Romero-Diaz, Daniela Duarte-Montero, Sebastian A. Gutierrez-Romero, Carlos O. Mendivil
Summary: Diabetes has a significant impact on bone health, with both T1D and T2D associated with a higher risk of fractures through different mechanisms. Chronic hyperglycemia induces non-enzymatic glycation of collagen, increasing the risk of fractures. Timely monitoring of fracture risk and appropriate treatment can greatly reduce the risk of fractures in diabetic patients.
Review
Nutrition & Dietetics
Lin Bai, Yue Zhou, Jie Zhang, Junpeng Ma
Summary: Type 2 diabetes mellitus (T2DM) is associated with dementia, and nutritional and metabolic treatments, such as the ketogenic diet (KD), may provide therapeutic benefits. The KD induces ketosis and can protect neurons in the aging brain, improve neuronal function, and restore neuronal metabolism. This review explores the potential role of the KD in preventing dementia in T2DM patients and highlights its neuroprotective effects, suggesting it as a future therapeutic strategy for T2DM-induced dementia.
Article
Medicine, General & Internal
Ermioni Tsarna, Anna Eleftheriades, Efthymia Tsomi, Georgia Ziogou, Panagiotis Vakas, Theodoros Panoskaltsis, Panagiotis Christopoulos
Summary: This study found that there was no association between certain food categories and gestational diabetes mellitus (GDM) diagnosis. However, intake of cereals and fruits and vegetables appeared to have a protective effect against GDM, while frequent tea consumption was linked to a higher risk. These results highlight the importance of changing dietary habits during pregnancy to adjust one's risk of metabolic pregnancy complications, such as GDM.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)