Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis

Chemoenzymatic Dynamic Kinetic Resolution: A Powerful Tool for the Preparation of Enantiomerically Pure Alcohols and Amines

(2015) Oscar Verho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combining a Clostridial Enzyme Exhibiting Unusual Active Site Plasticity with a Remarkably Facile Sigmatropic Rearrangement: Rapid, Stereocontrolled Entry into Densely Functionalized Fluorinated Phosphonates for Chemical Biology

(2015) Kaushik Panigrahi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expanding the Scope of Alcohol Dehydrogenases towards Bulkier Substrates: Stereo- and Enantiopreference for α,α-Dihalogenated Ketones

(2014) Kinga Kędziora et al.   ChemCatChem

Baker's-Yeast-Mediated Reduction of Sulfur-Containing Compounds

(2014) Rebecca E. Deasy et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Unexpected Beneficial Effect of ortho-Substituents on the (S)-Proline-Catalyzed Asymmetric Aldol Reaction of Acetone with Aromatic Aldehydes

(2014) Benjamin List et al.   SYNLETT

Baker’s Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane

(2014) Rebecca Deasy et al.   Catalysts

Expanding dynamic kinetic protocols: transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives

(2013) Aníbal Cuetos et al.   CHEMICAL COMMUNICATIONS

Substrate-Dependent Stereospecificity of Tyl-KR1: An Isolated Polyketide Synthase Ketoreductase Domain fromStreptomyces fradiae

(2013) Matthias Häckh et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biocatalytic retrosynthesis

(2013) Nicholas J Turner et al.   Nature Chemical Biology

Asymmetric Synthesis of cis-2,5-Disubstituted Pyrrolidine, the Core Scaffold of β3-AR Agonists

(2013) Feng Xu et al.   ORGANIC LETTERS

One-Pot Synthesis of Enantiopure 3,4-Dihydroisocoumarins through Dynamic Reductive Kinetic Resolution Processes

(2013) Juan Mangas-Sánchez et al.   ORGANIC LETTERS

A Highly Productive, Whole-Cell DERA Chemoenzymatic Process for Production of Key Lactonized Side-Chain Intermediates in Statin Synthesis

(2013) Matej Ošlaj et al.   PLoS One

Cobalt Precursors for High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation Catalysts

(2013) M. R. Friedfeld et al.   SCIENCE

Preparative access to medicinal chemistry related chiral alcohols using carbonyl reductase technology

(2013) Andrew S. Rowan et al.   TETRAHEDRON-ASYMMETRY

Dynamic Kinetic ResolutionviaHydrolase-Metal Combo Catalysis in Stereoselective Synthesis of Bioactive Compounds

(2012) Pilar Hoyos et al.   ADVANCED SYNTHESIS & CATALYSIS

Access to Enantiopure α-Alkyl-β-hydroxy Esters through Dynamic Kinetic Resolutions Employing Purified/Overexpressed Alcohol Dehydrogenases

(2012) Aníbal Cuetos et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Hydrogenation of α,α′-Disubstituted Cycloketones through Dynamic Kinetic Resolution: An Efficient Construction of Chiral Diols with Three Contiguous Stereocenters

(2012) Chong Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Benzaldehyde lyase-catalyzed diastereoselective C–C bond formation by simultaneous carboligation and kinetic resolution

(2012) Christoph R. Müller et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Halocarbocyclization Entry into the Oxabicyclo[4.3.1]decyl Exomethylene-δ-Lactone Cores of Linearifolin and Zaluzanin A: Exploiting Combinatorial Catalysis

(2012) Sandeep K. Ginotra et al.   ORGANIC LETTERS

Enantioselective organocatalytic aldol reaction using small organic molecules

(2012) Vishnumaya Bisai et al.   TETRAHEDRON

Organocatalyzed Dynamic Kinetic Resolution

(2011) Hélène Pellissier   ADVANCED SYNTHESIS & CATALYSIS

Enantioenriched Compounds via Enzyme-Catalyzed Redox Reactions

(2011) Mélanie Hall et al.   CHEMICAL REVIEWS

Chemoenzymatic Synthesis of Stegobinone and Stegobiol, Components of the Natural Sex Pheromone of the Drugstore Beetle (Stegobium paniceum L.)

(2011) Dimitris Kalaitzakis et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enzymatic reductions for the chemist

(2011) Frank Hollmann et al.   GREEN CHEMISTRY

Recent developments in dynamic kinetic resolution

(2011) Hélène Pellissier   TETRAHEDRON

Asymmetric synthesis of (−)-fosfomycin and its trans-(1S,2S)-diastereomer using a biocatalytic reduction as the key step

(2011) Christian P. Marocco et al.   TETRAHEDRON-ASYMMETRY

Recent advances in alcohol dehydrogenase-catalyzed asymmetric production of hydrophobic alcohols

(2011) Musa M. Musa et al.   Catalysis Science & Technology

Dynamic Kinetic Resolution of Amines and Amino Acids by Enzyme-Metal Cocatalysis

(2010) Yunwoong Kim et al.   ChemCatChem

A new dehydrogenase from Clostridium acetobutylicum for asymmetric synthesis: dynamic reductive kinetic resolution entry into the Taxotère side chain

(2010) Gregory A. Applegate et al.   CHEMICAL COMMUNICATIONS

A Two-Step, One-Pot Enzymatic Synthesis of 2-Substituted 1,3-Diols

(2010) Dimitris Kalaitzakis et al.   JOURNAL OF ORGANIC CHEMISTRY

Use of a Robust Dehydrogenase from an Archael Hyperthermophile in Asymmetric Catalysis−Dynamic Reductive Kinetic Resolution Entry into (S)-Profens

(2010) Jacob A. Friest et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoenzymatic synthesis of (2S)-2-arylpropanols through a dynamic kinetic resolution of 2-arylpropanals with alcohol dehydrogenases

(2010) Paola Galletti et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of All-Carbon, Quaternary Center-Containing Cyclohexenones through an Organocatalyzed, Multicomponent Coupling

(2010) Hua Yang et al.   ORGANIC LETTERS

Asymmetric phosphorylation through catalytic P(III) phosphoramidite transfer: Enantioselective synthesis of D-myo-inositol-6-phosphate

(2010) P. A. Jordan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Asymmetric Bromination

(2010) J. L. Gustafson et al.   SCIENCE

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Stereoselective Synthesis of Three Isomers of tert-Butyl 5-Hydroxy-4-methyl-3-oxohexanoate through Alcohol Dehydrogenase-Catalyzed Dynamic Kinetic Resolution

(2009) Steffen Lüdeke et al.   ADVANCED SYNTHESIS & CATALYSIS

Directed Evolution and Structural Characterization of a Simvastatin Synthase

(2009) Xue Gao et al.   CHEMISTRY & BIOLOGY

Chemoenzymatic Dynamic Kinetic Resolution of Alcohols and Amines

(2009) Jin Hee Lee et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Biocatalytic synthesis of atorvastatin intermediates

(2009) Jay M. Patel   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Synthesis of Optically Active Amino Acid Derivatives via Dynamic Kinetic Resolution

(2009) Yoon Kyung Choi et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Efficient Asymmetric Synthesis of Sitagliptin

(2009) Karl B. Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel fungi-catalyzed reduction of α-alkyl-β-keto esters

(2009) Silvana P. Ravía et al.   TETRAHEDRON-ASYMMETRY

Recent progress in biocatalysis for asymmetric oxidation and reduction

(2009) Tomoko Matsuda et al.   TETRAHEDRON-ASYMMETRY

Chemoenzymatic synthesis of the chiral side-chain of statins: application of an alcohol dehydrogenase catalysed ketone reduction on a large scale

(2008) Michael Wolberg et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Chemoenzymatic and microbial dynamic kinetic resolutions

(2008) Azlina Harun Kamaruddin et al.   CHIRALITY

Lessons from Nature: Biomimetic Organocatalytic Carbon−Carbon Bond Formations§

(2008) Dieter Enders et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective, Ketoreductase-Based Entry into Pharmaceutical Building Blocks: Ethanol as Tunable Nicotinamide Reductant

(2008) Sylvain Broussy et al.   ORGANIC LETTERS

Development of a Chemoenzymatic Manufacturing Process for Pregabalin

(2008) Carlos A. Martinez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalyzed Reactions in Optically Active Phosphonate Synthesis

(2008) Ewa Żymańczyk-Duda   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS