Article
Clinical Neurology
Gregor Broessner, Isabel Ellerbrock, Mareike M. Menz, Florian Frank, Michael Verius, Christian Gaser, Arne May
Summary: Voxel-based morphometry (VBM) is a widely used tool to study brain plasticity, development, and disease, but the source of T-1 signal changes is not fully understood. This study found significant gray matter volume changes in pain processing areas following pain stimulation, yet similar changes were observed in a control group without pain input. The results highlight the need for further research and control groups in longitudinal imaging studies.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Xiuli Wang, Bochao Cheng, Song Wang, Fengmei Lu, Ya Luo, Xipeng Long, Di Kong
Summary: The study found that PD and SAD may represent different anxiety sub-entities at the neuroanatomical phenotypes level, with specific neurostructural deficits in the right inferior frontal gyrus of PD patients and the left striatum and thalamus of SAD patients. There were no shared GMV alterations between the two disorders. These differences and specificities could potentially guide the development of diagnostic biomarkers for PD and SAD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Reuben Heyman-Kantor, Mina Rizk, M. Elizabeth Sublette, Harry Rubin-Falcone, Yashar Yousefzadeh Fard, Ainsley K. Burke, Maria A. Oquendo, Gregory M. Sullivan, Matthew S. Milak, Francesca Zanderigo, J. John Mann, Jeffrey M. Miller
Summary: The study found that BI scores were inversely correlated with GMV in unmedicated subjects with MDD and BD, but these correlations appeared to be driven by categorical diagnosis.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Yahui Liu, Jiajia Zhang, Meng Zhang, Xianrui Li, Kun Li, Bi Wang, Yongfeng Yang, Ruize Song, Yajing Si, Tianjun Ni, Xueke Wang, Yibo Geng, Qiaohua Chang, Haisan Zhang, Zhijun Zhang, Hongxing Zhang
Summary: This study found that patients with major depressive disorders have abnormalities in the frontal-limbic structures of the brain, specifically decreased gray matter volume in the right middle frontal and precentral gyri. Childhood trauma may be a contributing factor to these structural abnormalities and increased susceptibility to depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Xiang Huang, Junyu Lin, Huifang Shang, Jing Yang
Summary: In this study, a meta-analysis was conducted to investigate gray matter changes in patients with idiopathic dystonia. The results showed consistent widespread gray matter abnormalities in various brain regions. These abnormalities were shared among different subtypes of idiopathic dystonia and were not limited to the corticostriatal circuits.
JOURNAL OF NEUROLOGY
(2022)
Article
Behavioral Sciences
Handityo A. Putra, Kaechang Park, Fumio Yamashita, Yoshinori Nakagawa, Toshiya Murai
Summary: This study investigated the relationship between fatigue perception and regional gray matter volume (rGMV) in healthy middle-aged individuals and found correlations between fatigue perception and specific brain regions. Additionally, differences were observed between desk workers and non-desk workers in terms of the mechanisms of fatigue perception. Identifying gray matter regions associated with fatigue perception in healthy individuals may provide insights into the early progression of fatigue and facilitate the development of preventive measures.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Review
Psychiatry
Lei Li, Hua Yu, Ming Zhong, Siyi Liu, Wei Wei, Yajing Meng, Ming-li Li, Tao Li, Qiang Wang
Summary: This study used a meta-analysis approach to investigate brain structural changes in overweight and obese individuals. The results indicated lower gray matter volume in certain brain regions compared to lean controls. Furthermore, the study found a negative correlation between gray matter volume and BMI.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Huai-Bin Liang, Liao Dong, Yangyang Cui, Jing Wu, Wei Tang, Xiaoxia Du, Jian-Ren Liu
Summary: This study found significant structural changes and changes in functional connectivity (FC) patterns in the posterior cerebellar lobe of patients with somatic symptom disorder (SSD). These findings provide new insights into the psychological and neural substrates of SSD and may serve as a potential treatment target.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Genetics & Heredity
Shota Nishitani, Ryoko Kasaba, Daiki Hiraoka, Koji Shimada, Takashi X. Fujisawa, Hidehiko Okazawa, Akemi Tomoda
Summary: The study suggests that increasing reproductive efforts are associated with decelerated aging in mothers with one to four children, mediated by structural changes in the precuneus.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Erin E. O'Connor, Thomas A. Zeffiro, Oscar L. Lopez, James T. Becker
Summary: The study found that while HIV infection has a localized effect on the striatal structure, having a prior ADI is a strong predictor of smaller global and regional GMV. HIV infection and ADI have independent effects on brain structure, without associated accelerated lower volume with age.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Neurosciences
Yu Tang, Changhe Ren, Maohua Wang, Guidong Dai, Yan Xiao, Song Wang, Fugang Han, Guangxiang Chen
Summary: Neuroimaging studies have shown abnormalities in brain structure and function in patients with postherpetic neuralgia (PHN) and herpes zoster (HZ). This study found significant differences in gray matter volume and functional connectivity in the transition from HZ to PHN, particularly in the right putamen. These changes are closely associated with chronic pain and may provide new insights into the pathophysiology of PHN.
Article
Neurosciences
Feng-Yi Su, Jyun-Ru Chen, Chun-Ming Chen, Yen-Chih Huang, Shin-Lei Peng
Summary: This study identified patterns of gray matter volume changes with age in a young population, highlighting the influence of field strength on results and the importance of considering this factor when comparing brain differences across studies.
Review
Neurosciences
Teng Ma, Yuan-Yuan Ji, Lin-Feng Yan, Jia-Ji Lin, Ze-Yang Li, Wen Wang, Jin-Lian Li, Guang-Bin Cui
Summary: Gray matter volume (GMV) alteration in specific brain regions is associated with chronic pain comorbid depression. This study aims to explore the characteristic brain regions using voxel-based morphometry (VBM) studies on GMV alteration between chronic pain patients with depressive symptoms (CP-D) and healthy controls (HCs). The results show robust and reproducible GMV abnormalities in specific brain areas, suggesting their significant involvement in this comorbidity disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychiatry
Stuart B. Murray, Christina J. Duval, Ane A. Balkchyan, Ryan P. Cabeen, Jason M. Nagata, Arthur W. Toga, Steven J. Siegel, Kay Jann
Summary: Early-onset binge eating disorder (BED) may be characterized by diffuse morphological abnormalities in gray matter density, suggesting alterations in cortical architecture which may reflect decreased synaptic pruning and arborization, or decreased myelinated fibers and therefore inter-regional afferents.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Liu Tu, Fangyuan Zhou, Kei Omata, Wendi Li, Ruiwang Huang, Wei Gao, Zhenzhen Zhu, Yanyan Li, Chang Liu, Mengying Mao, Shuyu Zhang, Takashi Hanakawa
Summary: This study explores the anatomical changes and adaptations in the brain of adult alphabetic language speakers during long-term Chinese language learning. The results reveal that the participants who learned Chinese showed significantly greater gray matter volume in the left lingual gyrus. The reading accuracy of Chinese characters is positively correlated to the gray matter volume in the left lingual gyrus and fusiform gyrus across the two groups. Additionally, the duration of Chinese learning is positively correlated to the gray matter volume in the left inferior frontal gyrus in the learned group. These findings are consistent with previous functional imaging studies, highlighting the impact and adaptations of Chinese language learning on the brain.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Liyan Fan, Jinbo He, Yang Zheng, Yufeng Nie, Taolin Chen, Hongmei Zhang
Summary: This study found that individuals with Internet gaming disorder (IGD) have impairments in recognizing micro-expressions (MEs), particularly in recognizing happy MEs. The impairment in recognizing happy MEs is associated with social anxiety.
CURRENT PSYCHOLOGY
(2023)
Article
Neurosciences
Biqiu Tang, Wenjing Zhang, Jiang Liu, Shikuang Deng, Na Hu, Siyi Li, Youjin Zhao, Nian Liu, Jiaxin Zeng, Hengyi Cao, John A. Sweeney, Qiyong Gong, Shi Gu, Su Lui
Summary: Understanding how structural connectivity alterations affect dynamic function in schizophrenia patients, this study investigated the capacity of brain regions/networks to shift the system into easy-to-reach states. The results showed reduced controllability in default mode network, visual network, and subcortical regions, and increased controllability in somatomotor network. These alterations were also associated with impaired functional topology and increased temporal variability in dynamic functional connectivity.
Article
Psychiatry
Hengyi Cao, Xia Wei, Wenjing Zhang, Yuan Xiao, Jiaxin Zeng, John A. Sweeney, Qiyong Gong, Su Lui
Summary: This study provides an in-depth characterization of cerebellar dysconnectivity in early schizophrenia, revealing a common bidirectional dysconnectivity pattern that may be related to genetic factors.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Xinyue Wan, Pengfei Zhang, Weina Wang, Xintong Wu, Qiaoyue Tan, Xiaorui Su, Simin Zhang, Xibiao Yang, Shuang Li, Hanbing Shao, Qiang Yue, Qiyong Gong
Summary: This study used rs-fMRI to investigate the temporal features of functional connectivity states and changes in connectivity strength in sleep-related hypermotor epilepsy (SHE). The results showed that SHE patients exhibited two dFC states, with state 1 characterized by stronger connections within networks and state 2 characterized by stronger connections between networks. SHE patients had increased fractional time and mean dwell time in state 2, as well as a higher number of state transitions. The NBS analysis revealed increased connectivity strength between networks in SHE patients. These findings suggest that the patterns of dFC may represent adaptive and protective mechanisms in the brain against epileptic seizures.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Behavioral Sciences
Jing Jiang, Lei Li, Jinping Lin, Xinyu Hu, Youjin Zhao, John A. Sweeney, Qiyong Gong
Summary: Structural neuroimaging studies have found brain areas involved in the development of major depressive disorder (MDD). However, the results have been inconsistent due to variations in illness duration and effects of antidepressant treatment. This meta-analysis compared gray matter (GM) volumes in MDD patients with different medication status and illness duration, revealing potential effects of treatment and illness duration on brain structure. The analysis included 70 studies with a total of 3682 patients and 3469 controls, and identified decreased GM volume in frontal, temporal, and limbic regions of MDD patients. Drug effects were associated with larger GM volume in the right striatum and smaller GM volume in the right precuneus, while longer illness duration correlated with smaller GM volume in the right temporal gyrus. Similar GM decreases in the bilateral medial frontal cortex indicated a persistent alteration over the course of illness and treatment.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Engineering, Biomedical
Xueyang Xiao, Hao Cai, Qiaorong Huang, Bing Wang, Xiaoming Wang, Qiang Luo, Yinggang Li, Hu Zhang, Qiyong Gong, Xuelei Ma, Zhongwei Gu, Kui Luo
Summary: In this study, a dual-modality contrast agent, Gd-DOTA-TPBP, was successfully synthesized using an amphiphilic block polymer as a carrier. The contrast agent exhibited high resolution and sensitivity, making it a promising tool for early-stage tumor diagnosis.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiaoling Li, Zhenyu Duan, Xiaoting Chen, Dayi Pan, Qiang Luo, Lei Gu, Gang Xu, Yinggang Li, Hu Zhang, Qiyong Gong, Rongjun Chen, Zhongwei Gu, Kui Luo
Summary: Targeting the metabolic vulnerability of tumor cells is a promising anticancer strategy. Researchers have developed a nanomedicine called pOEG-b-D-SH@NP, which encapsulates maleimide-modified doxorubicin (Mal-DOX), to improve overall delivery efficiency and inhibit tumor metabolism through multiple pathways. The nanomedicine effectively depletes energy in colorectal cancer cells and shifts cell death from apoptosis to necroptosis. It also inhibits cellular oxidative phosphorylation and glycolysis, suppressing cancer growth in mouse models.
ADVANCED MATERIALS
(2023)
Article
Clinical Neurology
Feifei Zhang, Hongsheng Xie, Song Wang, Fei Li, Qiyong Gong, Zhiyun Jia
Summary: This study found that the volume of the right orbitofrontal cortex was negatively correlated with exercise addiction. The function of the right orbitofrontal cortex played an indirect role in exercise addiction and affected it through its volume. The volume of the right orbitofrontal cortex mediated the relationship between ability motivation and exercise addiction.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Xipeng Long, Lei Li, Xiuli Wang, Yuan Cao, Baolin Wu, Neil Roberts, Qiyong Gong, Graham J. Kemp, Zhiyun Jia
Summary: This study conducted a comprehensive meta-analysis of gray matter volume alterations in adolescents with major depressive disorder and bipolar disorder. The findings suggest that distinct patterns of GMV alterations in these two populations could aid in differentiation and provide potential diagnostic biomarkers.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
Lekai Luo, Lizhou Chen, Yuxia Wang, Qian Li, Ning He, Yuanyuan Li, Wanfang You, Yaxuan Wang, Fenghua Long, Lanting Guo, Kui Luo, John A. Sweeney, Qiyong Gong, Fei Li
Summary: This study uses sparse canonical correlation analysis to identify four distinct patterns of dynamic functional brain activity associated with attention-deficit/hyperactivity disorder (ADHD). It also finds that cognitive deficits mediate the relationship between brain dynamics and ADHD-related behaviors. These findings provide important insights into the behavioral and cognitive features of ADHD.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Zaixiang Fang, Ling Lin, Zhiqian Li, Lei Gua, Dayi Pan, Yunkun Li, Jie Chen, Haitao Ding, Xiaohe Tian, Qiyong Gong, Kui Luo
Summary: This study utilized nanotechnology to co-deliver chemotherapeutic drugs and photosensitizers using heparin as a carrier for synergistic cancer therapy, enhancing the efficacy of combination therapy. The co-assembled HP-PP nanoparticles significantly increased the stability and photostability of the drugs, resulting in enhanced cytotoxicity and a remarkable synergistic antitumor effect.
ACTA BIOMATERIALIA
(2023)
Article
Psychiatry
Xiqin Liu, Yajun Zhao, Xueling Suo, Xun Zhang, Nanfang Pan, Graham J. J. Kemp, Qiyong Gong, Song Wang
Summary: This study aimed to identify functional brain markers of COVID-specific vicarious traumatization (VT) and explore the psychological mechanism underlying the brain-VT link. The results revealed that VT was negatively correlated with functional connectivity density (FCD) in the right inferior temporal gyrus (ITG), and psychological resilience mediated the associations of ITG FCD and ITG-default mode network (DMN) functional connectivity with VT. This study provides new evidence on the brain basis of VT and underscores the importance of psychological resilience in the brain-VT relationship.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Wenjing Zhang, Naici Liu, Youjin Zhao, Chenyang Yao, Dan Yang, Chengmin Yang, Hui Sun, Xia Wei, John A. Sweeney, Huilou Liang, Miaoqi Zhang, Qiyong Gong, Su Lui
Summary: Repetitive transcranial magnetic stimulation (rTMS) is increasingly used to treat neuropsychiatric disorders. However, the exact mechanism of action remains unclear. In this study, the impact of inhibitory and excitatory rTMS on laminar diffusion profiles of neocortex was investigated. Different patterns of changes were observed, with increased fractional anisotropy (FA) in inhibitory rTMS and decreased FA in excitatory rTMS. Laminar analysis revealed the specific effects of rTMS on different cortical layers. These findings provide novel insights into the acute neurobiological effects of rTMS and its potential applications.
Article
Materials Science, Biomaterials
Yuting Jiang, Haojie Gu, Zhongyuan Cai, Shengxiang Fu, Yingzi Cao, Lingling Jiang, Changqiang Wu, Wei Chen, Chunchao Xia, Su Lui, Bin Song, Qiyong Gong, Hua Ai
Summary: Researchers developed a facile method to synthesize poly(acrylic acid)-coated manganese oxide nanoparticles (MnO2/PAA NPs), which exhibited good biocompatibility and high longitudinal relaxivity. The MnO2/PAA NPs with a particle size of 4.9 nm showed higher longitudinal relaxivity. In vivo magnetic resonance angiography experiments demonstrated that MnO2/PAA NPs had better angiographic performance and rapid clearance compared to Gadovist (Gd-DO3A-Butrol).
BIOMATERIALS SCIENCE
(2023)
Article
Neurosciences
Simin Zhang, Xibiao Yang, Qiaoyue Tan, Huaiqiang Sun, Di Chen, Yinying Chen, Hongjing Zhang, Yuan Yang, Qiyong Gong, Qiang Yue
Summary: This study investigated the changes in whole-brain cortical myelin and thickness induced by diffuse midline glioma and found significant differences among different groups. Additionally, a short-term survival prediction model was constructed using cortical features and tumor radiomics, which showed high accuracy in predicting patient survival.
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)
