An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia

The NMDA receptor ‘glycine modulatory site’ in schizophrenia: d-serine, glycine, and beyond

(2015) Darrick T Balu et al.   CURRENT OPINION IN PHARMACOLOGY

In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia

(2015) Matthew D. Puhl et al.   NEUROBIOLOGY OF DISEASE

The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease

(2015) J.G. Doria et al.   NEUROBIOLOGY OF DISEASE

Biased mGlu 5 -Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu 5 Modulation of NMDAR Currents

(2015) Jerri M. Rook et al.   NEURON

Determinants of different aspects of everyday outcome in schizophrenia: The roles of negative symptoms, cognition, and functional capacity

(2015) Martin T. Strassnig et al.   SCHIZOPHRENIA RESEARCH

Hippocampal Metaplasticity Is Required for the Formation of Temporal Associative Memories

(2014) J. Xu et al.   JOURNAL OF NEUROSCIENCE

Developing treatments for cognitive deficits in schizophrenia: The challenge of translation

(2014) JW Young et al.   JOURNAL OF PSYCHOPHARMACOLOGY

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Chronic D-serine reverses arc expression and partially rescues dendritic abnormalities in a mouse model of NMDA receptor hypofunction

(2014) Darrick T. Balu et al.   NEUROCHEMISTRY INTERNATIONAL

Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus

(2014) Matildé Le Bail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bridging the interval: Theory and neurobiology of trace conditioning

(2013) Jonathan D. Raybuck et al.   BEHAVIOURAL PROCESSES

Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease

(2013) JG Doria et al.   BRITISH JOURNAL OF PHARMACOLOGY

CA1 Pyramidal Cell Theta-Burst Firing Triggers Endocannabinoid-Mediated Long-Term Depression at Both Somatic and Dendritic Inhibitory Synapses

(2013) T. J. Younts et al.   JOURNAL OF NEUROSCIENCE

The contextual brain: implications for fear conditioning, extinction and psychopathology

(2013) Stephen Maren et al.   NATURE REVIEWS NEUROSCIENCE

Development of allosteric modulators of GPCRs for treatment of CNS disorders

(2013) Hilary Highfield Nickols et al.   NEUROBIOLOGY OF DISEASE

Modulation of behavior by scaffolding proteins of the post-synaptic density

(2013) Can Gao et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction

(2013) D. T. Balu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level

(2013) Yan Li et al.   Nature Communications

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

Neuronal d-serine regulates dendritic architecture in the somatosensory cortex

(2012) Darrick T. Balu et al.   NEUROSCIENCE LETTERS

AKT/GSK3 signaling pathway and schizophrenia

(2012) Effat S. Emamian   Frontiers in Molecular Neuroscience

Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction

(2011) Darrick T. Balu et al.   BRAIN RESEARCH

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

(2011) G Kirov et al.   MOLECULAR PSYCHIATRY

Strategies to Enhance N-Methyl-D-Aspartate Receptor-Mediated Neurotransmission in Schizophrenia, a Critical Review and Meta-Analysis

(2010) Guochuan Tsai et al.   CURRENT PHARMACEUTICAL DESIGN

Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology

(2010) L. M. DeVito et al.   GENES BRAIN AND BEHAVIOR

Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia

(2010) Darrick T. Balu et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior

(2008) A C Basu et al.   MOLECULAR PSYCHIATRY