期刊
NEUROSCIENCE LETTERS
卷 625, 期 -, 页码 64-69出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2016.04.046
关键词
Diabetes; Epigenetics; HDACs; DNA methylation
资金
- Lebanese American University, School of Arts and Sciences seed grant
- National Council for Scientific Research (CNRS) [699]
The incidence of diabetes is increasing worldwide. Diabetes is quickly becoming one of the leading causes of death. Diabetes is a genetic disease; however, the environment plays critical roles in its development and progression. Epigenetic changes often translate environmental stimuli to changes in gene expression. Changes in epigenetic marks and differential regulation of epigenetic modulators have been observed in different models of diabetes and its associated complications. In this minireview, we will focus DNA methylation, Histone acetylation and methylation and their roles in the pathogenesis of diabetes. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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