Review
Cell & Tissue Engineering
Wen-zhao Liu, Zhan-jun Ma, Jie-ru Li, Xue-wen Kang
Summary: SCI often leads to serious motor and sensory dysfunction of the limbs below the injured segment, causing physical, psychological harm and economic burden. MSC therapy for SCI has shown promise but faces challenges like low survival rate and immune rejection, while exosomes derived from MSCs have great potential in the treatment of SCI.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Rodrigo Montoto-Meijide, Rosa Meijide-Failde, Silvia Maria Diaz-Prado, Antonio Montoto-Marques
Summary: A systematic review shows that mesenchymal stem cell (MSC)-based cell therapy has significant efficacy and safety in the treatment of traumatic spinal cord injury (TSCI), leading to improvements in AIS grades, sensory scores, and to a lesser extent, motor scores. However, further research is needed to address the long-term safety and clinical implications due to limited scientific evidence available.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Hongli Chen, Yunhao Wang, Wenjun Tu, Hong Wang, Huijuan Yin, Hong Sha, Yingxin Li
Summary: After spinal cord injury, the combination of human umbilical cord mesenchymal stem cell transplantation and photobiomodulation significantly improved motor function, increased Nissl bodies, and promoted neurofilament repair. The in situ expression of NF-200 and glial fibrillary acidic protein in the damaged area was the highest in the combination treatment group.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jinsu Hwang, Sujeong Jang, Choonghyo Kim, Sungjoon Lee, Han-Seong Jeong
Summary: Neurological disorders pose a global health problem, and current pharmacological treatments have side effects. Mesenchymal stem cells (MSCs) have anti-inflammatory, anti-apoptotic, and immunomodulatory properties, and their secreted paracrine factors play a therapeutic role. Exosomes and MSC-derived miRNAs also regulate genes and alleviate neuropathological changes in neurological diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ilya Shulman, Tatyana Ageeva, Alexander Kostennikov, Sergei Ogurcov, Leysan Tazetdinova, Ilyas Kabdesh, Alexander Rogozhin, Ilnur Ganiev, Albert Rizvanov, Yana Mukhamedshina
Summary: Spinal cord injury (SCI) is a current medical and social problem that causes severe disability. The use of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) is a strategy to promote the recovery of spinal cord structure and function after trauma. This study evaluated the therapeutic potential of repeated intrathecal injection of autologous MSC-derived EVs in a pig model of subacute contused SCI. The results showed partial restoration of locomotor activity through remyelination of axons and timely reperfusion of nervous tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Si -Yu Chen, Rui-Lin Yang, Xiang-Chong Wu, De-Zhi Zhao, Sheng-Ping Fu, Feng-Qin Lin, Lin-Yan Li, Li-Mei Yu, Qian Zhang, Tao Zhang
Summary: Spinal cord injury is a highly destructive disease that lacks effective treatment. In recent years, mesenchymal stem cell transplantation has emerged as a more promising therapeutic option for promoting spinal cord injury repair through various mechanisms.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Neurosciences
Zhe-Lun Yang, Jian Rao, Fa-Bin Lin, Ze-Yan Liang, Xiong-Jie Xu, Yi-Ke Lin, Xin-Yao Chen, Chun-Hua Wang, Chun-Mei Chen
Summary: Spinal cord injury (SCI) has significant impacts on both patients' quality of life and their families. While cell therapy has made major breakthroughs in treating SCI, it also has disadvantages. In recent years, there has been growing interest in the potential therapeutic role of exosomes and exosomal ncRNAs in SCI treatment. They may be promising tools for treating spinal cord injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yong Xie, Yi Sun, Yudong Liu, Jinyun Zhao, Quanbo Liu, Jiaqi Xu, Yiming Qin, Rundong He, Feifei Yuan, Tianding Wu, Chunyue Duan, Liyuan Jiang, Hongbin Lu, Jianzhong Hu
Summary: This study explores a specific targeted treatment approach for spinal cord injury by identifying stable subpopulations of exosomes that can improve blood-spinal cord barrier integrity and promote neural function recovery.
Article
Biochemistry & Molecular Biology
Sirilak Somredngan, Kasem Theerakittayakorn, Hong Thi Nguyen, Apichart Ngernsoungnern, Piyada Ngernsoungnern, Pishyaporn Sritangos, Mariena Ketudat-Cairns, Sumeth Imsoonthornruksa, Nattawut Keeratibharat, Rangsirat Wongsan, Ruttachuk Rungsiwiwut, Rangsun Parnpai
Summary: Stem cell therapy using human umbilical cord Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs) induced into neurospheres can effectively recover spinal cord injury (SCI) and improve motor function in rats. Neurospheres induced by 10 μM Isx9 for 7 days showed the expression of neural stem/progenitor cell markers through the Wnt3A signaling pathway. Transplantation of these neurospheres into SCI rats resulted in normal movement and tissue recovery, with smaller cavity size in the injury area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Sheng-Ping Fu, Xiang-Chong Wu, Rui-Lin Yang, De-Zhi Zhao, Jie Cheng, Hu Qian, Jun Ao, Qian Zhang, Tao Zhang
Summary: Spinal Cord Injury (SCI) is a devastating neurological disorder with no effective treatment. Secondary inflammatory responses contribute to the difficulties in neurological recovery. Mesenchymal Stem Cells (MSCs) have shown therapeutic potential by regulating macrophage balance and facilitating tissue repair and regeneration.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell & Tissue Engineering
Katarzyna Pieczonka, Michael G. Fehlings
Summary: Spinal cord injury (SCI) has a significant impact on quality of life and finances. Neural stem/progenitor cell (NSPC) transplantation shows promise for spinal cord regeneration, but the integration of transplanted cells remains a challenge. This review proposes various techniques, including molecular cues and alternative methods, to guide the integration of grafted cells towards specific circuits. Future research in these areas may improve outcomes for SCI patients.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Review
Cell & Tissue Engineering
Sathish Muthu, Madhan Jeyaraman, Arun Gulati, Arunabh Arora
Summary: The authors analyzed the evidence on the efficacy and safety of MSC therapy for traumatic spinal cord injury, finding significant improvements in AIS grade, bladder function, etc., with a higher incidence of complications but no serious adverse events.
Review
Neurosciences
Ze-Yan Liang, Xiong-Jie Xu, Jian Rao, Zhe-Lun Yang, Chun-Hua Wang, Chun-Mei Chen
Summary: This review discusses the research progress of MSC-derived exosomal miRNAs in promoting M2 macrophage differentiation in SCI. Research has shown the potential therapeutic effects of exosomal miRNAs in promoting nerve function recovery in SCI patients.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Soo-Eun Sung, Min-Soo Seo, Young-In Kim, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, Minkyoung Sung, Sang-Gu Yim, Ju-Hyeon Lim, Hyun-Gyu Seok, Seung-Yun Yang, Gun-Woo Lee
Summary: This study demonstrated that exosomes isolated from human epidural adipose tissue-derived MSCs can help restore locomotor function in rats with SCI by reducing inflammatory response.
Review
Biochemistry & Molecular Biology
Giovanni Schepici, Serena Silvestro, Emanuela Mazzon
Summary: Spinal cord injury (SCI) is a devastating condition that causes permanent motor and sensory deficits. Researchers have been studying potential therapeutic strategies to mitigate the neuro-inflammatory response following injury. Recent studies have shown that exosomes-derived MSCs (MSC-EXOs) have promising effects as an innovative therapy for SCI patients.
Article
Clinical Neurology
Masahito Nakazaki, Shinichi Oka, Masanori Sasaki, Yuko Kataoka-Sasaki, Rie Onodera, Katsuya Komatsu, Satoshi Iihoshi, Manabu Hiroura, Akira Kawaguchi, Jeffery D. Kocsis, Osamu Honmou
JOURNAL OF NEUROSURGERY
(2020)
Article
Clinical Neurology
Hiroshi Nagahama, Masahiko Wanibuchi, Toru Hirano, Mitsuhiro Nakanishi, Hiroyuki Takashima
Summary: The cerebellum communicates with the cerebral cortex via the superior, middle, and inferior cerebellar peduncles (CPs). Diffusion tensor tractography (DTT) is a technique capable of depicting the major fiber bundles in CPs, but routine use for brainstem visualization remains challenging. Visualizing CPs using high-resolution DTT may aid in surgical planning and intraoperative guidance, but challenges exist related to the smallness and complexity of the brainstem.
ACTA NEUROCHIRURGICA
(2021)
Article
Cardiac & Cardiovascular Systems
Naomi Yasuda, Yosuke Kuroda, Toshiro Ito, Masanori Sasaki, Shinichi Oka, Ryo Ukai, Keitaro Nakanishi, Takuma Mikami, Tsuyoshi Shibata, Ryo Harada, Shuichi Naraoka, Takeshi Kamada, Nobuyoshi Kawaharada
Summary: The study found that MRI plays an important role in evaluating ischemic spinal cord injury after cardiovascular surgery and aortic events, clearly showing the sites of infarction. MRI can help reveal etiology and analyze infarction patterns in different cases.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Review
Veterinary Sciences
Ai Namioka, Takahiro Namioka, Masanori Sasaki, Jeffery D. Kocsis, Osamu Honmou
Summary: The study developed a new focal basilar artery occlusion model in rats that causes specific stroke symptoms. This procedure is relatively stable, offers higher survival rates and extended observation periods compared to other brainstem ischemia models.
Article
Clinical Neurology
Ryo Kiyose, Masanori Sasaki, Yuko Kataoka-Sasaki, Masahito Nakazaki, Hiroshi Nagahama, Hirotoshi Magota, Shinichi Oka, Ryo Ukar, Mitsuhiro Takemura, Takahiro Yokoyama, Jeffery D. Kocsis, Osamu Honmou
Summary: The study found that infused MSCs enhanced the therapeutic efficacy of MCA reperfusion in rats by improving behavioral function and restoring microvasculature.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Osamu Honmou, Toshihiko Yamashita, Tomonori Morita, Tsutomu Oshigiri, Ryosuke Hirota, Satoshi Iyama, Junji Kato, Yuichi Sasaki, Sumio Ishiai, Yoichi M. Ito, Ai Namioka, Takahiro Namioka, Masahito Nakazaki, Yuko Kataoka-Sasaki, Rie Onodera, Shinichi Oka, Masanori Sasaki, Stephen G. Waxman, Jeffery D. Kocsis
Summary: This study investigated the safety and feasibility of intravenous infusion of MSCs for spinal cord injury (SCI) patients, as well as the functional status after MSC infusion. Results showed no serious adverse events associated with MSC injection and improvements in neurological function and daily living ability in some patients after MSC infusion.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Neurosciences
Hirotoshi Magota, Masanori Sasaki, Yuko Kataoka-Sasaki, Shinichi Oka, Ryo Ukai, Ryo Kiyose, Rie Onodera, Jeffery D. Kocsis, Osamu Honmou
Summary: Repeated administration of mesenchymal stem cells (MSCs) in an ALS rat model prolongs survival period, protects motor functions, and reduces deterioration of locomotor activity. Compared to single infusion and vehicle infusion, the repeated-infusion group maintained gait ability and prevented the deterioration of motor function.
Article
Cell Biology
Masahito Nakazaki, Tomonori Morita, Karen L. Lankford, Philip W. Askenase, Jeffery D. Kocsis
Summary: Intravenous infusion of bone marrow-derived mesenchymal stem/stromal cells (MSCs) leads to the release of small extracellular vesicles (sEVs) that can target the injury site in spinal cord injury (SCI) rats and interact with M2 macrophages. Fractionated dosing of MSC-sEVs over 3 days is required to achieve therapeutic effects, mimicking the results of single MSC infusion. These findings suggest that the release of sEVs by MSCs over time induces a cascade of cellular responses leading to improved functional recovery.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Neurosciences
Masahito Nakazaki, Shinichi Oka, Hirotoshi Magota, Ryo Kiyose, Rie Onodera, Ryo Ukai, Yuko Kataoka-Sasaki, Masanori Sasaki, Osamu Honmou
Summary: This study retrospectively evaluated the antiplatelet effects of dabigatran compared to FXa inhibitors in patients with cardioembolic stroke, finding that dabigatran had less impact on platelet aggregation.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Nutrition & Dietetics
Mari Maeda-Yamamoto, Osamu Honmou, Masanori Sasaki, Akane Haseda, Hiroyo Kagami-Katsuyama, Toshihiko Shoji, Ai Namioka, Takahiro Namioka, Hirotoshi Magota, Shinichi Oka, Yuko Kataoka-Sasaki, Ryou Ukai, Mitsuhiro Takemura, Jun Nishihira
Summary: This study aimed to determine whether ingesting purple potatoes could improve stress response in healthy adults. The results showed that while purple potato intake did not increase the number of stem cells, it significantly improved psychological stress response, irritability, and depression as minor health complaints.
Article
Oncology
Masahito Nakazaki, Karen L. Lankford, Hideaki Yamamoto, Yoshiyuki Mae, Jeffery D. Kocsis
Summary: Intravenous delivery of both human and rat MSC-sEVs promotes body growth and motor function recovery in young adult rats with SCI. This therapeutic effect is likely due to the modulation of cytokines involved in growth-related hormonal pathways. MSC-sEVs have an impact on both metabolic and neurological deficits in SCI.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Pediatrics
Kojiro Terada, Masanori Sasaki, Hiroshi Nagahama, Yuko Kataoka-Sasaki, Shinichi Oka, Ryo Ukai, Takahiro Yokoyama, Yusuke Iizuka, Takuro Sakai, Shinobu Fukumura, Takeshi Tsugawa, Jeffery D. Kocsis, Osamu Honmou
Summary: In this study, the therapeutic efficacy of intravenous infusion of mesenchymal stem cells (MSCs) against perinatal brain injury in rats was tested. The results showed that infused MSCs improved neurological function and enhanced neuronal growth in the rats.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Takumi Hoshimaru, Naosuke Nonoguchi, Takuya Kosaka, Motomasa Furuse, Shinji Kawabata, Ryokichi Yagi, Yoshitaka Kurisu, Hideki Kashiwagi, Masahiro Kameda, Toshihiro Takami, Yuko Kataoka-Sasaki, Masanori Sasaki, Osamu Honmou, Ryo Hiramatsu, Masahiko Wanibuchi
Summary: ACTA2 may serve as a potential biomarker involved in brain invasion and distant recurrence in malignant gliomas.
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
