期刊
NEUROREPORT
卷 27, 期 9, 页码 671-676出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0000000000000594
关键词
activating transcription factor 4; growth arrest and DNA damage-inducible gene 34; Mini Mental State Examination; retrograde amnesia; Revised Hasegawa Dementia Scale
资金
- Ministry of Education, Science, Sports, and Culture of Japan
- Ministry of Agriculture, Forestry and Fisheries (MAFF)
- Japan Society for the Promotion of Science (JSPS)
- research project on the development of agricultural products and foods with health-promoting benefits (NARO), Japan
- Grants-in-Aid for Scientific Research [26460861, 26500006] Funding Source: KAKEN
Patients with Alzheimer's disease (AD) experience a wide array of cognitive deficits, which typically include the impairment of explicit memory. In previous studies, the authors reported that a flavonoid, quercetin, reduces the expression of ATF4 and delays memory deterioration in an early-stage AD mouse model. In the present study, the effects of long-term quercetin intake on memory recall were assessed using contextual fear conditioning in aged wildtype mice. In addition, the present study examined whether memory recall was affected by the intake of quercetin-rich onion (a new cultivar of hybrid onion 'Quergold') powder in early-stage AD patients. In-vivo analysis indicated that memory recall was enhanced in aged mice fed a quercetin-containing diet. Memory recall in early-stage AD patients, determined using the Revised Hasegawa Dementia Scale, was significantly improved by the intake of quercetin-rich onion (Quergold) powder for 4 weeks compared with the intake of control onion ('Mashiro' white onion) powder. These results indicate that quercetin might influence memory recall. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
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