Review
Biology
Oliwia Gawlik-Kotelnicka, Dominik Strzelecki
Summary: Metabolic disorders and depression often co-occur and may share similar pathophysiological mechanisms, such as hypothalamic-pituitary-adrenal axis dysregulation and immune system alterations. Current interventions have not yielded conclusive results, and a better understanding of the associations between these diseases can guide more effective treatment approaches.
Article
Gastroenterology & Hepatology
Mushegh A. Sahakyan, Dyre Kleive, Rachel G. Dille-Amdam, Trond Kjeseth, Kim Waardal, Bjorn Edwin, Linn S. Nymo, Kristoffer Lassen
Summary: Preoperative inflammatory markers, such as Glasgow prognostic score, modified Glasgow prognostic score, and C-reactive protein to albumin ratio, were associated with prognosis in pancreatic cancer patients undergoing pancreatectomy. However, their predictive role in Western populations remains unclear.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Cell Biology
Michael Macklin, Chelsea Thompson, Leticia Kawano-Dourado, Iazsmin Bauer Ventura, Camila Weschenfelder, Andres Trostchansky, Aline Marcadenti, Robert M. Tighe
Summary: Adipose tissue has functions beyond energy storage, including endocrine and immune functions. Dysfunction of adipose tissue can lead to detrimental consequences such as altered hormonal signaling and inflammation. More research is needed to understand the relationship between obesity and chronic lung conditions.
Article
Immunology
Theresa S. Kleih, Entringer Sonja, Scholaske Laura, Kathmann Norbert, DePunder Karin, Christine M. Heim, Pathik D. Wadhwa, Buss Claudia
Summary: This study examined the association between childhood maltreatment (CM), depressive symptoms, and proinflammatory state during pregnancy, finding that maternal depressive symptoms moderate the relationship between early life stress and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Psychiatry
Kelci Straka, Mai-Lan Tran, Summer Millwood, James Swanson, Kate Ryan Kuhlman
Summary: Inflammation has complex associations with depressive symptoms, with age potentially playing a significant role. Aging is associated with various changes in brain structure and function, yet the role of inflammation in depressive symptoms within a lifespan developmental framework has not received much attention.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Kate R. Kuhlman, Michael R. Irwin, Patricia A. Ganz, Steve W. Cole, Andrew W. Manigault, Catherine M. Crespi, Julienne E. Bower
Summary: This study found that the effects of inflammation on depressive symptoms vary across different age groups of women. High levels of inflammation were associated with increased somatic complaints, interpersonal problems, and positive affect, but only among younger women. Additionally, younger women reported more depressed affect when inflammation levels were higher.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Carmen Monthe-Dreze, Izzuddin M. Aris, Sheryl L. Rifas-Shiman, Nitin Shivappa, James R. Hebert, Emily Oken, Sarbattama Sen
Summary: Prenatal psychosocial stress and nutrition may program offspring adiposity, but their combined longitudinal associations in the offspring are poorly understood.
Article
Gastroenterology & Hepatology
Meredith A. J. Hullar, Isaac C. Jenkins, Timothy W. Randolph, Keith R. Curtis, Kristine R. Monroe, Thomas Ernst, John A. Shepherd, Daniel O. Stram, Iona Cheng, Bruce S. Kristal, Lynne R. Wilkens, Adrian Franke, Loic Le Marchand, Unhee Lim, Johanna W. Lampe
Summary: This study investigated the association of gut microbiome with hepatic adiposity among different ethnicities. The research found that NAFLD patients from various ethnic groups exhibited differences in bacterial composition and metabolism, but shared similar bacterial metabolic pathways.
Article
Immunology
Katja Dittrich, Katja Boedeker, Dorothea Kluczniok, Catherine Hindi Attar, Sibylle M. Winter, Stefan Roepke, Christine Heim, Sabine C. Herpertz, Felix Bermpohl
Summary: The study examines the association between major depressive disorder (MDD) and inflammation markers, suggesting that elevated levels of inflammation may persist even after MDD remission. Results indicate that physical abuse predicts CRP levels in the presence of remitted MDD, highlighting the potential influence of different types of early life maltreatment on inflammation profiles.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Dominik Schneble, Ahmed El-Gazzar, Zahra Kargarpour, Markus Kramer, Seda Metekol, Slagjana Stoshikj, Marco Idzko
Summary: P2RY2 signaling plays a cell-type-specific role in the house dust mite-driven model of allergic airway inflammation, mediating the production of proinflammatory cytokines and recruitment of immune cells in the airway inflammation process.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Sonia S. Anand, Matthias G. Friedrich, Douglas S. Lee, Phillip Awadalla, J. P. Despres, Dipika Desai, Russell J. de Souza, Trevor Dummer, Grace Parraga, Eric Larose, Scott A. Lear, Koon K. Teo, Paul Poirier, Karleen M. Schulze, Dorota Szczesniak, Jean-Claude Tardif, Jennifer Vena, Katarzyna Zatonska, Salim Yusuf, Eric E. Smith
Summary: This study investigated the association of adiposity on vascular brain injury and cognitive scores. The results showed that generalized and visceral adiposity were associated with reduced cognitive scores, even after adjusting for cardiovascular risk factors, educational level, and vascular brain injury.
Article
Cell Biology
Hai-long Yang, Meng-Meng Li, Man-Fei Zhou, Huai-Sha Xu, Fei Huan, Na Liu, Rong Gao, Jun Wang, Ning Zhang, Lei Jiang
Summary: This study investigated the mechanisms of depression induced by chronic restraint stress from the perspectives of inflammation, gut microbiota, and neurotransmitters. It was found that CRS led to inflammatory reactions, disturbances in neurotransmitter metabolism, and dysbiosis in gut microbiota. The study suggests potential links between microbiota dysbiosis and neurotransmitter metabolism in CRS-induced depression, providing new strategies for depression treatment.
Article
Geriatrics & Gerontology
Julia S. Nakamura, Eric S. Kim, Kelly E. Rentscher, Julienne E. Bower, Kate R. Kuhlman
Summary: The study identified a positive association between early-life stress and depressive symptoms, which was moderated by social contact and perceived support. Increased social contact and perceived support may protect individuals at higher risk of developing depressive symptoms due to early-life stress.
AGING & MENTAL HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Richard J. Webb, Mohsen Mazidi, Gregory Y. H. Lip, Andre P. Kengne, Maciej Banach, Ian G. Davies
Summary: This study investigated the impact of adiposity, diet, and inflammation on the discordance between apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C). The results showed that body mass index, dietary saturated fatty acids, dietary fiber, serum C-reactive protein, and uric acid were strongly associated with the discordance. Additionally, Mendelian randomization analysis indicated that higher body fat percentage was causally related to elevated ApoB.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Oncology
Logan Blankenship, Uday P. Pratap, Xue Yang, Zexuan Liu, Kristin A. Altwegg, Bindu Santhamma, Kumaraguruparan Ramasamy, Swapna Konda, Yidong Chen, Zhao Lai, Siyuan Zheng, Gangadhara R. Sareddy, Philip T. Valente, Edward R. Kost, Hareesh B. Nair, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Suryavathi Viswanadhapalli
Summary: The study demonstrates that obese conditions upregulate LIF/LIFR signaling, promoting progression of endometrioid endometrial cancer (EEC). The LIFR inhibitor EC359 shows potential in suppressing tumor progression in obese patients.
Review
Neurosciences
H. Fanet, L. Capuron, N. Castanon, F. Calon, S. Vancassel
Summary: Tetrahydrobipterin (BH4) plays a crucial role in the synthesis of important neurotransmitters and regulation of physiological processes, stimulated by immunological factors and acting as both an anti-inflammatory molecule and free radical scavenger. However, it is prone to autoxidation leading to oxidative stress, and alterations in BH4 levels are associated with various diseases.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Julie Lasselin, Mats Lekander, Sven Benson, Manfred Schedlowski, Harald Engler
Summary: Depression is a major cause of disability globally, with limited treatment options, but the emerging role of inflammation in its etiology and pathophysiology highlights the need for novel therapies. Experimental endotoxemia in healthy volunteers provides a safe and standardized translational approach to develop and test new therapeutic options against inflammation-associated depression, aiming to improve personalized treatment and increase overall response rates.
MOLECULAR PSYCHIATRY
(2021)
Article
Immunology
Lina S. Hansson, John Axelsson, Predrag Petrovic, Sofie Paues Goranson, Mats J. Olsson, Mats Lekander, Julie Lasselin
Summary: This pilot study found that experimentally induced inflammation affects the cognitive reappraisal of emotions and suggests that disgust stimuli might be more difficult to reappraise than general negative stimuli.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Behavioral Sciences
Arnaud Tognetti, Georgia Sarolidou, Julie Lasselin, Mats Lekander, Mats J. Olsson, Johan N. Lundstrom
Summary: The study found that acute systemic inflammation does not affect olfactory identification performance, and that odor identification performance is not associated with levels of circulating proinflammatory cytokines. Therefore, chronic systemic inflammation may be a more likely mechanism to explore in order to explain olfactory deficits observed in inflammatory diseases.
Article
Nutrition & Dietetics
Camille Monchaux De Oliveira, Line Pourtau, Sylvie Vancassel, Camille Pouchieu, Lucile Capuron, David Gaudout, Nathalie Castanon
Summary: Depressive disorders pose a major public health concern with rising prevalence and challenges in conventional antidepressant treatments. A preclinical study on saffron extract suggests its potential as an antidepressant by modulating neurotransmission and improving depressive-like behavior in mice, sharing common targets with conventional pharmacological antidepressants. This highlights the promising therapeutic relevance of nutritional interventions with saffron extracts in managing mood disorders.
Article
Immunology
Kristoffer N. T. Mansson, Julie Lasselin, Bianka Karshikoff, John Axelsson, Harald Engler, Manfred Schedlowski, Sven Benson, Predrag Petrovic, Mats Lekander
Summary: This study investigated the vulnerability factors to inflammation-induced sickness and anxiety responses in individuals, and found that the gray matter volume of the anterior insula plays a central role in the development of symptoms. The results suggest that anterior insula morphology may be a risk factor in inflammation-related psychopathologies.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Pierre Cardinal, Camille Monchaux de Oliveira, Julie Sauvant, Aline Foury, Muriel Darnaudery, Sylvie Vancassel, Nathalie Castanon, Lucile Capuron
Summary: The study compared the behavioral, inflammatory, and neurobiological impacts of chronic exposure to a high-fat diet and unpredictable chronic mild stress in mice. It found that inflammation-related depressive behaviors were mainly present in mice exposed to the high-fat diet, with specific activation of inflammatory pathways and downstream neurobiological changes. This experimental design validates a way to study the mechanisms underlying inflammation-driven depression in comparison to non-inflammatory depression.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Food Science & Technology
Dragan Milenkovic, Irena Krga, Anne-Laure Dinel, Christine Morand, Sophie Laye, Nathalie Castanon
Summary: The study revealed that anthocyanin-rich bilberry extract can affect gene expression in the hippocampus, regulating various biological processes such as neurogenesis, inflammation, and metabolism. This multi-target mode of action suggests that anthocyanins may exert neuroprotective effects by binding to top transcription factors, leading to the regulation of gene expression.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Pharmacology & Pharmacy
Camille Monchaux De Oliveira, Veronique De Smedt-Peyrusse, Jennifer Morael, Sylvie Vancassel, Lucile Capuron, David Gaudout, Line Pourtau, Nathalie Castanon
Summary: This study found that saffron extract alleviated depressive-like behavior induced by acute restraint stress in mice, reversed stress-induced neurotransmitter dysregulation, and modulated the expression of key enzymes in related metabolic pathways. These results provide important insights into the therapeutic relevance of nutritional interventions with saffron in depressed patients.
Article
Multidisciplinary Sciences
Cari M. Pick, Ahra Ko, Douglas T. Kenrick, Adi Wiezel, Alexandra S. Wormley, Edmond Awad, Laith Al-Shawaf, Oumar Barry, Yoella Bereby-Meyer, Watcharaporn Boonyasiriwat, Eduard Brandstatter, Suzan Ceylan-Batur, Bryan K. C. Choy, Ana Carla Crispim, Julio Eduardo Cruz, Daniel David, Oana A. David, Renata Pereira Defelipe, Pinar Elmas, Agustin Espinosa, Ana Maria Fernandez, Velichko H. Fetvadjiev, Stefka Fetvadjieva, Ronald Fischer, Silvia Galdi, Oscar Javier Galindo-Caballero, Elena V. Golovina, Galina M. Golovina, Luis Gomez-Jacinto, Sylvie Graf, Igor Grossmann, Pelin Gul, Peter Halama, Takeshi Hamamura, Shihui Han, Lina S. Hansson, Hidefumi Hitokoto, Martina Hrebickova, Darinka Ilic, Jennifer Lee Johnson, Mane Kara-Yakoubian, Johannes A. Karl, Jinseok P. Kim, Michal Kohut, Julie Lasselin, Hwaryung Lee, Norman P. Li, Anthonieta Looman Mafra, Oksana Malanchuk, Simone Moran, Asuka Murata, Jinkyung Na, Serigne Abdou Lahat Ndiaye, O. Jiaqing, Ike E. Onyishi, Eddieson Pasay-an, Muhammed Rizwan, Eric Roth, Sergio Salgado, Elena S. Samoylenko, Tatyana N. Savchenko, Catarina Sette, A. Timur Sevincer, Eric Skoog, Adrian Stanciu, Eunkook M. Suh, Daniel Sznycer, Thomas Talhelm, Fabian O. Ugwu, Ayse K. Uskul, Irem Uz, Jaroslava Varella Valentova, Marco Antonio Correa Varella, Liuqing Wei, Danilo Zambrano, Michael E. W. Varnum
Summary: This study adopts an evolutionary approach to examine the variations of fundamental social motives across human societies. By collecting data from 42 countries, the researchers are able to compare the differences and similarities in people's social motives across different cultures and time points.
Editorial Material
Immunology
Bianka Karshikoff, Mats Lekander, Julie Lasselin
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Correction
Multidisciplinary Sciences
Cari M. Pick, Ahra Ko, Douglas T. Kenrick, Adi Wiezel, Alexandra S. Wormley, Edmond Awad, Laith Al-Shawaf, Oumar Barry, Yoella Bereby-Meyer, Watcharaporn Boonyasiriwat, Eduard Brandstatter, Suzan Ceylan-Batur, Bryan K. C. Choy, Ana Carla Crispim, Julio Eduardo Cruz, Daniel David, Oana A. David, Renata Pereira Defelipe, Pinar Elmas, Agustin Espinosa, Ana Maria Fernandez, Velichko H. Fetvadjiev, Stefka Fetvadjieva, Ronald Fischer, Silvia Galdi, Oscar Javier Galindo-Caballero, Elena V. Golovina, Galina M. Golovina, Luis Gomez-Jacinto, Sylvie Graf, Igor Grossmann, Pelin Gul, Peter Halama, Takeshi Hamamura, Shihui Han, Lina S. Hansson, Hidefumi Hitokoto, Martina Hrebickova, Darinka Ilic, Jennifer Lee Johnson, Mane Kara-Yakoubian, Johannes A. Karl, Jinseok P. Kim, Michal Kohut, Julie Lasselin, Hwaryung Lee, Norman P. Li, Anthonieta Looman Mafra, Oksana Malanchuk, Simone Moran, Asuka Murata, Jinkyung Na, Serigne Abdou Lahat Ndiaye, O. Jiaqing, Ike E. Onyishi, Eddieson Pasay-an, Muhammed Rizwan, Eric Roth, Sergio Salgado, Elena S. Samoylenko, Tatyana N. Savchenko, Catarina Sette, A. Timur Sevincer, Eric Skoog, Adrian Stanciu, Eunkook M. Suh, Daniel Sznycer, Thomas Talhelm, Fabian O. Ugwu, Ayse K. Uskul, Irem Uz, Jaroslava Varella Valentova, Marco Antonio Correa Varella, Liuqing Wei, Danilo Zambrano, Michael E. W. Varnum
Editorial Material
Psychology, Biological
Julie Lasselin, Manfred Schedlowski
BIOLOGICAL PSYCHOLOGY
(2023)
Article
Immunology
Anna Andreasson, Arnaud Tognetti, Mike Jones, Mats Lekander, Julie Lasselin
Summary: The French translation of SicknessQ was evaluated in this study, and the results showed that this questionnaire is applicable in measuring sickness behavior in French-speaking populations.
BRAIN BEHAVIOR & IMMUNITY-HEALTH
(2023)
Article
Immunology
Julie Lasselin
Summary: The author explores the complexity and individual differences in inflammation-induced sickness behavior, advocating for a detailed study of its components and highlighting the potential interaction of psychosocial factors with inflammation. Encouraging psychoneuroimmunologists to return to the basic science of sickness behavior, the author emphasizes the importance of understanding and researching the intricacies of behavioral responses to inflammation.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2021)