Article
Chemistry, Analytical
Sam B. Choi, Tarlan Vatan, Theresa A. Alexander, Chenghang Zhang, Shyrice M. Mitchell, Colenso M. Speer, Peter Nemes
Summary: During brain development, the formation of axonal projections in the mouse visual system is influenced by both spontaneous retinal activity and visual experience. However, the precise proteomic changes in the retinorecipient targets during this developmental transition are still unknown.
ANALYTICAL CHEMISTRY
(2023)
Review
Neurosciences
Xiang Li, Wenjun Wang, Jianghong Yan, Fancai Zeng
Summary: This review discusses the role of glutamate transporters in Parkinson's disease, comparing the expression of different types of glutamate transporter genes using bioinformatics and suggesting that they may be potential targets for the treatment of PD.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Neurosciences
Cheng Zhao, Chunyu Wang, Hainan Zhang, Weiqian Yan
Summary: Parkinson's disease (PD) is a common neurodegenerative disease associated with multiple neurotransmitter pathways. Glutamate, the central excitatory neurotransmitter, plays a critical role in neuronal activity control. This review highlights the role of vesicular glutamate transporters (VGLUTs) in neurotransmitter and synaptic communication, as well as the significant alterations in Glutamate transmission and VGLUTs levels in PD.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biology
Thawann Malfatti, Barbara Ciralli, Markus M. Hilscher, Richardson N. Leao, Katarina E. Leao
Summary: Lowering the activity of the dorsal cochlear nucleus reduces tinnitus in mice, but lowering activity during noise exposure does not prevent noise-induced tinnitus. CaMKII alpha-positive cells in the dorsal cochlear nucleus play a significant role in maintaining the perception of tinnitus in mice.
Article
Medicine, Research & Experimental
Min Chen, Shiyao Min, Chen Zhang, Xuerui Hu, Shufeng Li
Summary: This study demonstrated that the novel EES strategy could effectively relieve tinnitus without impairment to hearing and cochlear structure of tinnitus animals. The reversal of tinnitus-related auditory-somatosensory plasticity in the cochlear nucleus was correlated with the tinnitus relief induced by the EES.
Article
Multidisciplinary Sciences
Celina Isabelle von Eiff, Sascha Fruehholz, Daniela Korth, Orlando Guntinas-Lichius, Stefan Robert Schweinberger
Summary: This study investigates the effects of time-synchronized facial information on vocal emotion recognition (VER) and finds that cochlear implant (CI) users perform worse in emotion classification tasks compared to individuals with normal hearing. The study also finds that CI users show larger benefits to VER when facial information is congruent with the auditory information, suggesting that they compensate for their auditory impairment through crossmodal integration.
Article
Neurosciences
Zhiping Mi, Eric E. Abrahamson, Angela Y. Ryu, Michael Malek-Ahmadi, Julia K. Kofler, Kenneth N. Fish, Robert A. Sweet, Victor L. Villemagne, Julie A. Schneider, Elliott J. Mufson, Milos D. Ikonomovic
Summary: Altered glutamatergic neurotransmission may contribute to impaired default mode network function in Alzheimer's disease (AD). The frontal cortex (FC) may undergo a glutamatergic plasticity response in prodromal AD, while the status of glutamatergic synapses in the precuneus (PreC) during clinical-neuropathological AD progression is not known.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Multidisciplinary Sciences
Jaerin Sohn, Mototaka Suzuki, Mohammed Youssef, Sayuri Hatada, Matthew E. Larkum, Yasuo Kawaguchi, Yoshiyuki Kubota
Summary: This study reveals that two presynaptic neural circuits regulate the spine dynamics of pyramidal cell dendrites during learning. New spines formed with corticocortical neurons are eliminated after skill acquisition, while persistent spines with axons from thalamic neurons enlarge. This suggests a division of labor in the neural circuits of the motor cortex during skill learning.
Article
Anatomy & Morphology
Carmen Alonso-Martinez, Mario Rubio-Teves, Cesar Porrero, Francisco Clasca
Summary: The thalamus serves as a crucial connection between the cortical and subcortical motor systems in the brain, and the inputs from the deep nuclei of the cerebellum, substantia nigra reticulata (SNr), and globus pallidus internus/substantia nigra pars reticulata (GPi/ENT) to the ventral nuclei of the mouse thalamus have been mapped in this study. It was found that the ventral nuclei receive inputs from all three systems, with different territories characterized by glutamatergic or GABAergic neurotransmission markers. This delineation of the mouse ventral motor nuclei based on inputs provides valuable insights into motor system organization.
FRONTIERS IN NEUROANATOMY
(2023)
Article
Multidisciplinary Sciences
Chong Guo, Vincent Huson, Evan Macosko, Wade G. Regehr
Summary: The authors demonstrate that graded molecular heterogeneity in cerebellar unipolar brush cells (UBCs) leads to a continuum of temporal responses, allowing for stable cell-autonomous basis for temporal integration and learning over multiple time scales.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Haoyu Liu, Ruiqing Zhou, Lanxiang Yin, Nana Si, Chenglin Yang, Chengqing Huang, Rongrong Wang, Xiangtao Chen
Summary: This study found that fi-asarone, the main component of Acorus tatarinowii, has sleep-promoting effects in mice. By reducing glutamate and promoting its conversion to the inhibitory neurotransmitter GABA, fi-asarone can suppress arousal and increase sleep duration. This study provides a new direction for the pharmacological applications of fi-asarone.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Tracy L. Fetterly, Max F. Oginsky, Allison M. Nieto, Yanaira Alonso-Caraballo, Zuleirys Santana-Rodriguez, Carrie R. Ferrario
Summary: Human fMRI studies indicate that insulin influences brain activity in regions related to reward and motivation, such as the nucleus accumbens. Insulin has concentration-dependent bidirectional effects on excitatory transmission in the NAc, with insulin receptor activation increasing transmission and IGF receptor activation decreasing transmission. Obesity leads to a loss of insulin receptor-mediated increase in excitatory transmission in the NAc, while preserving reductions in transmission mediated by IGF receptors.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Anatomy & Morphology
Mohammad Tufazzal Hussan, Akiko Sakai, Hideaki Matsui
Summary: Glutamate is an important neurotransmitter in the brain and plays a key role in both physiological and pathological neuronal functions. This article discusses the neuroprotective strategies used by the anoxia-tolerant freshwater turtle to maintain low levels of glutamate and investigates the potential application of these strategies in finding therapeutics for glutamatergic neurological disorders in humans. The glutamatergic circuits in the turtle brain are less described compared to mammalian and avian brains, but several candidate circuits have been identified. The integrated knowledge of glutamatergic pathways provides a fundamental basis for further functional studies in the turtle brain and offers insights into glutamate regulation and neural circuits in different species.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Neurosciences
Bartosz Pomierny, Weronika Krzyzanowska, Alicja Skorkowska, Jakub Jurczyk, Beata Bystrowska, Boguslawa Budziszewska, Joanna Pera
Summary: Brain ischemia is a major cause of death and disability worldwide, and the release of glutamate after ischemia induces neuronal excitotoxicity. VGLUT1 and VGLUT2 are involved in filling presynaptic vesicles with glutamate. This study explores the effect of cerebral ischemia on the expression of VGLUT1 and VGLUT2, and the impact of VGLUT inhibition on glutamate release and stroke outcome.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fei Li, Jacob Eriksen, Janet Finer-Moore, Robert M. Stroud, Robert H. Edwards
Summary: Originally identified as transporters for inorganic phosphate, solute carrier 17 (SLC17) family proteins are now known to play important roles in neurotransmission and substance flux, with mechanisms and substrate specificity gradually being revealed.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Amarins Nieske Heeringa, Pim van Dijk
Article
Neurosciences
Takaomi Kurioka, Min Young Lee, Amarins N. Heeringa, Lisa A. Beyer, Donald L. Swiderski, Ariane C. Kanicki, Lisa L. Kabara, David F. Dolan, Susan E. Shore, Yehoash Raphael
Article
Neurosciences
Amarins N. Heeringa, Calvin Wu, Susan E. Shore
JOURNAL OF NEUROSCIENCE
(2018)
Article
Audiology & Speech-Language Pathology
A. N. Heeringa, P. van Dijk
Article
Neurosciences
Amarins N. Heeringa, Calvin Wu, Christopher Chung, Michael West, David Martel, Leslie Liberman, M. Charles Liberman, Susan E. Shore
Article
Clinical Neurology
Roelina Hagewoud, Shamiso N. Whitcomb, Amarins N. Heeringa, Robbert Havekes, Jaap M. Koolhaas, Peter Meerlo
Article
Clinical Neurology
Amarins N. Heeringa, Martijn J. H. Agterberg, Pim van Dijk
FRONTIERS IN NEUROLOGY
(2014)
Article
Neurosciences
Amarins N. Heeringa, Pim van Dijk
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Review
Audiology & Speech-Language Pathology
Amarins N. Heeringa, Christine Koeppl
Article
Neurosciences
Amarins N. Heeringa, Lichun Zhang, Go Ashida, Rainer Beutelmann, Friederike Steenken, Christine Koeppl
JOURNAL OF NEUROSCIENCE
(2020)
Article
Geriatrics & Gerontology
Friederike Steenken, Amarins N. Heeringa, Rainer Beutelmann, Lichun Zhang, Sonny Bovee, Georg M. Klump, Christine Koeppl
Summary: The loss of inner hair cell-auditory nerve fiber synapses is considered an important factor in neural presbyacusis, and the neural index (NI) may not accurately reflect synapse loss in aged gerbils, especially in the presence of peripheral pathologies. Further research is needed to explore reliable clinical tools for assessing synapse loss in aged humans with peripheral hearing loss.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Amarins N. Heeringa, Christine Koppl
Summary: This study aims to investigate the response of the auditory nerve to naturally-spoken vowels in speech-shaped noise. By comparing different encoding schemes, it was found that spike timing patterns can extract the formant frequencies of vowels, while rate-based excitation patterns cannot. The results suggest that the difficulty in discriminating vowels originates peripherally.
Article
Neurosciences
Amarins N. Heeringa, Fiona Teske, Go Ashida, Christine Koeppl
Summary: Aging and cochlear degeneration lead to functional changes in auditory nerve fibers (ANFs). This study found that ANFs in aged gerbils had lower spontaneous rates (SRs) for low-frequency signals and a loss of low-SR fibers for high-frequency signals. The distribution of rate-level function (RLF) types also changed in aged ANFs. A physiologically based cochlear model was used to simulate these effects, revealing that the changes in SR and RLF types were due to both striatal degeneration and reduced basilar membrane gain.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Amarins N. Heeringa, Carolin Juechter, Rainer Beutelmann, Georg M. Klump, Christine Koeppl
Summary: Understanding speech in a noisy environment becomes more difficult with increasing age. This study on gerbils found that while the perception of speech-in-noise deteriorates with age, behavioral vowel discrimination remains unaffected.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.