Review
Behavioral Sciences
Arely Cruz-Sanchez, Jennifer Wilkin, Maithe Arruda-Carvalho
Summary: This review examines the expression of spontaneous recognition memory in young rodents through analyzing studies using four different tasks. Variability between studies is identified and classified, leading to exploration of the ontogeny and neural correlates of each task, with implications for cognitive assessment and potential intervention strategies.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Biochemistry & Molecular Biology
Xu-Dong Yu, Yan-Xin Mo, Zhiming He, James Reilly, Shao-Wen Tian, Xinhua Shu
Summary: The study investigated the effects of Urocanic acid (UCA) on memory consolidation and reconsolidation in a novel object recognition memory task. Results showed that immediate injection of UCA enhanced ORM memory performance, while injection 6 hours later did not have an effect.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Hinze Ho, Nejc Kejzar, Hiroki Sasaguri, Takashi Saito, Takaomi C. Saido, Bart De Strooper, Marius Bauza, Julija Krupic
Summary: Automated home-cage monitoring systems provide a valuable tool for comprehensive phenotyping of natural behaviors. This study presents a fully automated system for cognitive and behavioral phenotyping in mice, which includes various tests and long-term monitoring of locomotion, drinking, and quiescence patterns. The system achieves high accuracy in discriminating between mice with different lesions and predicting the genotype of an Alzheimer's disease mouse model.
CELL REPORTS METHODS
(2023)
Article
Behavioral Sciences
Fabian Vergara-Ovalle, Fructuoso Ayala-Guerrero, Carlos Rosas, Hugo Sanchez-Castillo
Summary: This study demonstrates that octopuses, like vertebrates, can differentiate between new and familiar objects through visual and tactile exploration. This new finding provides a guide for studying object recognition memory in octopuses and its developmental trajectory.
Review
Biochemistry & Molecular Biology
Hongji Wang, Changshui Xu
Summary: This article reviews the relationship and mechanisms between glial cells and inflammatory pain, and introduces the medicine composition that can effectively inhibit inflammatory pain. It provides new ideas for the study of pain mechanisms and treatment.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Jessica Aquino, Matheus A. Moreira, Nathalia C. L. Evangelista, Rafael S. Maior, Marilia Barros
Summary: By assessing the performance of capuchin monkeys on the SOR task, it was found that they are able to recognize objects after both short and long delays, while increasing the length of the familiarization phase does not significantly affect task performance. These results support the use of incidental learning paradigms to assess recognition memory in nonhuman primates.
Article
Behavioral Sciences
Andre W. C. Oliveira, Jessica V. N. Pacheco, Clara S. Costa, Jessica Aquino, Rafael S. Maior, Marilia Barros
Summary: The study found that the competitive muscarinic acetylcholine receptor antagonist scopolamine and the noncompetitive N-methylD-aspartate glutamate receptor antagonist MK-801 can both affect the performance of marmosets in the spontaneous object recognition task. The acetylcholinesterase inhibitor donepezil can reverse the memory deficit caused by the former.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Review
Immunology
Erliang Kong, Yongchang Li, Mengqiu Deng, Tong Hua, Mei Yang, Jian Li, Xudong Feng, Hongbin Yuan
Summary: Neuropathic pain is characterized by hyperalgesia and allodynia. Inflammation plays a role in the development of neuropathic pain, affecting synaptic transmission and regulated by glial cells. Glycometabolism reprogramming in inflammatory cells, specifically impaired oxidative phosphorylation and enhanced glycolysis, promotes neural inflammation in peripheral and central nervous system. Further research is needed to explore the role of glycometabolism in glial cells in neuropathic pain.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Mathematics, Applied
Sergey Makovkin, Tetyana Laptyeva, Sarika Jalan, Mikhail Ivanchenko
Summary: This study investigates the impact of mixed coupling on synchronization in a multiplex oscillatory network that mimics neural-glial systems. The results show that randomness in connections leads to dynamics similar to a completely random graph, with fine-tuning of synchronization and Kuramoto-type synchrony observed. Inhibitory interactions in the neural subnetwork layer weaken synchronization, but strong coupling with the glial layer mitigates this effect.
Article
Biochemistry & Molecular Biology
Sravani Pulya, Ashutosh Mahale, Yamini Bobde, Ganesh Routholla, Tarun Patel, Swati, Swati Biswas, Vivek Sharma, Onkar P. Kulkarni, Balaram Ghosh
Summary: The novel HDAC3 inhibitor PT3 has shown excellent blood-brain barrier permeability and selectivity, enhancing long-term memory in mice. PT3 treatment increased H3K9 acetylation and upregulated the expression of multiple genes associated with memory formation. These findings suggest PT3 as a potential therapeutic candidate for age-related memory loss and disorders like Alzheimer's disease.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Anuck Sawangjit, Maximilian Harkotte, Carlos N. Oyanedel, Niels Niethard, Jan Born, Marion Inostroza
Summary: Memory consolidation is promoted by both sleep and wakefulness, but their effects on hippocampal and nonhippocampal representations differ. Sleep consolidation involves event-context binding, while wake consolidation tends to strengthen context-independent representations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Neurosciences
Sujin Hyung, Ji-Hye Park, Kyuhwan Jung
Summary: Optogenetic techniques, combining optics and genetics, offer cell-specific targeting and precise control of excitable cells, providing valuable insights into the complex nervous system. The activation of neurons through optogenetics allows for the regulation of information processing and nerve structure development. Recent advancements in optogenetic glial manipulation have shown the potential for coordinating neuron-glia communication and supporting nerve fibers. Further research is needed to optimize the technique and explore its therapeutic applications.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Xiaoli Guo, Atsuko Kimura, Kazuhiko Namekata, Chikako Harada, Nobutaka Arai, Kohsuke Takeda, Hidenori Ichijo, Takayuki Harada
Summary: This study found that the lack of ASK1 in microglia/macrophages can reduce neuroinflammation in both early and later stages of experimental autoimmune encephalomyelitis (EAE), while the lack of ASK1 in astrocytes only improves neuroinflammation in the later stage. The deficiency of ASK1 in T cells and dendritic cells has no significant effect on the severity of EAE. These findings demonstrate the cell-type-specific roles of ASK1 and the phase-specific ASK1-dependent glial cell interactions in the pathophysiology of EAE.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Alexandria N. Hughes
Summary: Building a functional nervous system requires coordinated actions of many glial cells, including oligodendrocytes, microglia, and astrocytes. These non-neuronal, non-oligodendroglial cells play important roles in modifying myelination patterns in the CNS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Rena Kono, Yuji Ikegaya, Ryuta Koyama
Summary: Microglia and astrocytes are important phagocytic cells in the brain, responsible for maintaining brain homeostasis by engulfing various materials. While they have different phagocytic abilities, both cell types play crucial roles in clearance processes.
Article
Neurosciences
Dimitri De Bundel, Assia Fafouri, Zsolt Csaba, Ellen Loyens, Sophie Lebon, Vincent El Ghouzzi, Stephane Peineau, Guilan Vodjdani, Foteini Kiagiadaki, Najat Aourz, Jessica Coppens, Laura Walrave, Jeanelle Portelli, Patrick Vanderheyden, Siew Yeen Chai, Kyriaki Thermos, Veronique Bernard, Graham Collingridge, Stephane Auvin, Pierre Gressens, Ilse Smolders, Pascal Dournaud
JOURNAL OF NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Shanti Diwakarla, Erik Nylander, Alfhild Gronbladh, Sudarsana Reddy Vanga, Yasmin Shamsudin Khan, Hugo Gutierrez-de-Teran, Jonas Savmarker, Leelee Ng, Vi Pham, Thomas Lundback, Annika Jenmalm-Jensen, Richard Svensson, Per Artursson, Sofia Zelleroth, Karin Engen, Ulrika Rosenstrom, Mats Larhed, Johan Aqvist, Siew Yeen Chai, Mathias Hallberg
ACS CHEMICAL NEUROSCIENCE
(2016)
Article
Behavioral Sciences
Holly R. Yeatman, Anthony L. Albiston, Peta Burns, Siew Yeen Chai
NEUROBIOLOGY OF LEARNING AND MEMORY
(2016)
Article
Endocrinology & Metabolism
Anthony L. Albiston, Mauricio Cacador, Puspha Sinnayah, Peta Burns, Siew Yeen Chai
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Yijun Pan, Kwok H. C. Choy, Philip J. Marriott, Siew Y. Chai, Martin J. Scanlon, Christopher J. H. Porter, Jennifer L. Short, Joseph A. Nicolazzo
JOURNAL OF NEUROCHEMISTRY
(2018)
Review
Pharmacology & Pharmacy
Anthony L. Albiston, Shanti Diwakarla, Ruani N. Fernando, Simon J. Mountford, Holly R. Yeatman, Broden Morgan, Vi Pham, Jessica K. Holien, Michael W. Parker, Philip E. Thompson, Siew Yeen Chai
BRITISH JOURNAL OF PHARMACOLOGY
(2011)
Article
Peripheral Vascular Disease
Rui Yang, Ilse Smolders, Patrick Vanderheyden, Heidi Demaegdt, Ann Van Eeckhaut, Georges Vauquelin, Aneta Lukaszuk, Dirk Tourwe, Siew Yeen Chai, Anthony L. Albiston, Clara Nahmias, Thomas Walther, Alain G. Dupont
Article
Clinical Neurology
Ellen Loyens, Dimitri De Bundel, Heidi Demaegdt, Siew Yeen Chai, Patrick Vanderheyden, Yvette Michotte, Paul Gard, Ilse Smolders
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Chemistry, Medicinal
Simon J. Mountford, Anthony L. Albiston, William N. Charman, Leelee Ng, Jessica K. Holien, Michael W. Parker, Joseph A. Nicolazzo, Philip E. Thompson, Siew Yeen Chai
JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Article
Critical Care Medicine
Vi Pham, Anthony L. Albiston, Catherine E. Downes, Connie H. Y. Wong, Shanti Diwakarla, Leelee Ng, Seyoung Lee, Peter J. Crack, Siew Yeen Chai
JOURNAL OF NEUROTRAUMA
(2012)
Article
Peripheral Vascular Disease
Alexandros Nikolaou, Benoit Stijlemans, Damya Laoui, Elio Schouppe, Huyen T. T. Tran, Dirk Tourwe, Siew Y. Chai, Patrick M. L. Vanderheyden, Jo A. Van Ginderachter
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
(2014)
Article
Biochemistry & Molecular Biology
Stefan J. Hermans, David B. Ascher, Nancy C. Hancock, Jessica K. Holien, Belinda J. Michell, Siew Yeen Chai, Craig J. Morton, Michael W. Parker
Article
Pharmacology & Pharmacy
Shanti Diwakarla, Erik Nylander, Alfhild Gronbladh, Sudarsana Reddy Vanga, Yasmin Shamsudin Khan, Hugo Gutierrez-de-Teran, Leelee Ng, Vi Pham, Jonas Savmarker, Thomas Lundback, Annika Jenmalm-Jensen, Hanna Andersson, Karin Engen, Ulrika Rosenstrom, Mats Larhed, Johan Aqvist, Siew Yeen Chai, Mathias Hallberg
MOLECULAR PHARMACOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Sudarsana Reddy Vanga, Jonas Savmarker, Leelee Ng, Mats Larhed, Mathias Hallberg, Johan Aqvist, Anders Hallberg, Siew Yeen Chai, Hugo Gutierrez-de-Teran
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)