Article
Engineering, Environmental
Young Hwan Lee, Min -Sub Kim, Yoseop Lee, Duck-Hyun Kim, Jae-Seong Lee
Summary: Ocean acidification (OA) and nanoplastics (NPs) have a synergistic negative effect on copepod reproduction across generations, potentially posing a significant threat to the sustainability of copepod populations. The intergenerational reproductive impairments observed are associated with differential methylation patterns of specific genes, indicating the role of epigenetic modifications. These findings contribute valuable insight into the intergenerational toxicity and underlying molecular mechanisms of responses to NPs under OA conditions.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Ranran Zhou, Guanghua Lu, Zhenhua Yan, Runren Jiang, Yu Sun, Peng Zhang
Summary: This study investigated the epigenetic mechanism of DNA methylation in transgenerational effects induced by ethylhexyl salicylate (EHS) in zebrafish. The results showed that EHS could lead to changes in DNA methylation patterns in both maternal and paternal parents, and these changes were found to be inheritable in the offspring. The offspring displayed similar DNA methylation patterns to the paternal parents and showed increased locomotor activity. Furthermore, parental exposure to EHS was found to interfere with various biological systems in the offspring.
Article
Biochemistry & Molecular Biology
Jose Maria Costa-Junior, Sandra Mara Ferreira, Mirian Ayumi Kurauti, Diana L. Bernstein, Elena G. Ruano, Vasumathi Kameswaran, Jonathan Schug, Ricardo Freitas-Dias, Claudio C. Zoppi, Antonio C. Boschero, Camila A. M. de Oliveira, Gustavo J. Santos, Everardo M. Carneiro, Klaus H. Kaestner
Summary: Paternal exercise has a positive impact on the metabolic health of offspring, which can be achieved through transgenerational inheritance. The study showed that paternal exercise improves glucose tolerance and insulin sensitivity in the offspring, and this effect may be achieved by influencing the epigenetic mechanisms of transgenerational inheritance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Fabien Pierron, Guillemine Daffe, Flore Daramy, Debora Heroin, Aurelien Barre, Olivier Bouchez, Christelle Clerendeau, Alicia Romero-Ramirez, Macha Nikolski
Summary: Recent research has shown that environmentally-induced epigenetic changes can affect gene transcription across multiple generations, emphasizing the need to investigate the transgenerational impacts of pollutants for long-term population effects. A study on zebrafish over four generations examined the transgenerational effect of cadmium and found sex-dependent inheritance of DNA methylation changes linked to the estradiol receptor alpha gene. These changes were associated with single nucleotide polymorphisms and contributed to the rapid transgenerational adaptation of fish to cadmium.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Melanie Blanc, Philipp Antczak, Xavier Cousin, Christoph Grunau, Nikolai Scherbak, Joelle Ruegg, Steffen H. Keiter
Summary: The study revealed transgenerational neurotoxic effects of permethrin in zebrafish, with possible underlying mechanisms related to stable dysregulation of glutamatergic signaling.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Kaichi Yoshizaki, Ryuichi Kimura, Hisato Kobayashi, Shinya Oki, Takako Kikkawa, Lingling Mai, Kohei Koike, Kentaro Mochizuki, Hitoshi Inada, Yasuhisa Matsui, Tomohiro Kono, Noriko Osumi
Summary: Studies have shown that advanced paternal age may lead to hypo-methylation of sperm DNA, which in turn affects neurodevelopmental programs in offspring.
Review
Genetics & Heredity
Jana Svorcova
Summary: In recent years, increasing evidence suggests the non-genetic heredity of the effects of separation from parents, life-threatening events, and other traumatising experiences. This heredity is mediated by epigenetic regulations and can be transmitted over generations. The reviewed studies on transgenerational epigenetic inheritance (TEI) and intergenerational studies on trauma or stressful experiences reveal universal changes initiated by stress exposure at various levels of organization. Understanding these processes can help elucidate the evolutionary pathways of diseases and disorders associated with trauma exposure.
Review
Cell Biology
Nicholas O. Burton, Eric L. Greer
Summary: Inherited epigenetic information regulates complex organismal phenotypes and plays an important role in inheritance. The molecular mediators of non-genetic transmission of information are just starting to be understood. This study provides an intellectual framework for interpreting and understanding these findings, and defines the different mechanisms that mediate epigenetic inheritance.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rania Ahmed, Kenneth Blum, Panayotis K. Thanos
Summary: The world is currently facing a severe epidemic of psychoactive drug abuse, resulting in significant loss of life. Recent research has shown that long-term use of these drugs can cause heritable changes in gene expression, which may be passed down to future generations. Epigenetic biomarkers such as DNA methylation and histone modifications contribute to disease diagnoses.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Environmental Sciences
Millissia Ben Maamar, Eric Nilsson, Jennifer L. M. Thorson, Daniel Beck, Michael K. Skinner
Summary: Exposure to dioxin can promote the epigenetic transgenerational inheritance of disease susceptibility, and this study used EWAS to identify sperm DNA methylation biomarkers for specific transgenerational diseases, demonstrating the potential to develop similar biomarkers for humans to diagnose disease susceptibilities and facilitate preventative medicine.
ENVIRONMENTAL RESEARCH
(2021)
Article
Marine & Freshwater Biology
Noemi Colinas, Javier Montero-Pau, Maria Jose Carmona, Raffaella Sabatino, Andrea Di Cesare, Ester Maria Eckert, Eduardo M. Garcia-Roger
Summary: A non-genetic transgenerational effect on sexual reproduction was observed in Brachionus plicatilis clones from more predictable environments, indicating a potential role of estradiol in this effect. However, the molecular basis of this effect is still unknown. The expression of the edh gene involved in estradiol synthesis increased across generations in clones from the more predictable ponds, but no differences were found in the meth gene.
Review
Biochemistry & Molecular Biology
Thanvi Srikant, Anjar Tri Wibowo
Summary: This article focuses on epiallelic variations in plants, particularly on methylated regions. It is still uncertain whether variations at individual methylated cytosines serve any regulatory function. Most epialleles in the form of methylated regions have not been assigned any biological function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Keren Xu, Shaobo Li, Ivo S. Muskens, Natalina Elliott, Swe Swe Myint, Priyatama Pandey, Helen M. Hansen, Libby M. Morimoto, Alice Y. Kang, Xiaomei Ma, Catherine Metayer, Beth A. Mueller, Irene Roberts, Kyle M. Walsh, Steve Horvath, Joseph L. Wiemels, Adam J. Smith
Summary: The study revealed that accelerated epigenetic aging in the blood of Down syndrome (DS) patients begins prenatally and is associated with somatic GATA1 mutations. DS newborns showed a significant increase in DNAmSkinBloodClock, but were not associated with epigenetic gestational age acceleration.
Article
Multidisciplinary Sciences
Paul Winchester, Eric Nilsson, Daniel Beck, Michael K. Skinner
Summary: This study identified epigenetic biomarkers associated with preterm birth and indicated potential contributions from paternal germline and female offspring epigenetic inheritance to preterm birth susceptibility.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Mohd Hafiz Rothi, Eric Lieberman Greer
Summary: Heredity is mostly determined by DNA sequences, but some traits are regulated by non-genetic information, known as transgenerational epigenetic inheritance. Studies have shown that changes in epigenetic modifications are correlated with transgenerational phenotypes. Future research in this field aims to establish causal relationships rather than just correlations.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)