Article
Neurosciences
Gustavo Sudre, Luke Norman, Marine Bouyssi-Kobar, Jolie Price, Gauri Ganesh Shastri, Philip Shaw
Summary: In this study, a mega-analysis was conducted on more than 6000 participants, revealing differences in the structural connections formed by the brain's white matter tracts in individuals with ADHD. These differences were not found in relation to mood, anxiety, or other externalizing problems. The small effect sizes of the ADHD-associated microstructural differences highlight the limited clinical utility of this imaging modality when used alone.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Elisabeth Burnor, Dora Cserbik, Devyn L. Cotter, Clare E. Palmer, Hedyeh Ahmadi, Sandrah P. Eckel, Kiros Berhane, Rob McConnell, Jiu-Chiuan Chen, Joel Schwartz, Raymond Jackson, Megan M. Herting
Summary: The study suggests that annual exposure to PM2.5 during childhood is associated with increased restricted isotropic diffusion and decreased mean diffusivity of specific white matter tracts, potentially reflecting differences in the composition of white matter microarchitecture.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chunxiang Zhang, Xin Zhao, Zitao Zhu, Kaiyu Wang, Brianna F. Moon, Bohao Zhang, Sayed Noman Sadat, Jinxia Guo, Jieaoxue Bao, Ding Zhang, Xiaoan Zhang
Summary: This study aimed to investigate the value of diffusion tensor imaging (DTI) combined with serum C-reactive protein (CRP) and procalcitonin (PCT) in evaluating alterations of white matter (WM) microstructure in preterm infants with necrotizing enterocolitis (NEC). The results showed that preterm infants with NEC had reduced FA values and elevated MD values in specific WM regions, and these changes were correlated with serum CRP and PCT levels. The combination of WM, CRP, and PCT showed improved performance in detecting and evaluating WM microstructure alterations in preterm infants with NEC.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Clinical Neurology
Qiuying Tao, Jinghan Dang, Xiaoyu Niu, Xinyu Gao, Mengzhe Zhang, Zhengui Yang, Yinhuan Xu, Miaomiao Yu, Jingliang Cheng, Shaoqiang Han, Yong Zhang
Summary: This study conducted a comprehensive meta-analysis using correlated coordinate data to explore abnormalities in white matter microarchitecture and changes in gray matter volume in patients with obsessive-compulsive disorder (OCD). The results showed that OCD patients had altered white matter in regions such as the right lenticular nucleus, corpus callosum, left insula, right cerebellum, gyrus rectal, and left inferior parietal gyri. Additionally, the gray matter volume of OCD patients was found to be increased in the left striatum and left precentral gyrus, and decreased in the right inferior frontal gyrus triangular part, right superior temporal gyrus, and right hippocampus.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neuroimaging
Qihui Niu, Jianyu Li, Lei Yang, Zitong Huang, Mingmin Niu, Xueqin Song, Yuanchao Zhang, Youhui Li
Summary: In this study, the researchers investigated alterations in intracortical myelin and white matter microstructure in patients with obsessive-compulsive disorder (OCD). They found that OCD patients exhibited abnormal intracortical myelination and reduced white matter microstructure. These abnormalities may contribute to the disrupted brain connectivity and inhibitory control in OCD.
NEUROIMAGE-CLINICAL
(2022)
Article
Behavioral Sciences
Lillian M. Dipnall, Danah Hourani, Simone Darling, Vicki Anderson, Emma Sciberras, Timothy J. Silk
Summary: This study aimed to investigate the relationship between white matter organization and working memory in children with ADHD. The results showed that children with ADHD had poorer working memory, smaller volume, and lower AFD of the left SLF-II compared to healthy controls. Further analysis revealed that volume of the left SLF-II mediated the relationship between ADHD and working memory performance.
Article
Genetics & Heredity
Chun-Hung Yeh, Rung-Yu Tseng, Hsing-Chang Ni, Luca Cocchi, Jung-Chi Chang, Mei-Yun Hsu, En-Nien Tu, Yu-Yu Wu, Tai-Li Chou, Susan Shur-Fen Gau, Hsiang-Yuan Lin
Summary: This study aims to provide a comprehensive understanding of white matter alterations in individuals with autism spectrum disorder (ASD), particularly those with intellectual impairment (II) and/or minimally verbal (MV) status. The results suggest that ASD patients show specific white matter changes that are associated with symptoms and cognitive abilities.
Article
Multidisciplinary Sciences
Dong-Kyun Lee, Hyeongrae Lee, Vin Ryu, Sung-Wan Kim, Seunghyong Ryu
Summary: This study found that alterations in white matter microstructure may be a common neuroanatomical characteristic of bipolar disorder, regardless of being psychotic or non-psychotic. Both psychotic and non-psychotic bipolar disorder patients showed decreased fractional anisotropy (FA) and increased mean diffusion (MD) in certain white matter areas compared to healthy controls. However, psychotic bipolar disorder patients showed more widespread connectivity disruptions in the brain.
Review
Immunology
Enling He, Min Liu, Sizhu Gong, Xiyao Fu, Yue Han, Fang Deng
Summary: Depressive disorder is closely related to white matter changes, which may be caused by impaired cerebral blood flow, blood-brain barrier dysfunction, inflammatory factors, genes, and environmental factors. White matter changes are associated with clinical variables such as diagnosis, severity, and treatment efficacy in patients with depression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Guang-Hui Fu, Wai Chen, Hai-Mei Li, Yu-Feng Wang, Lu Liu, Qiu-Jin Qian
Summary: This study investigated the potential roles of lncRNAs in the genetic etiology of ADHD and provided preliminary evidence supporting the involvement of RNF219-AS1 in the pathophysiology of ADHD in line with the RDoC framework.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Genetics & Heredity
Christina Andica, Koji Kamagata, Eiji Kirino, Wataru Uchida, Ryusuke Irie, Syo Murata, Shigeki Aoki
Summary: Evidence suggests that specific NODDI measures are strongly associated with white matter microstructural changes in autism, potentially offering higher accuracy and specificity in diagnosing and assessing the condition's behavioral characteristics compared to traditional DTI measures.
Article
Neuroimaging
Sangma Xie, Junjie Zhuo, Ming Song, Congying Chu, Yue Cui, Yunchun Chen, Huaning Wang, Lihua Li, Tianzi Jiang
Summary: This study found that there are alterations in the peripheral regions of white matter tracts in schizophrenia patients, as evidenced by higher diffusivity values. However, there are no significant differences in the core regions of these tracts. Furthermore, unaffected first-degree relatives of schizophrenia patients show differences in diffusivity values in specific tracts, indicating a genetic vulnerability.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Clinical Neurology
Komal Bharti, Giulia Conte, Silvia Tommasin, Costanza Gianni, Antonio Suppa, Giovanni Mirabella, Francesco Cardona, Patrizia Pantano
Summary: This study compared early structural white matter changes in drug-naive children with Tourette syndrome (TS) and early-onset obsessive-compulsive disorder (OCD) using diffusion tensor imaging (DTI). The results showed different alterations in white matter microstructure in TS with or without OCD compared to OCD alone, suggesting that TS+OCD is a subtype of TS while OCD has independent pathophysiological mechanisms affecting white matter development.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Dong Dong, Koichi Hosomi, Nobuhiko Mori, Yoshi-ichiro Kamijo, Yohei Furotani, Daisuke Yamagami, Yu-ichiro Ohnishi, Yoshiyuki Watanabe, Takeshi Nakamura, Fumihiro Tajima, Haruhiko Kishima, Youichi Saitoh
Summary: Through contrastive analysis, we identified white matter brain regions that show microstructural changes in patients with neuropathic pain (NP) after spinal cord injury (SCI). The results showed that compared to the non-NP group, the NP group exhibited higher values of FA in the posterior body and splenium of the corpus callosum, which may be related to central sensitization or network hyperexcitability.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Riccardo Manca, Sarah A. Jones, Annalena Venneri
Summary: Apathy is a common symptom in Alzheimer's disease and this study investigates the relationship between white matter damage and apathy. The study finds that apathetic patients have more severe neuropsychiatric symptoms and increased white matter damage. This damage may disrupt communication between different functional networks, resulting in motivational deficits and cognitive decline.
Correction
Psychology, Clinical
Pascal-M Aggensteiner, Nathalie E. Holz, Boris W. Bottinger, Sarah Baumeister, Sarah Hohmann, Julia E. Werhahn, Jilly Naaijen, Shahrzad Ilbegi, Jeffrey C. Glennon, Pieter J. Hoekstra, Andrea Dietrich, Renee Kleine Deters, Melanie C. Saam, Ulrike M. E. Schulze, David J. Lythgoe, Arjun Sethi, Michael C. Craig, Mathilde Mastroianni, Ilyas Sagar-Ouriaghli, Paramala J. Santosh, Mireia Rosa, Nuria Bargallo, Josefina Castro-Fornieles, Celso Arango, Maria J. Penzol, Jorge Vidal, Barbara Franke, Marcel P. Zwiers, Jan K. Buitelaar, Susanne Walitza, Tobias Banaschewski, Daniel Brandeis
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Jianfeng Zhang, Dong-Qiang Liu, Shufang Qian, Xiujuan Qu, Peiwen Zhang, Nai Ding, Yu-Feng Zang
Summary: This study investigates the neural correlates of fMRI-ALFF by comparing the amplitude differences between eyes-closed and eyes-open states in fMRI and MEG. The results show that MEG-ALFF increases at parietal sensors, overlapping with the EC-EO differences observed in fMRI. These findings suggest that the amplitude in MEG reflects distinct physiological information and that fMRI-ALFF may be related to the ALFF in neural activity.
Article
Psychology, Clinical
Nathalie E. Holz, Dorothea L. Floris, Alberto Llera, Pascal M. Aggensteiner, Seyed Mostafa Kia, Thomas Wolfers, Sarah Baumeister, Boris Boettinger, Jeffrey C. Glennon, Pieter J. Hoekstra, Andrea Dietrich, Melanie C. Saam, Ulrike M. E. Schulze, David J. Lythgoe, Steve C. R. Williams, Paramala Santosh, Mireia Rosa-Justicia, Nuria Bargallo, Josefina Castro-Fornieles, Celso Arango, Maria J. Penzol, Susanne Walitza, Andreas Meyer-Lindenberg, Marcel Zwiers, Barbara Franke, Jan Buitelaar, Jilly Naaijen, Daniel Brandeis, Christian Beckmann, Tobias Banaschewski, Andre F. Marquand
Summary: This study aimed to reveal the neurobiological characteristics of disruptive behavior disorders (DBD) by integrating individual deviation patterns from multiple imaging modalities. The results showed that DBD patients exhibited increased age-related deviations in the amygdala, suggesting a possible maturational delay. Furthermore, the study identified neural signatures associated with aggression, including the default mode network (DMN), striatum, and amygdala.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychology, Developmental
Edmund J. S. Sonuga-Barke, Stephen P. Becker, Sven Bolte, Francisco Xavier Castellanos, Barbara Franke, Jeffrey H. Newcorn, Joel T. Nigg, Luis Augusto Rohde, Emily Simonoff
Summary: The article provides a comprehensive overview of the scientific field of ADHD, covering clinical characteristics, risk factors, causal processes, and neurobiological pathways. The authors also discuss the future of the ADHD construct in light of recent conceptual reformulations.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Neurosciences
Juan Yue, Na Zhao, Yang Qiao, Zi-Jian Feng, Yun-Song Hu, Qiu Ge, Tian-Qing Zhang, Zhu-Qian Zhang, Jue Wang, Yu-Feng Zang
Summary: This study tested the reliability and validity of a new functional magnetic resonance imaging (fMRI) metric called Wavelet-ALFF, and applied it to investigate the modulation effect of repetitive transcranial magnetic stimulation (rTMS). The results showed that Wavelet-ALFF had higher reliability and validity compared to the previous metric FFT-ALFF, especially in higher frequency bands. Wavelet db2-ALFF showed the best reliability and validity, suggesting it can be a powerful tool for examining regional spontaneous brain activities in future studies.
HUMAN BRAIN MAPPING
(2023)
Article
Genetics & Heredity
Ditte Demontis, G. Bragi Walters, Georgios Athanasiadis, Raymond Walters, Karen Therrien, Trine Tollerup Nielsen, Leila Farajzadeh, Georgios Voloudakis, Jaroslav Bendl, Biau Zeng, Wen Zhang, Jakob Grove, Thomas D. Als, Jinjie Duan, F. Kyle Satterstrom, Jonas Bybjerg-Grauholm, Marie Baekved-Hansen, Olafur O. Gudmundsson, Sigurdur H. Magnusson, Gisli Baldursson, Katrin Davidsdottir, Gyda S. Haraldsdottir, Esben Agerbo, Gabriel E. Hoffman, Soren Dalsgaard, Joanna Martin, Marta Ribases, Dorret Boomsma, Maria Soler Artigas, Nina Roth Mota, Daniel Howrigan, Sarah E. Medland, Tetyana Zayats, Veera M. Rajagopal, Merete Nordentoft, Ole Mors, David M. Hougaard, Preben Bo Mortensen, Mark J. Daly, Stephen Faraone, Hreinn Stefansson, Panos Roussos, Barbara Franke, Thomas Werge, Benjamin M. Neale, Kari Stefansson, Anders D. Borglum
Summary: This study conducted a meta-analysis of genome-wide association studies on ADHD and identified 27 significant genetic loci associated with ADHD. They also found that these loci were enriched with genes involved in early brain development. Moreover, they discovered an increased load of rare protein-truncating variants in ADHD, implicating SORCS3 as a potential gene involved in ADHD.
Review
Behavioral Sciences
Mandy Meijer, Barbara Franke, Carmen Sandi, Marieke Klein
Summary: DNA methylation is an important epigenetic mechanism that plays a role in the interaction between genes and the environment, and is associated with externalizing behaviors and psychiatric disorders. Previous studies on externalizing behaviors have been limited in sample size, leading to a lack of candidate genes and biomarkers with strong evidence. In this study, we conducted a systematic literature review and identified candidate genes and biological systems for attention-deficit/hyperactivity disorder (ADHD) and aggressive behaviors based on epigenome-wide association studies (EWAS) conducted in peripheral tissue and cord blood. The findings suggest the involvement of neuronal processes and cell marker genes in ADHD, and the relevance of astrocytes and granulocytes to both ADHD and aggression-related behaviors. Only a small proportion of the significant epigenetic findings can be directly explained by genetic factors associated with ADHD. Larger sample sizes and harmonization of assessment instruments are needed to advance the field.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Genetics & Heredity
Yingjie Shi, Emma Sprooten, Peter Mulders, Janna Vrijsen, Janita Bralten, Ditte Demontis, Anders D. Borglum, G. Bragi Walters, Kari Stefansson, Philip van Eijndhoven, Indira Tendolkar, Barbara Franke, Nina Roth Mota
Summary: This study examines the genetic liability for eight major psychiatric disorders using a dimensional framework. The findings show that the genetic predisposition for depression is primarily reflected in the negative valence domain. This study adds evidence to the ongoing discussion about the misalignment between current psychiatric classification and genetic etiology.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2023)
Meeting Abstract
Neurosciences
Yingjie Shi, Nina Roth Mota, Ditte Demontis, Anders Borglum, Barbara Franke, Emma Sprooten
BIOLOGICAL PSYCHIATRY
(2023)
Article
Neuroimaging
Julia E. Werhahn, Lukasz Smigielski, Seda Sacu, Susanna Mohl, David Willinger, Jilly Naaijen, Leandra M. Mulder, Jeffrey C. Glennon, Pieter J. Hoekstra, Andrea Dietrich, Renee Kleine Deters, Pascal M. Aggensteiner, Nathalie E. Holz, Sarah Baumeister, Tobias Banaschewski, Melanie C. Saam, Ulrike M. E. Schulze, David J. Lythgoe, Arjun Sethi, Michael Craig, Mathilde Mastroianni, Ilyas Sagar-Ouriaghli, Paramala J. Santosh, Mireia Rosa, Nuria Bargallo, Josefina Castro-Fornieles, Celso Arango, Maria J. Penzol, Marcel P. Zwiers, Barbara Franke, Jan K. Buitelaar, Susanne Walitza, Daniel Brandeis
Summary: This study identifies the relationship between resting state functional connectivity (rsFC) and aggression subtypes, highlighting the importance of considering comorbid symptoms. The findings suggest that hypothesis-free brain connectivity measures can disentangle distinct dimensions of aggression in youths.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Zi-Jian Feng, Qiu-Ying Song, Yu Han, Zi-Yu Wei, Cong Fu, Yu-Feng Zang
Summary: This case report investigates the short-term effects of functional connectivity-guided rTMS with coil handle orientations of posterior-anterior 45 degrees (PA45 degrees) and posterior-anterior 135 degrees (PA135 degrees) on a patient with insomnia. The results show that the PA45 degrees orientation outperforms the PA135 degrees orientation in both resting-state functional magnetic resonance imaging and motor evoked potentials outcomes. Additionally, a 9-day rTMS treatment leads to improvements in symptoms of depression and anxiety, as well as a modest enhancement in sleep quality.
CLINICAL NEUROPHYSIOLOGY PRACTICE
(2023)
Article
Neurosciences
Ashlea Segal, Linden Parkes, Kevin Aquino, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F. Beckmann, Lars T. Westlye, Ole A. Andreassen, Andrew Zalesky, Ben J. Harrison, Christopher G. Davey, Carles Soriano-Mas, Narcis Cardoner, Jeggan Tiego, Murat Yucel, Leah Braganza, Chao Suo, Michael Berk, Sue Cotton, Mark A. Bellgrove, Andre F. Marquand, Alex Fornito
Summary: Traditional case-control research often ignores the substantial individual heterogeneity among people with mental illness. This study provides a comprehensive, multiscale characterization of gray matter volume differences in six mental disorders. The results show that individual deviations in regional gray matter volume are highly heterogeneous, but some of these deviations are embedded within common functional circuits and networks.
NATURE NEUROSCIENCE
(2023)
Meeting Abstract
Mathematical & Computational Biology
Ashlea Segal, Linden Parkes, Kevin Aquino, Andrew Zalesky, Ben J. Harrison, Jeggan Tiego, Murat Yucel, Leah Braganza, Chao Suo, Mark Bellgrove, Alex Fornito, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F. Beckmann, Lars T. Westlye, Ole A. Andreassen, Christopher Davey, Carles Soriano-Mas, Narcis Cardoner, Michael Berk, Sue Cotton, Andre F. Marquand
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2023)