Article
Biochemistry & Molecular Biology
Leila Safaeian, Fatemeh Shafiee, Samira Haghighatnazar
Summary: The study showed that andrographolide can enhance cardiomyocyte viability, decrease the toxicities of doxorubicin and arsenic trioxide, potentially through regulating TLR4 expression and oxidative/antioxidant capacities.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Sanchaita Mondal, Sujata Das, Pradip Kumar Mahapatra, Krishna Das Saha
Summary: This study successfully prepared Morin-vitamin E-beta-cyclodextrin inclusion complex loaded chitosan nanoparticles (M-Vit.E-CD-CS NPs) and demonstrated their hepatoprotective efficacy against arsenic-induced toxicity. The nanoparticles were characterized in terms of size, shape, and structure, and showed good encapsulation and drug loading efficacy. Treatment with the nanoparticles inhibited arsenic-induced liver damage and inflammation, and restored liver function and antioxidant levels.
Review
Engineering, Environmental
Shalini Thakkar, Ludovic F. Dumee, Manish Gupta, Braj Raj Singh, Wenrong Yang
Summary: The rising cases of arsenic contamination globally necessitate the urgent development of efficient detection systems. This paper focuses on current arsenic detection mechanisms, with a special emphasis on nano-enabled methods and novel nano solutions, while also discussing prospects for arsenic detection in water.
Article
Polymer Science
Kexin Tian, Heping Li, Bin Zhao, Yue Su, Zhiming Zou, Wenli Wang
Summary: The use of biomass resources with high activity and low toxicity in the preparation of nanomaterials for biomedical applications has been a topic of interest in nanometer biomaterials research. This study successfully synthesized a nanomaterial called GA-BX/AD-g-IA using bagasse xylan/andrographolide as raw materials. The synthesized nanomaterial showed significantly altered morphology and exhibited good anticancer activity.
Article
Environmental Sciences
Miao Liu, Fengxia Sun, Yuzhen Lv, Yuxin Xu, Ming Li, Yujun Wang, Xiting Yin, Hao Jiang
Summary: The study demonstrated that N-ZrO2-BC has strong adsorption and fixation properties on arsenic (V) in soil and water, significantly improving the stabilization efficiency of arsenic in soil and meeting the quality standards.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Chen
Summary: 18-β-Glycyrrhetinic acid has promising hepatoprotective effects against cholestatic liver injury, improving liver histology and reducing oxidative stress, inflammation, apoptosis, impaired autophagy, and fibrosis.
Article
Environmental Sciences
Xiaoxiao Hao, HongGuang Sun, Yong Zhang, Shiyin Li, Zhongbo Yu
Summary: This study investigated the co-transport dynamics of arsenic and micro/nano-plastics in saturated soil through laboratory experiments and model analysis. The results showed that the presence of nano-plastic particles hindered arsenic transport, while microplastics facilitated it. This study improved the understanding and quantification of the co-transport of arsenic and micro/nano-plastics in soil.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Yanli Kong, Bingjie Xu, Fan Lu, Zhao Han, Jiangya Ma, Zhonglin Chen, Jimin Shen
Summary: In this study, 15%CaO-doped nano zero-valent iron (15%CaO-nZVI) was synthesized and found to have a high adsorption capacity for As(V) removal from acid wastewater, removing over 97% of As(V) under optimal conditions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Chemistry, Analytical
Chenghua Zong, Xiaoting Jin, Juewen Liu
Summary: This article critically reviews the recent advances in arsenic detection using biomolecules and nanomaterials, discussing interactions between arsenic and gold, thiol, and DNA aptamers. It suggests that bio/nano systems show promise for arsenic detection and future research directions may include fundamental studies, searching for more specific arsenic binding materials and aptamers, incorporation of sensors into portable devices, and more systematic testing of sensors in real samples.
TRENDS IN ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Fahad S. Alshehri, Nasser M. Alorfi
Summary: Vancomycin has a high risk of causing liver injury, but resveratrol can protect the liver from its toxicity. The study showed that co-treatment with resveratrol prevented the elevation of liver damage markers and the depletion of antioxidants caused by vancomycin. In addition, resveratrol prevented the degeneration of liver cells induced by vancomycin.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenshuai Wang, Yaohan Zhang, Xinchao Liu, Zonghui Liu, Le Jia, Jianjun Zhang
Summary: The present study aimed to investigate the hepatoprotective effects of Oudemansiella radicata residues polysaccharides (RPS). The results demonstrated that RPS showed significant protection against carbon tetrachloride (CCl4)-induced liver injury. The possible mechanisms included anti-oxidation, anti-inflammation, anti-apoptosis, and anti-fibrosis effects. These findings suggested that RPS could be used as a promising diet supplement or medication for hepatic diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Wenjun Miao, Rong Huang, Xiaoli Huang, Fei Gao, Xiangpeng Leng, Qiu Li
Summary: In this study, polysaccharides from grape pomace (GPPs) were characterized and evaluated. GPPs were found to be heteropolysaccharides rich in arabinose, galactose, and glucuronic acid, with irregular clusters on the surface. In vitro assays showed concentration-dependent antioxidant activity of GPPs. In vivo experiments demonstrated that GPPs decreased levels of inflammatory markers and oxidative stress indicators, while increasing levels of antioxidant enzymes in serum and liver tissues. The histopathological examination further confirmed the hepatoprotective effects of GPPs.
Article
Food Science & Technology
Zuoxu Hou, Xiao Wang, Zefeng Yang, Zhiwei Deng, Jin Zhang, Jintao Zhong, Shanrui Liu, Yuanyuan Hu, Hongxun Sang
Summary: Plant-derived exosome-like nanovesicles from pomegranate (PENs) demonstrated therapeutic potential for nonalcoholic fatty liver disease (NAFLD) by improving mitochondrial function and reducing lipid accumulation. In cell experiments, PENs were internalized by HepG2 cells and ameliorated palmitic acid-induced lipid accumulation and mitochondrial dysfunction. In mouse experiments, oral administration of PENs accumulated in the liver and effectively alleviated NAFLD induced by high-fat diet, with improvements in mitochondrial function and antioxidant capacity. These findings provide new mechanistic insights into pomegranate's hepatoprotective effects and highlight the therapeutic potential of PENs for NAFLD.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Environmental Sciences
Yan Chen, Zhenhong Wang, Zhuanxi Luo, Yao Zhao, Jincong Yu
Summary: The study showed that Microcystis aeruginosa was more sensitive to As(V) associated with nano-Fe2O3. The increase in efflux rate constants of As compared to uptake rate constants in algal cells affected by different levels of nano-Fe2O3 led to a decrease in As(V) bioconcentration factor with increasing nano-Fe2O3.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Chen
Summary: Plumbagin has the potential to protect the liver from cholestatic damage by regulating multiple intracellular signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)