Article
Biochemistry & Molecular Biology
Arthur B. Ribeiro, Saulo D. Ozelin, Lucas H. D. da Silva, Francisco Rinaldi-Neto, Karoline S. Freitas, Heloiza D. Nicolella, Larissa D. R. de Souza, Ricardo A. Furtado, Wilson Roberto Cunha, Denise C. Tavares
Summary: Asiatic acid (AA) demonstrated antiproliferative activity in tumor cells, inducing DNA damage leading to cell cycle arrest and apoptosis, and also exhibited antioxidant effects.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Plant Sciences
Ioanna Efthimiou, Dimitris Vlastos, Vassilios Triantafyllidis, Antonios Eleftherianos, Maria Antonopoulou
Summary: This study investigated the genotoxic and cytotoxic activity of Betula pendula leaf extract and found that it exhibited antigenotoxic potential. The mixture of the extract with mitomycin-C showed significant antigenotoxic activity at low concentrations.
Article
Biochemistry & Molecular Biology
Jorge Luis Fuentes, Carlos Adolfo Pedraza Barrera, Diego Armando Villamizar Mantilla, Silvia Juliana Florez Gonzalez, Lady Johanna Sierra, Raquel Elvira Ocazionez, Elena E. Stashenko
Summary: This study investigated the sunscreen properties of extracts from ornamental plants in Colombia. The results showed that extract from P. latifolia had broad-spectrum photoprotection and was safer for human cells.
Article
Multidisciplinary Sciences
Neelam Iqbal, Antonios Anastasiou, Zabeada Aslam, El Mostafa Raif, Thuy Do, Peter Giannoudis, Animesh Jha
Summary: Bone healing is a complex process that requires careful management to prevent negative outcomes. In the face of decreasing antibiotic effectiveness, alternative treatments like nanoparticles are receiving increased attention. Cerium oxide nanoparticles with a higher Ce3+ ion content showed enhanced antibacterial efficacy in the study.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Amina Iftekhar, Hilmar Berger, Nassim Bouznad, Julian Heuberger, Francesco Boccellato, Ulrich Dobrindt, Heiko Hermeking, Michael Sigal, Thomas F. Meyer
Summary: Genotoxic colibactin-producing pks+ Escherichia coli infection induces characteristics of colorectal cancer cells in organoids, including enhanced proliferation, Wnt independence, and impaired differentiation. Mutations in genes related to the p53 pathway contribute to Wnt-independence in these organoids, suggesting a functional interplay between p53 and Wnt pathways in promoting transformation. The basis of transformation in these organoids is proposed to be larger chromosomal alterations and aneuploidy, consistent with the early appearance of chromosomal instability in colorectal cancer.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yulin Sun, Hongjuan Wang, Huan Chen, Sen Zhang, Jun Li, Jingni Zhang, Jianlu Tian, Youyu Zhang, Hongwei Hou, Qingyuan Hu
Summary: This study investigated the effects of nicotine on the cytotoxicity and genotoxicity of NNK using BEAS-2B cells expressing CYP2A13. The results showed that CYP2A13 caused cytotoxicity and genotoxicity of NNK in BEAS-2B cells, and the addition of nicotine could inhibit the toxicity of NNK.
Article
Environmental Sciences
Tuukka Ihantola, Maija-Riitta Hirvonen, Mika Ihalainen, Henri Hakkarainen, Olli Sippula, Jarkko Tissari, Stefanie Bauer, Sebastiano Di Bucchianico, Narges Rastak, Anni Hartikainen, Jani Leskinen, Pasi Yli-Pirila, Maria-Viola Martikainen, Mirella Miettinen, Heikki Suhonen, Teemu J. Ronkko, Miika Kortelainen, Heikki Lamberg, Hendryk Czech, Patrick Martens, Juergen Orasche, Bernhard Michalke, Ali Oender Yildirim, Jorma Jokiniemi, Ralf Zimmermann, Pasi Jalava
Summary: The study compared the toxicological responses of spruce and brown coal combustion aerosols on human alveolar epithelial cells, showing both aerosols causing cytotoxic and genotoxic effects on the cells.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Aminah G. Alotaibi, Jia Li, Nigel J. Gooderham
Summary: The study revealed that the inflammation mediator TNF-alpha can enhance DNA damage induced by BaP and PhIP in colon cancer epithelial cells, without affecting the gene expression levels of the AhR signaling pathways. Additionally, functional p53 suppresses TNF-alpha-induced DNA damage, while the JNK signaling pathway plays a crucial role in this process.
Article
Biochemistry & Molecular Biology
Michaela Blazickova, Jaroslav Blasko, Robert Kubinec, Katarina Kozics
Summary: Thymol derivatives have cytotoxic and genotoxic effects on colorectal cancer cells, with acetic acid thymol ester showing stronger effects than thymol beta-D-glucoside. Thymol and its derivatives have potential in the prevention and treatment of colorectal cancer, but further research is needed.
Article
Engineering, Environmental
Qian-Yuan Wu, Lu-Lin Yang, Ye Du, Zi-Fan Liang, Wen-Long Wang, Zhi-Min Song, De-Xiu Wu
Summary: This study found that ozonation of wastewater generates various toxic byproducts, with formaldehyde contributing the most to cytotoxicity and genotoxicity in the absence of bromide. However, ozonation generally increases the overall toxicity of wastewater, especially when bromide is present.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Taygun Timocin, Mehmet Arslan, Hasan Basri Ila
Summary: Rhus coriaria's methanol extract (RCE) demonstrated cytotoxic effects in short-term treatments in vitro, but did not show genotoxic or cytotoxic effects in vivo.
DRUG AND CHEMICAL TOXICOLOGY
(2021)
Article
Materials Science, Biomaterials
Xin Li, Khan Zara Ahmad, Jie He, Hongxia Li, Xin Wang, Zijian Feng, Xiansong Wang, Guangxia Shen, Xianting Ding
Summary: A silver nanomaterial called Ag Nano Flowers (AgNFs) was developed as an effective drug carrier and adjuvant to restore drug susceptibility in multidrug-resistant bacteria. The combination therapy of AgNFs with antibiotics significantly reduced the doses of both compounds and eradicated drug-resistant bacteria by enhancing bacterial respiration and up-regulating the tricarboxylic acid cycle.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Public, Environmental & Occupational Health
Karoly Nagy, Roba Argaw Tessema, Istvan Szasz, Tamara Smeirat, Alaa Al Rajo, Balazs Adam
Summary: The study compared the cytogenetic effect of the active ingredient glyphosate and three marketed GBHs on isolated human white blood cells, indicating that the co-formulants in herbicide formulations may interact with the active ingredient, increasing toxicity.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Aida Kalantari, Michael J. James, Lauren A. Renaud, Mylene Perreault, Catherine E. Monahan, Mary N. McDonald, David L. Hava, Vincent M. Isabella
Summary: E. coli Nissle (EcN) is a non-pathogenic probiotic bacterium that has been used for gut health. Concerns have been raised about the presence of the pks gene cluster, which is associated with colorectal cancer. However, the deletion of the pks island does not affect the robustness and activity of EcN.
Article
Pharmacology & Pharmacy
Victor M. Rodrigues, Wogenes N. Oliveira, Daniel T. Pereira, Everton N. Alencar, Dayanne L. Porto, Cicero F. S. Aragao, Susana M. G. Moreira, Hugo A. O. Rocha, Lucas Amaral-Machado, Eryvaldo S. T. Egito
Summary: The aim of this study was to produce and characterize copaiba oil nanocapsules (CopNc) and to evaluate their hemocompatibility, cytotoxicity, and genotoxicity. The results showed that CopNc exhibited suitable stability and physicochemical properties, along with a remarkable safety profile on lung cells. These findings provide a foundation for further utilizing CopNc for the development of phytotherapeutic medicine intended for pulmonary delivery of copaiba oil.
Article
Biotechnology & Applied Microbiology
Stefana Cvetkovic, Branislav Nastasijevic, Dragana Mitic-Culafic, Stefana Dukanovic, Dina Tenji, Jelena Knezevic-Vukcevic, Biljana Nikolic
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2020)
Article
Biotechnology & Applied Microbiology
Anita Klaus, Wan Abd Al Qadr Imad Wan-Mohtar, Biljana Nikolic, Stefana Cvetkovic, Jovana Vunduk
Summary: Four types of mycelial extracts from Pleurotus flabellatus were studied for their antioxidant, anticandidal, and cytotoxic activities. Endopolysaccharide (EN) and hot alkali (AE) extracts showed the most promising results, particularly in terms of selective anticancer activity against colorectal carcinoma cells.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2021)
Correction
Biotechnology & Applied Microbiology
Anita Klaus, Wan Abd Al Qadr Imad Wan-Mohtar, Biljana Nikolic, Stefana Cvetkovic, Jovana Vunduk
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Marina Jovanovic, Dina Tenji, Biljana Nikolic, Tatjana Srdic-Rajic, Emilija Svircev, Dragana Mitic-Culafic
Summary: Extracts from Polygonum aviculare and Persicaria amphibia, rich in dietary polyphenolics, showed synergistic cytotoxicity when combined with doxorubicin against hepatocarcinoma cells by interfering with apoptosis, cell cycle, and expression of Keap1-Nrf2 genes involved in cytoprotection, indicating a potential pathway for chemotherapy improvement.
Article
Biochemistry & Molecular Biology
Sinisa Durasevic, Snezana Pejic, Ilijana Grigorov, Gorana Nikolic, Dragana Mitic-Culafic, Milan Dragicevic, Jelena Dordevic, Nevena Todorovic Vukotic, Neda Dordevic, Ana Todorovic, Dunja Drakulic, Filip Veljkovic, Snezana B. Pajovic, Zoran Todorovic
Summary: For TAA-induced liver toxicity, the hepatoprotective effects are more significant with a lower dose of C60.
Article
Food Science & Technology
Marina Jovanovic, Snezana Zlatanovic, Darko Micic, Dragan Bacic, Dragana Mitic-Culafic, Mihal Duris, Stanislava Gorjanovic
Summary: A yogurt premix based on beetroot pomace flour (BPF) was developed, showing improved particle size, flowability, storability, and health benefits including inhibition of colon cancer cell viability and anti-Escherichia activity. The yogurt products had acceptable palatability in both humans and dogs, demonstrating positive consumer attitudes towards using granulated BPF as a premix for yogurts. This study represents a novel approach in utilizing LAB granulated with BPF for a fermented beverage, marking a step towards a fresh yogurt formula fortified with natural dietary fiber and antioxidants.
Article
Biotechnology & Applied Microbiology
Stefana Dukanovi, Tea Ganic, Branka Loncarevic, Stefana Cvetkovic, Biljana Nikolic, Dina Tenji, Danijela Randjelovic, Dragana Mitic-Culafic
Summary: This study demonstrated the novel antibiofilm activity of emodin against Staphylococcus aureus, with strong antibacterial effects and inhibition of biofilm formation. Emodin was also found to affect biofilm structure, respiration, and gene expression, indicating multiple pathways of action against the pathogen.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Stefana Cvetkovic, Stefana Vuletic, Jovana Vunduk, Anita Klaus, Dragana Mitic-Culafic, Biljana Nikolic
Summary: The study investigated the UV-protective and antioxidative properties of yellow gentian extracts and found that they have a strong protective effect against UVC and UVA radiation. These findings suggest the potential use of yellow gentian extracts in developing health products. However, further research is recommended to explore the underlying molecular mechanisms.
Review
Infectious Diseases
Ina Gajic, Jovana Kabic, Dusan Kekic, Milos Jovicevic, Marina Milenkovic, Dragana Mitic Culafic, Anika Trudic, Lazar Ranin, Natasa Opavski
Summary: Antimicrobial resistance poses a significant threat to global public health. Accurate and rapid detection of antibiotic resistance and appropriate treatment methods are crucial for controlling its emergence. However, traditional testing methods are time-consuming and costly, highlighting the need for innovative approaches.
Article
Biochemistry & Molecular Biology
Tamara Carevic, Marina Kostic, Biljana Nikolic, Dejan Stojkovic, Marina Sokovic, Marija Ivanov
Summary: Hesperetin exhibits significant inhibitory effects on the growth and biofilm formation of Candida species, and shows promising results in inhibiting polymicrobial biofilm formation. However, it has cytotoxic effects at antibacterial concentrations and has lower inhibitory potential towards Staphylococcus aureus. Further research is needed for the antibacterial application of hesperetin.
Article
Horticulture
Sladana Todorovic, Marija Peric, Biljana Nikolic, Boris Mandic, Stefana Cvetkovic, Milica Bogdanovic, Suzana Zivkovic
Summary: The aim of this study was to compare the chemical composition and biological activity of wild- and in vitro grown Rindera umbellata. HPLC-DAD and GC-MS/FID were used for analysis, and antioxidant activity and cytotoxicity were monitored. The results showed higher levels of total flavonoids and rosmarinic acid in in vitro samples, while wild-growing samples had higher levels of lithospermic B acid. The MTT test showed that colorectal HT-29 cells were more sensitive to wild-growing and 0.3 M sucrose samples.
Article
Biotechnology & Applied Microbiology
Marina Jovanovic, Petar Vojvodic, Dina Tenji, Nina Tomic, Jovana Nesic, Dragana Mitic-Culafic, Jelena Miocinovic
Summary: The aim of this research was to develop acid-coagulated fresh soft quark-type cheese fermented with the potential psychobiotic strain L. reuteri DSM 17938, to enhance its bioactivity, sensory acceptability, and overall likeability. The cheese samples enriched with mushroom powders showed high abundance of lactic acid bacteria and exhibited cytotoxicity to colon cancer cell line HCT116, as well as favorable growth for probiotic Escherichia coli Nissle 1917. Sensory evaluation revealed high scores for all samples.
FERMENTATION-BASEL
(2023)
Article
Plant Sciences
Milica Maxsimovic, Marina Jovanovic, Biljana Nixolic, Nina Tomic, Dina Tenji, Tatjana Stevic, Dragana Mitic Culafic
Summary: The cytotoxicity and antimicrobial properties of Persicaria amphibia, an aquatic macrophyte, were studied. Results showed that it can reduce the viability of lung cancer cells and exhibit antimicrobial effects, suggesting its potential use in health and pharmaceutical research.
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)