Review
Biochemistry & Molecular Biology
Joanna Sikora, Abdel-Mouttalib Ouagazzal
Summary: Alterations in zinc homeostasis have long been implicated in Parkinson's disease, with both deficiency and excess of intracellular zinc levels playing a role in the pathophysiology. Zn2+ acts as a synaptic transmitter in the brain, particularly in glutamatergic neurons projecting to the striatum. Overactivation of the cortico-striatal glutamatergic system is a key feature contributing to the development of PD symptoms and dopaminergic neurotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Maxwell B. Wang, Matthew J. Boring, Michael J. Ward, R. Mark Richardson, Avniel Singh Ghuman
Summary: The mechanism of deep brain stimulation (DBS) for Parkinson's disease remains unclear, but studies have shown that DBS can increase high beta and gamma band synchrony in cortical circuitry, potentially relating to clinical benefits. Compared to healthy controls, DBS introduces greater synchrony in cortical circuitry, while its effect on subcortical normalization is minimal.
Review
Immunology
Md Reyaz Alam, Shamsher Singh
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons, resulting in motor and non-motor symptoms. Recent research suggests that targeting opioid and cannabinoid receptors as well as the NLRP3 pathway may provide novel therapeutic approaches for Parkinson's disease management.
INFLAMMOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yan Wang, Miao Wang, Chrishan S. Samuel, Robert E. Widdop
Summary: Cardiac fibrosis, characterized by increased ECM deposition, is a hallmark of most cardiovascular diseases and inhibition of fibrosis could improve outcomes in heart failure patients. However, pharmacological treatment targeting ECM buildup remains limited. Animal models are important for understanding fibrosis pathogenesis and identifying new therapeutic targets.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Diana M. Hendrickx, Pierre Garcia, Amer Ashrafi, Alessia Sciortino, Kristopher J. Schmit, Heike Kollmus, Nathalie Nicot, Tony Kaoma, Laurent Vallar, Manuel Buttini, Enrico Glaab
Summary: Our study compared Ventral midbrain transcriptomics profiles from alpha-synuclein transgenic mice with a progressive, early PD-like striatal neurodegeneration across different ages using pathway, gene set, and network analysis methods.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Cell Biology
Laura J. Gledhill, Anna-Marie Babey
Summary: Studies have shown a link between opioid receptor desensitization and nitric oxide levels, with implications for kinase recruitment and peroxynitrite-mediated protein regulation. New experimental advances have identified additional potential signaling candidates such as zinc, HINT1, mi-RNA, and RGSZ, previously not associated with the process.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Che-Wei Chang, Mark D. Evans, Xinxing Yu, Gui-Qiu Yu, Lennart Mucke
Summary: The protein tau plays a crucial role in brain disorders, and reducing its levels can prevent network hypersynchrony and counteract brain disorders with abnormally increased excitation-inhibition ratios.
Editorial Material
Neurosciences
Pedro Espinosa, Camilla Bellone
Summary: This study uncovers the functional relevance of excitatory glycine receptors in the neocortex and amygdala, providing exciting new insights into their role in brain function.
Review
Food Science & Technology
Tarana Arman, John D. Clarke
Summary: Microcystins are toxins produced by cyanobacteria that can enter the human body through various means and have multiple toxic effects, primarily targeting the intestine, liver, and kidney. Exposure to other hepatotoxic insults may potentiate microcystin toxicity and increase the risk of chronic diseases. More research is needed to understand human toxicokinetics and the role of multifactorial exposures in disease pathogenesis and progression.
Review
Health Care Sciences & Services
Thomas F. Tropea, Alice Chen-Plotkin
Summary: There is a significant overlap between Alzheimer's Disease (AD) and Parkinson's Disease (PD) in terms of neuropathology, biomarkers, and mechanisms. AD biomarkers are associated with cognitive decline and dementia in PD patients. Precision medicine approaches may successfully identify PD patients most likely to develop concomitant AD, providing an ideal cohort for trials of AD-directed therapies in PD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Frederikke E. Sembach, Mette Ostergaard, Niels Vrang, Bo Feldt-Rasmussen, Keld Fosgerau, Jacob Jelsing, Lisbeth N. Fink
Summary: The lack of animal models replicating the clinical features of human DKD has hindered progress in its treatment for the past 25 years. Better predictive models are needed for future research to improve clinical outcomes.
DRUG DISCOVERY TODAY
(2021)
Review
Neurosciences
Alexandra Petiet
Summary: Parkinson's disease is a major neurodegenerative disease characterized by massive degeneration of dopaminergic neurons, Lewy bodies, and neuroinflammation. Magnetic resonance imaging plays a crucial role in the diagnosis and monitoring of disease progression and treatment.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Sanne K. Meles, Wolfgang H. Oertel, Klaus L. Leenders
Summary: Understanding the early stages of Parkinson's disease is crucial for developing new therapeutic strategies. Studying patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) and non-manifest mutation carriers can provide insights into disease progression. Neuroimaging biomarkers, such as dopamine transporter (DAT) single photon emission computed tomography (SPECT), can help monitor disease progression and identify individuals at specific risk for phenoconversion.
MOLECULAR MEDICINE
(2021)
Review
Neurosciences
Nikolaus Wenger, Arend Vogt, Matej Skrobot, Elisa L. Garulli, Burce Kabaoglu, Christina Salchow-Hoemmen, Thomas Schauer, Daniel Kroneberg, Michael K. Schuhmann, Christoph Harms, Matthias Endres, Ioannis U. Isaias, Philip Tovote, Robert Blum, Chi Wang Ip
Summary: This article summarizes strategies for modeling parkinsonian gait in rodents and discusses the relationship between clinical research findings and motor deficits and network oscillations in animal models. The article suggests that future research should incorporate behavioral tests with higher cognitive demands and emphasizes that basic research should benefit from evolving signal processing strategies from clinical research.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Robert Brendza, Xiaoying Gao, Kimberly L. Stark, Han Lin, Seung-Hye Lee, Changyun Hu, Hao Cai, Danielle DiCara, Yi-Chun Hsiao, Hai Ngu, Oded Foreman, Miriam Baca, Monika Dohse, Jean-Phillipe Fortin, Racquel Corpuz, Dhaya Seshasayee, Amy Easton, Gai Ayalon, Isidro Hotzel, Ben Chih
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized by motor dysfunction and cognitive decline. Antibodies that target the C-terminal region of alpha synuclein can reduce the uptake and accumulation of toxic aggregates, and block the spread of pathology in PD models. These findings support the development of alpha synuclein antibodies as a potential therapeutic strategy for PD patients.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Chemistry, Analytical
Blake T. Seaton, Daniel F. Hill, Stephen L. Cowen, Michael L. Heien
ANALYTICAL CHEMISTRY
(2020)
Article
Anesthesiology
Taylor A. Gee, Nathan C. Weintraub, Dong Lu, Caroline E. Phelps, Edita Navratilova, Michael L. Heien, Frank Porreca
Article
Clinical Neurology
Lindsey M. Crown, Mitchell J. Bartlett, Jean-Paul L. Wiegand, Allison J. Eby, Emily J. Monroe, Kathleen Gies, Luke Wohlford, Matthew J. Fell, Torsten Falk, Stephen L. Cowen
FRONTIERS IN NEUROLOGY
(2020)
Article
Chemistry, Multidisciplinary
James R. Siegenthaler, Breanna C. Gushiken, Daniel F. Hill, Stephen L. Cowen, Michael L. Heien
Article
Biochemistry & Molecular Biology
Mitchell J. Bartlett, Omar S. Mabrouk, Lajos Szabo, Andrew J. Flores, Kate L. Parent, Jean M. Bidlack, Michael L. Heien, Robert T. Kennedy, Robin Polt, Scott J. Sherman, Torsten Falk
Summary: The study examined a glycopeptide BBI-11008 with selective delta-opioid receptor agonism, showing good central penetration and effects on levodopa-induced dyskinesia in rats. The results suggest a balance of mu- and delta-opioid agonism is required for modulation in this model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Kimberly F. Young, Rebeca Gardner, Victoria Sariana, Susan A. Whitman, Mitchell J. Bartlett, Torsten Falk, Helena W. Morrison
Summary: This study found that post-stroke injury is more severe in male and postmenopausal female mice compared to premenopausal female mice. Microglia undergo a transformation into less ramified cells after stroke, but this transformation is region-dependent rather than sex group-dependent. Additionally, the number of phagocytic microglia is significantly increased in the distal ipsilateral regions of postmenopausal mice compared to other sex groups.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Tony Ye, Mitchell J. Bartlett, Scott J. Sherman, Torsten Falk, Stephen L. Cowen
Summary: This study focused on the impact of LID on neural circuitry and synchrony, investigated the effects of L-DOPA dosage and exposure duration on these impacts, and explored the effects of sub-anesthetic ketamine treatment on LID. Novel neural signatures were identified related to LID and ketamine treatment.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Biochemical Research Methods
Blake T. Seaton, Michael L. Heien
Summary: In vivo electrochemistry is crucial for neuroscience in understanding progressive neurological disorders, such as Parkinson's disease. However, chronic experiments present challenges due to issues like immune response and biofouling from electrode implantation. The commonly used Ag/AgCl reference electrode lacks long-term potential stability, necessitating the exploration of biocompatible materials like iridium oxide and boron-doped diamond for improved chronic measurements.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Hojin Shin, Abhinav Goyal, J. Hudson Barnett, Aaron E. Rusheen, Jason Yuen, Rohan Jha, Sang Mun Hwang, Yumin Kang, Cheonho Park, Hyun-U Cho, Charles D. Blaha, Kevin E. Bennet, Yoonbae Oh, Michael L. Heien, Dong Pyo Jang, Kendall H. Lee
Summary: N-MCSWV is a novel voltammetric technique that allows quantitative measurements of extracellular levels of serotonin and other substances in vivo. When used with PEDOT:Nafion-coated carbon fiber microelectrodes, it can continuously monitor tonic serotonin concentrations in the brain of rats.
ANALYTICAL CHEMISTRY
(2021)
Article
Neurosciences
Ayumi E. Pottenger, Mitchell J. Bartlett, Scott J. Sherman, Torsten Falk, Helena W. Morrison
Summary: The study demonstrated that sub-anesthetic ketamine can alleviate motor dysfunction in Parkinson's disease patients caused by prolonged use of L-DOPA. The mechanism of ketamine's therapeutic effects may involve inflammation and microglia phagocytic functions.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Hoseok Choi, Hojin Shin, Hyun U. Cho, Charles D. Blaha, Michael L. Heien, Yoonbae Oh, Kendall H. Lee, Dong Pyo Jang
Summary: In this study, the performance of PCR and deep learning in analyzing FSCV data of neurotransmitters was compared. The results showed that deep learning had higher accuracy and discrimination performance than PCR for mixture analysis and performed well in in vivo testing.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Chemistry, Medicinal
Lajos Z. Szabo, Parthasadhireddy Tanguturi, Hannah J. Goodman, Sara Sprober, Chenxi Liu, Fahad Al-Obeidi, Mitchell J. Bartlett, Torsten Falk, Vlad K. Kumirov, M. Leandro Heien, John M. Streicher, Robin Polt
Summary: Acute and chronic pain are commonly managed with opioids, although their use is associated with negative side effects and the opioid crisis. Oxytocin, a pituitary hormone, shows promise as an alternative analgesic and treatment for opioid use disorder. However, its clinical use is limited by its unstable pharmacokinetics. Stable oxytocin analogues with improved brain penetrance have been developed, demonstrating selectivity for the oxytocin receptor and potent antinociception in mice, indicating their potential for further clinical investigation.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Neurosciences
Mitchell J. Bartlett, Andrew J. Flores, Tony Ye, Saskia Smidt, Hannah K. Dollish, Jennifer A. Stancati, Drew C. Farrell, Kate L. Parent, Kristian P. Doyle, David G. Besselsen, Michael L. Heien, Stephen L. Cowen, Kathy Steece-Collier, Scott J. Sherman, Torsten Falk
EXPERIMENTAL NEUROLOGY
(2020)
Article
Biology
Mitchell J. Bartlett, Lisa Y. So, Lajos Szabo, David P. Skinner, Kate L. Parent, Michael L. Heien, Todd W. Vanderah, Robin Polt, Scott J. Sherman, Torsten Falk
BMC RESEARCH NOTES
(2020)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)